| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Ahré. Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control. Diabetes & metabolism. vol 41. issue 6 Suppl 1. 2016-11-11. PMID:26774018. |
clinical trials have verified that these physiological effects as a result of combining insulin with glp-1 receptor agonists or dpp-4 inhibitors can indeed result in improved glycaemia, with limited risks of hypoglycaemia and weight gain. |
2016-11-11 |
2023-08-13 |
Not clear |
| Marion Bretault, Suzanne Laroche, Jean-Marc Lacorte, Charles Barsamian, Michel Polak, Marie-Laure Raffin-Sanson, Philippe Touraine, Jean-Luc Bouillot, Sebastien Czernichow, Claire Carett. Postprandial GLP-1 Secretion After Bariatric Surgery in Three Cases of Severe Obesity Related to Craniopharyngiomas. Obesity surgery. vol 26. issue 5. 2016-11-08. PMID:26922186. |
we hypothesized that this discrepancy could be partly explained by differences in glp-1 secretion after surgery since patients with craniopharyngioma present a significantly higher degree of insulin resistance and hyperinsulinism than common obese control. |
2016-11-08 |
2023-08-13 |
Not clear |
| M Nauc. Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes, obesity & metabolism. vol 18. issue 3. 2016-11-04. PMID:26489970. |
these agents exert their effect via the incretin system, specifically targeting the receptor for the incretin hormone glucagon-like peptide 1 (glp-1), which is partly responsible for augmenting glucose-dependent insulin secretion in response to nutrient intake (the 'incretin effect'). |
2016-11-04 |
2023-08-13 |
Not clear |
| M M Smits, L Tonneijck, M H A Muskiet, M H H Kramer, D L Cahen, D H van Raalt. Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas. Diabetes, obesity & metabolism. vol 18. issue 3. 2016-11-04. PMID:26500045. |
the gastrointestinal hormone glucagon-like peptide-1 (glp-1) lowers postprandial glucose concentrations by regulating pancreatic islet-cell function, with stimulation of glucose-dependent insulin and suppression of glucagon secretion. |
2016-11-04 |
2023-08-13 |
Not clear |
| P Ritz, C Vaurs, M Barigou, H Hanair. Hypoglycaemia after gastric bypass: mechanisms and treatment. Diabetes, obesity & metabolism. vol 18. issue 3. 2016-11-04. PMID:26508374. |
pharmacological treatment with acarbose is efficient, but other drugs still need to be validated in a greater number of subjects (insulin, glucagon, calcium channel blockers, somatostatin analogues and glp-1 analogues). |
2016-11-04 |
2023-08-13 |
human |
| Isabel González-Mariscal, Susan M Krzysik-Walker, Wook Kim, Michael Rouse, Josephine M Ega. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. Molecular and cellular endocrinology. vol 423. 2016-11-04. PMID:26724516. |
upon exogenous glp-1 treatment, cb1(-/-) mice had increased glucose-stimulated insulin secretion. |
2016-11-04 |
2023-08-13 |
mouse |
| Andrew C Calabria, Lawrenshey Charles, Stephanie Givler, Diva D De Leó. Postprandial Hypoglycemia in Children after Gastric Surgery: Clinical Characterization and Pathophysiology. Hormone research in paediatrics. vol 85. issue 2. 2016-11-02. PMID:26694545. |
children with pph have an exaggerated glp-1 response to a meal with an exaggerated insulin surge and subsequent hypoglycemia. |
2016-11-02 |
2023-08-13 |
Not clear |
| Andrew C Calabria, Lawrenshey Charles, Stephanie Givler, Diva D De Leó. Postprandial Hypoglycemia in Children after Gastric Surgery: Clinical Characterization and Pathophysiology. Hormone research in paediatrics. vol 85. issue 2. 2016-11-02. PMID:26694545. |
we evaluated the role of glp-1 in the pathogenesis of pph by examining the effects of glp-1 receptor blockade on glucose and insulin response to a meal. |
2016-11-02 |
2023-08-13 |
Not clear |
| Tom J Hazell, Hashim Islam, Logan K Townsend, Matt S Schmale, Jennifer L Copelan. Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms. Appetite. vol 98. 2016-11-02. PMID:26721721. |
this review of relevant research suggests blood redistribution during exercise may be important for suppressing ghrelin, while other mechanisms involving cytokine release, changes in plasma glucose and insulin concentrations, sns activity, and muscle metabolism likely mediate changes in the anorexigenic signals pyy and glp-1. |
2016-11-02 |
2023-08-13 |
Not clear |
| Anne-Barbara Witte, Linda Hilsted, Jens Juul Holst, Peter Thelin Schmid. Peptide YY3-36 and glucagon-like peptide-1 in functional dyspepsia. Secretion and role in symptom generation. Scandinavian journal of gastroenterology. vol 51. issue 4. 2016-11-01. PMID:26503455. |
the aim was to investigate postprandial changes in plasma pyy3-36, glp-1, glucose and insulin, and the relationship between pyy3-36, glp-1, dyspeptic symptoms, and satiety measurements. |
2016-11-01 |
2023-08-13 |
Not clear |
| Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Hakmo Lee, Sung Soo Chung, Dong-Sik Ham, Ji-Won Kim, Kun-Ho Yoon, Kyong Soo Park, Hye Seung Jun. Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells. Islets. vol 7. issue 5. 2016-11-01. PMID:26744903. |
incretin-based therapy such as glp-1 receptor agonists and dpp-4 inhibitors for type 2 diabetes mellitus is characterized by glucose-dependent insulin secretion and glucose-inhibited glucagon secretion. |
2016-11-01 |
2023-08-13 |
mouse |
| Lene Ring Madsen, Jens Juel Christianse. [A 45-fold liraglutide overdose did not cause hypoglycaemia]. Ugeskrift for laeger. vol 177. issue 5. 2016-10-31. PMID:25650514. |
by mimicking the effects of the native glp-1, it enhances the glucose-dependent secretion of insulin, suppresses elevated glucagon secretion, increases satiety and slows down gastric emptying. |
2016-10-31 |
2023-08-13 |
Not clear |
| Eun Ky Kim, Tae Jung Oh, Lee-Kyung Kim, Young Min Ch. Improving Effect of the Acute Administration of Dietary Fiber-Enriched Cereals on Blood Glucose Levels and Gut Hormone Secretion. Journal of Korean medical science. vol 31. issue 2. 2016-10-28. PMID:26839476. |
on day 2, the levels of plasma glucose, glp-1, glucose-dependent insulinotropic polypeptide (gip), and insulin were measured. |
2016-10-28 |
2023-08-13 |
human |
| Eun Ky Kim, Tae Jung Oh, Lee-Kyung Kim, Young Min Ch. Improving Effect of the Acute Administration of Dietary Fiber-Enriched Cereals on Blood Glucose Levels and Gut Hormone Secretion. Journal of Korean medical science. vol 31. issue 2. 2016-10-28. PMID:26839476. |
however, there were no differences in the plasma insulin, glucagon, glp-1, and gip levels. |
2016-10-28 |
2023-08-13 |
human |
| Matthew C Cane, John Parrington, Patrik Rorsman, Antony Galione, Guy A Rutte. The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion. Cell calcium. vol 59. issue 1. 2016-10-26. PMID:26769314. |
ca(2+) signals are central to the stimulation of insulin secretion from pancreatic β-cells by glucose and other agents, including glucagon-like peptide-1 (glp-1). |
2016-10-26 |
2023-08-13 |
mouse |
| J Hukkanen, J Rysa, K A Makela, K-H Herzig, J Hakkola, M J Savolaine. The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 6. 2016-10-24. PMID:26769831. |
rifampicin treatment did not affect glucose, insulin, glp-1, gip, glucagon, and peptide yy levels statistically significantly. |
2016-10-24 |
2023-08-13 |
human |
| Chien-Ning Huang, Chau-Jong Wang, Yi-Sun Yang, Chih-Li Lin, Chiung-Huei Pen. Hibiscus sabdariffa polyphenols prevent palmitate-induced renal epithelial mesenchymal transition by alleviating dipeptidyl peptidase-4-mediated insulin resistance. Food & function. vol 7. issue 1. 2016-10-19. PMID:26514092. |
recently, we reported hpe inhibited dipeptidyl-peptidase-4 (dpp-4, the enzyme degrades type 1 glucagon-like peptide (glp-1)), which mediated insulin resistance signals leading to emt. |
2016-10-19 |
2023-08-13 |
rat |
| Yan Yang, Delin Ma, Weijie Xu, Fuqiong Chen, Tingting Du, Wenzhu Yue, Shiying Shao, Gang Yua. Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level. Molecular and cellular neurosciences. vol 70. 2016-10-13. PMID:26640240. |
our previous study identified that hyperphosphorylation of tau protein, which is one of the pathophysiologic hallmarks of ad, also occurred in t2d rats' brain; while glucagon-like peptide-1 (glp-1) mimetics, a type of drug used in t2d, could decrease the phosphorylation of tau, probably via augmenting insulin signaling pathway. |
2016-10-13 |
2023-08-13 |
rat |
| Roger Reidelberger, Alvin Haver, Krista Anders, Bettye Apenteng, Craig Lani. Effects of solid-phase extraction of plasma in measuring gut metabolic hormones in fasted and fed blood of lean and diet-induced obese rats. Physiological reports. vol 4. issue 10. 2016-10-13. PMID:27207785. |
glucagon-like peptide-1 (glp-1), peptide yy (3-36) [pyy(3-36)], amylin, ghrelin, insulin, and leptin are thought to act as hormonal signals from periphery to brain to control food intake. |
2016-10-13 |
2023-08-13 |
rat |
| Roger Reidelberger, Alvin Haver, Krista Anders, Bettye Apenteng, Craig Lani. Effects of solid-phase extraction of plasma in measuring gut metabolic hormones in fasted and fed blood of lean and diet-induced obese rats. Physiological reports. vol 4. issue 10. 2016-10-13. PMID:27207785. |
individual enzyme-linked immunoassays and a multiplex assay were used to measure active glp-1, total pyy, active amylin, active ghrelin, insulin, leptin, and total gip in response to (1) addition of known amounts of the peptides to lean and obese plasma, (2) a large meal in lean and obese rats, and (3) intravenous infusions of anorexigenic doses of glp-1, pyy(3-36), amylin, and leptin in lean rats. |
2016-10-13 |
2023-08-13 |
rat |