| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward O List, Darlene E Berryman, Reetobrata Basu, Mathew Buchman, Kevin Funk, Prateek Kulkarni, Silvana Duran-Ortiz, Yanrong Qian, Elizabeth A Jensen, Jonathan A Young, Gozde Yildirim, Shoshana Yakar, John J Kopchic. The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH? Endocrinology. vol 161. issue 8. 2021-01-04. PMID:32556100. |
gh treatment increased circulating insulin levels and impaired insulin sensitivity; in contrast, both measures were unchanged in ghv-treated mice. |
2021-01-04 |
2023-08-13 |
mouse |
| Edward O List, Darlene E Berryman, Reetobrata Basu, Mathew Buchman, Kevin Funk, Prateek Kulkarni, Silvana Duran-Ortiz, Yanrong Qian, Elizabeth A Jensen, Jonathan A Young, Gozde Yildirim, Shoshana Yakar, John J Kopchic. The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH? Endocrinology. vol 161. issue 8. 2021-01-04. PMID:32556100. |
our findings demonstrate that ghv can stimulate insulin-like growth factor-1 and subsequent longitudinal body growth in gh-deficient mice similar to gh, but unlike gh, ghv promoted growth without inhibiting insulin action and without promoting the growth of prlr-positive cancers in vitro. |
2021-01-04 |
2023-08-13 |
mouse |
| Stefanie de Groot, Bas Röttgering, Hans Gelderblom, Hanno Pijl, Karoly Szuhai, Judith R Kroe. Unraveling the Resistance of IGF-Pathway Inhibition in Ewing Sarcoma. Cancers. vol 12. issue 12. 2020-12-26. PMID:33260481. |
in this review, multiple possible mechanisms of resistance to igf-targeted therapies are discussed, including activated insulin signaling, pituitary-driven feedback loops through growth hormone (gh) secretion and autocrine loops. |
2020-12-26 |
2023-08-13 |
Not clear |
| Caroline S Firmenich, Nadine Schnepel, Kathrin Hansen, Marion Schmicke, Alexandra S Muscher-Bans. Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants. The British journal of nutrition. vol 123. issue 6. 2020-12-17. PMID:31775916. |
moreover, ionised ca and insulin concentrations as well as mrna and protein expression levels of hepatic proteins involved in gh signalling were quantified. |
2020-12-17 |
2023-08-13 |
Not clear |
| Caroline S Firmenich, Nadine Schnepel, Kathrin Hansen, Marion Schmicke, Alexandra S Muscher-Bans. Modulation of growth hormone receptor-insulin-like growth factor 1 axis by dietary protein in young ruminants. The British journal of nutrition. vol 123. issue 6. 2020-12-17. PMID:31775916. |
due to the protein-reduced diet, concentrations of ionised ca, insulin and igf1 decreased significantly, whereas gh concentrations remained unchanged. |
2020-12-17 |
2023-08-13 |
Not clear |
| Dong Young Kang, Nipin Sp, Eun Seong Jo, Hyoung Do Kim, Il Ho Kim, Se Won Bae, Kyoung-Jin Jang, Young Mok Yan. Non‑toxic sulfur enhances growth hormone signaling through the JAK2/STAT5b/IGF‑1 pathway in C2C12 cells. International journal of molecular medicine. vol 45. issue 3. 2020-11-30. PMID:31894268. |
insulin‑like growth factor‑1 (igf‑1) regulates cell growth, glucose uptake and protein metabolism, and is required for growth hormone (gh) signaling‑mediated insulin production and secretion. |
2020-11-30 |
2023-08-13 |
mouse |
| Vikram Singh Shekhawat, Shobhit Bhansali, Pinaki Dutta, Kanchan Kumar Mukherjee, Kim Vaiphei, Rakesh Kochhar, Saroj K Sinha, Naresh Sachdeva, Anura V Kurpad, Kishor Bhat, Sunder Mudaliar, Anil Bhansal. Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:30948746. |
chronic gh excess induces an equipoise insulin resistance in patients of acromegaly irrespective of their glycaemic status. |
2020-10-27 |
2023-08-13 |
Not clear |
| Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis, Chen Che. Dapagliflozin restores insulin and growth hormone secretion in obese mice. The Journal of endocrinology. vol 245. issue 1. 2020-10-19. PMID:31977312. |
the well-documented hormonal disturbance in a general obese population is characterised by an increase in insulin secretion and a decrease in growth hormone (gh) secretion. |
2020-10-19 |
2023-08-13 |
mouse |
| Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis, Chen Che. Dapagliflozin restores insulin and growth hormone secretion in obese mice. The Journal of endocrinology. vol 245. issue 1. 2020-10-19. PMID:31977312. |
by applying an emerging anti-diabetic drug, the sodium-glucose cotransporter 2 inhibitor, dapagliflozin (1 mg/kg/day for 10 weeks), to a hyperphagic obese mouse model, we observed a significant improvement in insulin and gh secretion as early as 4 weeks after the initiation of the treatment. |
2020-10-19 |
2023-08-13 |
mouse |
| Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis, Chen Che. Dapagliflozin restores insulin and growth hormone secretion in obese mice. The Journal of endocrinology. vol 245. issue 1. 2020-10-19. PMID:31977312. |
restoration of pathological disturbance of insulin and gh secretion reduced fat accumulation and preserved lean body mass in the obese animal model. |
2020-10-19 |
2023-08-13 |
mouse |
| Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis, Chen Che. Dapagliflozin restores insulin and growth hormone secretion in obese mice. The Journal of endocrinology. vol 245. issue 1. 2020-10-19. PMID:31977312. |
such phenotypic improvement followed with concurrent improvements in glucose and lipid metabolism, insulin sensitivity, as well as the expression of metabolic genes that were regulated by insulin and gh. |
2020-10-19 |
2023-08-13 |
mouse |
| Yakun Yang, Song Han, Zuocheng Yang, Pengfei Wang, Chang-Xiang Yan, Ning Li. Increased serum nesfatin-1 levels in patients with acromegaly. Medicine. vol 99. issue 40. 2020-10-19. PMID:33019423. |
however, there was no published data about nesfatin-1 levels in acromegaly.we evaluated serum nesfatin-1 levels in 13 patients with acromegaly at baseline and postoperatively, and in 21 age- and body mass index (bmi)-matched healthy subjects.compared with the healthy subjects, patients with acromegaly had significantly increased levels of serum insulin, high-density lipoprotein cholesterol, triglyceride, and growth hormone (gh). |
2020-10-19 |
2023-08-13 |
human |
| Jingfang Liu, Xulei Tang, Jianguo Cheng, Liting Wang, Xiaomei Yang, Yan Wan. Analysis of the clinical and molecular characteristics of a child with achondroplasia: A case report. Experimental and therapeutic medicine. vol 9. issue 5. 2020-10-01. PMID:26136890. |
the patient showed normal responses to gh provocation tests with l-dopa (peak gh concentration, 42.38 ng/ml) and insulin (peak gh concentration, 23.29 ng/ml during hypoglycemia), but a blunted response to a gh provocation test with arginine (peak gh concentration, 7.31 ng/ml). |
2020-10-01 |
2023-08-13 |
human |
| Ying Xue, Yiqing Gao, Shuqin Wang, Pei Wan. An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. Experimental and therapeutic medicine. vol 11. issue 5. 2020-10-01. PMID:27168784. |
in conclusion, 0.1 u/kg of gh is beneficial to children with ghd in attaining a satisfactory height, but it leads to insulin resistance. |
2020-10-01 |
2023-08-13 |
human |
| Reiko Horikawa, Toshiaki Tanaka, Hiromi Nishinaga, Yoshihisa Ogawa, Susumu Yokoy. The influence of a long-term growth hormone treatment on lipid and glucose metabolism: a randomized trial in short Japanese children born small for gestational age. International journal of pediatric endocrinology. vol 2016. 2020-10-01. PMID:27799945. |
long-term growth hormone (gh) treatments in short children born small for gestational age (sga) restore lipid metabolism, but also increase insulin resistance. |
2020-10-01 |
2023-08-13 |
Not clear |
| Eun Mi Choi, Nani Jung, Ye Jee Shim, Hee Joung Choi, Joon Sik Kim, Heung Sik Kim, Kwang Soon Song, Hee Jung Lee, Sang Pyo Ki. Short stature and growth hormone deficiency in a girl with encephalocraniocutaneous lipomatosis and Jaffe-Campanacci syndrome: a case report. Annals of pediatric endocrinology & metabolism. vol 21. issue 4. 2020-10-01. PMID:28164079. |
using the insulin stimulation and levo-dihydroxyphenylalanine tests, gh deficiency was confirmed. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sang Soo Lee, A-Leum Han, Moon Bae Ahn, Shin Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung, Byung-Kyu Su. Growth without growth hormone in combined pituitary hormone deficiency caused by pituitary stalk interruption syndrome. Annals of pediatric endocrinology & metabolism. vol 22. issue 1. 2020-10-01. PMID:28443260. |
the patient's blood gh and insulin-like growth factor-i levels were consistently subnormal, although her insulin levels were normal. |
2020-10-01 |
2023-08-13 |
Not clear |
| Koki Nishihara, Ryoko Kobayashi, Yutaka Suzuki, Katsuyoshi Sato, Kazuo Katoh, Sanggun Ro. Post-prandial decrease in plasma growth hormone levels is not related to the increase in plasma insulin levels in goats. Asian-Australasian journal of animal sciences. vol 30. issue 12. 2020-10-01. PMID:28728377. |
in the present study, we examined whether the post-prandial reduction in plasma growth hormone (gh) levels is related to the increase in plasma insulin levels in ruminants. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shin-Hye Kim, Mi-Jung Par. Effects of growth hormone on glucose metabolism and insulin resistance in human. Annals of pediatric endocrinology & metabolism. vol 22. issue 3. 2020-10-01. PMID:29025199. |
in this paper, we review the metabolic effects of gh on peripheral tissues focusing on glucose metabolism and insulin resistance, and discuss results from human studies on the long-term effects of gh administration on insulin resistance and hyperglycemia. |
2020-10-01 |
2023-08-13 |
human |
| Jagannath M Sherigar, Joline De Castro, Yong Mei Yin, Debra Guss, Smruti R Mohant. Glycogenic hepatopathy: A narrative review. World journal of hepatology. vol 10. issue 2. 2020-10-01. PMID:29527255. |
one of the essential elements in the pathophysiology of development of gh is the wide fluctuation in both glucose and insulin levels. |
2020-10-01 |
2023-08-13 |
Not clear |