| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle A Kovalaske, Gunjan Y Gandh. Incretins in the ICU: is insulin on its way out? Critical care (London, England). vol 13. issue 4. 2010-01-28. PMID:19591659. |
small exploratory studies suggest that glp-1 safely reduces hyperglycemia without causing hypoglycemia, a key advantage over insulin if efficacy is established in larger studies. |
2010-01-28 |
2023-08-12 |
Not clear |
| Christina Rye Underwood, Patrick Garibay, Lotte Bjerre Knudsen, Sven Hastrup, Günther H Peters, Rainer Rudolph, Steffen Reedtz-Rung. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. The Journal of biological chemistry. vol 285. issue 1. 2010-01-26. PMID:19861722. |
activation of the glp-1 receptor potentiates the synthesis and release of insulin from pancreatic beta-cells in a glucose-dependent manner. |
2010-01-26 |
2023-08-12 |
Not clear |
| A-B Witte, P Grybäck, J J Holst, L Hilsted, P M Hellström, H Jacobsson, P T Schmid. Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man. Regulatory peptides. vol 158. issue 1-3. 2010-01-25. PMID:19651163. |
gastric emptying (scintigraphy), appetite ratings (vas), and plasma concentrations of insulin, glucose, glp-1 and pyy were measured. |
2010-01-25 |
2023-08-12 |
Not clear |
| A-B Witte, P Grybäck, J J Holst, L Hilsted, P M Hellström, H Jacobsson, P T Schmid. Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man. Regulatory peptides. vol 158. issue 1-3. 2010-01-25. PMID:19651163. |
neither form influenced glucose or glp-1 concentrations, but both decreased the postprandial rise in insulin. |
2010-01-25 |
2023-08-12 |
Not clear |
| Gareth E Lim, Molie Xu, Jane Sun, Tianru Jin, Patricia L Brubake. The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819966. |
insulin induced a 1.4-fold increase in l cell glp-1 release; however, secretion was potentiated to 2.1-fold in the presence of the f-actin depolymerizing agent, latrunculin b, suggesting that f-actin functions as a permissive barrier. |
2010-01-19 |
2023-08-12 |
Not clear |
| Gareth E Lim, Molie Xu, Jane Sun, Tianru Jin, Patricia L Brubake. The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819966. |
in murine glutag l cells, insulin stimulated f-actin depolymerization and cdc42 activation simultaneously, and these events occurred prior to detectable increases in insulin-induced glp-1 release. |
2010-01-19 |
2023-08-12 |
Not clear |
| Gareth E Lim, Molie Xu, Jane Sun, Tianru Jin, Patricia L Brubake. The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819966. |
after insulin treatment, cdc42-dependent p21-activated kinase-1 (pak1) activation was also detected, and transfection of small-interfering rna against cdc42 or of dominant-negative cdc42(t17n) impaired insulin-stimulated pak1 activation, actin remodeling, and glp-1 secretion. |
2010-01-19 |
2023-08-12 |
Not clear |
| Gareth E Lim, Molie Xu, Jane Sun, Tianru Jin, Patricia L Brubake. The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819966. |
knockdown or inhibition of cdc42 and pak1 activities also prevented activation of mapk/erk (mek)-1/2-erk1/2 by insulin, which was previously identified as a critical pathway for insulin-regulated glp-1 release. |
2010-01-19 |
2023-08-12 |
Not clear |
| Gareth E Lim, Molie Xu, Jane Sun, Tianru Jin, Patricia L Brubake. The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819966. |
taken together, these data identify a novel signaling pathway in the endocrine l cell, whereby cdc42 regulates actin remodeling, activation of the cannonical 1/2-erk1/2 pathway and pak1, and glp-1 secretion in response to insulin. |
2010-01-19 |
2023-08-12 |
Not clear |
| Sohita Dhillon, Juliane Webe. Saxagliptin. Drugs. vol 69. issue 15. 2010-01-15. PMID:19791828. |
this increases glp-1 levels, stimulates insulin secretion and reduces postprandial glucagon and glucose levels. |
2010-01-15 |
2023-08-12 |
Not clear |
| Talib Abbas, Emilie Faivre, Christian Hölsche. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19573562. |
previous studies have shown that the incretin glucagon-like peptide 1 (glp-1) helps to normalise insulin signalling in type 2 diabetes. |
2010-01-12 |
2023-08-12 |
mouse |
| Chien-Chi Lin, Kristi S Anset. Glucagon-like peptide-1 functionalized PEG hydrogels promote survival and function of encapsulated pancreatic beta-cells. Biomacromolecules. vol 10. issue 9. 2009-12-30. PMID:19586041. |
further, the glp-1 immobilized peg hydrogels enhance the survival and insulin secretion of encapsulated islets. |
2009-12-30 |
2023-08-12 |
Not clear |
| Masayuki Arakawa, Chie Ebato, Tomoya Mita, Takahisa Hirose, Ryuzo Kawamori, Yoshio Fujitani, Hirotaka Watad. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochemical and biophysical research communications. vol 390. issue 3. 2009-12-29. PMID:19836346. |
these findings suggest that long-term glp-1 treatment results in insulin sensitization of peripheral organs, rather than enhancement of beta-cell proliferation and function, particularly when animals are fed high-fat diet. |
2009-12-29 |
2023-08-12 |
mouse |
| Luciene R Carraro-Lacroix, Gerhard Malnic, Adriana C C Girard. Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. American journal of physiology. Renal physiology. vol 297. issue 6. 2009-12-28. PMID:19776173. |
the gut incretin hormone glucagon-like peptide 1 (glp-1) is released in response to ingested nutrients and enhances insulin secretion. |
2009-12-28 |
2023-08-12 |
Not clear |
| Ryuichi Moriya, Takashi Shirakura, Junko Ito, Satoshi Mashiko, Toru Se. Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. American journal of physiology. Endocrinology and metabolism. vol 297. issue 6. 2009-12-23. PMID:19808907. |
interestingly, oral administration of mdg significantly increased plasma gip, glp-1, and insulin levels and reduced blood glucose levels during an intraperitoneal glucose tolerance test. |
2009-12-23 |
2023-08-12 |
mouse |
| Keiko Tanaka-Amino, Yoshifumi Hatakeyama, Shoji Takakura, Seitaro Muto. Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats. Pharmacological research. vol 60. issue 4. 2009-12-22. PMID:19520592. |
glucagon-like peptide-1 (glp-1), an incretin hormone, is essential for the regulation of insulin secretion and glucose homeostasis. |
2009-12-22 |
2023-08-12 |
rat |
| Shin-ya Ueda, Takahiro Yoshikawa, Yoshihiro Katsura, Tatsuya Usui, Shigeo Fujimot. Comparable effects of moderate intensity exercise on changes in anorectic gut hormone levels and energy intake to high intensity exercise. The Journal of endocrinology. vol 203. issue 3. 2009-12-21. PMID:19737911. |
blood samples were obtained during three sessions for measurements of glucose, insulin, pyy(3-36), and glp-1, which includes glp-1 (7-36) amide and glp-1 (9-36) amide. |
2009-12-21 |
2023-08-12 |
human |
| Hirofumi Noguchi, Koichi Oishi, Michiko Ueda, Hiroshi Yukawa, Shuji Hayashi, Naoya Kobayashi, Marlon F Levy, Shinichi Matusmot. Establishment of mouse pancreatic stem cell line. Cell transplantation. vol 18. issue 5. 2009-12-16. PMID:19775518. |
the hn#13 cells, which had the highest expression of insulin mrna after induction, expressed pdx-1 transcription factor, glucagon-like peptide-1 (glp-1) receptor, and cytokeratin-19 (duct-like cells). |
2009-12-16 |
2023-08-12 |
mouse |
| Atsuhiko Ichimura, Akira Hirasawa, Takafumi Hara, Gozoh Tsujimot. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins & other lipid mediators. vol 89. issue 3-4. 2009-12-15. PMID:19460454. |
ffar1 is expressed mainly in pancreatic beta-cells and mediates insulin secretion, whereas gpr120 is expressed abundantly in the intestine and promotes the secretion of glucagon-like peptide-1 (glp-1). |
2009-12-15 |
2023-08-12 |
Not clear |
| R E Steinert, B Poller, M C Castelli, K Friedman, A R Huber, J Drewe, C Beglinge. Orally administered glucagon-like peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subjects. Clinical pharmacology and therapeutics. vol 86. issue 6. 2009-12-15. PMID:19727071. |
the pd profile was consistent with reported pharmacology; glp-1 significantly stimulated basal insulin release (p < 0.027), with marked effects on glucose levels. |
2009-12-15 |
2023-08-12 |
human |