| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jose Donato, John J Kopchic. New findings on brain actions of growth hormone and potential clinical implications. Reviews in endocrine & metabolic disorders. 2023-12-07. PMID:38060062. |
the classical effects of gh comprise the stimulation of cell proliferation, tissue and body growth, lipolysis, and insulin resistance. |
2023-12-07 |
2023-12-10 |
Not clear |
| Naohiro Nomura, Yuko Tanabe, Miki Minami, Junji Takaya, Kazunari Kanek. Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes. Case reports in pediatrics. vol 2023. 2023-12-01. PMID:38025494. |
growth hormone therapy has been shown to induce transient insulin resistance in children, and there is concern regarding the diabetogenic potential of gh therapy in children born small for gestational age (sga). |
2023-12-01 |
2023-12-07 |
Not clear |
| Naohiro Nomura, Yuko Tanabe, Miki Minami, Junji Takaya, Kazunari Kanek. Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes. Case reports in pediatrics. vol 2023. 2023-12-01. PMID:38025494. |
growth hormone therapy has been shown to induce transient insulin resistance in children, and there is concern regarding the diabetogenic potential of gh therapy in children born small for gestational age (sga). |
2023-11-29 |
2023-12-07 |
Not clear |
| Vanderlan O Batista, Michael Kellner, Roberto Salvatori, Walter Oliveira, André Faro, Lucas B Santos, Enaldo V Melo, Alecia Ao Santos, Carla R P Oliveira, Viviane C Campos, Cynthia S Barros-Oliveira, Elenilde G Santos, Nathalie O Santana, Keila R Villar-Gouy, Ângela C O Leal, Rivia S Amorim, Davi A Oliveira Simões, Manuel H Aguiar-Oliveir. Cognitive performance during senescence in untreated congenital isolated GH deficiency. Endocrine connections. 2023-11-29. PMID:38019109. |
individuals with untreated isolated gh deficiency (ighd) due to a mutation in the ghrh receptor gene from itabaianinha brazil have increased insulin sensitivity, normal life expectancy, and an extended healthspan, i.e., the period of life free from disabilities. |
2023-11-29 |
2023-12-07 |
human |
| Yange Yu, Zhaoyan Zhu, Mengxia Ding, Bingxin Wang, Yadong Tian, Ruirui Jiang, Guirong Sun, Ruili Han, Xiangtao Kang, Fengbin Yan, Yujie Gu. Effect of Pseudostellaria heterophylla polysaccharide on the growth and liver metabolism of chicks. Journal of animal science. 2023-11-06. PMID:37931159. |
the results showed that compared with group a, there were significant reduction in average daily feed intake (adfi) and feed-to-weight ratio (f/g) at 14 d, 21 d, 28 d (p < 0.05), significant increase in average daily gain (adg) at 21 d, 28 d (p < 0.05), significantly increased levels of total protein (tp), albumin (alb), insulin (ins), thyroxine (t3), growth hormone (gh) at 14 d, 28 d (p < 0.05), significantly decreased levels of glucose (glu), total cholesterol (tc), glucagon (gc), triglyceride (tg) at 28 d in group c (p < 0.05). |
2023-11-06 |
2023-11-08 |
Not clear |
| Jun Huang, Sohana Siyar, Rita Sharma, Isabella Herrig, Lauren Wise, Spencer Aidt, Edward List, John J Kopchick, Vishwajeet Puri, Kevin Y Le. Adipocyte Subpopulations Mediate Growth Hormone-induced Lipolysis and Glucose Tolerance in Male Mice. Endocrinology. vol 164. issue 11. 2023-10-30. PMID:37897489. |
in adipose tissue, growth hormone (gh) stimulates lipolysis, leading to an increase in plasma free fatty acid levels and a reduction in insulin sensitivity. |
2023-10-30 |
2023-11-08 |
mouse |
| Indrayani Jadhav, Swarupa Chakol. Effects of Type 1 Diabetes Mellitus on Linear Growth: A Comprehensive Review. Cureus. vol 15. issue 9. 2023-10-20. PMID:37859903. |
moreover, the linear growth depends on the interaction between the gonadotropin hormone, luteinizing hormone (lh), follicle-stimulating hormone (fsh), and sex steroid hormones axis and gh-igf-1; there's a rise in gh during puberty, which has an effect on the estrogen and testosterone, which leads to the pulsatile secretion of gh, this increment leads to insulin resistance. |
2023-10-20 |
2023-11-08 |
Not clear |
| Holger Marten. Invited Review: Increasing Milk Yield and Negative Energy Balance: A Gordian Knot for Dairy Cows? Animals : an open access journal from MDPI. vol 13. issue 19. 2023-10-14. PMID:37835703. |
the hormonal framework for this metabolic environment is the high concentration of growth hormone (gh), the low concentration of insulin in connection with gh-dependent insulin resistance and the low concentration of igf-1, the so-called gh-igf-1 axis. |
2023-10-14 |
2023-10-15 |
Not clear |
| Emi Okamura, Kaori Ikeda, Fumika Mano-Usui, Sachiko Kawashima, Aki Kondo, Nobuya Inagak. Augmentation of Growth Hormone by Chewing in Females. Nutrients. vol 15. issue 16. 2023-08-26. PMID:37630818. |
blood samples were taken before and after ingestion (0, 15, 30, and 60 min); gh, acylated ghrelin, glucose, insulin, amino acids, and lactate were measured. |
2023-08-26 |
2023-09-07 |
Not clear |
| Jaime Guevara-Aguirre, Gabriela Peña, William Acosta, Gabriel Pazmiño, Jannette Saavedra, Lina Soto, Daniela Lescano, Alexandra Guevara, Antonio Wd Gavilane. Cancer in GH excess and GH deficit. Endocrine-related cancer. 2023-07-10. PMID:37428642. |
along with absent action of gh and igf-i, els individuals also have low serum insulin levels and decreased insulin resistance. |
2023-07-10 |
2023-08-14 |
human |
| Haruki Yamano, Hiroshi Horike, Yutaka Taguchi, Yudai Inabu, Toshihisa Sugino, Nonomi Suzuki, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Hideyuki Takahash. Effect of Ca-octanoate supplementation on concentrations of ghrelin and ghrelin-related hormones in plasma and milk of beef cattle. Heliyon. vol 9. issue 6. 2023-06-14. PMID:37313147. |
we aimed to evaluate the effect of dietary calcium (ca)-octanoate supplementation on concentrations of ghrelin, growth hormone (gh), insulin-like growth factor-1 (igf-1), and insulin in plasma and milk of beef cattle during late gestation and early postpartum. |
2023-06-14 |
2023-08-14 |
cattle |
| Tao Wang, Junquan Tian, Wenxuan Su, Fan Yang, Jie Yin, Qian Jiang, Yuying Li, Kang Yao, Tiejun Li, Yulong Yi. Effect of Ornithine α-Ketoglutarate on Intestinal Microbiota and Serum Inflammatory Cytokines in Dextran Sulfate Sodium Induced Colitis. Nutrients. vol 15. issue 11. 2023-06-11. PMID:37299439. |
our results demonstrated that 1% okg supplementation increased body weight, serum growth hormone (gh), insulin (ins), alkaline phosphatase (alp), tyr, and his and decreased urea nitrogen (bun), nh |
2023-06-11 |
2023-08-14 |
mouse |
| He Zhang, Xiaoxi Yan, Ailian Lin, Pengke Xia, Yong S. Inhibition of ghrelin activity by the receptor antagonist [D-Lys3]-GHRP-6 enhances hepatic fatty acid oxidation and gluconeogenesis in a growing pig model. Peptides. 2023-06-10. PMID:37301480. |
moreover, dlys treatment changed the dynamics of serum metabolic parameters, including glucose, nefa, tba, insulin, gh, leptin, and cortisol. |
2023-06-10 |
2023-08-14 |
Not clear |
| Rishi P Nair, Atul Kumar Gupta, Puneet Pareek, Bharti Devnani, Sandeep Kumar Bairwa, Pawan K Garg, Divya Aggarwal, Smily Sharma, Tushar Mitta. Is Hypoglycemia Secondary to Metastatic Retroperitoneal Sarcoma -A Therapeutic Challenge? Case Report and Review of Literature. Current problems in cancer. vol 47. issue 3. 2023-06-01. PMID:37263114. |
the occurrence of hypo-insulinemic hypoglycemia with low gh and igf-1 should prompt consideration of the secretion of a hypoglycemic substance impeding the secretion of insulin and gh, such as igf-2 or one of its related substances. |
2023-06-01 |
2023-08-14 |
Not clear |
| Xiaohui Li, Biao Zhou, Yuan Yao, Guang Wang, Hua Men. Reduced Growth Hormone Predicts Worsening Adipose Tissue Insulin Resistance in Adults with Obesity. Obesity facts. 2023-05-26. PMID:37231915. |
few studies have investigated the role of gh in adipose tissue insulin resistance (adipo-ir). |
2023-05-26 |
2023-08-14 |
Not clear |
| Sutharinee Likitnukul, Sumpun Thammacharoen, Orada Sriwatananukulkit, Chanathip Duangtha, Ruedee Hemstapat, Chotchanit Sunrat, Supachoke Mangmool, Darawan Pinthon. Short-Term Growth Hormone Administration Mediates Hepatic Fatty Acid Uptake and De Novo Lipogenesis Gene Expression in Obese Rats. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189668. |
obesity causes a decrease in growth hormone (gh) levels and an increase in insulin levels. |
2023-05-16 |
2023-08-14 |
human |
| Sutharinee Likitnukul, Sumpun Thammacharoen, Orada Sriwatananukulkit, Chanathip Duangtha, Ruedee Hemstapat, Chotchanit Sunrat, Supachoke Mangmool, Darawan Pinthon. Short-Term Growth Hormone Administration Mediates Hepatic Fatty Acid Uptake and De Novo Lipogenesis Gene Expression in Obese Rats. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189668. |
long-term gh treatment increased lipolytic activity as opposed to decreasing insulin sensitivity. |
2023-05-16 |
2023-08-14 |
human |
| Sutharinee Likitnukul, Sumpun Thammacharoen, Orada Sriwatananukulkit, Chanathip Duangtha, Ruedee Hemstapat, Chotchanit Sunrat, Supachoke Mangmool, Darawan Pinthon. Short-Term Growth Hormone Administration Mediates Hepatic Fatty Acid Uptake and De Novo Lipogenesis Gene Expression in Obese Rats. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189668. |
nonetheless, it is possible that short-term gh administration had no impact on insulin sensitivity. |
2023-05-16 |
2023-08-14 |
human |
| Mari C Vázquez-Borrego, Mercedes Del Río-Moreno, Maxim Pyatkov, André Sarmento-Cabral, Mariyah Mahmood, Natalie Pelke, Magdalena Wnek, Jose Cordoba-Chacon, David J Waxman, Michelle A Puchowicz, Owen P McGuinness, Rhonda D Kinema. Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis. Metabolism: clinical and experimental. 2023-05-14. PMID:37182789. |
gh may control steatosis indirectly by altering systemic insulin sensitivity and substrate delivery to the liver and/or by the direct actions of gh on hepatocyte function. |
2023-05-14 |
2023-08-14 |
Not clear |
| Patricia Mora-Criollo, Reetobrata Basu, Yanrong Qian, Kevin Funk, Stephen Bell, Jonathan A Young, Edward O List, Jaime A Costales, Jaime Guevara-Aguirre, Mario J Grijalva, John J Kopchic. High growth hormone serum partially protects mice against Trypanosoma cruzi infection. FEBS open bio. 2023-05-10. PMID:37163287. |
interestingly, inactivating mutations in the gh receptor in humans result in laron syndrome (ls), a clinical entity characterized by increased serum levels of gh and decreased insulin growth factor-1 (igf-1). |
2023-05-10 |
2023-08-14 |
mouse |