| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michal M Masternak, Andrzej Bartke, Feiya Wang, Adam Spong, Adam Gesing, Yimin Fang, Adam B Salmon, Larry F Hughes, Teresa Liberati, Ravneet Boparai, John J Kopchick, Reyhan Westbroo. Metabolic effects of intra-abdominal fat in GHRKO mice. Aging cell. vol 11. issue 1. 2012-06-20. PMID:22040032. |
we conclude that in the absence of gh signaling, the secretory activity of visceral fat is profoundly altered and unexpectedly promotes enhanced insulin sensitivity. |
2012-06-20 |
2023-08-12 |
mouse |
| Soo Kyoung Kim, Sunghwan Suh, Ji In Lee, Kyu Yeon Hur, Jae Hoon Chung, Moon-Kyu Lee, Yong-Ki Min, Jae Hyeon Kim, Jong-Hyun Kim, Kwang-Won Ki. The ability of β-cells to compensate for insulin resistance is restored with a reduction in excess growth hormone in Korean acromegalic patients. Journal of Korean medical science. vol 27. issue 2. 2012-05-31. PMID:22323865. |
the aim of this study was to assess the prevalence of diabetes and to study the effects of excess growth hormone (gh) on insulin sensitivity and β-cell function in korean acromegalic patients. |
2012-05-31 |
2023-08-12 |
Not clear |
| Soo Kyoung Kim, Sunghwan Suh, Ji In Lee, Kyu Yeon Hur, Jae Hoon Chung, Moon-Kyu Lee, Yong-Ki Min, Jae Hyeon Kim, Jong-Hyun Kim, Kwang-Won Ki. The ability of β-cells to compensate for insulin resistance is restored with a reduction in excess growth hormone in Korean acromegalic patients. Journal of Korean medical science. vol 27. issue 2. 2012-05-31. PMID:22323865. |
patients underwent a 75 g oral glucose tolerance test with measurements of gh, glucose, insulin, and c-peptide levels. |
2012-05-31 |
2023-08-12 |
Not clear |
| Anton Luger, Anders F Mattsson, Maria Koltowska-Häggström, Maria Thunander, Miklos Góth, Johan Verhelst, Roger Ab. Incidence of diabetes mellitus and evolution of glucose parameters in growth hormone-deficient subjects during growth hormone replacement therapy: a long-term observational study. Diabetes care. vol 35. issue 1. 2012-05-15. PMID:22074727. |
growth hormone (gh) deficiency is associated with insulin resistance and diabetes. |
2012-05-15 |
2023-08-12 |
human |
| R Manjarín, J P Steibel, R N Kirkwood, N P Taylor, N L Trottie. Transcript abundance of hormone receptors, mammalian target of rapamycin pathway-related kinases, insulin-like growth factor I, and milk proteins in porcine mammary tissue. Journal of animal science. vol 90. issue 1. 2012-05-04. PMID:21821816. |
selected genes included those encoding for receptors of gh (ghr), insulin (insr), glucocorticoid (nr3c1), prolactin (prlr), igf-i (igf-i), mtor (frap1), and p70s6 kinases (rps6kb1), and the milk proteins α-lactalbumin (lalba) and β-casein (csn2). |
2012-05-04 |
2023-08-12 |
cattle |
| P Frisk, S M Rössner, S Norgren, J Arvidson, J Gustafsso. Glucose metabolism and body composition in young adults treated with TBI during childhood. Bone marrow transplantation. vol 46. issue 10. 2012-04-20. PMID:21151187. |
we propose that the decreased insulin sensitivity may primarily be explained by the adverse body composition, which may owe to long-standing gh deficiency. |
2012-04-20 |
2023-08-12 |
Not clear |
| P J D Delhanty, A J van der Lel. Ghrelin and glucose homeostasis. Peptides. vol 32. issue 11. 2012-04-16. PMID:21396419. |
ghrelin plays an important physiological role in modulating gh secretion, insulin secretion and glucose metabolism. |
2012-04-16 |
2023-08-12 |
Not clear |
| Hongqiong Zhao, Swe Yannaing, Sint Thanthan, Hideto Kuwayam. Sulfated gastrin stimulates ghrelin and growth hormone release but inhibits insulin secretion in cattle. Peptides. vol 32. issue 11. 2012-04-16. PMID:22001226. |
this study was designed to determine the effects of gastrin on the circulating levels of ghrelin, growth hormone (gh), insulin, glucagon and glucose in ruminants. |
2012-04-16 |
2023-08-12 |
cattle |
| C L Adam, T Bake, P A Findlay, J S Milne, R P Aitken, J M Wallac. Effects of altered glucose supply and adiposity on expression of hypothalamic energy balance regulatory genes in late gestation growth restricted ovine fetuses. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 7. 2012-03-19. PMID:21616134. |
insulin receptor mrna in the arc was increased in h, h+early gh and h+late gh fetuses and correlated negatively with fetal plasma insulin. |
2012-03-19 |
2023-08-12 |
Not clear |
| M D Culle. Somatostatin-dopamine chimeras: a novel approach to treatment of neuroendocrine tumors. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 12. 2012-03-15. PMID:21989554. |
the chimeric sst/da compounds are also quite potent and efficacious in suppressing both gh and igf1 in vivo when tested in nonhuman primates, with no effect on either insulin secretion or glycemic control. |
2012-03-15 |
2023-08-12 |
Not clear |
| M Colak, T Shimizu, N Matsunaga, C Murayama, S Nagashima, M Kataoka, C Kawashima, M Matsui, H A van Dorland, R M Bruckmaier, A Miyamot. Oestradiol enhances plasma growth hormone and insulin-like growth factor-I concentrations and increased the expression of their receptors mRNAs in the liver of ovariectomized cows. Reproduction in domestic animals = Zuchthygiene. vol 46. issue 5. 2012-02-28. PMID:21323755. |
many metabolic hormones, growth hormone (gh), insulin-like growth factor-i (igf-i) and insulin affect ovarian functions. |
2012-02-28 |
2023-08-12 |
cattle |
| M Colak, T Shimizu, N Matsunaga, C Murayama, S Nagashima, M Kataoka, C Kawashima, M Matsui, H A van Dorland, R M Bruckmaier, A Miyamot. Oestradiol enhances plasma growth hormone and insulin-like growth factor-I concentrations and increased the expression of their receptors mRNAs in the liver of ovariectomized cows. Reproduction in domestic animals = Zuchthygiene. vol 46. issue 5. 2012-02-28. PMID:21323755. |
this study aimed to determine the effect of sex steroids on the plasma profiles of gh, igf-i and insulin and their receptors in the liver and adipose tissues of dairy cows. |
2012-02-28 |
2023-08-12 |
cattle |
| M Colak, T Shimizu, N Matsunaga, C Murayama, S Nagashima, M Kataoka, C Kawashima, M Matsui, H A van Dorland, R M Bruckmaier, A Miyamot. Oestradiol enhances plasma growth hormone and insulin-like growth factor-I concentrations and increased the expression of their receptors mRNAs in the liver of ovariectomized cows. Reproduction in domestic animals = Zuchthygiene. vol 46. issue 5. 2012-02-28. PMID:21323755. |
the animals were euthanized after the experiment, and liver and adipose tissues samples were quantitatively analysed using real-time pcr for the expression of mrna for the gh (ghr), igf-i (igfr-i) and insulin (ir) receptor mrnas. |
2012-02-28 |
2023-08-12 |
cattle |
| M Colak, T Shimizu, N Matsunaga, C Murayama, S Nagashima, M Kataoka, C Kawashima, M Matsui, H A van Dorland, R M Bruckmaier, A Miyamot. Oestradiol enhances plasma growth hormone and insulin-like growth factor-I concentrations and increased the expression of their receptors mRNAs in the liver of ovariectomized cows. Reproduction in domestic animals = Zuchthygiene. vol 46. issue 5. 2012-02-28. PMID:21323755. |
oestradiol benzoate significantly increased the number of peaks (p < 0.05), pulse amplitude (p < 0.05) and area under the curve (auc; p < 0.01) for plasma gh; moreover, it increased plasma igf-i concentration (p < 0.05), but it had no effect on the plasma insulin profile. |
2012-02-28 |
2023-08-12 |
cattle |
| Andrzej Bartk. Pleiotropic effects of growth hormone signaling in aging. Trends in endocrinology and metabolism: TEM. vol 22. issue 11. 2012-02-23. PMID:21852148. |
mice lacking gh or gh receptor outlive their normal siblings and exhibit symptoms of delayed aging associated with improved insulin signaling and increased stress resistance. |
2012-02-23 |
2023-08-12 |
mouse |
| Manuel D Gahete, José Córdoba-Chacón, Chike V Anadumaka, Qing Lin, Jens C Brüning, C Ronald Kahn, Raúl M Luque, Rhonda D Kinema. Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. Endocrinology. vol 152. issue 12. 2012-02-16. PMID:21990313. |
when caloric intake is moderated, elevated gh improves glucose clearance, despite low/normal insulin sensitivity, which may be explained in part by enhanced igf-i and insulin output. |
2012-02-16 |
2023-08-12 |
mouse |
| Manuel D Gahete, José Córdoba-Chacón, Chike V Anadumaka, Qing Lin, Jens C Brüning, C Ronald Kahn, Raúl M Luque, Rhonda D Kinema. Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. Endocrinology. vol 152. issue 12. 2012-02-16. PMID:21990313. |
however, when caloric intake is in excess, elevated gh promotes hepatic lipid accumulation, insulin resistance, hyperglycemia, and ketosis. |
2012-02-16 |
2023-08-12 |
mouse |
| J G Miquet, J F Giani, C S Martinez, M C Muñoz, L González, A I Sotelo, R K Boparai, M M Masternak, A Bartke, F P Dominici, D Tury. Prolonged exposure to GH impairs insulin signaling in the heart. Journal of molecular endocrinology. vol 47. issue 2. 2012-01-30. PMID:21727153. |
prolonged exposure to gh impairs insulin signaling in the heart. |
2012-01-30 |
2023-08-12 |
mouse |
| J G Miquet, J F Giani, C S Martinez, M C Muñoz, L González, A I Sotelo, R K Boparai, M M Masternak, A Bartke, F P Dominici, D Tury. Prolonged exposure to GH impairs insulin signaling in the heart. Journal of molecular endocrinology. vol 47. issue 2. 2012-01-30. PMID:21727153. |
given that insulin is important for cardiac growth and function, and considering that gh excess induces hyperinsulinemia, insulin resistance, and cardiac alterations, it is of interest to study insulin sensitivity in this tissue under chronic conditions of elevated gh. |
2012-01-30 |
2023-08-12 |
mouse |
| MaryKathleen Heneghan, Ramin Alemzade. Cushing disease as possible cause of persistent growth failure despite growth hormone therapy in a small for gestational age male. Pituitary. vol 14. issue 4. 2012-01-26. PMID:19771523. |
we report the case of an 11-year-old caucasian male who developed early adrenarche, hypertension and insulin resistance on gh therapy for sga and profound short stature (ht -5 sd). |
2012-01-26 |
2023-08-12 |
Not clear |