| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Yoshida, Rika Tsuhako, Chihiro Sugita, Masahiko Kurokaw. Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice. Biological & pharmaceutical bulletin. vol 44. issue 3. 2021-10-14. PMID:33642550. |
long-term (11-week) consumption of gh tended to reduce body weight and the fasting blood glucose concentration of the hfd-fed mice, and ameliorated glucose intolerance and insulin resistance, according to glucose and insulin tolerance tests. |
2021-10-14 |
2023-08-13 |
mouse |
| Hiroki Yoshida, Rika Tsuhako, Chihiro Sugita, Masahiko Kurokaw. Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice. Biological & pharmaceutical bulletin. vol 44. issue 3. 2021-10-14. PMID:33642550. |
short-term (2-week) consumption of gh did not affect the hfd-induced increases in body weight or fasting blood glucose, and it did not ameliorate glucose intolerance or insulin resistance. |
2021-10-14 |
2023-08-13 |
mouse |
| Junichi Suzuki, Tatsuhiko Urakami, Ichiro Moriok. Greater insulin resistance in short children born small-for-gestational age than in children with growth hormone deficiency at the early period of growth hormone therapy. Pediatrics international : official journal of the Japan Pediatric Society. vol 63. issue 10. 2021-10-13. PMID:33453088. |
we compared insulin resistance and glucose metabolism during growth hormone (gh) therapy between 43 short children born small-for-gestational age (sga) and 42 children identify as growth hormone deficiency (ghd). |
2021-10-13 |
2023-08-13 |
Not clear |
| Hideki Ohshima, Hisashi Adachi, Mika Enomoto, Ako Fukami, Sachiko Nakamura, Yume Nohara, Akiko Sakaue, Nagisa Morikawa, Hitoshi Hamamura, Kenta Toyomasu, Maki Yamamoto, Yoshihiro Fukumot. Association between growth hormone and hypertension in a general population. Hypertension research : official journal of the Japanese Society of Hypertension. vol 43. issue 12. 2021-10-12. PMID:32601398. |
insulin-like growth factors are polypeptides, with arrays similar to insulin, and insulin-like growth factor 1 (igf-1) is secreted via stimulation by growth hormone (gh) in the liver. |
2021-10-12 |
2023-08-13 |
human |
| Hideki Ohshima, Hisashi Adachi, Mika Enomoto, Ako Fukami, Sachiko Nakamura, Yume Nohara, Akiko Sakaue, Nagisa Morikawa, Hitoshi Hamamura, Kenta Toyomasu, Maki Yamamoto, Yoshihiro Fukumot. Association between growth hormone and hypertension in a general population. Hypertension research : official journal of the Japanese Society of Hypertension. vol 43. issue 12. 2021-10-12. PMID:32601398. |
next, we found that bmi, systolic and diastolic bps, insulin, homa-ir, total cholesterol, hdl-cholesterol, triglycerides, smoking, and alcohol intake were associated with gh quartiles, indicating that hypertension was inversely associated with gh but not igf-1. |
2021-10-12 |
2023-08-13 |
human |
| Jaime Guevara-Aguirre, Enrique Teran, Daniela Lescano, Carolina Guevara, Alexandra Guevara, Jannette Saavedra, Patricio Procel, Clive Wasserfall, Antonio W D Gavilane. Assessing insulin sensitivity and resistance in syndromes of severe short stature. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 53-54. 2021-10-12. PMID:32763832. |
individuals affected with two genetic syndromes identified in ecuador have severe short stature and diminished insulin secretion, along with essentially different gh counterregulatory effects on insulin action, which leads to the appearance of opposing metabolic phenotypes. |
2021-10-12 |
2023-08-13 |
human |
| Florica Sandru, Adelina Popa, Dan Nicolae Paduraru, Alexandru Filipescu, Mara Carsote, Adina Ghemigia. Skin anomalies in acromegalic patients (Review of the practical aspects). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630684. |
acromegaly is a hormonal disorder which occurs as the result of growth hormone (gh) and insulin growth factor 1 (igf-1) over-secretion; both hormones are related to skin anomalies. |
2021-10-12 |
2023-08-13 |
human |
| Nicholas A Trito. Growth hormone deficiency in adults with Cushing's disease. Best practice & research. Clinical endocrinology & metabolism. vol 35. issue 2. 2021-09-20. PMID:33272904. |
untreated gh deficiency is associated with increased visceral adiposity, decreased lean mass, bone mass, and exercise capacity, impaired linear growth (in children), dyslipidemia, insulin resistance and impaired quality of life. |
2021-09-20 |
2023-08-13 |
Not clear |
| Xuehan Lu, Lili Huang, Zhengxiang Huang, Dandan Feng, Richard J Clark, Chen Che. LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity. Frontiers in endocrinology. vol 12. 2021-09-14. PMID:34512549. |
in this review, we will analyze leap-2's effects from a metabolic point of view with a focus on metabolic hormones (e.g., ghrelin, gh, and insulin), and discuss leap-2's potential as a promising therapeutic target for obesity. |
2021-09-14 |
2023-08-13 |
Not clear |
| Jose Donato, Frederick Wasinski, Isadora C Furigo, Martin Metzger, Renata Frazã. Central Regulation of Metabolism by Growth Hormone. Cells. vol 10. issue 1. 2021-08-26. PMID:33440789. |
in this regard, gh stimulates lipolysis in white adipose tissue and antagonizes insulin's effects on glycemic control. |
2021-08-26 |
2023-08-13 |
Not clear |
| Mark A Sherida. Coordinate regulation of feeding, metabolism, and growth: Perspectives from studies in fish. General and comparative endocrinology. vol 312. 2021-08-23. PMID:34329604. |
many factors involved with the control of feeding [e.g., cholecystokinin (cck) and ghrelin (grln)], energy metabolism [e.g., insulin (ins), glucagon (glu), glucagon-like peptide (glp), and somatostatins (ss), produced in the endocrine pancreas; and leptin (lep) produced broadly], and growth [e.g., grln, growth hormone (gh), insulin-like growth factors (igfs), gh receptors (ghr), igf receptors (igfr)] interact at various levels. |
2021-08-23 |
2023-08-13 |
Not clear |
| Layla Damen, Lionne N Grootjen, Stephany H Donze, Alicia F Juriaans, Laura C G de Graaff, Janielle A E M van der Velden, Anita C S Hokken-Koeleg. Three years of growth hormone treatment in young adults with Prader-Willi Syndrome previously treated with growth hormone in childhood: Effects on glucose homeostasis and metabolic syndrome. Clinical endocrinology. vol 93. issue 4. 2021-08-18. PMID:32609902. |
continuation of gh maintains body composition, but gh is known to induce insulin resistance, which might affect glucose homeostasis. |
2021-08-18 |
2023-08-13 |
Not clear |
| Nicholas A Tritos, Beverly M K Bille. Current concepts of the diagnosis of adult growth hormone deficiency. Reviews in endocrine & metabolic disorders. vol 22. issue 1. 2021-08-16. PMID:32959175. |
in adults, growth hormone (gh) deficiency is associated with increased visceral adiposity, decreased lean body mass, bone mineral density and exercise capacity, dyslipidemia, insulin resistance, increased cardiometabolic and fracture risk, and impaired quality of life. |
2021-08-16 |
2023-08-13 |
Not clear |
| Nicholas A Tritos, Beverly M K Bille. Current concepts of the diagnosis of adult growth hormone deficiency. Reviews in endocrine & metabolic disorders. vol 22. issue 1. 2021-08-16. PMID:32959175. |
these tests involve the administration of a pharmacologic agent that normally stimulates gh release from pituitary somatotrophs, including insulin, glucagon, growth hormone releasing hormone-arginine or macimorelin, followed by sampling of serum specimens at regular intervals for gh assay. |
2021-08-16 |
2023-08-13 |
Not clear |
| Edward O List, Reetobrata Basu, Silvana Duran-Ortiz, Jackson Krejsa, Elizabeth A Jense. Mouse models of growth hormone deficiency. Reviews in endocrine & metabolic disorders. vol 22. issue 1. 2021-08-16. PMID:33033978. |
furthermore, the absence of gh action in these mouse lines leads to enhanced insulin sensitivity (likely due to the lack of gh's diabetogenic actions), delayed onset for a number of age-associated physiological declines (including cognition, cancer, and neuromusculoskeletal frailty), reduced cellular senescence, and ultimately, extended lifespan. |
2021-08-16 |
2023-08-13 |
mouse |
| Jaime Guevara-Aguirre, Camila Bautista, Carlos Torres, Gabriela Peña, Carolina Guevara, Cristina Palacios, Alexandra Guevara, Antonio W D Gavilane. Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador. Reviews in endocrine & metabolic disorders. vol 22. issue 1. 2021-08-16. PMID:33047268. |
it was also noted that absent gh counter-regulation induces a decrease in insulin resistance (ir), which results in low but highly efficient insulin levels which properly handle metabolic substrates. |
2021-08-16 |
2023-08-13 |
human |
| Joseph A M J L Jansse. Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer. International journal of molecular sciences. vol 22. issue 15. 2021-08-16. PMID:34360563. |
hyperinsulinemia disturbs the balance of the insulin-gh-igf axis and shifts the insulin : gh ratio towards insulin and away from gh. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yuxiang Su. Thrifty Hormone Ghrelin: The Secret of Aging Muscularly. Journal of aging science. vol 8. issue Suppl 3. 2021-08-10. PMID:34368393. |
ag induces growth hormone (gh) secretion, increases food intake, and promotes adiposity and insulin resistance via its receptor, |
2021-08-10 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
disruption of endocrine hormonal balance (i.e., increased levels of insulin, and reduced levels of growth hormone, gh) often occurs in pre-obesity and obesity. |
2021-08-09 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
using distinct intracellular signaling pathways to control cell and body metabolism, gh and insulin also regulate each other's secretion to maintain overall metabolic homeostasis. |
2021-08-09 |
2023-08-13 |
Not clear |