| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Daousi, J P H Wilding, S Aditya, B H Durham, J Cleator, J H Pinkney, L R Ranganat. Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes. Clinical endocrinology. vol 71. issue 2. 2009-09-28. PMID:19178509. |
apart from their role in insulin secretion and glucose homeostasis, the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) exert a number of extra-pancreatic effects which in the case of gip remain largely unknown. |
2009-09-28 |
2023-08-12 |
human |
| Zaza Kokrashvili, Bedrich Mosinger, Robert F Margolske. T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686115. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that underlies the augmented insulin release from the pancreas in response to glucose in the gut lumen more than to intravenous injected glucose (the "incretin effect"). |
2009-09-25 |
2023-08-12 |
mouse |
| Zaza Kokrashvili, Bedrich Mosinger, Robert F Margolske. T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686115. |
knockout mice lacking alpha-gustducin or t1r3 have deficiencies in secretion of glp-1 and in the regulation of plasma levels of insulin and glucose. |
2009-09-25 |
2023-08-12 |
mouse |
| Per M Hellströ. GLP-1: broadening the incretin concept to involve gut motility. Regulatory peptides. vol 156. issue 1-3. 2009-09-18. PMID:19362109. |
the incretin effect of the gut peptide hormone glucagon-like peptide-1 (glp-1) is a combined result of inhibition of gastric emptying and stimulation of insulin secretion via an incretin mechanism. |
2009-09-18 |
2023-08-12 |
rat |
| Michael Camiller. Peripheral mechanisms in the control of appetite and related experimental therapies in obesity. Regulatory peptides. vol 156. issue 1-3. 2009-09-18. PMID:19409936. |
important signals such as glp-1 and pyy that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. |
2009-09-18 |
2023-08-12 |
Not clear |
| Ixchel M Brennan, Kate L Feltrin, Nivasinee S Nair, Trygve Hausken, Tanya J Little, Diana Gentilcore, Judith M Wishart, Karen L Jones, Michael Horowitz, Christine Feinle-Bisse. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American journal of physiology. Gastrointestinal and liver physiology. vol 297. issue 3. 2009-09-10. PMID:19556358. |
effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma glp-1 and insulin, and energy intake in healthy lean women. |
2009-09-10 |
2023-08-12 |
Not clear |
| Ixchel M Brennan, Kate L Feltrin, Nivasinee S Nair, Trygve Hausken, Tanya J Little, Diana Gentilcore, Judith M Wishart, Karen L Jones, Michael Horowitz, Christine Feinle-Bisse. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American journal of physiology. Gastrointestinal and liver physiology. vol 297. issue 3. 2009-09-10. PMID:19556358. |
gastric emptying influences energy intake, glycemia, and plasma glucagon-like peptide-1 (glp-1), insulin, and cholecystokinin (cck) release. |
2009-09-10 |
2023-08-12 |
Not clear |
| Ixchel M Brennan, Kate L Feltrin, Nivasinee S Nair, Trygve Hausken, Tanya J Little, Diana Gentilcore, Judith M Wishart, Karen L Jones, Michael Horowitz, Christine Feinle-Bisse. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American journal of physiology. Gastrointestinal and liver physiology. vol 297. issue 3. 2009-09-10. PMID:19556358. |
during the follicular phase, gastric emptying was slower (p < 0.05), and blood glucose (p < 0.01), plasma glp-1 and insulin (p < 0.05), hunger (p < 0.01), and energy intake (p < 0.05) were lower compared with the luteal phase, with no differences for cck or between the two follicular phase visits. |
2009-09-10 |
2023-08-12 |
Not clear |
| Ixchel M Brennan, Kate L Feltrin, Nivasinee S Nair, Trygve Hausken, Tanya J Little, Diana Gentilcore, Judith M Wishart, Karen L Jones, Michael Horowitz, Christine Feinle-Bisse. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American journal of physiology. Gastrointestinal and liver physiology. vol 297. issue 3. 2009-09-10. PMID:19556358. |
there were inverse relationships between energy intake, blood glucose, and plasma glp-1 and insulin concentrations with the amount of glucose drink remaining in the stomach at t = 90 min (r < -0.6, p < 0.05). |
2009-09-10 |
2023-08-12 |
Not clear |
| Ixchel M Brennan, Kate L Feltrin, Nivasinee S Nair, Trygve Hausken, Tanya J Little, Diana Gentilcore, Judith M Wishart, Karen L Jones, Michael Horowitz, Christine Feinle-Bisse. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American journal of physiology. Gastrointestinal and liver physiology. vol 297. issue 3. 2009-09-10. PMID:19556358. |
in conclusion, in healthy women 1) gastric emptying of glucose is slower, and glycemia, plasma glp-1 and insulin, hunger, and energy intake are less during the follicular compared with the luteal phase; 2) energy intake, glycemia, and plasma glp-1 and insulin are related to gastric emptying; and 3) these parameters are reproducible when assessed twice during the follicular phase. |
2009-09-10 |
2023-08-12 |
Not clear |
| Daniel A de Luis, Manuel Gonzalez Sagrado, Rosa Conde, Rocio Aller, Olatz Izaol. The effects of two different hypocaloric diets on glucagon-like peptide 1 in obese adults, relation with insulin response after weight loss. Journal of diabetes and its complications. vol 23. issue 4. 2009-09-03. PMID:18413175. |
the aim of this study was to compare the effect of two diets on circulating glp-1 levels and the relation with insulin response after weight loss. |
2009-09-03 |
2023-08-12 |
Not clear |
| Guido Bosch, Adronie Verbrugghe, Myriam Hesta, Jens J Holst, Antonius F B van der Poel, Geert P J Janssens, Wouter H Hendrik. The effects of dietary fibre type on satiety-related hormones and voluntary food intake in dogs. The British journal of nutrition. vol 102. issue 2. 2009-09-03. PMID:19144213. |
postprandial blood samples were obtained to determine postprandial plasma glucose, insulin, total peptide tyrosine-tyrosine (pyy), total glucagon-like peptide-1 (glp-1) and total ghrelin concentrations. |
2009-09-03 |
2023-08-12 |
dog |
| Kasper Aaboe, Thure Krarup, Sten Madsbad, Jens Juul Hols. GLP-1: physiological effects and potential therapeutic applications. Diabetes, obesity & metabolism. vol 10. issue 11. 2009-08-20. PMID:18435775. |
in humans, glp-1 stimulates insulin secretion and inhibits glucagon and gastrointestinal secretions and motility. |
2009-08-20 |
2023-08-12 |
Not clear |
| Noriyasu Kamei, Mariko Morishita, Kozo Takayam. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides. Journal of controlled release : official journal of the Controlled Release Society. vol 136. issue 3. 2009-08-14. PMID:19250953. |
among the 16 peptide drugs possessing different isoelectric points, it was observed that only gastrin, insulin and glucagon-like peptide-1 (glp-1) bound to d-r8 (d-form arginine octamer, a typical cpp), and subsequently their intestinal absorption increased by coadministration of d-r8. |
2009-08-14 |
2023-08-12 |
rat |
| Luan Shu, Aleksey V Matveyenko, Julie Kerr-Conte, Jae-Hyoung Cho, Christopher H S McIntosh, Kathrin Maedle. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Human molecular genetics. vol 18. issue 13. 2009-08-13. PMID:19386626. |
also, insulin secretion stimulated by glucose, glp-1 and gip, but not kcl or cyclic adenosine monophosphate (camp) was impaired in sitcf7l2-treated isolated human islets. |
2009-08-13 |
2023-08-12 |
mouse |
| Teresa Salvatore, Ornella Carbonara, Domenico Cozzolino, Roberto Torella, Ferdinando C Sass. Progress in the oral treatment of type 2 diabetes: update on DPP-IV inhibitors. Current diabetes reviews. vol 5. issue 2. 2009-08-11. PMID:19442094. |
defects of glp-1 characterize type 2 diabetes as a primary or perhaps consequent phenomenon, resulting in inappropriately low insulin secretion after oral ingestion of nutrients. |
2009-08-11 |
2023-08-12 |
Not clear |
| M Karaca, C Magnan, C Karga. Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention. Diabetes & metabolism. vol 35. issue 2. 2009-08-05. PMID:19251449. |
glucagon-like peptide-1 (glp-1), an incretin, enhances beta-cell survival (by activating beta-cell proliferation and differentiation, and inhibiting beta-cell apoptosis), thus contributing to the long-term regulation of insulin secretion by maintaining a functional beta-cell mass. |
2009-08-05 |
2023-08-12 |
Not clear |
| Jun-ichi Eiki, Kaori Saeki, Norihiro Nagano, Tomoharu Iino, Mari Yonemoto, Yoko Takayenoki-Iino, Satoru Ito, Teruyuki Nishimura, Yoshiyuki Sato, Makoto Bamba, Hitomi Watanabe, Kaori Sasaki, Sumika Ohyama, Akio Kanatani, Toshio Nagase, Toshihiko Yad. A selective small molecule glucagon-like peptide-1 secretagogue acting via depolarization-coupled Ca(2+) influx. The Journal of endocrinology. vol 201. issue 3. 2009-07-30. PMID:19332449. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that potentiates insulin secretion in a glucose-dependent manner. |
2009-07-30 |
2023-08-12 |
rat |
| Margriet A B Veldhorst, Arie G Nieuwenhuizen, Ananda Hochstenbach-Waelen, Klaas R Westerterp, Marielle P K J Engelen, Robert-Jan M Brummer, Nicolaas E P Deutz, Margriet S Westerterp-Planteng. Effects of complete whey-protein breakfasts versus whey without GMP-breakfasts on energy intake and satiety. Appetite. vol 52. issue 2. 2009-07-29. PMID:19101599. |
to compare the effects of whey versus whey without glycomacropeptide (gmp) in a high and a normal amount of protein in a breakfast custard on satiety and energy intake (ei), taking concentrations of amino acids (aa), glucose, insulin, glucagon-like peptide 1 (glp-1) and ghrelin into account. |
2009-07-29 |
2023-08-12 |
Not clear |
| W Fujimoto, T Miki, T Ogura, M Zhang, Y Seino, L S Satin, H Nakaya, S Sein. Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice. Diabetologia. vol 52. issue 5. 2009-07-29. PMID:19266181. |
we have previously reported that glucose-stimulated insulin secretion (gsis) is induced by glucagon-like peptide-1 (glp-1) in mice lacking atp-sensitive k(+) (k(atp)) channels (kir6.2(-/-) mice [up-to-date symbol for kir6.2 gene is kcnj11]), in which glucose alone does not trigger insulin secretion. |
2009-07-29 |
2023-08-12 |
mouse |