| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Lupi, S Del Guerra, V D'Aleo, U Boggi, F Filipponi, P Marchett. The direct effects of GLP-1 and GIP, alone or in combination, on human pancreatic islets. Regulatory peptides. vol 165. issue 2-3. 2011-04-14. PMID:20472004. |
following prolonged exposure to the incretins, improved insulin secretion was observed, and transcription of insulin, pdx-1 and bcl-2 was increased in both non-diabetic and diabetic islets, with the combination of glp-1 and gip showing more significant effects. |
2011-04-14 |
2023-08-12 |
human |
| M A Kebede, T Alquier, M G Latour, V Poitou. Lipid receptors and islet function: therapeutic implications? Diabetes, obesity & metabolism. vol 11 Suppl 4. 2011-04-12. PMID:19817784. |
gpr119 is expressed in pancreatic beta-cells and enteroendocrine l-cells, and augments circulating insulin levels both through its direct insulinotropic action on beta-cells and through fa stimulation of glucagon-like peptide 1 (glp-1) secretion. |
2011-04-12 |
2023-08-12 |
Not clear |
| Yanmei Liu, Hassan Mziaut, Anna Ivanova, Michele Solimen. beta-Cells at the crossroads: choosing between insulin granule production and proliferation. Diabetes, obesity & metabolism. vol 11 Suppl 4. 2011-04-12. PMID:19817789. |
both of these major adaptive behaviours are positively regulated by several extrinsic factors, such as glucose, glp-1, insulin and growth hormones (gh). |
2011-04-12 |
2023-08-12 |
Not clear |
| P M Hellströ. GLP-1 playing the role of a gut regulatory compound. Acta physiologica (Oxford, England). vol 201. issue 1. 2011-04-11. PMID:20518750. |
the incretin hormones originating in the gut, particularly glp-1, exert multiple antihyperglycaemic actions such as enhancement of glucose-dependent insulin secretion, suppression of glucagon secretion, slowing of gastric emptying with an ensuing decrease in food intake and weight loss. |
2011-04-11 |
2023-08-12 |
human |
| Stéphane Dalle, Magalie A Ravier, Gyslaine Bertran. Emerging roles for β-arrestin-1 in the control of the pancreatic β-cell function and mass: new therapeutic strategies and consequences for drug screening. Cellular signalling. vol 23. issue 3. 2011-04-11. PMID:20849951. |
importantly, recent studies found that β-arrestin-1 mediates glp-1 signalling to insulin secretion, glp-1 antiapoptotic effect by phosphorylating the proapoptotic protein bad through erk1/2 activation, and pacap potentiation of glucose-induced long-lasting erk1/2 activation controlling irs-2 expression. |
2011-04-11 |
2023-08-12 |
Not clear |
| Ju-Young Kim, Dong-Mee Lim, Chan Il Moon, Kyung-Jin Jo, Seong-Kyu Lee, Haing-Woon Baik, Ki-Ho Lee, Kang-Woo Lee, Keun-Young Park, Byung-Joon Ki. Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3β activity. Journal of Korean medical science. vol 25. issue 11. 2011-04-07. PMID:21060752. |
glucagon like peptide-1 (glp-1) has effects on preservation of β-cell mass and its insulin secretory function. |
2011-04-07 |
2023-08-12 |
human |
| Gary J Grover, Lee Koetzner, Joan Wicks, Roland J Gahler, Michael R Lyon, Raylene A Reimer, Simon Woo. Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats. Life sciences. vol 88. issue 9-10. 2011-04-07. PMID:21115020. |
effects of the soluble fiber complex polyglycoplex® (pgx®) on glycemic control, insulin secretion, and glp-1 levels in zucker diabetic rats. |
2011-04-07 |
2023-08-12 |
rat |
| Gary J Grover, Lee Koetzner, Joan Wicks, Roland J Gahler, Michael R Lyon, Raylene A Reimer, Simon Woo. Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats. Life sciences. vol 88. issue 9-10. 2011-04-07. PMID:21115020. |
the effects of the novel water soluble, viscous fiber complex polyglycoplex® [(α-d-glucurono-α-d-manno-β-d-manno-β-d-gluco), (α-l-gulurono-β-d mannurono), β-d-gluco-β-d-mannan (pgx®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (glp-1) levels were determined in zucker diabetic rats (zdfs). |
2011-04-07 |
2023-08-12 |
rat |
| Gary J Grover, Lee Koetzner, Joan Wicks, Roland J Gahler, Michael R Lyon, Raylene A Reimer, Simon Woo. Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats. Life sciences. vol 88. issue 9-10. 2011-04-07. PMID:21115020. |
such fibers are thought to improve glycemic control through increased glp-1 induced insulin secretion. |
2011-04-07 |
2023-08-12 |
rat |
| Maria P Yavropoulou, John G Yovo. Central regulation of glucose-dependent insulinotropic polypeptide secretion. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094900. |
glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide-1 (glp-1) are potent stimulators of glucose-dependent insulin secretion, a phenomenon known as incretin effect. |
2011-04-05 |
2023-08-12 |
Not clear |
| Douglas A Velásquez, Daniel Beiroa, María J Vázquez, Amparo Romero, Miguel López, Carlos Diéguez, Ruben Nogueira. Central GLP-1 actions on energy metabolism. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094905. |
glucagon-like peptide 1 (glp-1) is secreted mainly by the intestine in a nutrient-dependent manner and stimulates glucose-induced insulin secretion, inhibits gastric emptying, food intake, and glucagon secretion. |
2011-04-05 |
2023-08-12 |
Not clear |
| Douglas A Velásquez, Daniel Beiroa, María J Vázquez, Amparo Romero, Miguel López, Carlos Diéguez, Ruben Nogueira. Central GLP-1 actions on energy metabolism. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094905. |
more recently, it has been also demonstrated that within the central nervous system, glp-1 also exerts important metabolic actions inhibiting food intake, increasing insulin secretion, and modulating behavioral responses. |
2011-04-05 |
2023-08-12 |
Not clear |
| Colin A Leech, Oleg G Chepurny, George G Hol. Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094904. |
glucagon-like peptide-1 (glp-1) binds its class ii g protein-coupled receptor to stimulate cyclic adenosine monophosphate (camp) production and to potentiate the glucose metabolism-dependent secretion of insulin from pancreatic β cells located within the islets of langerhans. |
2011-04-05 |
2023-08-12 |
human |
| Colin A Leech, Oleg G Chepurny, George G Hol. Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094904. |
prior clinical studies demonstrate that this camp-mediated action of glp-1 to potentiate glucose-stimulated insulin secretion (gsis) is of major therapeutic importance when evaluating the abilities of glp-1 receptor (glp-1r) agonists to lower levels of blood glucose in type 2 diabetic subjects. |
2011-04-05 |
2023-08-12 |
human |
| Per M Hellströ. Glucagon-like peptide-1 gastrointestinal regulatory role in metabolism and motility. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094906. |
the incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), work together to reduce postprandial hyperglycemia by glucose-dependent insulin secretion and inhibition of glucagon release, as well as inhibition of gi motility and gastric emptying. |
2011-04-05 |
2023-08-12 |
human |
| Christian Hölsche. The role of GLP-1 in neuronal activity and neurodegeneration. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094907. |
the incretin glucagon-like peptide-1 (glp-1) is a hormone that facilitates insulin release under high blood sugar conditions. |
2011-04-05 |
2023-08-12 |
mouse |
| Christian Hölsche. The role of GLP-1 in neuronal activity and neurodegeneration. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094907. |
interestingly, glp-1 also has very similar growth factor like properties as insulin, and has been shown to protect neurons from toxic effects. |
2011-04-05 |
2023-08-12 |
mouse |
| Kristine J Hare, Filip K Kno. Incretin-based therapy and type 2 diabetes. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094909. |
therefore, the actions of glp-1 and gip, which include potentiation of meal-induced insulin secretion and trophic effects on the beta-cell, have attracted a lot of interest. |
2011-04-05 |
2023-08-12 |
Not clear |
| Unmesh Shah, Timothy J Kowalsk. GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094910. |
the activation of gpr119 increases the intracellular accumulation of camp, leading to enhanced glucose-dependent insulin secretion from pancreatic β-cells and increased release of the gut peptides glp-1 (glucagon-like peptide 1), gip (glucose-dependent insulinotropic peptide) and pyy (polypeptide yy). |
2011-04-05 |
2023-08-12 |
Not clear |
| Kathleen J Griffioen, Ruiqian Wan, Eitan Okun, Xin Wang, Mary Rachael Lovett-Barr, Yazhou Li, Mohamed R Mughal, David Mendelowitz, Mark P Mattso. GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons. Cardiovascular research. vol 89. issue 1. 2011-04-04. PMID:20736238. |
whereas glp-1 acts in the periphery to inhibit glucagon secretion and stimulate insulin release, it also acts in the central nervous system to mediate autonomic control of feeding, body temperature, and cardiovascular function. |
2011-04-04 |
2023-08-12 |
Not clear |