| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaime Guevara-Aguirre, Camila Bautista, Carlos Torres, Gabriela Peña, Carolina Guevara, Cristina Palacios, Alexandra Guevara, Antonio W D Gavilane. Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador. Reviews in endocrine & metabolic disorders. vol 22. issue 1. 2021-08-16. PMID:33047268. |
it was also noted that absent gh counter-regulation induces a decrease in insulin resistance (ir), which results in low but highly efficient insulin levels which properly handle metabolic substrates. |
2021-08-16 |
2023-08-13 |
human |
| Joseph A M J L Jansse. Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer. International journal of molecular sciences. vol 22. issue 15. 2021-08-16. PMID:34360563. |
hyperinsulinemia disturbs the balance of the insulin-gh-igf axis and shifts the insulin : gh ratio towards insulin and away from gh. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yuxiang Su. Thrifty Hormone Ghrelin: The Secret of Aging Muscularly. Journal of aging science. vol 8. issue Suppl 3. 2021-08-10. PMID:34368393. |
ag induces growth hormone (gh) secretion, increases food intake, and promotes adiposity and insulin resistance via its receptor, |
2021-08-10 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
disruption of endocrine hormonal balance (i.e., increased levels of insulin, and reduced levels of growth hormone, gh) often occurs in pre-obesity and obesity. |
2021-08-09 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
using distinct intracellular signaling pathways to control cell and body metabolism, gh and insulin also regulate each other's secretion to maintain overall metabolic homeostasis. |
2021-08-09 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
therefore, a comprehensive understanding of insulin and gh balance is essential for understanding endocrine hormonal contributions to energy storage and utilization. |
2021-08-09 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
in this review we summarize the actions of, and interactions between, insulin and gh at the cellular level, and highlight the association between the insulin/gh ratio and energy metabolism, as well as fat accumulation. |
2021-08-09 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Michael J Waters, Chen Che. Insulin and Growth Hormone Balance: Implications for Obesity. Trends in endocrinology and metabolism: TEM. vol 31. issue 9. 2021-08-09. PMID:32416957. |
use of the [insulin]:[gh] ratio as a biomarker for predicting the development of obesity is proposed. |
2021-08-09 |
2023-08-13 |
Not clear |
| Silvana Duran-Ortiz, Kathryn L Corbin, Ishrat Jahan, Nicholas B Whitticar, Sarah E Morris, Ania N Bartholomew, Kira G Slepchenko, Hannah L West, Ibiagbani Mercy Max Harry, Edward O List, John J Kopchick, Craig S Nunemake. Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences. American journal of physiology. Endocrinology and metabolism. vol 320. issue 6. 2021-07-30. PMID:33938235. |
in the endocrine pancreas, growth hormone (gh) is known to promote pancreatic islet growth and insulin secretion. |
2021-07-30 |
2023-08-13 |
mouse |
| N Ceron-Romero, N Taofeek, A Thomas, E Vroonland, K Sanmartin, M Verghese, E Heinen, J A Vizcarr. Capromorelin, a ghrelin receptor agonist, increases feed intake and body weight gain in broiler chickens (Gallus gallus domesticus). Poultry science. vol 100. issue 8. 2021-07-28. PMID:34182219. |
therefore, we evaluated the effect of a ghrelin receptor agonist (capromorelin) on fi, adg, water intake (wi), animal behavior and concentrations of ghrelin, glucose, growth hormone (gh) and insulin in broiler chickens. |
2021-07-28 |
2023-08-13 |
Not clear |
| Astrid Hjelholt, Morten Høgild, Ann Mosegaard Bak, Mai Christiansen Arlien-Søborg, Amanda Bæk, Niels Jessen, Bjørn Richelsen, Steen Bønløkke Pedersen, Niels Møller, Jens Otto Lunde Jørgense. Growth Hormone and Obesity. Endocrinology and metabolism clinics of North America. vol 49. issue 2. 2021-07-26. PMID:32418587. |
obesity reversibly suppresses gh secretion driven by elevated ffa levels, whereas serum igf-i levels remain normal or elevated due to elevated portal insulin levels. |
2021-07-26 |
2023-08-13 |
Not clear |
| Joseph A M J L Jansse. Mechanisms of putative IGF-I receptor resistance in active acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 52. 2021-07-05. PMID:32339897. |
although igf-i can directly improve insulin sensitivity and glucose uptake in muscles, the excessive gh secretion in active acromegaly frequently leads to insulin resistance, glucose intolerance and even diabetes. |
2021-07-05 |
2023-08-13 |
Not clear |
| Rita Sharma, John J Kopchick, Vishwajeet Puri, Vishva M Sharm. Effect of growth hormone on insulin signaling. Molecular and cellular endocrinology. vol 518. 2021-06-29. PMID:32966863. |
gh antagonizes insulin action via various molecular pathways. |
2021-06-29 |
2023-08-13 |
Not clear |
| Rita Sharma, John J Kopchick, Vishwajeet Puri, Vishva M Sharm. Effect of growth hormone on insulin signaling. Molecular and cellular endocrinology. vol 518. 2021-06-29. PMID:32966863. |
chronic gh secretion suppresses the anti-lipolytic action of insulin and increases ffa flux into the systemic circulation; thus, promoting lipotoxicity, which causes pathophysiological problems, including insulin resistance. |
2021-06-29 |
2023-08-13 |
Not clear |
| Shayma Ahmed, Ashraf Soliman, Vincenzo De Sanctis, Fawzia Alyafie, Nada Alaaraj, Noor Hamed, Hamdy A Ali, Abdulla Kama. Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH). Acta bio-medica : Atenei Parmensis. vol 92. issue 2. 2021-06-25. PMID:33988135. |
both antagonize the peripheral effects of insulin and directly influences glucose metabolism patients and methods: we studied cortisol and gh secretion in newborn infants with hh during spontaneous hypoglycemia. |
2021-06-25 |
2023-08-13 |
Not clear |
| Lekha Jain, Tayaza Fadason, William Schierding, Mark H Vickers, Justin M O'Sullivan, Jo K Perr. 3D interactions with the growth hormone locus in cellular signalling and cancer-related pathways. Journal of molecular endocrinology. vol 64. issue 4. 2021-06-24. PMID:32106092. |
egenes were found to be enriched in gh/ghr-related cellular signalling pathways including mapk, pi3k-akt-mtor, erbb and insulin signalling, suggesting that these pathways may be co-regulated with gh signalling. |
2021-06-24 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Xuehan Lu, Lili Huang, Chunhong Zhang, Johannes D Veldhuis, Michael A Cowley, Chen Che. Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 1. 2021-06-15. PMID:33368660. |
in conclusion, hexarelin treatment stimulated the pulsatile gh secretion and reduced the fat accumulation in visceral depots and liver in obese mc4rko mice with improved insulin sensitivity without altered levels of insulin or igf-1. |
2021-06-15 |
2023-08-13 |
mouse |
| Jaemeun Lee, Kyungchan Kim, Jae Hyun Cho, Jin Young Bae, Timothy P O'Leary, James D Johnson, Yong Chul Bae, Eun-Kyoung Ki. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32644973. |
acute rs-induced inhibition of pvn insulin expression in adult mice decreased both pituitary growth hormone (gh) mrna level and serum gh concentration, which were attenuated by overexpression of pvn insulin. |
2021-06-11 |
2023-08-13 |
mouse |
| Jaemeun Lee, Kyungchan Kim, Jae Hyun Cho, Jin Young Bae, Timothy P O'Leary, James D Johnson, Yong Chul Bae, Eun-Kyoung Ki. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32644973. |
notably, pvn insulin knockdown or chronic rs in young mice hindered normal growth via the downregulation of gh gene expression and secretion, whereas pvn insulin overexpression in young mice prevented chronic rs-induced growth retardation by elevating gh production. |
2021-06-11 |
2023-08-13 |
mouse |
| Jaemeun Lee, Kyungchan Kim, Jae Hyun Cho, Jin Young Bae, Timothy P O'Leary, James D Johnson, Yong Chul Bae, Eun-Kyoung Ki. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32644973. |
our results suggest that in both normal and stressful conditions, insulin synthesized in the parvocellular pvn neurons plays an important role in the regulation of pituitary gh production and body length, unveiling a physiological function of brain-derived insulin. |
2021-06-11 |
2023-08-13 |
mouse |