| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie Hansen, Karina R Hjøllund, Bolette Hartmann, Astrid Plamboeck, Carolyn F Deacon, Nicolai J Wewer Albrechtsen, Jens J Hols. Important species differences regarding lymph contribution to gut hormone responses. Peptides. vol 71. 2016-06-17. PMID:26048091. |
glp-1 is secreted from the gut upon nutrient intake and stimulates insulin secretion. |
2016-06-17 |
2023-08-13 |
Not clear |
| Giovanni Pacini, Bo Ahré. Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice. Peptides. vol 71. 2016-06-17. PMID:26119909. |
glucagon and glp-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice. |
2016-06-17 |
2023-08-13 |
mouse |
| Giovanni Pacini, Bo Ahré. Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice. Peptides. vol 71. 2016-06-17. PMID:26119909. |
it was found that at 1min after glucose injection alone, insulin rose to a peak level and this peak, as well as the 50min area under the insulin curve (auc insulin) were dose-dependently augmented by glp-1 and glucagon. |
2016-06-17 |
2023-08-13 |
mouse |
| Giovanni Pacini, Bo Ahré. Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice. Peptides. vol 71. 2016-06-17. PMID:26119909. |
also in vitro, both glucagon and glp-1 augmented insulin secretion; however, there was no difference between the combined stimulation of insulin secretion by glp-1 and glucagon together compared with either hormone alone. |
2016-06-17 |
2023-08-13 |
mouse |
| Giovanni Pacini, Bo Ahré. Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice. Peptides. vol 71. 2016-06-17. PMID:26119909. |
we conclude that the acute combined administration of the strongly insulinotropic glp-1 and glucagon, both in vivo and in vitro, did not induce any additive or synergistic action on glucose-stimulated insulin secretion. |
2016-06-17 |
2023-08-13 |
mouse |
| Lauryn M Nyhoff, Timothy D Heden, Heather J Leidy, Nathan C Winn, Young-Min Park, John P Thyfault, Jill A Kanale. Prior exercise does not alter the incretin response to a subsequent meal in obese women. Peptides. vol 71. 2016-06-17. PMID:26188172. |
frequent blood samples were analyzed for glucose, lactate, insulin, glucagon, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), and c-peptide concentrations throughout 280min of testing. |
2016-06-17 |
2023-08-13 |
human |
| Igor B Mekjavic, Mojca Amon, Roger Kölegård, Stylianos N Kounalakis, Liz Simpson, Ola Eiken, Michail E Keramidas, Ian A Macdonal. The Effect of Normobaric Hypoxic Confinement on Metabolism, Gut Hormones, and Body Composition. Frontiers in physiology. vol 7. 2016-06-17. PMID:27313541. |
before, and at the end of each exposure, subjects completed a meal tolerance test (mtt), during which blood glucose, insulin, glp-1, ghrelin, peptide-yy, adrenaline, noradrenaline, leptin, and gastro-intestinal blood flow and appetite sensations were measured. |
2016-06-17 |
2023-08-13 |
human |
| Jin Shang, Jing Li, Mark P Keller, Hans E Hohmeier, Yong Wang, Yue Feng, Heather H Zhou, Xiaolan Shen, Mary Rabaglia, Mufaddal Soni, Alan D Attie, Christopher B Newgard, Nancy A Thornberry, Andrew D Howard, Yun-Ping Zho. Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. Molecular endocrinology (Baltimore, Md.). vol 29. issue 9. 2016-06-14. PMID:26218441. |
in this study, we investigated the potential involvement of micrornas (mirnas) in the effect of glp-1 on glucose-stimulated insulin secretion. |
2016-06-14 |
2023-08-13 |
mouse |
| Jin Shang, Jing Li, Mark P Keller, Hans E Hohmeier, Yong Wang, Yue Feng, Heather H Zhou, Xiaolan Shen, Mary Rabaglia, Mufaddal Soni, Alan D Attie, Christopher B Newgard, Nancy A Thornberry, Andrew D Howard, Yun-Ping Zho. Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. Molecular endocrinology (Baltimore, Md.). vol 29. issue 9. 2016-06-14. PMID:26218441. |
glp-1 failed to increase mir-132 or mir-212 expression levels in the 832/13 line of ins-1 cells, which lacks robust camp and insulin responses to glp-1 treatment. |
2016-06-14 |
2023-08-13 |
mouse |
| Jin Shang, Jing Li, Mark P Keller, Hans E Hohmeier, Yong Wang, Yue Feng, Heather H Zhou, Xiaolan Shen, Mary Rabaglia, Mufaddal Soni, Alan D Attie, Christopher B Newgard, Nancy A Thornberry, Andrew D Howard, Yun-Ping Zho. Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. Molecular endocrinology (Baltimore, Md.). vol 29. issue 9. 2016-06-14. PMID:26218441. |
overexpression of mir-132 or mir-212 significantly enhanced glucose-stimulated insulin secretion in both 832/3 and 832/13 cells, and restored insulin responses to glp-1 in ins-1 832/13 cells. |
2016-06-14 |
2023-08-13 |
mouse |
| Ameneh Cheshmehkani, Ilya S Senatorov, Praveen Kandi, Monalisa Singh, April Britt, Renee Hayslett, Nader H Monir. Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 64. issue 10. 2016-06-14. PMID:26275932. |
additionally, ffar4 stimulates secretion of the insulin secretagogue glucagon-like peptide-1 (glp-1) from the gi tract and acts as a dietary sensor to regulate energy availability. |
2016-06-14 |
2023-08-13 |
human |
| Limei Liu, Jian Liu, Xiaoxing Y. Dipeptidyl peptidase-4 inhibitor MK-626 restores insulin secretion through enhancing autophagy in high fat diet-induced mice. Biochemical and biophysical research communications. vol 470. issue 3. 2016-06-14. PMID:26802468. |
glucagon like-peptide-1 (glp-1) level and insulin secretion were measured by elisa. |
2016-06-14 |
2023-08-13 |
mouse |
| Sarah L Greig, Lesley J Scot. Insulin Degludec/Liraglutide: A Review in Type 2 Diabetes. Drugs. vol 75. issue 13. 2016-06-13. PMID:26242767. |
insulin degludec/liraglutide (xultophy(®)), a fixed-ratio combination of an ultra-long-acting insulin analogue and a glucagon-like protein-1 (glp-1) receptor agonist, is available in the eu for the management of inadequately controlled type 2 diabetes. |
2016-06-13 |
2023-08-13 |
Not clear |
| Sarah L Greig, Lesley J Scot. Insulin Degludec/Liraglutide: A Review in Type 2 Diabetes. Drugs. vol 75. issue 13. 2016-06-13. PMID:26242767. |
in insulin-naive patients, add-on insulin degludec/liraglutide provided significantly greater improvements in glycated haemoglobin (hba1c) levels than add-on insulin degludec, liraglutide or placebo, or unchanged glp-1 receptor agonists (i.e. |
2016-06-13 |
2023-08-13 |
Not clear |
| Manuel Gil-Lozano, W Kelly Wu, Alexandre Martchenko, Patricia L Brubake. High-Fat Diet and Palmitate Alter the Rhythmic Secretion of Glucagon-Like Peptide-1 by the Rodent L-cell. Endocrinology. vol 157. issue 2. 2016-06-10. PMID:26646204. |
herein the role of the endogenous corticosterone rhythm on the pattern of glp-1 and insulin nutrient-induced responses was examined in corticosterone pellet-implanted rats. |
2016-06-10 |
2023-08-13 |
rat |
| Manuel Gil-Lozano, W Kelly Wu, Alexandre Martchenko, Patricia L Brubake. High-Fat Diet and Palmitate Alter the Rhythmic Secretion of Glucagon-Like Peptide-1 by the Rodent L-cell. Endocrinology. vol 157. issue 2. 2016-06-10. PMID:26646204. |
diurnal variations in glp-1 and insulin nutrient-induced responses were maintained in animals lacking an endogenous corticosterone rhythm, suggesting that glucocorticoids are not the predominant entrainment factor for l-cell rhythmic activity. |
2016-06-10 |
2023-08-13 |
rat |
| Manuel Gil-Lozano, W Kelly Wu, Alexandre Martchenko, Patricia L Brubake. High-Fat Diet and Palmitate Alter the Rhythmic Secretion of Glucagon-Like Peptide-1 by the Rodent L-cell. Endocrinology. vol 157. issue 2. 2016-06-10. PMID:26646204. |
in addition to hyperglycemia, hyperinsulinemia, insulin resistance, and disorganization of feeding behavior, high-fat high-sucrose-fed rats showed a total abrogation of the diurnal variation in glp-1 and insulin nutrient-induced responses, with comparable levels of both hormones at the normal peak (5:00 pm) and trough (5:00 am) of their daily pattern. |
2016-06-10 |
2023-08-13 |
rat |
| M Charokopou, H Vioix, B Verheggen, L A Eddowes, M Griffiths, Z Gabriel, K Tolley, M Sibarti. Cost-Effectiveness of Saxagliptin Compared To Glp-1 Analogues As An Add-On To Insulin in the Treatment of Type 2 Diabetes Mellitus From A Uk Health Care Perspective. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. vol 17. issue 7. 2016-06-10. PMID:27200661. |
cost-effectiveness of saxagliptin compared to glp-1 analogues as an add-on to insulin in the treatment of type 2 diabetes mellitus from a uk health care perspective. |
2016-06-10 |
2023-08-13 |
Not clear |
| Mukul R Jain, Amit A Joharapurkar, Rajesh H Bahekar, Harilal Patel, Pradip Jadav, Samadhan G Kshirsagar, Vishal J Patel, Kartikkumar N Patel, Vikram K Ramanathan, Pankaj R Patel, Ranjit C Desa. Pharmacological characterization of ZYDPLA1, a novel long-acting dipeptidyl peptidase-4 inhibitor. Journal of diabetes. vol 7. issue 5. 2016-06-07. PMID:25327540. |
dipeptidyl peptidase-4 (dpp-4) is responsible for degradation of glucagon-like peptide 1 (glp-1) and gastric inhibitory polypeptide (gip), the endogenous incretins that stimulate glucose-dependent insulin secretion. |
2016-06-07 |
2023-08-13 |
Not clear |
| Joel Lindgren, Essam Refai, Sergei V Zaitsev, Lars Abrahmsén, Per-Olof Berggren, Amelie Eriksson Karlströ. A GLP-1 receptor agonist conjugated to an albumin-binding domain for extended half-life. Biopolymers. vol 102. issue 3. 2016-05-30. PMID:24549714. |
insulin release upon stimulation was shown to be glucose-dependent, showing no significant difference between the three different glp-1-abd conjugates and unconjugated glp-1 analogue. |
2016-05-30 |
2023-08-12 |
mouse |