| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adriana P Kuker, Wei Shen, Zhezhen Jin, Simran Singh, Jun Chen, Jeffrey N Bruce, Pamela U Fred. Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly. Journal of the Endocrine Society. vol 5. issue 3. 2021-05-14. PMID:33553983. |
in active acromegaly, the lipolytic and insulin antagonistic effects of growth hormone (gh) excess alter adipose tissue (at) deposition, reduce body fat, and increase insulin resistance. |
2021-05-14 |
2023-08-13 |
Not clear |
| Fernanda Nastri Gouvêa, Caio Santos Pennacchi, Najla Doutel Assaf, Luana de Oliveira Branco, Paula Barbosa Costa, Patrícia Alves Dos Reis, Sofia Borin-Crivellent. Acromegaly in dogs and cats. Annales d'endocrinologie. vol 82. issue 2. 2021-05-07. PMID:33727117. |
the main clinical signs are related to insulin resistance and the anabolic effect induced by gh: polyuria, polydipsia, polyphagia, increased tissue growth, weight gain, prognathism, and other changes. |
2021-05-07 |
2023-08-13 |
Not clear |
| Andre Sarmento-Cabral, Mercedes Del Rio-Moreno, Mari C Vazquez-Borrego, Mariyah Mahmood, Elena Gutierrez-Casado, Natalie Pelke, Grace Guzman, Papasani V Subbaiah, Jose Cordoba-Chacon, Shoshana Yakar, Rhonda D Kinema. GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner. The Journal of endocrinology. vol 248. issue 1. 2021-04-28. PMID:33112796. |
reconstitution of hepatocyte igf1 in male ahepghrkd lowered gh and normalized insulin, whole body lipid utilization and wat mass. |
2021-04-28 |
2023-08-13 |
mouse |
| M F Lunesu, G C Bomboi, A Marzano, A Comin, A Prandi, P Sechi, P S Nicolussi, M Decandia, C Manca, A S Atzori, G Molle, A Canna. Metabolic and hormonal control of energy utilization and partitioning from early to mid lactation in Sarda ewes and Saanen goats. Journal of dairy science. vol 104. issue 3. 2021-04-14. PMID:33455748. |
blood samples were collected in the morning to analyze glucose, nonesterified fatty acids (nefa), growth hormone (gh), insulin, and insulin-like growth factor i (igf-i). |
2021-04-14 |
2023-08-13 |
Not clear |
| M F Lunesu, G C Bomboi, A Marzano, A Comin, A Prandi, P Sechi, P S Nicolussi, M Decandia, C Manca, A S Atzori, G Molle, A Canna. Metabolic and hormonal control of energy utilization and partitioning from early to mid lactation in Sarda ewes and Saanen goats. Journal of dairy science. vol 104. issue 3. 2021-04-14. PMID:33455748. |
goats had higher plasma gh concentration and lower plasma insulin content than ewes (4.78 vs. 1.31 ng/ml ± 0.47; 0.11 vs. 0.26 μg/l ± 0.02). |
2021-04-14 |
2023-08-13 |
Not clear |
| Fang Zhang, Mert Icyuz, Zhenghui Liu, Michael Fitch, Liou Y Su. Insulin sensitivity in long-lived growth hormone-releasing hormone knockout mice. Aging. vol 12. issue 18. 2021-04-02. PMID:32640420. |
we conducted hyperinsulinemic-euglycemic clamp to investigate mechanisms underlying enhanced insulin sensitivity in growth hormone (gh) deficient mice. |
2021-04-02 |
2023-08-13 |
mouse |
| Weihao Wang, Zhengxiang Huang, Lili Huang, Lyn Gao, Ling Cui, Michael Cowley, Lixin Guo, Chen Che. Time-restricted feeding restored insulin-growth hormone balance and improved substrate and energy metabolism in MC4RKO obese mice. Neuroendocrinology. 2021-03-18. PMID:33735897. |
series of blood samples were collected for 6 h pulsatile gh profile, glucose tolerance test and insulin tolerance test at 5, 8, and 9 weeks of trf, respectively. |
2021-03-18 |
2023-08-13 |
mouse |
| Laura Ramírez, Nora Sanguineti, Paula Scaglia, Ana Keselman, María Gabriela Ballerini, Liliana Karabatas, Estefanía Landi, Julia Castro, Sabina Domené, Patricia Pennisi, Héctor Jasper, Rodolfo A Rey, Martín Vázquez, Horacio Domené, Ignacio Bergadá, Mariana Gutiérre. A novel heterozygous STAT5B variant in a patient with short stature and partial growth hormone insensitivity (GHI). Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 50. 2021-03-16. PMID:31902742. |
the most frequent monogenic causes of growth hormone insensitivity (ghi) include defects in genes encoding the gh receptor itself (ghr), the signal transducer and activator of transcription (stat5b), the insulin like-growth factor type i (igf1) and the acid-labile subunit (igfals). |
2021-03-16 |
2023-08-13 |
Not clear |
| Awatef Alotaibi, Ahmad Habib, Moutaz Osman, Khaled Alzahrani, Faisal Alzahran. Pseudoacromegaly Associated with Non-Functioning Pituitary Adenoma. European journal of case reports in internal medicine. vol 7. issue 12. 2021-02-12. PMID:33313006. |
here, we present a case of pseudoacromegaly with an acromegaloid phenotype, normal igf levels, a supressed gh response to an oral glucose tolerance test, moderate insulin resistance and non-functioning pituitary microadenoma. |
2021-02-12 |
2023-08-13 |
Not clear |
| Serpil Taheri, Zuleyha Karaca, Minoo Rassoulzadegan, Ecmel Mehmetbeyoglu, Gokmen Zararsiz, Elif Funda Sener, Kezban Korkmaz Bayram, Esra Tufan, Mustafa Caglar Sahin, Mert Kahraman Marasli, Mehmet Memis, Halit Canatan, Figen Ozturk, Fatih Tanriverdi, Kursad Unluhizarci, Fahrettin Kelestimu. The Characterization of Sex Differences in Hypoglycemia-Induced Activation of HPA Axis on the Transcriptomic Level. Cellular and molecular neurobiology. 2021-02-05. PMID:33544274. |
activation of the hypothalamic-pituitary-adrenal (hpa) axis using an insulin tolerance test (itt) is a medical diagnostic procedure that is frequently used in humans to assess the hpa and growth-hormone (gh) axes. |
2021-02-05 |
2023-08-13 |
mouse |
| Yunxia Guo, Zhaofang Liu, Ming Wan. NFKB1-mediated downregulation of microRNA-106a promotes oxidative stress injury and insulin resistance in mice with gestational hypertension. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505119. |
this study intended to investigate the role of nfkb1 in oxidative stress injury and insulin resistance in gestational hypertension (gh) mice. |
2021-01-30 |
2023-08-13 |
mouse |
| Yunxia Guo, Zhaofang Liu, Ming Wan. NFKB1-mediated downregulation of microRNA-106a promotes oxidative stress injury and insulin resistance in mice with gestational hypertension. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505119. |
after nfkb1, mir-106a, and flot2 were altered in gh mice by lentiviral vector, oxidative stress markers in liver tissues were examined by colorimetry, and insulin resistance was assessed by fasting blood glucose and fasting insulin levels. |
2021-01-30 |
2023-08-13 |
mouse |
| Yunxia Guo, Zhaofang Liu, Ming Wan. NFKB1-mediated downregulation of microRNA-106a promotes oxidative stress injury and insulin resistance in mice with gestational hypertension. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505119. |
oxidative stress injury and insulin resistance in gh mice and apoptosis and inflammation of hepatocytes from gh mice were decreased after silencing nfkb1 or flot2 or overexpressing mir-106a. |
2021-01-30 |
2023-08-13 |
mouse |
| Yunxia Guo, Zhaofang Liu, Ming Wan. NFKB1-mediated downregulation of microRNA-106a promotes oxidative stress injury and insulin resistance in mice with gestational hypertension. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505119. |
these findings provided evidence demonstrating the inhibitory effect of nfkb1 silencing on oxidative stress injury and insulin resistance in gh mice via mir-106a upregulation and flot2 downregulation. |
2021-01-30 |
2023-08-13 |
mouse |
| Kohzo Takebayashi, Sho Furukawa, Takenori Okumura, Mio Kubo, Atsushi Ujiie, Mototaka Yamauchi, Hiroyuki Shinozaki, Kenji Hara, Takafumi Tsuchiya, Yuko Ono, Toshihiko Inukai, Koshi Hashimot. Severe Non-Islet Cell Hypoglycemia From Ileum-Origin Gastrointestinal Stromal Tumor Producing Insulin-Like Growth Factor-2 in a Patient With Liver Cirrhosis Due to Chronic Hepatitis B. Journal of clinical medicine research. vol 12. issue 12. 2021-01-16. PMID:33447317. |
although circulating insulin, c-peptide, and insulin-like growth factor-1 (igf-1) levels were significantly decreased, in contrast to our expectations, the growth hormone (gh) level was slightly elevated. |
2021-01-16 |
2023-08-13 |
Not clear |
| Edward O List, Darlene E Berryman, Reetobrata Basu, Mathew Buchman, Kevin Funk, Prateek Kulkarni, Silvana Duran-Ortiz, Yanrong Qian, Elizabeth A Jensen, Jonathan A Young, Gozde Yildirim, Shoshana Yakar, John J Kopchic. The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH? Endocrinology. vol 161. issue 8. 2021-01-04. PMID:32556100. |
gh treatment increased circulating insulin levels and impaired insulin sensitivity; in contrast, both measures were unchanged in ghv-treated mice. |
2021-01-04 |
2023-08-13 |
mouse |
| Edward O List, Darlene E Berryman, Reetobrata Basu, Mathew Buchman, Kevin Funk, Prateek Kulkarni, Silvana Duran-Ortiz, Yanrong Qian, Elizabeth A Jensen, Jonathan A Young, Gozde Yildirim, Shoshana Yakar, John J Kopchic. The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH? Endocrinology. vol 161. issue 8. 2021-01-04. PMID:32556100. |
our findings demonstrate that ghv can stimulate insulin-like growth factor-1 and subsequent longitudinal body growth in gh-deficient mice similar to gh, but unlike gh, ghv promoted growth without inhibiting insulin action and without promoting the growth of prlr-positive cancers in vitro. |
2021-01-04 |
2023-08-13 |
mouse |
| Stefanie de Groot, Bas Röttgering, Hans Gelderblom, Hanno Pijl, Karoly Szuhai, Judith R Kroe. Unraveling the Resistance of IGF-Pathway Inhibition in Ewing Sarcoma. Cancers. vol 12. issue 12. 2020-12-26. PMID:33260481. |
in this review, multiple possible mechanisms of resistance to igf-targeted therapies are discussed, including activated insulin signaling, pituitary-driven feedback loops through growth hormone (gh) secretion and autocrine loops. |
2020-12-26 |
2023-08-13 |
Not clear |
| Caroline S Firmenich, Nadine Schnepel, Kathrin Hansen, Marion Schmicke, Alexandra S Muscher-Bans. Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants. The British journal of nutrition. vol 123. issue 6. 2020-12-17. PMID:31775916. |
moreover, ionised ca and insulin concentrations as well as mrna and protein expression levels of hepatic proteins involved in gh signalling were quantified. |
2020-12-17 |
2023-08-13 |
Not clear |
| Caroline S Firmenich, Nadine Schnepel, Kathrin Hansen, Marion Schmicke, Alexandra S Muscher-Bans. Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants. The British journal of nutrition. vol 123. issue 6. 2020-12-17. PMID:31775916. |
due to the protein-reduced diet, concentrations of ionised ca, insulin and igf1 decreased significantly, whereas gh concentrations remained unchanged. |
2020-12-17 |
2023-08-13 |
Not clear |