| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Keith Campbell, Michael E Cobble, Timothy S Reid, Mansur E Shomal. Distinguishing among incretin-based therapies. Pathophysiology of type 2 diabetes mellitus: potential role of incretin-based therapies. The Journal of family practice. vol 59. issue 9 Suppl 1. 2010-12-07. PMID:20824239. |
in addition to improving insulin resistance and pancreatic β-cell dysfunction, the glp-1 agonists and dpp-4 inhibitors improve the impaired incretin response, as well as increase insulin secretion and reduce glucagon secretion, both in a glucose-dependent manner. |
2010-12-07 |
2023-08-12 |
Not clear |
| E Tomas, V Stanojevic, J F Habene. GLP-1 (9-36) amide metabolite suppression of glucose production in isolated mouse hepatocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 9. 2010-12-02. PMID:20645222. |
the glucoincretin hormone glucagon-like peptide-1 (glp-1) augments glucose-stimulated insulin secretion and is in use as an effective treatment for diabetes. |
2010-12-02 |
2023-08-12 |
mouse |
| E Tomas, V Stanojevic, J F Habene. GLP-1 (9-36) amide metabolite suppression of glucose production in isolated mouse hepatocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 9. 2010-12-02. PMID:20645222. |
these findings support direct insulinomimetic actions of the glp-1 metabolite on gluconeogenesis in hepatocytes that are independent of insulin action and the glp-1 receptor, and suggest that glp-1 (9-36) amide-based peptides might present a novel therapy for the treatment of excessive hepatic glucose production in individuals with insulin-resistant diabetes. |
2010-12-02 |
2023-08-12 |
mouse |
| Que Liu, Lisa Adams, Anatoly Broyde, Rayne Fernandez, Alain D Baron, David G Parke. The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats. Cardiovascular diabetology. vol 9. 2010-11-23. PMID:20678234. |
activation of glucagon-like peptide-1 (glp-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. |
2010-11-23 |
2023-08-12 |
rat |
| Caina Li, Yi Huan, Ning Shen, Lixia Ji, Sujuan Sun, Shuainan Liu, Quan Liu, Lihui Gao, Fenlai Tan, Yanping Wang, Zhufang She. A novel GLP-1 analog, BPI3006, with potent DPP IV resistance and good glucoregulatory effect. Biochemical and biophysical research communications. vol 400. issue 4. 2010-11-23. PMID:20804731. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that decreases postprandial glycemic excursions by enhancing insulin secretion but with short half-life due to rapid inactivation by enzymatic n-terminal truncation. |
2010-11-23 |
2023-08-12 |
mouse |
| Li Yang, Xiaoming Li, Yong Ji, Alison B Kohan, David Q-H Wang, Philip N Howles, David Y Hui, Jianghua Lai, Patrick Ts. Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 5. 2010-11-12. PMID:20651007. |
since gip and glp-1 promote the actions of insulin, we hypothesized that ezetimibe may affect the secretion of gip and glp-1 by enteroendocrine cells into lymph in response to the intestinal absorption of a mixed meal (ensure). |
2010-11-12 |
2023-08-12 |
mouse |
| L Wang, F Guo, S Wei, R Zha. Neonatal intramuscular injection of plasmid DNA encoding GLP-1 reduces serum insulin level and modifies skeletal muscle myosin heavy chain composition in adult rats. Physiological research. vol 59. issue 4. 2010-10-19. PMID:19929145. |
neonatal intramuscular injection of plasmid dna encoding glp-1 reduces serum insulin level and modifies skeletal muscle myosin heavy chain composition in adult rats. |
2010-10-19 |
2023-08-12 |
rat |
| L Wang, F Guo, S Wei, R Zha. Neonatal intramuscular injection of plasmid DNA encoding GLP-1 reduces serum insulin level and modifies skeletal muscle myosin heavy chain composition in adult rats. Physiological research. vol 59. issue 4. 2010-10-19. PMID:19929145. |
these results indicate that neonatal exposure of healthy pups to ectopic glp-1 causes growth retardation with decreased serum insulin as well as muscle type-dependent modifications in myhc type composition and metabolic gene expression in adult rats. |
2010-10-19 |
2023-08-12 |
rat |
| Maria Tzefos, Jacqueline L Oli. Glucagon-like peptide-1 analog and insulin combination therapy in the management of adults with type 2 diabetes mellitus. The Annals of pharmacotherapy. vol 44. issue 7-8. 2010-10-08. PMID:20530705. |
to evaluate the efficacy and tolerability of combination glucagon-like peptide-1 (glp-1) analogs and insulin in the management of type 2 diabetes mellitus (t2dm) in adults. |
2010-10-08 |
2023-08-12 |
Not clear |
| Kristine Juul Har. Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus. Danish medical bulletin. vol 57. issue 9. 2010-10-08. PMID:20816021. |
patients were investigated on a third occasion with glp-1 infusions after an over-night normalisation of pg using adjustable insulin infusions. |
2010-10-08 |
2023-08-12 |
human |
| Kristine Juul Har. Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus. Danish medical bulletin. vol 57. issue 9. 2010-10-08. PMID:20816021. |
the glucose-lowering effect of glp-1 is due to both insulin stimulation leading to peripheral glucose disposal and glucagon inhibition resulting in decreased stimulation of hepatic glucose production. |
2010-10-08 |
2023-08-12 |
human |
| Bernardo Nuche-Berenguer, Sergio Portal-Núñez, Paola Moreno, Nieves González, Alicia Acitores, Ana López-Herradón, Pedro Esbrit, Isabel Valverde, María L Villanueva-Peñacarrill. Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor. Journal of cellular physiology. vol 225. issue 2. 2010-10-07. PMID:20506394. |
[(125)i]-glp-1 specific binding to mc3t3-e1 cells was time- and temperature-dependent, reaching maximal value at 30 min at 25 degrees c; in these conditions, [(125)i]-glp-1 binding was dissociable, and displaced by glp-1, partially by glp-2, but not by exendin-4 (ex-4), exendin-9 (ex-9), glucagon or insulin; scatchard analysis of the unlabeled glp-1 data showed high and low affinity binding sites; cross-linking of glp-1 binding revealed an estimated 70 kda band, almost undetectable in the presence of 10(-6) m glp-1. |
2010-10-07 |
2023-08-12 |
rat |
| Bernardo Nuche-Berenguer, Sergio Portal-Núñez, Paola Moreno, Nieves González, Alicia Acitores, Ana López-Herradón, Pedro Esbrit, Isabel Valverde, María L Villanueva-Peñacarrill. Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor. Journal of cellular physiology. vol 225. issue 2. 2010-10-07. PMID:20506394. |
glp-1, ex-9, insulin or glucagon failed to modify cellular camp content, while glp-2 and ex-4 increased it. |
2010-10-07 |
2023-08-12 |
rat |
| Nicolai M Doliba, Wei Qin, Sergei A Vinogradov, David F Wilson, Franz M Matschinsk. Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets. American journal of physiology. Endocrinology and metabolism. vol 299. issue 3. 2010-10-06. PMID:20606076. |
fatty acids, acetylcholine, and glp-1 enhance insulin secretion in a glucose-dependent manner. |
2010-10-06 |
2023-08-12 |
mouse |
| Nicolai M Doliba, Wei Qin, Sergei A Vinogradov, David F Wilson, Franz M Matschinsk. Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets. American journal of physiology. Endocrinology and metabolism. vol 299. issue 3. 2010-10-06. PMID:20606076. |
at a fixed concentration of 0.5 mm, pa markedly inhibited acetylcholine-stimulated insulin release, the rise of intracellular ca(2+), and enhancement of camp production but did not influence the effects of glp-1 on these parameters of islet cell function. |
2010-10-06 |
2023-08-12 |
mouse |
| Nicolai M Doliba, Wei Qin, Sergei A Vinogradov, David F Wilson, Franz M Matschinsk. Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets. American journal of physiology. Endocrinology and metabolism. vol 299. issue 3. 2010-10-06. PMID:20606076. |
we thus demonstrate that pa acutely reduces the total oxygen consumption response to glucose, glucose-dependent acetylcholine stimulation of insulin release, ca(2+), and camp metabolism, whereas glp-1's actions on these parameters remain unaffected or potentiated. |
2010-10-06 |
2023-08-12 |
mouse |
| Antonis Voutetakis, Ana P Cotrim, Anne Rowzee, Changyu Zheng, Trushar Rathod, Tulin Yanik, Y Peng Loh, Bruce J Baum, Niamh X Cawle. Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland. Endocrinology. vol 151. issue 9. 2010-10-04. PMID:20610567. |
when expressed in neuro2a and cos7 cells, an active form of glp-1 was specifically detected by ria in the conditioned medium of transduced cells, showed resistance to degradation by dipeptidyl-peptidase iv, and induced the secretion of insulin from nit1 pancreatic beta-cells in vitro. |
2010-10-04 |
2023-08-12 |
mouse |
| Cassandra Koole, Denise Wootten, John Simms, Celine Valant, Rohan Sridhar, Owen L Woodman, Laurence J Miller, Roger J Summers, Arthur Christopoulos, Patrick M Sexto. Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. Molecular pharmacology. vol 78. issue 3. 2010-09-21. PMID:20547734. |
the glucagon-like peptide-1 (glp-1) receptor is a key regulator of insulin secretion and a major therapeutic target for treatment of diabetes. |
2010-09-21 |
2023-08-12 |
Not clear |
| Seema Hooda, J Jacques Matte, Thavaratnam Vasanthan, Ruurd T Zijlstr. Dietary oat beta-glucan reduces peak net glucose flux and insulin production and modulates plasma incretin in portal-vein catheterized grower pigs. The Journal of nutrition. vol 140. issue 9. 2010-09-16. PMID:20660287. |
net glucose and scfa flux and insulin secretion into the portal vein might be associated with the incretins glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1). |
2010-09-16 |
2023-08-12 |
Not clear |
| Seema Hooda, J Jacques Matte, Thavaratnam Vasanthan, Ruurd T Zijlstr. Dietary oat beta-glucan reduces peak net glucose flux and insulin production and modulates plasma incretin in portal-vein catheterized grower pigs. The Journal of nutrition. vol 140. issue 9. 2010-09-16. PMID:20660287. |
in conclusion, dietary supplementation of 6% oat beta-glucan concentrate decreased net glucose flux, increased net scfa flux, and decreased peak apparent insulin production, changes that were associated with gip and glp-1 mediation. |
2010-09-16 |
2023-08-12 |
Not clear |