| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabien Plisson, Timothy A Hill, Justin M Mitchell, Huy N Hoang, Aline D de Araujo, Weijun Xu, Adam Cotterell, David J Edmonds, Robert V Stanton, David R Derksen, Paula M Loria, David A Griffith, David A Price, Spiros Liras, David P Fairli. Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. European journal of medicinal chemistry. vol 127. 2017-02-21. PMID:27823886. |
glucagon-like peptide (glp-1) is an endogenous hormone that induces insulin secretion from pancreatic islets and modified forms are used to treat diabetes mellitus type 2. |
2017-02-21 |
2023-08-13 |
Not clear |
| Robert I Osborne, Wenyu Ming, Jason S Troutt, Robert W Siegel, Robert J Konra. A dual-monoclonal, sandwich immunoassay specific for glucagon like peptide-19-36/7 (GLP-19-36/7). Clinical biochemistry. vol 49. issue 12. 2017-02-14. PMID:27208557. |
glucagon-like peptide-1 (glp-1) is a peptide hormone secreted by intestinal l-cells which stimulates glucose-dependent insulin secretion. |
2017-02-14 |
2023-08-13 |
Not clear |
| Shigeharu Numao, Hiroshi Kawano, Naoya Endo, Yuka Yamada, Masaki Takahashi, Masayuki Konishi, Shizuo Sakamot. Short-term high-fat diet alters postprandial glucose metabolism and circulating vascular cell adhesion molecule-1 in healthy males. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 41. issue 8. 2017-02-13. PMID:27454856. |
the concentrations of plasma glucose, insulin, glucagon-like peptide-1 (glp-1), intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 (vcam-1) were determined at rest and during mtt. |
2017-02-13 |
2023-08-13 |
Not clear |
| Maeve Shannon, Brian Green, Gary Willars, Jodie Wilson, Natalie Matthews, Joanna Lamb, Anna Gillespie, Lisa Connoll. The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction. Toxicology letters. vol 265. 2017-02-13. PMID:27890806. |
these adverse events may play a role in the pathogenesis of obesity as outlined in the obesogen hypothesis by impairing glp-1 secretion, related satiety responses and glucose-stimulated insulin release. |
2017-02-13 |
2023-08-13 |
Not clear |
| Enas S Gad, Sawsan A Zaitone, Yasser M Moustaf. Pioglitazone and exenatide enhance cognition and downregulate hippocampal beta amyloid oligomer and microglia expression in insulin-resistant rats. Canadian journal of physiology and pharmacology. vol 94. issue 8. 2017-02-10. PMID:27389824. |
exenatide, a long lasting glucagon-like peptide-1 (glp-1) analogue, enhances insulin signaling and shows neuroprotective properties. |
2017-02-10 |
2023-08-13 |
rat |
| Elizabeth Mary Lamos, Stephen N Davi. Pharmacokinetic evaluation of fixed-ratio combination of insulin degludec and liraglutide in the treatment of type 2 diabetes. Expert opinion on drug metabolism & toxicology. vol 12. issue 10. 2017-02-10. PMID:27467569. |
combination therapy of basal insulin and glp-1 receptor agonist therapy appears to provide a balance between glycemic efficacy, hypoglycemia and weight gain. |
2017-02-10 |
2023-08-13 |
Not clear |
| Yusuke Seino, Ryuya Maekawa, Hidetada Ogata, Yoshitaka Hayash. Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186352. |
recently, it was reported that gip and glp-1-producing cells are present also in pancreatic islets, and islet-derived gip and glp-1 contribute to glucose-induced insulin secretion from pancreatic β-cells. |
2017-02-08 |
2023-08-13 |
Not clear |
| David D'Alessi. Is GLP-1 a hormone: Whether and When? Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186356. |
moreover, antagonism of systemic glp-1 action impairs insulin secretion in the fasting state, suggesting that the glp-1r is active even when plasma glp-1 levels are low and unchanging. |
2017-02-08 |
2023-08-13 |
Not clear |
| David D'Alessi. Is GLP-1 a hormone: Whether and When? Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186356. |
taken together, these data support a model whereby glp-1 acts through neural or paracrine mechanisms to regulate physiologic insulin secretion. |
2017-02-08 |
2023-08-13 |
Not clear |
| Akihiro Mori, Kaori Ueda, Peter Lee, Hitomi Oda, Katsumi Ishioka, Toshiro Arai, Toshinori Sak. Effect of Acarbose, Sitagliptin and combination therapy on blood glucose, insulin, and incretin hormone concentrations in experimentally induced postprandial hyperglycemia of healthy cats. Research in veterinary science. vol 106. 2017-02-03. PMID:27234550. |
therefore, the objective of this study was to determine the potential use of ac or stgp alone and in combination for diabetic cats, by observing their effect on short-term post-prandial serum glucose, insulin, and incretin hormone (active glucagon-like peptide-1 (glp-1) and total glucose dependent insulinotropic polypeptide (gip)) concentrations in five healthy cats, following ingestion of a meal with maltose. |
2017-02-03 |
2023-08-13 |
human |
| Eun Ju Ba. DPP-4 inhibitors in diabetic complications: role of DPP-4 beyond glucose control. Archives of pharmacal research. vol 39. issue 8. 2017-01-27. PMID:27502601. |
its mechanism of action for lowering blood glucose is essentially via inhibition of the rapid degradation of incretin hormones, such as glucagon-like peptide (glp)-1 and gastric inhibitory polypeptide (gip), thus the plasma concentration of glp-1 increases, which promotes insulin secretion from the pancreatic β cells and suppresses glucagon secretion from the α cells. |
2017-01-27 |
2023-08-13 |
Not clear |
| Mark P Plummer, Palash Kar, Caroline E Cousins, Kylie Lange, Marianne J Chapman, Michael A Nauck, Michael Horowitz, Juris J Meier, Adam M Dean. The insulinotropic effect of pulsatile compared with continuous intravenous delivery of GLP-1. Diabetologia. vol 59. issue 5. 2017-01-23. PMID:26831299. |
in healthy individuals, both insulin and glucagon-like peptide 1 (glp-1) are secreted in a pulsatile fashion. |
2017-01-23 |
2023-08-13 |
Not clear |
| Young-Sun Lee, Hee-Sook Ju. Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control. Mediators of inflammation. vol 2016. 2017-01-17. PMID:27110066. |
glp-1 has beneficial effects for glucose homeostasis by stimulating insulin secretion from pancreatic beta-cells, delaying gastric emptying, decreasing plasma glucagon, reducing food intake, and stimulating glucose disposal. |
2017-01-17 |
2023-08-13 |
Not clear |
| Alastair D Green, Srividya Vasu, R Charlotte Moffett, Peter R Flat. Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins. Biochimie. vol 125. 2017-01-13. PMID:27015674. |
co-culture of clonal beta cells with glp-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins. |
2017-01-13 |
2023-08-13 |
Not clear |
| Alastair D Green, Srividya Vasu, R Charlotte Moffett, Peter R Flat. Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins. Biochimie. vol 125. 2017-01-13. PMID:27015674. |
we investigated the direct effects on insulin releasing min6 cells of chronic exposure to glp-1, glucagon or a combination of both peptides secreted from glutag l-cell and αtc1.9 alpha-cell lines in co-culture. |
2017-01-13 |
2023-08-13 |
Not clear |
| Alastair D Green, Srividya Vasu, R Charlotte Moffett, Peter R Flat. Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins. Biochimie. vol 125. 2017-01-13. PMID:27015674. |
min6, glutag and αtc1.9 cell lines exhibited high cellular hormone content and release of insulin, glp-1 and glucagon, respectively. |
2017-01-13 |
2023-08-13 |
Not clear |
| Céline Gleizes, Guillaume Kreutter, Malak Abbas, Mohamad Kassem, Andrei Alexandru Constantinescu, Julie Boisramé-Helms, Blandine Yver, Florence Toti, Laurence Kessle. β cell membrane remodelling and procoagulant events occur in inflammation-driven insulin impairment: a GLP-1 receptor dependent and independent control. Journal of cellular and molecular medicine. vol 20. issue 2. 2017-01-09. PMID:26607759. |
β cell membrane remodelling and procoagulant events occur in inflammation-driven insulin impairment: a glp-1 receptor dependent and independent control. |
2017-01-09 |
2023-08-13 |
Not clear |
| Céline Gleizes, Guillaume Kreutter, Malak Abbas, Mohamad Kassem, Andrei Alexandru Constantinescu, Julie Boisramé-Helms, Blandine Yver, Florence Toti, Laurence Kessle. β cell membrane remodelling and procoagulant events occur in inflammation-driven insulin impairment: a GLP-1 receptor dependent and independent control. Journal of cellular and molecular medicine. vol 20. issue 2. 2017-01-09. PMID:26607759. |
our results confirm an integrative β-cell response to glp-1 that targets receptor-mediated signalling and membrane remodelling pointing at the coupling of insulin secretion and inflammation-driven procoagulant events. |
2017-01-09 |
2023-08-13 |
Not clear |
| Yukiko K Kaneko, Tomohisa Ishikaw. [Regulation of Lipid Metabolism by Diacylglycerol Kinases in Pancreatic β-cells]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 136. issue 3. 2017-01-09. PMID:26935087. |
in addition to this primary mechanism through katp channels, insulin secretion is regulated by cyclic amp and diacylglycerol (dag), which mediate the effects of receptor agonists such as glp-1 and acetylcholine. |
2017-01-09 |
2023-08-13 |
mouse |
| Yukari Taked. [Theoretical Investigations into the Quantitative Mechanisms Underlying the Regulation of [cAMP]i, Membrane Excitability and [Ca(2+)]i during GLP-1 Stimulation in Pancreatic β Cells]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 136. issue 3. 2017-01-09. PMID:26935088. |
glucose-dependent insulin secretion is synergistically enhanced by glucagon-like peptide-1 (glp-1), which increases [camp]i and activates protein kinase a (pka) and exchange protein activated by camp (epac). |
2017-01-09 |
2023-08-13 |
Not clear |