| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukari Takeda, Takao Shimayoshi, George G Holz, Akinori Nom. Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells. American journal of physiology. Cell physiology. vol 310. issue 5. 2016-08-01. PMID:26741144. |
glucagon-like peptide-1 (glp-1) is an intestinally derived blood glucose-lowering hormone that potentiates glucose-stimulated insulin secretion from pancreatic β-cells. |
2016-08-01 |
2023-08-13 |
mouse |
| Yukari Takeda, Takao Shimayoshi, George G Holz, Akinori Nom. Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells. American journal of physiology. Cell physiology. vol 310. issue 5. 2016-08-01. PMID:26741144. |
it also served to drive and pace ca(2+) oscillations that are significant when evaluating how glp-1 stimulates insulin secretion. |
2016-08-01 |
2023-08-13 |
mouse |
| Emily M Hawes, Joseph Wehby, Anne Mounse. What next when metformin isn't enough for type 2 diabetes? The Journal of family practice. vol 65. issue 2. 2016-08-01. PMID:26977458. |
this patient-centered case vignette offers insight into how best to choose among additional oral agents, basal insulin, or the newer glp-1 receptor agonists. |
2016-08-01 |
2023-08-13 |
Not clear |
| Gloria Torres, Pablo E Morales, Marina García-Miguel, Ignacio Norambuena-Soto, Benjamín Cartes-Saavedra, Gonzalo Vidal-Peña, David Moncada-Ruff, Fernanda Sanhueza-Olivares, Alejandra San Martín, Mario Chion. Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochemical pharmacology. vol 104. 2016-07-19. PMID:26807480. |
glp-1 plays a very important role in the glucose homeostasis by stimulating glucose-dependent insulin secretion, inhibiting glucagon secretion, inhibiting gastric emptying, reducing appetite and food intake. |
2016-07-19 |
2023-08-13 |
Not clear |
| Mark M Smits, Daniel H van Raalte, Lennart Tonneijck, Marcel H A Muskiet, Mark H H Kramer, Djuna L Cahe. GLP-1 based therapies: clinical implications for gastroenterologists. Gut. vol 65. issue 4. 2016-07-18. PMID:26786687. |
the gut-derived incretin hormone, glucagon-like peptide 1 (glp-1) lowers postprandial blood glucose levels by stimulating insulin and inhibiting glucagon secretion. |
2016-07-18 |
2023-08-13 |
Not clear |
| Rajeev Jai. Utility of Saxagliptin in the Treatment of Type 2 Diabetes: Review of Efficacy and Safety. Advances in therapy. vol 32. issue 11. 2016-07-12. PMID:26578430. |
the intestinal hormone, glucagon-like peptide-1 (glp-1), secreted in response to nutrient ingestion, increases insulin secretion from pancreatic β-cells and reduces glucagon secretion from pancreatic α-cells. |
2016-07-12 |
2023-08-13 |
Not clear |
| Rajeev Jai. Utility of Saxagliptin in the Treatment of Type 2 Diabetes: Review of Efficacy and Safety. Advances in therapy. vol 32. issue 11. 2016-07-12. PMID:26578430. |
saxagliptin is a dpp-4 inhibitor that prevents the degradation of endogenous glp-1 and prolongs its actions on insulin and glucagon secretion. |
2016-07-12 |
2023-08-13 |
Not clear |
| Deepak K Rajpal, Jean-Louis Klein, David Mayhew, Joyce Boucheron, Aaron T Spivak, Vinod Kumar, Karen Ingraham, Mark Paulik, Lihong Chen, Stephanie Van Horn, Elizabeth Thomas, Ganesh Sathe, George P Livi, David J Holmes, James R Brow. Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models. PloS one. vol 10. issue 12. 2016-07-06. PMID:26709835. |
however, only ceftazidime showed significant, dose dependent improvement in key metabolic variables including glucose, insulin, protein tyrosine tyrosine (pyy) and glucagon-like peptide-1 (glp-1). |
2016-07-06 |
2023-08-13 |
mouse |
| Fumiyo Kubo, Takeshi Miyatsuka, Shugo Sasaki, Mitsuyoshi Takahara, Yuichi Yamamoto, Naoki Shimo, Hirotaka Watada, Hideaki Kaneto, Maureen Gannon, Taka-aki Matsuoka, Iichiro Shimomur. Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice. Biochemical and biophysical research communications. vol 471. issue 1. 2016-07-06. PMID:26854076. |
glucagon-like peptide 1 (glp-1) has been shown to play important roles in maintaining β-cell functions, such as insulin secretion and proliferation. |
2016-07-06 |
2023-08-13 |
mouse |
| Santina Bruzzone, Mirko Magnone, Elena Mannino, Giovanna Sociali, Laura Sturla, Chiara Fresia, Valeria Booz, Laura Emionite, Antonio De Flora, Elena Zocch. Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats. PloS one. vol 10. issue 10. 2016-06-30. PMID:26488296. |
in addition, oral administration of aba significantly increased plasma glp-1 and insulin levels in rats. |
2016-06-30 |
2023-08-13 |
human |
| Gian Paolo Fadini, Mattia Albiero, Angelo Avogar. Direct effects of DPP-4 inhibition on the vasculature. Reconciling basic evidence with lack of clinical evidence. Vascular pharmacology. vol 73. 2016-06-29. PMID:26254108. |
dipeptidyl peptidase-4 inhibitors (dpp-4i) lower blood glucose by protecting the incretin hormone glucagon-like peptide-1 (glp-1) from enzymatic degradation, thereby restoring meal-stimulated insulin release. |
2016-06-29 |
2023-08-13 |
Not clear |
| Kirsten Kampmann, Sandra Ueberberg, Bjoern A Menge, Thomas G K Breuer, Waldemar Uhl, Andrea Tannapfel, Juris J Meie. Abundance and turnover of GLP-1 producing L-cells in ileal mucosa are not different in patients with and without type 2 diabetes. Metabolism: clinical and experimental. vol 65. issue 3. 2016-06-29. PMID:26892519. |
the gastrointestinal hormone glp-1 is released from enteroendocrine l-cells and augments postprandial insulin secretion. |
2016-06-29 |
2023-08-13 |
Not clear |
| Hyeon-Kyu Go, Md Mahbubur Rahman, Gi-Beum Kim, Chong-Sam Na, Choon-Ho Song, Jin-Shang Kim, Shang-Jin Kim, Hyung-Sub Kan. Antidiabetic Effects of Yam (Dioscorea batatas) and Its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-Induced Diabetes. Nutrients. vol 7. issue 10. 2016-06-28. PMID:26501316. |
the objective of this study was to investigate the therapeutic efficacies of crude yam (dioscorea batatas) powder (py), water extract of yam (ey), and allantoin (the active constituent of yam) in streptozotocin (stz)-induced diabetic rats with respect to glucose, insulin, glucagon-like peptide-1 (glp-1), c-peptide, glycated hemoglobin (hbalc), lipid metabolism, and oxidative stress. |
2016-06-28 |
2023-08-13 |
rat |
| Hyeon-Kyu Go, Md Mahbubur Rahman, Gi-Beum Kim, Chong-Sam Na, Choon-Ho Song, Jin-Shang Kim, Shang-Jin Kim, Hyung-Sub Kan. Antidiabetic Effects of Yam (Dioscorea batatas) and Its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-Induced Diabetes. Nutrients. vol 7. issue 10. 2016-06-28. PMID:26501316. |
there were also significant increases (p < 0.001) in insulin (100% as 0.22 ± 0.00 ng/ml, 173%, 209%, and 177%), glp-1 (100% as 18.4 ± 0.7 pmol/ml, 160%, 166%, and 162%), and c-peptide (100% as 2.56 ± 0.10 ng/ml, 129%, 132%, and 130%). |
2016-06-28 |
2023-08-13 |
rat |
| Hyeon-Kyu Go, Md Mahbubur Rahman, Gi-Beum Kim, Chong-Sam Na, Choon-Ho Song, Jin-Shang Kim, Shang-Jin Kim, Hyung-Sub Kan. Antidiabetic Effects of Yam (Dioscorea batatas) and Its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-Induced Diabetes. Nutrients. vol 7. issue 10. 2016-06-28. PMID:26501316. |
the results indicate that yam and allantoin have antidiabetic effects by modulating antioxidant activities, lipid profiles and by promoting the release of glp-1, thereby improving the function of β-cells maintaining normal insulin and glucose levels. |
2016-06-28 |
2023-08-13 |
rat |
| Yu Mi Kang, Chang Hee Jun. Cardiovascular Effects of Glucagon-Like Peptide-1 Receptor Agonists. Endocrinology and metabolism (Seoul, Korea). vol 31. issue 2. 2016-06-28. PMID:27118277. |
the benefits of glp-1 ras are derived from their pleiotropic effects, which include glucose-dependent insulin secretion, suppressed glucagon secretion, and reduced appetite. |
2016-06-28 |
2023-08-13 |
human |
| Alastair D Green, Srividya Vasu, Neville H McClenaghan, Peter R Flat. Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Archiv : European journal of physiology. vol 467. issue 10. 2016-06-27. PMID:25559846. |
incubation with the incretin gut hormones glp-1 and gip caused dose-dependent stimulation of insulin secretion from 1.1b4 cell monolayers and pseudoislets. |
2016-06-27 |
2023-08-13 |
human |
| Nagendra Yaluri, Shalem Modi, Maykel López Rodríguez, Alena Stančáková, Johanna Kuusisto, Tarja Kokkola, Markku Laaks. Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells. PloS one. vol 10. issue 11. 2016-06-27. PMID:26561346. |
impaired insulin secretion caused by simvastatin treatment were efficiently restored by gpr119 or glp-1 receptor stimulation and by direct activation of camp-dependent signaling pathways with forskolin. |
2016-06-27 |
2023-08-13 |
mouse |
| Huinan Zhang, Jingru Meng, Xubo Li, Shimeng Zhou, Di Qu, Ning Wang, Min Jia, Xue Ma, Xiaoxing Lu. Pro-GLP-1, a Pro-drug of GLP-1, is neuroprotective in cerebral ischemia. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 70. 2016-06-24. PMID:25640912. |
however, pro-glp-1 had no effect on blood glucose and insulin levels which indicated that neuroprotection was mediated by the activation of glp-1 receptor in the brain. |
2016-06-24 |
2023-08-13 |
mouse |
| P V Svidnicki, N de Carvalho Leite, A C Venturelli, R L Camargo, M R Vicari, M C de Almeida, R F Artoni, V Nogaroto, S Grassioll. Swim training restores glucagon-like peptide-1 insulinotropic action in pancreatic islets from monosodium glutamate-obese rats. Acta physiologica (Oxford, England). vol 209. issue 1. 2016-06-17. PMID:23746147. |
glucagon-like peptide-1 (glp-1) is an important modulator of insulin secretion by endocrine pancreas. |
2016-06-17 |
2023-08-12 |
rat |