| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chiara Dalla Man, Francesco Micheletto, Airani Sathananthan, Robert A Rizza, Adrian Vella, Claudio Cobell. A model of GLP-1 action on insulin secretion in nondiabetic subjects. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179243. |
glucagon-like peptide-1 (glp-1)-based therapies for diabetes have aroused interest because of their effects on insulin secretion and glycemic control. |
2010-06-08 |
2023-08-12 |
human |
| Chiara Dalla Man, Francesco Micheletto, Airani Sathananthan, Robert A Rizza, Adrian Vella, Claudio Cobell. A model of GLP-1 action on insulin secretion in nondiabetic subjects. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179243. |
four models of glp-1 action on insulin secretion were considered. |
2010-06-08 |
2023-08-12 |
human |
| Chiara Dalla Man, Francesco Micheletto, Airani Sathananthan, Robert A Rizza, Adrian Vella, Claudio Cobell. A model of GLP-1 action on insulin secretion in nondiabetic subjects. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179243. |
all models share the common assumption that insulin secretion is made up of two components, one proportional to glucose rate of change through dynamic responsivity, phi(d), and one proportional to glucose through static responsivity, phi(s), but differing by modality of glp-1 control. |
2010-06-08 |
2023-08-12 |
human |
| Chiara Dalla Man, Francesco Micheletto, Airani Sathananthan, Robert A Rizza, Adrian Vella, Claudio Cobell. A model of GLP-1 action on insulin secretion in nondiabetic subjects. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179243. |
the model that best fit c-peptide data assumes that above-basal insulin secretion depends linearly on glp-1 concentration and its rate of change. |
2010-06-08 |
2023-08-12 |
human |
| Chiara Dalla Man, Francesco Micheletto, Airani Sathananthan, Robert A Rizza, Adrian Vella, Claudio Cobell. A model of GLP-1 action on insulin secretion in nondiabetic subjects. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179243. |
under glp-1 stimulus, pi = 12.6 +/- 0.71% per pmol/l, meaning that an increase of 5 pmol/l in peripheral glp-1 concentrations induces an approximately 60% increase in over-basal insulin secretion. |
2010-06-08 |
2023-08-12 |
human |
| Patricia L Brubake. Minireview: update on incretin biology: focus on glucagon-like peptide-1. Endocrinology. vol 151. issue 5. 2010-06-08. PMID:20305008. |
the incretin hormone, glucagon-like peptide-1 (glp-1), is now being used in the clinic to enhance insulin secretion and reduce body weight in patients with type 2 diabetes. |
2010-06-08 |
2023-08-12 |
Not clear |
| Soushou Lee, Daisuke Yabe, Kyoko Nohtomi, Michiya Takada, Ryou Morita, Yutaka Seino, Tsutomu Hiran. Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes. Endocrine journal. vol 57. issue 2. 2010-06-07. PMID:19881250. |
we concluded that intact glp-1 levels are comparable between non-diabetics and t2dm, suggesting that impaired insulin secretion in japanese t2dm is not attributable to defect in glp-1 secretion. |
2010-06-07 |
2023-08-12 |
human |
| Meena Asmar, Michael Bache, Filip K Knop, Sten Madsbad, Jens J Hols. Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans? The Journal of clinical endocrinology and metabolism. vol 95. issue 5. 2010-05-28. PMID:20194711. |
amylin, cosecreted with insulin, has like glucagon-like peptide-1 (glp-1) been reported to inhibit glucagon secretion, delay gastric emptying, and reduce appetite and food intake. |
2010-05-28 |
2023-08-12 |
Not clear |
| Urd Kielgast, Meena Asmar, Sten Madsbad, Jens J Hols. Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients. The Journal of clinical endocrinology and metabolism. vol 95. issue 5. 2010-05-28. PMID:20207828. |
the mechanism by which glucagon-like peptide-1 (glp-1) suppresses glucagon secretion is uncertain, and it is not determined whether endogenous insulin is a necessary factor for this effect. |
2010-05-28 |
2023-08-12 |
Not clear |
| Norio Harada, Nobuya Inagak. [Incretin and incretin-based therapies]. Nihon rinsho. Japanese journal of clinical medicine. vol 68. issue 5. 2010-05-27. PMID:20446595. |
gip and glp-1 potentiate glucose-induced insulin secretion by binding gip receptor and glp-1 receptor, respectively, on pancreatic beta-cell and increasing intracellular camp concentration (incretin effect). |
2010-05-27 |
2023-08-12 |
human |
| Norio Harada, Nobuya Inagak. [Incretin and incretin-based therapies]. Nihon rinsho. Japanese journal of clinical medicine. vol 68. issue 5. 2010-05-27. PMID:20446595. |
gip and glp-1 have not only pancreatic effect, such as potentiation of insulin secretion, but also many extrapancreatic effects. |
2010-05-27 |
2023-08-12 |
human |
| Norio Harada, Nobuya Inagak. [Incretin and incretin-based therapies]. Nihon rinsho. Japanese journal of clinical medicine. vol 68. issue 5. 2010-05-27. PMID:20446595. |
glp-1 was target peptide as anti-diabetic drug, because insulin secretion in response to glp-1 infusion was intact in type 2 diabetic patients. |
2010-05-27 |
2023-08-12 |
human |
| El-Sayed Khafagy, Mariko Morishita, Kozo Takayam. The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides. International journal of pharmaceutics. vol 388. issue 1-2. 2010-05-20. PMID:20060451. |
shuffle (r,k fix) 2 significantly increased the nasal absorption of insulin, glucagon-like-peptide-1 (glp-1) and exendin-4, compared with the absorption seen with l-penetratin. |
2010-05-20 |
2023-08-12 |
rat |
| El-Sayed Khafagy, Mariko Morishita, Kozo Takayam. The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides. International journal of pharmaceutics. vol 388. issue 1-2. 2010-05-20. PMID:20060451. |
in addition, the calculated binding ratio between cpp and drug proved a critical aspect in enhancing the absorption of insulin and glp-1. |
2010-05-20 |
2023-08-12 |
rat |
| Nitika Arora Gupta, Jamie Mells, Richard M Dunham, Arash Grakoui, Jeffrey Handy, Neeraj Kumar Saxena, Frank A Anani. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology (Baltimore, Md.). vol 51. issue 5. 2010-05-14. PMID:20225248. |
glp-1 functions as an incretin and stimulates glucose-mediated insulin production by pancreatic beta cells. |
2010-05-14 |
2023-08-12 |
human |
| Yukihiro Fujita, Rhonda D Wideman, Ali Asadi, Gary K Yang, Robert Baker, Travis Webber, Tianjiao Zhang, Rennian Wang, Ziliang Ao, Garth L Warnock, Yin Nam Kwok, Timothy J Kieffe. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology. vol 138. issue 5. 2010-05-07. PMID:20138041. |
glucose-dependent insulinotropic polypeptide (gip) and the proglucagon product glucagon-like peptide-1 (glp-1) are gastrointestinal hormones that are released in response to nutrient intake and promote insulin secretion. |
2010-05-07 |
2023-08-12 |
Not clear |
| Eleanor J Beck, Linda C Tapsell, Marijka J Batterham, Susan M Tosh, Xu-Feng Huan. Oat beta-glucan supplementation does not enhance the effectiveness of an energy-restricted diet in overweight women. The British journal of nutrition. vol 103. issue 8. 2010-04-30. PMID:19930764. |
anthropometric and metabolic variables (blood glucose level, insulin, total cholesterol (tc), ldl, hdl, tag and leptin), together with markers of appetite regulation (cholecystokinin (cck), glucagon-like peptide-1 (glp-1), ghrelin, peptide yy (pyy) and pyy3-36) were measured at baseline and at 3 months. |
2010-04-30 |
2023-08-12 |
Not clear |
| Leila J Karhunen, Kristiina R Juvonen, Sanna M Flander, Kirsi-Helena Liukkonen, Liisa Lähteenmäki, Maritta Siloaho, David E Laaksonen, Karl-Heinz Herzig, Matti I Uusitupa, Kaisa S Poutane. A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. The Journal of nutrition. vol 140. issue 4. 2010-04-30. PMID:20147463. |
serum insulin and plasma glucose, ghrelin, glucagon-like peptide 1 (glp-1), and peptide yy (pyy) concentrations were determined for 2 h following the meals. |
2010-04-30 |
2023-08-12 |
human |
| Leila J Karhunen, Kristiina R Juvonen, Sanna M Flander, Kirsi-Helena Liukkonen, Liisa Lähteenmäki, Maritta Siloaho, David E Laaksonen, Karl-Heinz Herzig, Matti I Uusitupa, Kaisa S Poutane. A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. The Journal of nutrition. vol 140. issue 4. 2010-04-30. PMID:20147463. |
postprandial glucose, insulin, ghrelin, glp-1, and pyy responses all differed among the meals (p
| 2010-04-30 |
2023-08-12 |
human |
|
| Eva Tomas, Joel F Habene. Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis. Trends in endocrinology and metabolism: TEM. vol 21. issue 2. 2010-04-27. PMID:20018525. |
whereas glp-1(7-36)amide stimulates glucose-dependent insulin secretion, glp-1(9-36)amide has only weak partial insulinotropic agonist activities on the glp-1 receptor, but suppresses hepatic glucose production, exerts antioxidant cardioprotective actions and reduces oxidative stress in vasculature tissues. |
2010-04-27 |
2023-08-12 |
Not clear |