| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Willy Marcos Valencia, Hermes Jose Flore. A new angle for glp-1 receptor agonist: the medical economics argument. Editorial on: Huetson P, Palmer JL, Levorsen A, et al. Cost-effectiveness of the once-daily glp-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway. J Med Econ 2015: 1-13 [Epub ahead of print]. Journal of medical economics. vol 18. issue 12. 2016-08-24. PMID:26337323. |
cost-effectiveness of the once-daily glp-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in norway. |
2016-08-24 |
2023-08-13 |
Not clear |
| Willy Marcos Valencia, Hermes Jose Flore. A new angle for glp-1 receptor agonist: the medical economics argument. Editorial on: Huetson P, Palmer JL, Levorsen A, et al. Cost-effectiveness of the once-daily glp-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway. J Med Econ 2015: 1-13 [Epub ahead of print]. Journal of medical economics. vol 18. issue 12. 2016-08-24. PMID:26337323. |
glp-1 ra are effective in combination with insulin, and even slightly superior or at least equal to short-acting insulin in t2d; however, since they work in the incretin system, they may not be effective in long-standing disease. |
2016-08-24 |
2023-08-13 |
Not clear |
| Maria S Svane, Kirstine N Bojsen-Møller, Signe Nielsen, Nils B Jørgensen, Carsten Dirksen, Flemming Bendtsen, Viggo B Kristiansen, Bolette Hartmann, Jens J Holst, Sten Madsba. Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery. American journal of physiology. Endocrinology and metabolism. vol 310. issue 7. 2016-08-23. PMID:26786780. |
this study confirms the importance of glp-1 for glucose tolerance after rygb via increased insulin and attenuated glucagon secretion in the postprandial state, whereas amplification of the gip signal (or other dpp-4-sensitive glucose-lowering mechanisms) did not appear to contribute to the improved glucose tolerance seen after rygb. |
2016-08-23 |
2023-08-13 |
Not clear |
| Francesca Urbano, Agnese Filippello, Antonino Di Pino, Davide Barbagallo, Stefania Di Mauro, Alessandro Pappalardo, Agata Maria Rabuazzo, Michele Purrello, Francesco Purrello, Salvatore Pir. Altered expression of uncoupling protein 2 in GLP-1-producing cells after chronic high glucose exposure: implications for the pathogenesis of diabetes mellitus. American journal of physiology. Cell physiology. vol 310. issue 7. 2016-08-22. PMID:26739488. |
glucagon-like peptide-1 (glp-1) is a gut l-cell hormone that enhances glucose-stimulated insulin secretion. |
2016-08-22 |
2023-08-13 |
Not clear |
| Francesca Urbano, Agnese Filippello, Antonino Di Pino, Davide Barbagallo, Stefania Di Mauro, Alessandro Pappalardo, Agata Maria Rabuazzo, Michele Purrello, Francesco Purrello, Salvatore Pir. Altered expression of uncoupling protein 2 in GLP-1-producing cells after chronic high glucose exposure: implications for the pathogenesis of diabetes mellitus. American journal of physiology. Cell physiology. vol 310. issue 7. 2016-08-22. PMID:26739488. |
however, although defective glp-1 secretion has been correlated with insulin resistance, little is known about the direct effects of chronic high glucose concentrations, which are typical in diabetes patients, on glp-1-secreting cell function. |
2016-08-22 |
2023-08-13 |
Not clear |
| Jonathon N Winnay, Marie H Solheim, Ercument Dirice, Masaji Sakaguchi, Hye-Lim Noh, Hee Joon Kang, Hirokazu Takahashi, Kishan K Chudasama, Jason K Kim, Anders Molven, C Ronald Kahn, Pål R Njølsta. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. The Journal of clinical investigation. vol 126. issue 4. 2016-08-15. PMID:26974159. |
in addition, mutant mice displayed defective insulin secretion and glp-1 action on islets in vivo and in vitro. |
2016-08-15 |
2023-08-13 |
mouse |
| Geyang Xu, Xiaosi Hong, Hong Tang, Sushi Jiang, Fenting Liu, Zhemin Shen, Ziru Li, Weizhen Zhan. Ghrelin regulates GLP-1 production through mTOR signaling in L cells. Molecular and cellular endocrinology. vol 416. 2016-08-11. PMID:26279396. |
glucagon-like peptide (glp-1), an intestinal incretin produced in l-cells and released in response to meal intake, functions to promote insulin secretion and to decrease plasma glucose. |
2016-08-11 |
2023-08-13 |
mouse |
| J Versmisse. Combination therapy of GLP-1 analogues and insulin: do the benefits outweigh the costs? The Netherlands journal of medicine. vol 72. issue 10. 2016-08-10. PMID:26219754. |
combination therapy of glp-1 analogues and insulin: do the benefits outweigh the costs? |
2016-08-10 |
2023-08-13 |
Not clear |
| E F S van Velsen, J Lamers, V Blok, R J M van Leendert, R M Kiewiet-Kempe. A prospective study of concomitant GLP-1 analogue and insulin use in type 2 diabetes in clinical practice. The Netherlands journal of medicine. vol 72. issue 10. 2016-08-09. PMID:26219757. |
a prospective study of concomitant glp-1 analogue and insulin use in type 2 diabetes in clinical practice. |
2016-08-09 |
2023-08-13 |
Not clear |
| E F S van Velsen, J Lamers, V Blok, R J M van Leendert, R M Kiewiet-Kempe. A prospective study of concomitant GLP-1 analogue and insulin use in type 2 diabetes in clinical practice. The Netherlands journal of medicine. vol 72. issue 10. 2016-08-09. PMID:26219757. |
a small number of studies have shown a significant reduction in hba1c, weight and total daily insulin dose when a glucagon-like-peptide-1 (glp-1) analogue was added in type 2 diabetes patients already on insulin treatment. |
2016-08-09 |
2023-08-13 |
Not clear |
| E F S van Velsen, J Lamers, V Blok, R J M van Leendert, R M Kiewiet-Kempe. A prospective study of concomitant GLP-1 analogue and insulin use in type 2 diabetes in clinical practice. The Netherlands journal of medicine. vol 72. issue 10. 2016-08-09. PMID:26219757. |
therefore, in a clinical setting, we investigated the effect of adding glp-1 analogues in patients with type 2 diabetes already using insulin with respect to glycaemic control, body weight and insulin dose. |
2016-08-09 |
2023-08-13 |
Not clear |
| b' Volkan Solmaz, Bilge Piri \\xc3\\x87\\xc4\\xb1nar, G\\xc3\\xbcrkan Yi\\xc4\\x9fitt\\xc3\\xbcrk, T\\xc3\\xbcrker \\xc3\\x87avu\\xc5\\x9fo\\xc4\\x9flu, Dilek Ta\\xc5\\x9fk\\xc4\\xb1ran, Oytun Erba\\xc5\\x9. Exenatide reduces TNF-\\xce\\xb1 expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats. European journal of pharmacology. vol 765. 2016-08-08. PMID:26386291.' |
glucogan-like peptide 1 (glp-1) facilitates insulin release from pancreas under hyperglycemic conditions. |
2016-08-08 |
2023-08-13 |
rat |
| Naresh Ramesh, Sima Mortazavi, Suraj Unniappa. Nesfatin-1 stimulates cholecystokinin and suppresses peptide YY expression and secretion in mice. Biochemical and biophysical research communications. vol 472. issue 1. 2016-08-08. PMID:26920055. |
post-prandial insulin secretion is predominantly regulated by incretins glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2016-08-08 |
2023-08-13 |
mouse |
| Divya P Kumar, Amon Asgharpour, Faridoddin Mirshahi, So Hyun Park, Sichen Liu, Yumi Imai, Jerry L Nadler, John R Grider, Karnam S Murthy, Arun J Sanya. Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis. The Journal of biological chemistry. vol 291. issue 13. 2016-08-05. PMID:26757816. |
glucagon released from pancreatic α cells and glucagon-like peptide 1 (glp-1) released from intestinal l cells regulate insulin secretion. |
2016-08-05 |
2023-08-13 |
mouse |
| Divya P Kumar, Amon Asgharpour, Faridoddin Mirshahi, So Hyun Park, Sichen Liu, Yumi Imai, Jerry L Nadler, John R Grider, Karnam S Murthy, Arun J Sanya. Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis. The Journal of biological chemistry. vol 291. issue 13. 2016-08-05. PMID:26757816. |
the effect of tgr5-mediated glp-1 from α cells on insulin release from islets could be blocked by glp-1 receptor antagonist. |
2016-08-05 |
2023-08-13 |
mouse |
| N J Bamford, C L Baskerville, P A Harris, S R Baile. Postprandial glucose, insulin, and glucagon-like peptide-1 responses of different equine breeds adapted to meals containing micronized maize. Journal of animal science. vol 93. issue 7. 2016-08-02. PMID:26440006. |
the aim of this study was to compare postprandial glucose, insulin, and glp-1 responses of different equine breeds adapted to twice-daily meals containing micronized maize. |
2016-08-02 |
2023-08-13 |
Not clear |
| N J Bamford, C L Baskerville, P A Harris, S R Baile. Postprandial glucose, insulin, and glucagon-like peptide-1 responses of different equine breeds adapted to meals containing micronized maize. Journal of animal science. vol 93. issue 7. 2016-08-02. PMID:26440006. |
after 12 wk of acclimation, serial blood samples were collected from all animals over a 14-h period to measure concentrations of glucose, insulin, and glp-1, with meals fed immediately after the 0 and 8 h samples. |
2016-08-02 |
2023-08-13 |
Not clear |
| N J Bamford, C L Baskerville, P A Harris, S R Baile. Postprandial glucose, insulin, and glucagon-like peptide-1 responses of different equine breeds adapted to meals containing micronized maize. Journal of animal science. vol 93. issue 7. 2016-08-02. PMID:26440006. |
correlation analysis demonstrated a strong positive association between concentrations of insulin and glp-1 over time (rs = 0.752; p < 0.001). |
2016-08-02 |
2023-08-13 |
Not clear |
| N J Bamford, C L Baskerville, P A Harris, S R Baile. Postprandial glucose, insulin, and glucagon-like peptide-1 responses of different equine breeds adapted to meals containing micronized maize. Journal of animal science. vol 93. issue 7. 2016-08-02. PMID:26440006. |
the increased insulin concentrations in ponies and andalusian horses may partly reflect lower insulin sensitivity but could also be attributed to increased glp-1 release. |
2016-08-02 |
2023-08-13 |
Not clear |
| Simone Queiroz Pantaleão, Vinicius Gonçalves Maltarollo, Sheila Cruz Araujo, Jadson Castro Gertrudes, Kathia Maria Honori. Molecular docking studies and 2D analyses of DPP-4 inhibitors as candidates in the treatment of diabetes. Molecular bioSystems. vol 11. issue 11. 2016-08-01. PMID:26399297. |
dipeptidyl peptidase-4 (dpp-4) is an important biological target related to the treatment of diabetes as dpp-4 inhibitors can lead to an increase in the insulin levels and a prolonged activity of glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip), being effective in glycemic control. |
2016-08-01 |
2023-08-13 |
Not clear |