| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana Rosolen Tavares, Renata Frazao, Jose Donat. Understanding the role of growth hormone in situations of metabolic stress. The Journal of endocrinology. 2022-11-03. PMID:36327147. |
the presented data indicate that gh increases hunger perception/food intake, fat mobilization, blood glucose levels and insulin resistance, as well as produces changes in energy expenditure and neuroendocrine responses during metabolic challenges. |
2022-11-03 |
2023-08-14 |
Not clear |
| Edward O List, Darlene E Berryman, Julie Slyby, Silvana Duran-Ortiz, Kevin Funk, Elise S Bisset, Susan E Howlett, John J Kopchic. Disruption of growth hormone receptor in adipocytes improves insulin sensitivity and lifespan in mice. Endocrinology. 2022-08-11. PMID:35952979. |
our results show that disrupting the gh receptor gene in adipocytes improved insulin sensitivity at advanced age and increased lifespan in male adghrko mice. |
2022-08-11 |
2023-08-14 |
mouse |
| Jesús Á F Tresguerres, Isabel Fernández-Tresguerres, José Viña, Lisa Rancan, Sergio D Paredes, Beatriz Linillos-Pradillo, Elena Var. Effects of GH on the Aging Process in Several Organs: Mechanisms of Action. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887196. |
gh treatment decreased plasma levels and increased pancreatic production of insulin and restored differentiation parameters in these animals. |
2022-07-27 |
2023-08-14 |
mouse |
| Kai Yoshimura, Masaaki Yamamoto, Tomoya Inoue, Hidenori Fukuoka, Keiji Iida, Wataru Ogaw. Coexistence of growth hormone, adrenocorticotropic hormone, and testosterone deficiency associated with coronavirus disease 2019: a case followed up for 15 months. Endocrine journal. 2022-07-13. PMID:35831125. |
an insulin tolerance test performed 3 months later revealed impaired acth, cortisol, and growth hormone (gh) responses, indicative of combined hypopituitarism. |
2022-07-13 |
2023-08-14 |
Not clear |
| Fatema Abdulwahab Khamdan, Milaan A Shah, Maryam Ahmed Khamdan, Eman Albasr. Acromegaly Presenting with Resistant Acne Vulgaris. Case reports in dermatology. vol 14. issue 2. 2022-07-11. PMID:35813834. |
hormones, particularly growth hormone (gh), insulin-like growth factor-1, insulin, crh, and glucocorticoids, play a major role in the pathogenesis and exacerbation of acne. |
2022-07-11 |
2023-08-14 |
Not clear |
| Bouricha Molka, Bourdenet Gwladys, Bosquet Dorian, Moussot Lucie, Benkhalifa Mustapha, Cabry Rosalie, Gubler Brigitte, Khorsi-Cauet Hafida, Benkhalifa Monce. Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes. Frontiers in physiology. vol 13. 2022-06-30. PMID:35770187. |
insulin growth factor i (igf1) is another ovarian growth factor that mediates the fsh and gh actions. |
2022-06-30 |
2023-08-14 |
human |
| Cosimo Giannini, Concetta Mastromauro, Nella Polidori, Francesco Chiarelli, Angelika Moh. Metabolic changes across tertiles of delta changes in height-SDS during growth hormone therapy in children with Growth Hormone Deficiency (GHD). Hormone research in paediatrics. 2022-06-30. PMID:35772388. |
metabolic changes across tertiles of delta changes in height-sds during growth hormone therapy in children with growth hormone deficiency (ghd) introduction: obesity, dyslipidemia, hypertension, insulin resistance, are components of the metabolic syndrome and in adults are positively affected by growth hormone (gh) treatment. |
2022-06-30 |
2023-08-14 |
Not clear |
| Ling Cui, Chunlu Tan, Lili Huang, Weihao Wang, Zhengxiang Huang, Fang Geng, Mengjun Wu, Xiaolin Chen, Michael Cowley, Ferdinand Roelfsema, Chen Che. Dapagliflozin partially restores reproductive function in MC4R KO obese female mice. The Journal of endocrinology. 2022-05-25. PMID:35612570. |
melanocortin-4-receptor knock-out (mc4r ko) mouse is an over-eating obese model with hyperphagia, hyperinsulinemia, reduced growth hormone (gh), and insulin resistance. |
2022-05-25 |
2023-08-13 |
mouse |
| Marina C Muñoz, Verónica G Piazza, Valeria Burghi, Jorge F Giani, Carolina S Martinez, Nadia S Cicconi, Nadia V Muia, Yimin Fang, Sergio Lavandero, Ana I Sotelo, Andrzej Bartke, Patricia A Pennisi, Fernando P Dominici, Johanna G Mique. Insulin signaling in the heart is directly and early impaired by growth hormone. Journal of molecular endocrinology. 2022-05-24. PMID:35608964. |
considering the important role of insulin in the heart and the well-established anti-insulin effects of gh, cardiac insulin resistance may play a role in the cardiopathology observed in acromegalic patients. |
2022-05-24 |
2023-08-13 |
mouse |
| Marina C Muñoz, Verónica G Piazza, Valeria Burghi, Jorge F Giani, Carolina S Martinez, Nadia S Cicconi, Nadia V Muia, Yimin Fang, Sergio Lavandero, Ana I Sotelo, Andrzej Bartke, Patricia A Pennisi, Fernando P Dominici, Johanna G Mique. Insulin signaling in the heart is directly and early impaired by growth hormone. Journal of molecular endocrinology. 2022-05-24. PMID:35608964. |
as conditions of prolonged exposure to gh are associated with a concomitant increase of circulating gh, igf-1 and insulin levels, to dissect the direct effects of gh, in this study we evaluated the activation of insulin signaling in the heart using four different models: 1) transgenic mice overexpressing gh, with chronically elevated gh, igf-1 and insulin circulating levels, 2) liver igf-1-deficient mice, with chronically elevated gh and insulin but decreased igf-1 circulating levels, 3) mice treated with gh for a short period of time, and 4) primary culture of rat cardiomyocytes incubated with gh. |
2022-05-24 |
2023-08-13 |
mouse |
| Marina C Muñoz, Verónica G Piazza, Valeria Burghi, Jorge F Giani, Carolina S Martinez, Nadia S Cicconi, Nadia V Muia, Yimin Fang, Sergio Lavandero, Ana I Sotelo, Andrzej Bartke, Patricia A Pennisi, Fernando P Dominici, Johanna G Mique. Insulin signaling in the heart is directly and early impaired by growth hormone. Journal of molecular endocrinology. 2022-05-24. PMID:35608964. |
despite the differences in the development of cardiomegaly and in the metabolic alterations among the three experimental mouse models analysed, exposure to gh was consistently associated with a decreased response to acute insulin stimulation in the heart at the receptor level and through the pi3k/akt pathway. |
2022-05-24 |
2023-08-13 |
mouse |
| Marina C Muñoz, Verónica G Piazza, Valeria Burghi, Jorge F Giani, Carolina S Martinez, Nadia S Cicconi, Nadia V Muia, Yimin Fang, Sergio Lavandero, Ana I Sotelo, Andrzej Bartke, Patricia A Pennisi, Fernando P Dominici, Johanna G Mique. Insulin signaling in the heart is directly and early impaired by growth hormone. Journal of molecular endocrinology. 2022-05-24. PMID:35608964. |
moreover, a blunted response to insulin stimulation of this signaling pathway was also observed in cultured cardiomyocytes of neonatal rats incubated with gh. |
2022-05-24 |
2023-08-13 |
mouse |
| Marina C Muñoz, Verónica G Piazza, Valeria Burghi, Jorge F Giani, Carolina S Martinez, Nadia S Cicconi, Nadia V Muia, Yimin Fang, Sergio Lavandero, Ana I Sotelo, Andrzej Bartke, Patricia A Pennisi, Fernando P Dominici, Johanna G Mique. Insulin signaling in the heart is directly and early impaired by growth hormone. Journal of molecular endocrinology. 2022-05-24. PMID:35608964. |
therefore, the key novel finding of this work is that impairment of insulin signaling in the heart is a direct and early event observed as a consequence of exposure to gh, which may play a major role in the development of cardiac pathology. |
2022-05-24 |
2023-08-13 |
mouse |
| Cosimo Giannini, Nella Polidori, Costanza Renata Neri, Ebe D'Adamo, Francesco Chiarelli, Angelika Moh. Gut hormones secretion across clusters of Metabolic Syndrome in prepubertal children with obesity. Hormone research in paediatrics. 2022-05-17. PMID:35580566. |
anthropometric parameters, blood pressure (bp), fasting insulin and glycaemia, lipid profile, transaminases and gh concentration were determined. |
2022-05-17 |
2023-08-13 |
Not clear |
| Phillip Yeoh, Andrew A Dwyer, Ella Anghel, Pierre M Bouloux, Bernard Khoo, Shern Chew, Florian Wernig, Paul Carroll, Simon J B Aylwin, Stephanie E Baldeweg, William Drake, Jeannie Todd, Lindiwe Mangena, Ashley Grossma. A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases. International journal of endocrinology. vol 2022. 2022-04-25. PMID:35465075. |
the insulin tolerance test (itt) is the gold standard endocrine test used to assess the integrity of the growth hormone (gh) and cortisol axes. |
2022-04-25 |
2023-08-13 |
Not clear |
| Aaron Hanukoglu, Regina Weisglas. Is the fear from insulin tolerance test in the evaluation of short stature justified? European journal of pediatrics. 2022-04-23. PMID:35459965. |
among growth hormone (gh) provocative tests, insulin tolerance test (itt) is considered a valuable test in children with short stature to diagnose gh deficiency. |
2022-04-23 |
2023-08-13 |
Not clear |
| George M Bright, Michael O Thorne. A GH secretagogue receptor agonist (LUM-201) elicits greater GH responses than standard GH secretagogues in subjects of a pediatric GH deficiency trial. Hormone research in paediatrics. 2022-03-30. PMID:35354138. |
iabstract: introduction: lum-201 (ibutamoren, formerly mk-0677) is an orally administered gh secretagogue receptor agonist under development for treatment of paediatric growth hormone deficiency (pghd) methods: the gh response to a single dose of lum-201 and to other gh secretagogues used for diagnosis of pghd were compared in 68 pediatric subjects participating in a trial for growth hormone deficiency results: lum-201 elicited greater gh responses than observed in ghd diagnostic tests with arginine, glucagon, clonidine, l-dopa and insulin induced hypoglycemia (median and interquartile ranges 15.0 ng/ml (3.5, 49) versus 5.5 ng/ml (1.8, 7.6) (p < 0.0001). |
2022-03-30 |
2023-08-13 |
human |
| Ningping Gong, Jakob Lundin, Daniel Morgenroth, Mark A Sheridan, Erik Sandblom, Björn Thrandur Björnsso. Roles of leptin in initiation of acquired growth hormone resistance and control of metabolism in rainbow trout. American journal of physiology. Regulatory, integrative and comparative physiology. 2022-03-16. PMID:35293250. |
catabolic conditions often induce concomitant changes in plasma leptin (lep), growth hormone (gh) and insulin growth factor i (igf-i) levels in teleost fish, but it is unclear whether these parts of the endocrine system are responding independently or functionally linked. |
2022-03-16 |
2023-08-13 |
Not clear |
| Ravi Sonkar, Ryan Berry, Mary N Latimer, Sumanth D Prabhu, Martin E Young, Stuart J Fran. Augmented Cardiac Growth Hormone Signaling Contributes to Cardiomyopathy Following Genetic Disruption of the Cardiomyocyte Circadian Clock. Frontiers in pharmacology. vol 13. 2022-03-07. PMID:35250583. |
gh acts in part through induction of insulin-like growth factor 1 (igf1), and excess gh/igf1 signaling has been linked to pathologies such as insulin resistance, acromegaly, and cardiomyopathy. |
2022-03-07 |
2023-08-13 |
mouse |
| Zhiyuan Fang, Xinwei Li, Shu Wang, Qianming Jiang, Juan J Loor, Xiuhuan Jiang, Lingxue Ju, Hao Yu, Taiyu Shen, Men Chen, Yuxiang Song, Zhe Wang, Xiliang Du, Guowen Li. Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis. Journal of dairy science. 2022-03-06. PMID:35248377. |
additionally, ketotic dairy cows exhibited higher serum concentrations of gh, il-18, and tnf-α, and lower serum concentration of insulin. |
2022-03-06 |
2023-08-13 |
Not clear |