| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bernardo Nuche-Berenguer, Paola Moreno, Pedro Esbrit, Sonia Dapía, José R Caeiro, Jesús Cancelas, Juan J Haro-Mora, María L Villanueva-Peñacarrill. Effect of GLP-1 treatment on bone turnover in normal, type 2 diabetic, and insulin-resistant states. Calcified tissue international. vol 84. issue 6. 2009-07-28. PMID:19219381. |
compared to n, plasma glucose and insulin were, respectively, higher and lower in t2d; osteocalcin (oc) and tartrate-resistant alkaline phosphatase 5b were lower; phosphate in ir showed a tendency to be higher; pth was not different in t2d and ir; all parameters were unchanged after glp-1 infusion. |
2009-07-28 |
2023-08-12 |
rat |
| Diana L William. Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis. Endocrinology. vol 150. issue 7. 2009-07-24. PMID:19389830. |
early reports suggested that glp-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central glp-1 reduces food intake and body weight. |
2009-07-24 |
2023-08-12 |
Not clear |
| Shin-ya Ueda, Takahiro Yoshikawa, Yoshihiro Katsura, Tatsuya Usui, Hayato Nakao, Shigeo Fujimot. Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males. The Journal of endocrinology. vol 201. issue 1. 2009-07-23. PMID:19158129. |
blood samples were obtained at 30 min intervals during both sessions for measurement of glucose, insulin, glucagon, ghrelin, peptide yy (pyy), and glucagon-like peptide-1 (glp-1). |
2009-07-23 |
2023-08-12 |
human |
| Bo Ahrén, Maria Sörhede Winzell, Giovanni Pacin. The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice. The Journal of endocrinology. vol 197. issue 1. 2009-07-07. PMID:18372244. |
glp-1 in stimulating insulin secretion was increased in the high-fat diet fed mice: the lowest effective dose of glp-1 was 650 pmol/kg in normal mice and 13 pmol/kg in the high-fat diet fed mice. |
2009-07-07 |
2023-08-12 |
mouse |
| Bo Ahrén, Maria Sörhede Winzell, Giovanni Pacin. The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice. The Journal of endocrinology. vol 197. issue 1. 2009-07-07. PMID:18372244. |
we conclude that 1) the incretin effect contributes by approximately 50% to insulin secretion by the oral glucose in normal mice, 2) this effect is markedly exaggerated in insulin-resistant mice fed a high-fat diet, and 3) this augmented incretin contribution in the high-fat fed mice may partially be explained by glp-1. |
2009-07-07 |
2023-08-12 |
mouse |
| A J Scheen, N Paquo. [Vildagliptin (Galvus) and fixed combination vildagliptine-metformin (Eucreas) in the treatment of type 2 diabetes]. Revue medicale de Liege. vol 64. issue 3. 2009-07-07. PMID:19418936. |
it potentiates the insulin secretory response (incretin effect) by enhancing the endogenous post-prandial response of glp-1 (incretin enhancer) in a glucose-dependent manner. |
2009-07-07 |
2023-08-12 |
Not clear |
| Christopher H S McIntosh, Scott Widenmaier, Su-Jin Ki. Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). Vitamins and hormones. vol 80. 2009-06-23. PMID:19251046. |
both gip and glucagon-like peptide-1 (glp-1) stimulate insulin secretion in a glucose-dependent manner and are thus classified as incretins. |
2009-06-23 |
2023-08-12 |
Not clear |
| Xibao Liu, Norio Harada, Shunsuke Yamane, Lisa Kitajima, Saeko Uchida, Akihiro Hamasaki, Eri Mukai, Kentaro Toyoda, Chizumi Yamada, Yuichiro Yamada, Yutaka Seino, Nobuya Inagak. Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice. Life sciences. vol 84. issue 25-26. 2009-06-23. PMID:19358859. |
however, the magnitude of the effects of enhanced glp-1 and gip signaling by long-term dpp-iv inhibition on body weight and insulin secretion has not been determined. |
2009-06-23 |
2023-08-12 |
mouse |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
we studied blood glucose, plasma levels of insulin, glp-1, and gip, and gastric emptying (by a breath test) in 7 healthy humans after intragastric infusions of 1) 50 g sucrose in water to a total volume of 500 ml (approximately 290 mosmol/l), 2) 80 mg sucralose in 500 ml normal saline (approximately 300 mosmol/l, 0.4 mm sucralose), 3) 800 mg sucralose in 500 ml normal saline (approximately 300 mosmol/l, 4 mm sucralose), and 4) 500 ml normal saline (approximately 300 mosmol/l), all labeled with 150 mg 13c-acetate. |
2009-06-17 |
2023-08-12 |
mouse |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
glp-1, gip, and insulin also increased after sucrose (p=0.0001) but not after either load of sucralose or saline. |
2009-06-17 |
2023-08-12 |
mouse |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
we conclude that sucralose, delivered by intragastric infusion, does not stimulate insulin, glp-1, or gip release or slow gastric emptying in healthy humans. |
2009-06-17 |
2023-08-12 |
mouse |
| Anita Mofidi Najjar, Patricia M Parsons, Alison M Duncan, Lindsay E Robinson, Rickey Y Yada, Terry E Graha. The acute impact of ingestion of breads of varying composition on blood glucose, insulin and incretins following first and second meals. The British journal of nutrition. vol 101. issue 3. 2009-06-11. PMID:18570696. |
blood was sampled for 3 h following bread ingestion and a further 2 h after the second meal for determination of glucose, insulin, paracetamol (indirect marker of gastric emptying), glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1). |
2009-06-11 |
2023-08-12 |
human |
| Jun Ding, Yan Gao, Jing Zhao, Hong Yan, Shi-ying Guo, Qin-xian Zhang, Ling-song Li, Xiang Ga. Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating glucagon-like peptide 1 in mice. Endocrinology. vol 150. issue 5. 2009-06-08. PMID:19116343. |
finally, administering the glp-1 receptor agonist exendin-4 to pax6(m/+) mice largely reversed their abnormal food intake, glycemic excursion, and insulin secretion. |
2009-06-08 |
2023-08-12 |
mouse |
| Margriet A B Veldhorst, Arie G Nieuwenhuizen, Ananda Hochstenbach-Waelen, Anneke J A H van Vught, Klaas R Westerterp, Marielle P K J Engelen, Robert-Jan M Brummer, Nicolaas E P Deutz, Margriet S Westerterp-Planteng. Dose-dependent satiating effect of whey relative to casein or soy. Physiology & behavior. vol 96. issue 4-5. 2009-05-26. PMID:19385022. |
appetite profile (visual analogue scales) and amino acid concentrations were determined for 4 h whereas plasma glucose, insulin, active glucagon-like peptide 1 (glp-1), and active ghrelin concentrations were determined for 3 h; the sensitive moment for lunch was determined. |
2009-05-26 |
2023-08-12 |
human |
| Margriet A B Veldhorst, Arie G Nieuwenhuizen, Ananda Hochstenbach-Waelen, Anneke J A H van Vught, Klaas R Westerterp, Marielle P K J Engelen, Robert-Jan M Brummer, Nicolaas E P Deutz, Margriet S Westerterp-Planteng. Dose-dependent satiating effect of whey relative to casein or soy. Physiology & behavior. vol 96. issue 4-5. 2009-05-26. PMID:19385022. |
whey triggered the strongest responses in concentrations of active glp-1 (p<0.05) and insulin (p<0.05) compared with casein and/or soy. |
2009-05-26 |
2023-08-12 |
human |
| H B Vaidya, R K Goya. Glucagon like peptides-1 modulators as newer target for diabetes. Current drug targets. vol 9. issue 10. 2009-05-22. PMID:18855626. |
glucoregulatory actions of glp-1 include glucose-dependent enhancement of insulin secretion, inhibition of glucagon secretion, slowing of gastric emptying and reduction of food intake. |
2009-05-22 |
2023-08-12 |
Not clear |
| Yusuke Moritoh, Koji Takeuchi, Masatoshi Hazam. Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. The Journal of pharmacology and experimental therapeutics. vol 329. issue 2. 2009-05-22. PMID:19208898. |
a similar treatment with pioglitazone (0.03%), an insulin sensitizer, did not affect plasma dpp-4 activity or glp-1 levels. |
2009-05-22 |
2023-08-12 |
mouse |
| P V Højberg, T Vilsbøll, R Rabøl, F K Knop, M Bache, T Krarup, J J Holst, S Madsba. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia. vol 52. issue 2. 2009-05-15. PMID:19037628. |
the aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to gip and glp-1 in patients with type 2 diabetes. |
2009-05-15 |
2023-08-12 |
Not clear |
| Rhonda D Wideman, Sarah L Gray, Scott D Covey, Gene C Webb, Timothy J Kieffe. Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 1. 2009-05-05. PMID:18941442. |
glucagon-like peptide-1 (glp-1) has received much attention as a new treatment for diabetes because of its multiple blood glucose-lowering effects, including glucose-dependent enhancement of insulin secretion, inhibition of gastric emptying, and promotion of the survival and growth of insulin-producing beta-cells. |
2009-05-05 |
2023-08-12 |
mouse |
| Pernille Fog Svendsen, Lisbeth Nilas, Sten Madsbad, Jens Juul Hols. Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin. Metabolism: clinical and experimental. vol 58. issue 5. 2009-05-04. PMID:19375579. |
in normal subjects, the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are responsible for 70% of the insulin response during a meal; but in diabetic subjects and other insulin-resistant conditions, the incretin effect is impaired. |
2009-05-04 |
2023-08-12 |
human |