| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mads Halbirk, Helene Nørrelund, Niels Møller, Jens Juul Holst, Ole Schmitz, Roni Nielsen, Jens Erik Nielsen-Kudsk, Søren Steen Nielsen, Torsten Toftegaard Nielsen, Hans Eiskjaer, Hans Erik Bøtker, Henrik Wigger. Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure. American journal of physiology. Heart and circulatory physiology. vol 298. issue 3. 2010-04-02. PMID:20081109. |
glp-1 infusion increased circulating insulin levels and reduced plasma glucose concentration but had no major cardiovascular effects in patients without diabetes but with compensated hf. |
2010-04-02 |
2023-08-12 |
Not clear |
| M Hoenig, E T Jordan, D C Ferguson, F de Vrie. Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats. Domestic animal endocrinology. vol 38. issue 2. 2010-04-01. PMID:19781890. |
oral glucose leads to a differential response in glucose, insulin, and glp-1 in lean versus obese cats. |
2010-04-01 |
2023-08-12 |
Not clear |
| M Hoenig, E T Jordan, D C Ferguson, F de Vrie. Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats. Domestic animal endocrinology. vol 38. issue 2. 2010-04-01. PMID:19781890. |
there were significant differences between lean and obese cats in the areas under the curve for glucose, insulin, and glp-1. |
2010-04-01 |
2023-08-12 |
Not clear |
| M Hoenig, E T Jordan, D C Ferguson, F de Vrie. Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats. Domestic animal endocrinology. vol 38. issue 2. 2010-04-01. PMID:19781890. |
the low glp-1 concentrations in obese cats might indicate a contribution of glp-1 to the lower insulin sensitivity of obese cats, but this hypothesis needs to be further investigated. |
2010-04-01 |
2023-08-12 |
Not clear |
| Li Wang, Jing Wu, Hongwei Cao, Rong Chen, Nanyan Zhang, Jianfang Fu, Bin Gao, Jing Zhang, Rongrong Hou, Chaowu Tang, Qiuhe J. The correlation between intestinal gonadotropin-releasing hormone (GnRH) and proglucagon in hyperlipidemic rats and Goto-Kakizaki (GK) rats. Endocrine pathology. vol 20. issue 4. 2010-03-18. PMID:19669946. |
this may imply that, compared with the ileum and colon, the jejunum had greater impact on glucose metabolism; furthermore, gnrh might interact with intestinal glp-1 and glp-2 through the paracrine and autocrine ways and then regulate glucose metabolism and insulin secretion. |
2010-03-18 |
2023-08-12 |
rat |
| Jeffrey S Freema. Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus. Cleveland Clinic journal of medicine. vol 76 Suppl 5. 2010-03-16. PMID:19952298. |
nutrient intake stimulates the secretion of the gastrointestinal incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), which exert glucose-dependent insulinotropic effects and assist pancreatic insulin and glucagon in maintaining glucose homeostasis. |
2010-03-16 |
2023-08-12 |
Not clear |
| Quan Shang, Monica Saumoy, Jens Juul Holst, Gerald Salen, Guorong X. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 3. 2010-03-15. PMID:20044510. |
colesevelam improves insulin resistance in a diet-induced obesity (f-dio) rat model by increasing the release of glp-1. |
2010-03-15 |
2023-08-12 |
rat |
| Quan Shang, Monica Saumoy, Jens Juul Holst, Gerald Salen, Guorong X. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 3. 2010-03-15. PMID:20044510. |
it is unlikely that the improvement is attributable to decreased bile acid flux to the liver but is likely secondary to induced glp-1 secretion, which improves insulin release. |
2010-03-15 |
2023-08-12 |
rat |
| Atsuo Tahara, Akiko Matsuyama-Yokono, Ryosuke Nakano, Yuka Someya, Masahiko Hayakawa, Masayuki Shibasak. Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors. Pharmacological reports : PR. vol 61. issue 5. 2010-02-26. PMID:19904014. |
in addition, asp8497 dose-dependently and significantly improved glucose tolerance with a concomitant increase in plasma glucagon-like peptide 1 (glp-1) and insulin levels at both 0.5 h and 8 h after dosing. |
2010-02-26 |
2023-08-12 |
rat |
| Sunmin Park, Sang Mee Hong, Il Sung Ahn, Yang Jin Kim, Jung Bok Le. Huang-Lian-Jie-Du-Tang supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce improved glucose tolerance by potentiating insulinotropic actions in islets in 90% pancreatectomized diabetic rats. Bioscience, biotechnology, and biochemistry. vol 73. issue 11. 2010-02-24. PMID:19897925. |
through the elevation of intracellular camp levels, fsc rs, hljdt, and hljdt-m increased insulin secretion in min6 cells and glp-1 secretion in nci-h716 cells. |
2010-02-24 |
2023-08-12 |
rat |
| Yuka Someya, Ryosuke Nakano, Atsuo Tahara, Toshiyuki Takasu, Asako Takeuchi, Itsuro Nagase, Akiko Matsuyama-Yokono, Masahiro Hayakawa, Masao Sasamata, Keiji Miyata, Yasuo Uchiyam. Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure. European journal of pharmacology. vol 622. issue 1-3. 2010-02-17. PMID:19766107. |
the dipeptidyl peptidase (dpp)-iv inhibitor asp8497, (2s,4s)-4-fluoro-1-({[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino}acetyl)pyrrolidine-2-carbonitrile monofumarate, inhibits the degradation of glucagon-like peptide-1 (glp-1), an incretin hormone, and promotes insulin secretion in a glucose-dependent manner. |
2010-02-17 |
2023-08-12 |
mouse |
| Remy Burcelin, Matteo Serino, Cendrine Cabo. A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism. Current opinion in pharmacology. vol 9. issue 6. 2010-02-08. PMID:19800290. |
this is due to the dogma that proposes that upon glucose absorption glp-1 is secreted into the hepatoportal blood flow, binds to its receptor at the surface of the insulin secreting beta cells, and triggers the secretion of insulin to control glycemia. |
2010-02-08 |
2023-08-12 |
Not clear |
| Urd Kielgast, Jens J Holst, Sten Madsba. Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists. Current diabetes reviews. vol 5. issue 4. 2010-02-05. PMID:19925391. |
the major effects of glp-1 are to increase glucose-induced insulin secretion and reduce glucagon release, but glp-1 also inhibits gastric emptying rate and reduces appetite and bodyweight in obese subjects. |
2010-02-05 |
2023-08-12 |
human |
| Urd Kielgast, Jens J Holst, Sten Madsba. Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists. Current diabetes reviews. vol 5. issue 4. 2010-02-05. PMID:19925391. |
suggestions for future studies of glp-1 treatment in type 1 diabetes may include early treatment in order to preserve beta-cell mass and prolong the remission period, but should also take a potential insulin sparing effect and changes in the risk of hypoglycemia into account. |
2010-02-05 |
2023-08-12 |
human |
| David Nathanson, Ozlem Erdogdu, John Pernow, Qimin Zhang, Thomas Nyströ. Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo. Regulatory peptides. vol 157. issue 1-3. 2010-02-02. PMID:19595708. |
this unexpected finding prompted us to ascertain that the exenatide preparation was biologically active, and both exenatide (10(-11) mol/l) and glp-1 (10(-9) mol/l) significantly increased insulin secretion in pancreatic beta-cells from ob/ob mice in vitro. |
2010-02-02 |
2023-08-12 |
mouse |
| Junko Hanato, Kazuki Kuriyama, Takahiro Mizumoto, Kazuhiro Debari, Junya Hatanaka, Satomi Onoue, Shizuo Yamad. Liposomal formulations of glucagon-like peptide-1: improved bioavailability and anti-diabetic effect. International journal of pharmaceutics. vol 382. issue 1-2. 2010-02-02. PMID:19698772. |
in intraperitoneal glucose tolerance testing in rats, marked improvement of hypoglycemic effects were observed in anionic liposomal formulation of glp-1 (100 nmol/kg) with 1.7-fold higher increase of insulin secretion, as compared to glp-1 solution. |
2010-02-02 |
2023-08-12 |
rat |
| James D Johnson, Ziliang Ao, Peter Ao, Hong Li, Long-Jun Dai, Zehua He, May Tee, Kathryn J Potter, Agnieszka M Klimek, R Mark Meloche, David M Thompson, C Bruce Verchere, Garth L Warnoc. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell transplantation. vol 18. issue 8. 2010-02-01. PMID:19500470. |
treating human islets with the glp-1 agonist exenatide ameliorated the immunosuppressant-induced defects in glucose-stimulated insulin release. |
2010-02-01 |
2023-08-12 |
mouse |
| Kristin R Freeland, Charlotte Wilson, Thomas M S Woleve. Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects. The British journal of nutrition. vol 103. issue 1. 2010-02-01. PMID:19664300. |
since glp-1 may increase insulin sensitivity and secretion, these results may provide a mechanism for the epidemiological association between high cereal fibre intake and reduced risk for diabetes. |
2010-02-01 |
2023-08-12 |
human |
| Unmesh Sha. GPR119 agonists: a promising new approach for the treatment of type 2 diabetes and related metabolic disorders. Current opinion in drug discovery & development. vol 12. issue 4. 2010-01-28. PMID:19562648. |
the activation of gpr119 increases the intracellular accumulation of camp, leading to enhanced glucose-dependent insulin secretion and increased levels of the incretin hormones glp-1 (glucagon-like peptide 1) and gip (glucose-dependent insulinotropic peptide). |
2010-01-28 |
2023-08-12 |
human |
| Michelle A Kovalaske, Gunjan Y Gandh. Incretins in the ICU: is insulin on its way out? Critical care (London, England). vol 13. issue 4. 2010-01-28. PMID:19591659. |
incretins such as glucagon-like peptide-1 (glp-1) are gut-derived hormones that stimulate insulin secretion and suppress glucagon secretion, thus playing a key role in glucose homeostasis. |
2010-01-28 |
2023-08-12 |
Not clear |