| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edwin T Parlevliet, Judith E de Leeuw van Weenen, Johannes A Romijn, Hanno Pij. GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet. American journal of physiology. Endocrinology and metabolism. vol 299. issue 2. 2010-07-21. PMID:20530733. |
the capacities of insulin to stimulate glucose disposal and inhibit glucose production were reinforced by glp-1. |
2010-07-21 |
2023-08-12 |
mouse |
| Edwin T Parlevliet, Judith E de Leeuw van Weenen, Johannes A Romijn, Hanno Pij. GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet. American journal of physiology. Endocrinology and metabolism. vol 299. issue 2. 2010-07-21. PMID:20530733. |
also, glp-1 treatment reinforced the inhibitory action of insulin on vldl-tg production. |
2010-07-21 |
2023-08-12 |
mouse |
| Edwin T Parlevliet, Judith E de Leeuw van Weenen, Johannes A Romijn, Hanno Pij. GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet. American journal of physiology. Endocrinology and metabolism. vol 299. issue 2. 2010-07-21. PMID:20530733. |
in conclusion, peripheral administration of glp-1 reinforces the ability of insulin to suppress endogenous glucose and vldl-tg production (but not lipolysis) and boosts its capacity to stimulate glucose disposal in high-fat-fed c57bl/6 mice. |
2010-07-21 |
2023-08-12 |
mouse |
| David A D'Alessi. Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target? Diabetes. vol 59. issue 7. 2010-07-21. PMID:20587800. |
taking aim at islet hormones with glp-1: is insulin or glucagon the better target? |
2010-07-21 |
2023-08-12 |
Not clear |
| David P Bradley, Roger Kulstad, Dale A Schoelle. Exenatide and weight loss. Nutrition (Burbank, Los Angeles County, Calif.). vol 26. issue 3. 2010-07-14. PMID:20152707. |
it is categorized as an incretin due to its activation of glp-1 receptors in pancreatic beta-cells leading to insulin exocytosis in a glucose-dependent manner. |
2010-07-14 |
2023-08-12 |
Not clear |
| Alexander Harkavyi, Peter S Whitto. Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection. British journal of pharmacology. vol 159. issue 3. 2010-07-13. PMID:20128800. |
thus, the effects of glp-1 receptor stimulation are not based upon insulin replacement but an apparent repair of the pancreas. |
2010-07-13 |
2023-08-12 |
Not clear |
| Lihong Chen, Judi McNulty, Don Anderson, Yaping Liu, Christopher Nystrom, Sarah Bullard, Jon Collins, Anthony L Handlon, Ryan Klein, Angela Grimes, David Murray, Roger Brown, David Krull, Bill Benson, Elena Kleymenova, Katja Remlinger, Andrew Young, Xiaozhou Ya. Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20413600. |
an oral glucose tolerance test showed a significant increase in glucose-stimulated glucagon-like peptide 1 (glp-1), peptide yy (pyy), and insulin release in rats treated with cholestyramine. |
2010-07-13 |
2023-08-12 |
rat |
| Lauri T Haltia, Eriika Savontaus, Tero Vahlberg, Juha O Rinne, Valtteri Kaasine. Acute hormonal changes following intravenous glucose challenge in lean and obese human subjects. Scandinavian journal of clinical and laboratory investigation. vol 70. issue 4. 2010-07-13. PMID:20429700. |
glucose bolus on insulin, leptin, ghrelin, peptide yy (pyy), free fatty acids (ffa), glucagon and glucagon-like peptide-1 (glp-1) concentrations together with self-reported satiety ratings in lean and obese human subjects. |
2010-07-13 |
2023-08-12 |
human |
| Taisuke Mochida, Tohru Hira, Hiroshi Har. The corn protein, zein hydrolysate, administered into the ileum attenuates hyperglycemia via its dual action on glucagon-like peptide-1 secretion and dipeptidyl peptidase-IV activity in rats. Endocrinology. vol 151. issue 7. 2010-07-05. PMID:20410194. |
to observe the effect of luminal zeinh itself on glp-1 secretion and glycemia, ip glucose tolerance tests were performed in conscious rats with ileal and jugular catheters, and plasma glucose, insulin, and glp-1 (total and active) were measured. |
2010-07-05 |
2023-08-12 |
rat |
| Taisuke Mochida, Tohru Hira, Hiroshi Har. The corn protein, zein hydrolysate, administered into the ileum attenuates hyperglycemia via its dual action on glucagon-like peptide-1 secretion and dipeptidyl peptidase-IV activity in rats. Endocrinology. vol 151. issue 7. 2010-07-05. PMID:20410194. |
these results indicate that the ileal administration of a dietary peptide, zeinh, has the dual functions of inducing glp-1 secretion and inhibiting glp-1 degradation, resulting in the enhancement of insulin secretion and the prevention of hyperglycemia in rats. |
2010-07-05 |
2023-08-12 |
rat |
| Lei Tian, Jie Gao, Jianqiang Hao, Yu Zhang, Huimin Yi, Timothy D O'Brien, Robert Sorenson, Jian Luo, Zhiguang Gu. Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor. Endocrinology. vol 151. issue 7. 2010-07-05. PMID:20444936. |
regulatory t cells in thymus and secondary lymph nodes, tgf-beta1 and glp-1 in plasma, and the insulin content in the pancreas were measured. |
2010-07-05 |
2023-08-12 |
mouse |
| Lei Tian, Jie Gao, Jianqiang Hao, Yu Zhang, Huimin Yi, Timothy D O'Brien, Robert Sorenson, Jian Luo, Zhiguang Gu. Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor. Endocrinology. vol 151. issue 7. 2010-07-05. PMID:20444936. |
plasma tgf-beta1 and glp-1, the insulin content, and both insulin(+) and brdu(+) beta-cells in pancreas were also significantly increased. |
2010-07-05 |
2023-08-12 |
mouse |
| Brian Furman, Wee Kiat Ong, Nigel J Pyn. Cyclic AMP signaling in pancreatic islets. Advances in experimental medicine and biology. vol 654. 2010-06-24. PMID:20217503. |
cyclic 3'5'amp (camp) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet beta-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (glp-1 and gip). |
2010-06-24 |
2023-08-12 |
Not clear |
| Bernardo Léo Wajchenber. Clinical approaches to preserve beta-cell function in diabetes. Advances in experimental medicine and biology. vol 654. 2010-06-24. PMID:20217513. |
the long-term improvement was demonstrated with short-term intensive insulin therapy of newly diagnosed dm2, the use of antiapoptotic drugs such as glitazones, and the use of glucagon-like peptide-1 receptor agonists (glp-1 mimetics), not inactivated by the enzyme dipeptidyl peptidase 4 and/or to inhibit that enzyme (glp-1 enhancers). |
2010-06-24 |
2023-08-12 |
Not clear |
| Barry D Kerr, Peter R Flatt, Victor A Gaul. Effects of gamma-glutamyl linker on DPP-IV resistance, duration of action and biological efficacy of acylated glucagon-like peptide-1. Biochemical pharmacology. vol 80. issue 3. 2010-06-22. PMID:20417187. |
glp-1, lira-gammaglu and liraglutide increased insulin secretion compared to glucose (1.5-3.0-fold; p<0.05 to p<0.001). |
2010-06-22 |
2023-08-12 |
Not clear |
| Giovanni Pacini, Karl Thomaseth, Bo Ahré. Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice. Metabolism: clinical and experimental. vol 59. issue 7. 2010-06-17. PMID:20153002. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) potently augment insulin response to glucose. |
2010-06-17 |
2023-08-12 |
mouse |
| Giovanni Pacini, Karl Thomaseth, Bo Ahré. Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice. Metabolism: clinical and experimental. vol 59. issue 7. 2010-06-17. PMID:20153002. |
insulin clearance, previously shown to be abridged by 46% with glp-1, was reduced only by a nonsignificant (p = .27) 21% with gip. |
2010-06-17 |
2023-08-12 |
mouse |
| Raffaele Marfella, Michelangela Barbieri, Rodolfo Grella, Maria Rosaria Rizzo, Giovanni Francesco Nicoletti, Giuseppe Paoliss. Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations. Journal of diabetes and its complications. vol 24. issue 2. 2010-06-14. PMID:19261490. |
during a standardized meal, glucagon-like peptide-1 (glp-1), glucagon, and insulin were measured. |
2010-06-14 |
2023-08-12 |
human |
| Bruno Guerci, Charles Halte. [New hypoglycemic agents in type 2 diabetes]. La Revue du praticien. vol 60. issue 4. 2010-06-10. PMID:20465123. |
the effects of glp-1 on insulin secretion and glucagon are observed only at high glucose levels (glucose-dependent effects). |
2010-06-10 |
2023-08-12 |
Not clear |
| Chiara Dalla Man, Francesco Micheletto, Airani Sathananthan, Robert A Rizza, Adrian Vella, Claudio Cobell. A model of GLP-1 action on insulin secretion in nondiabetic subjects. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179243. |
a model of glp-1 action on insulin secretion in nondiabetic subjects. |
2010-06-08 |
2023-08-12 |
human |