| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Scott C Forbes, Gordon J Bel. The acute effects of a low and high dose of oral L-arginine supplementation in young active males at rest. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 36. issue 3. 2011-08-18. PMID:21574873. |
there was no significant difference between conditions for no(x), gh, igf-1, or insulin. |
2011-08-18 |
2023-08-12 |
human |
| Scott C Forbes, Gordon J Bel. The acute effects of a low and high dose of oral L-arginine supplementation in young active males at rest. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 36. issue 3. 2011-08-18. PMID:21574873. |
based on these findings, a low dose of l-arginine was just as effective at increasing plasma l-arginine concentrations as a high dose; however, neither dose was able to promote a significant increase in no(x), gh, igf-1, or insulin at rest. |
2011-08-18 |
2023-08-12 |
human |
| Yingjie Wu, Chengyu Liu, Hui Sun, Archana Vijayakumar, Pejman Raeisi Giglou, Ruifang Qiao, Joshua Oppenheimer, Shoshana Yakar, Derek LeRoit. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. The Journal of clinical investigation. vol 121. issue 6. 2011-08-17. PMID:21555853. |
insulin, growth hormone (gh), and insulin-like growth factor-1 (igf-1) play key roles in the regulation of β cell growth and function. |
2011-08-17 |
2023-08-12 |
mouse |
| Yingjie Wu, Chengyu Liu, Hui Sun, Archana Vijayakumar, Pejman Raeisi Giglou, Ruifang Qiao, Joshua Oppenheimer, Shoshana Yakar, Derek LeRoit. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. The Journal of clinical investigation. vol 121. issue 6. 2011-08-17. PMID:21555853. |
here we have employed a rat insulin ii promoter-driven (rip-driven) cre recombinase to disrupt the gh receptor in β cells (βghrko). |
2011-08-17 |
2023-08-12 |
mouse |
| Yingjie Wu, Chengyu Liu, Hui Sun, Archana Vijayakumar, Pejman Raeisi Giglou, Ruifang Qiao, Joshua Oppenheimer, Shoshana Yakar, Derek LeRoit. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. The Journal of clinical investigation. vol 121. issue 6. 2011-08-17. PMID:21555853. |
therefore, gh receptor plays critical roles in glucose-stimulated insulin secretion and β cell compensation in response to a high-fat diet. |
2011-08-17 |
2023-08-12 |
mouse |
| Christopher J Child, Alan G Zimmermann, Robin S Scott, Gordon B Cutler, Tadej Battelino, Werner F Blu. Prevalence and incidence of diabetes mellitus in GH-treated children and adolescents: analysis from the GeNeSIS observational research program. The Journal of clinical endocrinology and metabolism. vol 96. issue 6. 2011-08-05. PMID:21490076. |
gh has an insulin antagonist effect, and gh treatment has therefore been suggested to impair glucose metabolism and increase risk of diabetes mellitus. |
2011-08-05 |
2023-08-12 |
Not clear |
| Adam Gesing, Andrzej Bartke, Feiya Wang, Malgorzata Karbownik-Lewinska, Michal M Masterna. Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal. Biological chemistry. vol 392. issue 5. 2011-08-03. PMID:21391871. |
growth hormone (gh) receptor knockout (ghrko) mice are highly insulin sensitive and long-lived. |
2011-08-03 |
2023-08-12 |
mouse |
| Raul M Luque, Qing Lin, José Córdoba-Chacón, Papasani V Subbaiah, Thorsten Buch, Ari Waisman, Hugo Vankelecom, Rhonda D Kinema. Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes. PloS one. vol 6. issue 1. 2011-08-02. PMID:21283519. |
these results suggest the age-related decline in gh helps to preserve systemic insulin sensitivity, and in the context of moderate caloric intake, prevents the deterioration in metabolic function. |
2011-08-02 |
2023-08-12 |
mouse |
| Raul M Luque, Qing Lin, José Córdoba-Chacón, Papasani V Subbaiah, Thorsten Buch, Ari Waisman, Hugo Vankelecom, Rhonda D Kinema. Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes. PloS one. vol 6. issue 1. 2011-08-02. PMID:21283519. |
however, in the context of excess caloric intake, low gh leads to impaired insulin output, and thereby could contribute to the development of diabetes. |
2011-08-02 |
2023-08-12 |
mouse |
| T Chiba, H Yamaza, I Shimokaw. Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction. Current genomics. vol 8. issue 7. 2011-07-14. PMID:19412415. |
caloric restriction (cr) reduces plasma concentration of insulin, growth hormone (gh), and igf-i. |
2011-07-14 |
2023-08-12 |
Not clear |
| Susana Sangiao-Alvarellos, Fernando Cordid. Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. International journal of peptides. vol 2010. 2011-07-14. PMID:20700401. |
rnas for ghrelin as well as ghsr are expressed in the pancreas of rats and humans and several studies propose that ghrelin could have an important function in glucose homeostasis and insulin release, independent of gh secretion. |
2011-07-14 |
2023-08-12 |
mouse |
| Johannes D Veldhuis, Cyril Y Bower. Integrating GHS into the Ghrelin System. International journal of peptides. vol 2010. 2011-07-14. PMID:20798846. |
principal actions of this peptidergic system include stimulation of gh release via combined hypothalamopituitary mechanisms, orexigenesis (appetitive enhancement), insulinostasis (inhibition of insulin secretion), cardiovascular effects (decreased mean arterial pressure and vasodilation), stimulation of gastric motility and acid secretion, adipogenesis with repression of fat oxidation, and antiapoptosis (antagonism of endothelial, neuronal, and cardiomyocyte death). |
2011-07-14 |
2023-08-12 |
Not clear |
| Meropi Toumba, Nicos Skordi. Osteoporosis syndrome in thalassaemia major: an overview. Journal of osteoporosis. vol 2010. 2011-07-14. PMID:20976089. |
gh and insulin growth factors (igfs) have anabolic effect in bone formation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Emily Jane Gallagher, Derek LeRoit. Is growth hormone resistance/IGF-1 reduction good for you? Cell metabolism. vol 13. issue 4. 2011-07-12. PMID:21459318. |
gh, igf-1, and insulin are emerging as important and independent mediators of tumor development and aging. |
2011-07-12 |
2023-08-12 |
Not clear |
| Emily Jane Gallagher, Derek LeRoit. Is growth hormone resistance/IGF-1 reduction good for you? Cell metabolism. vol 13. issue 4. 2011-07-12. PMID:21459318. |
two recent studies report that humans with gh-receptor deficiency are protected from developing cancer through alterations in gh, igf-1, and insulin signaling, decreasing the susceptibility of cells to dna damage and abnormal proliferation. |
2011-07-12 |
2023-08-12 |
Not clear |
| Yoshihisa Ohtani, Tomo Yonezawa, Sang-Houn Song, Tatsuyuki Takahashi, Astrid Ardiyanti, Katsuyoshi Sato, Akihiko Hagino, Sang-gun Roh, Kazuo Kato. Gene expression and hormonal regulation of adiponectin and its receptors in bovine mammary gland and mammary epithelial cells. Animal science journal = Nihon chikusan Gakkaiho. vol 82. issue 1. 2011-07-08. PMID:21269367. |
therefore we examined the messenger rna (mrna) expression levels of adiponectin and its receptors in various bovine tissues and mammary glands among different lactation stages, and the effects of lactogenic hormones (insulin, dexamethasone and prolactin) and growth hormone (gh) on mrna expression of the adipors in cultured bovine mammary epithelial cells (bmec). |
2011-07-08 |
2023-08-12 |
cattle |
| Toshihiko Iwanaga, Takashi Miki, Hiromi Takahashi-Iwanag. Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice. Biomedical research (Tokyo, Japan). vol 32. issue 1. 2011-06-15. PMID:21383513. |
since the somatostatin inhibition of both insulin and gh release is regulated mainly by sstr1 and sstr5, the primary cilia expressing sstr3 may be involved in a signaling which differs from that via other sstr subtypes expressing in cell bodies. |
2011-06-15 |
2023-08-12 |
mouse |
| Matteo Nicola Dario Di Minno, Salvatore Pezzullo, Vittorio Palmieri, Carolina Di Somma, Roberta Lupoli, Domenico Valle, Gaetano Lombardi, Giovanni Di Minn. Protein C and protein S changes in GH-deficient adults on r-HGH replacement therapy: correlations with PAI-1 and t-PA plasma levels. Thrombosis research. vol 126. issue 6. 2011-05-23. PMID:20920820. |
in ghd adults on replacement therapy with recombinant human gh (r-hgh), %Δ pai-1 and %Δ t-pa are related to %Δ insulin changes. |
2011-05-23 |
2023-08-12 |
human |
| Andrzej Bartk. Growth hormone, insulin and aging: the benefits of endocrine defects. Experimental gerontology. vol 46. issue 2-3. 2011-04-29. PMID:20851173. |
longevity of mice can be increased by spontaneous or experimentally induced mutations that interfere with the biosynthesis or actions of growth hormone (gh), insulin-like growth factor 1 (igf-1), or insulin in the adipose tissue. |
2011-04-29 |
2023-08-12 |
mouse |
| Yanmei Liu, Hassan Mziaut, Anna Ivanova, Michele Solimen. beta-Cells at the crossroads: choosing between insulin granule production and proliferation. Diabetes, obesity & metabolism. vol 11 Suppl 4. 2011-04-12. PMID:19817789. |
both of these major adaptive behaviours are positively regulated by several extrinsic factors, such as glucose, glp-1, insulin and growth hormones (gh). |
2011-04-12 |
2023-08-12 |
Not clear |