| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C David Roll. Aging and the Mammalian regulatory triumvirate. Aging and disease. vol 1. issue 2. 2012-08-23. PMID:22396860. |
a temporal framework linking circadian rhythms and clocks to aging rates identifies a specific window of target of rapamycin (tor) signaling associated with growth hormone (gh) and insulin-like growth factor (igf-1) (largely exclusive of insulin) in early sleep. |
2012-08-23 |
2023-08-12 |
Not clear |
| Diana van Heems. Insulin, IGF-1 and longevity. Aging and disease. vol 1. issue 2. 2012-08-23. PMID:22396862. |
however, the increased complexity of the mammalian insulin/igf-1 system has made it difficult to separate the roles of insulin, gh and igf-1 in mammalian longevity. |
2012-08-23 |
2023-08-12 |
mouse |
| Archana Vijayakumar, Shoshana Yakar, Derek Leroit. The intricate role of growth hormone in metabolism. Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22654802. |
growth hormone (gh), a master regulator of somatic growth, also regulates carbohydrate and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 (igf-1). |
2012-08-23 |
2023-08-12 |
human |
| Archana Vijayakumar, Shoshana Yakar, Derek Leroit. The intricate role of growth hormone in metabolism. Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22654802. |
data from human and rodent studies reveal the importance of gh in insulin synthesis and secretion, lipid metabolism and body fat remodeling. |
2012-08-23 |
2023-08-12 |
human |
| Matthew C Luc. Growth hormone regulation of follicular growth. Reproduction, fertility, and development. vol 24. issue 1. 2012-08-14. PMID:22394714. |
the major impact that gh has on reproduction, therefore, may be secondary to its systemic effects on metabolism (including insulin sensitivity) or secondary to the capacity for gh to control igf1 secretion. |
2012-08-14 |
2023-08-12 |
Not clear |
| Matthew C Luc. Growth hormone regulation of follicular growth. Reproduction, fertility, and development. vol 24. issue 1. 2012-08-14. PMID:22394714. |
future studies of gh should focus on its direct effects on the follicle as well as its indirect effects mediated by shifts in nutrient metabolism, insulin sensitivity, igf1 and igfbp. |
2012-08-14 |
2023-08-12 |
Not clear |
| Nir Barzilai, Derek M Huffman, Radhika H Muzumdar, Andrzej Bartk. The critical role of metabolic pathways in aging. Diabetes. vol 61. issue 6. 2012-07-25. PMID:22618766. |
the aging process is characterized metabolically by insulin resistance, changes in body composition, and physiological declines in growth hormone (gh), insulin-like growth factor-1 (igf-1), and sex steroids. |
2012-07-25 |
2023-08-12 |
Not clear |
| Adam Gesing, Michal M Masternak, Feiya Wang, Malgorzata Karbownik-Lewinska, Andrzej Bartk. Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension. Age (Dordrecht, Netherlands). vol 34. issue 2. 2012-07-24. PMID:21431351. |
mice homozygous for the targeted disruption of the growth hormone (gh) receptor (ghr) gene (gh receptor knockout; ghrko; ko) are hypoinsulinemic, highly insulin sensitive, normoglycemic, and long-lived. |
2012-07-24 |
2023-08-12 |
mouse |
| Adam Gesing, Michal M Masternak, Feiya Wang, Malgorzata Karbownik-Lewinska, Andrzej Bartk. Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension. Age (Dordrecht, Netherlands). vol 34. issue 2. 2012-07-24. PMID:21431351. |
these data are consistent with a model in which alterations of gh signaling and/or insulin sensitivity lead to increased lifespan mediated by decreased renal expression of pro-apoptotic genes. |
2012-07-24 |
2023-08-12 |
mouse |
| Holly M Brown-Borg, Andrzej Bartk. GH and IGF1: roles in energy metabolism of long-living GH mutant mice. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 67. issue 6. 2012-07-23. PMID:22466316. |
of the multiple theories to explain exceptional longevity, the most robust of these has centered on the reduction of three anabolic protein hormones, growth hormone (gh), insulin-like growth factor, and insulin. |
2012-07-23 |
2023-08-12 |
mouse |
| K Sato, T Takahashi, Y Kobayashi, A Hagino, S G Roh, K Kato. Apelin is involved in postprandial responses and stimulates secretion of arginine-vasopressin, adrenocorticotropic hormone, and growth hormone in the ruminant. Domestic animal endocrinology. vol 42. issue 3. 2012-07-17. PMID:22177697. |
therefore, the aims of this study were to investigate the following: (1) changes in plasma apelin concentrations in response to food intake under conditions of hydration (free access to water) or dehydration (water restriction), and (2) the effects of intravenous administration of apelin on plasma concentrations of arginine-vasopressin (avp), acth, gh, and insulin. |
2012-07-17 |
2023-08-12 |
Not clear |
| K Sato, T Takahashi, Y Kobayashi, A Hagino, S G Roh, K Kato. Apelin is involved in postprandial responses and stimulates secretion of arginine-vasopressin, adrenocorticotropic hormone, and growth hormone in the ruminant. Domestic animal endocrinology. vol 42. issue 3. 2012-07-17. PMID:22177697. |
in experiment 2 with the use of sheep and hydration conditions, the intravenous administration of apelin ([pyr(1)]-apelin-13; 0.5 mg/head) caused a tendency to increase or caused a significant increase in plasma concentrations of avp, acth, gh, insulin, and glucose. |
2012-07-17 |
2023-08-12 |
Not clear |
| G Balercia, L Giovannini, F Paggi, M Spaziani, N Tahani, M Boscaro, A Lenzi, A Radicion. Growth hormone deficiency in the transition period: body composition and gonad function. Journal of endocrinological investigation. vol 34. issue 9. 2012-07-16. PMID:21697646. |
retesting during the transition period, involving measurement of igf-i plus a provocative test (insulin tolerance test or ghrh + arginine test), is thus necessary to establish any persistent gh deficiency requiring additional replacement therapy. |
2012-07-16 |
2023-08-12 |
Not clear |
| Carla R P Oliveira, Rafael A Meneguz-Moreno, Manuel H Aguiar-Oliveira, José A S Barreto-Filh. Emerging role of the GH/IGF-I on cardiometabolic control. Arquivos brasileiros de cardiologia. vol 97. issue 5. 2012-07-11. PMID:22189610. |
experiments with animal models indicate an important role of gh on insulin resistance although the igf-i role is not yet completely established. |
2012-07-11 |
2023-08-12 |
Not clear |
| Carla R P Oliveira, Roberto Salvatori, Jose A S Barreto-Filho, Ivina E S Rocha, Andrea Mari, Rossana M C Pereira, Viviane C Campos, Menilsson Menezes, Elenilde Gomes, Rafael A Meneguz-Moreno, Vanessa P Araújo, Natália T F Leite, Adão C Nascimento-Junior, Maria I T Farias, Thaisa A R Viscente, Raquel D C Araújo, Enaldo V Melo, Manuel H Aguiar-Oliveir. Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. The Journal of clinical endocrinology and metabolism. vol 97. issue 3. 2012-07-06. PMID:22170707. |
gh reduces insulin sensitivity (is), whereas igf-i increases it. |
2012-07-06 |
2023-08-12 |
Not clear |
| Shirin Hasani-Ranjbar, Ehsan Soleymani Far, Ramin Heshmat, Hamid Rajabi, Hassan Kosar. Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men. Endocrine. vol 41. issue 1. 2012-07-02. PMID:21983797. |
time course responses of serum gh, insulin, igf-1, igfbp1, and igfbp3 concentrations after heavy resistance exercise in trained and untrained men. |
2012-07-02 |
2023-08-12 |
human |
| Shirin Hasani-Ranjbar, Ehsan Soleymani Far, Ramin Heshmat, Hamid Rajabi, Hassan Kosar. Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men. Endocrine. vol 41. issue 1. 2012-07-02. PMID:21983797. |
analysis of data showed that a session of heavy resistance exercise induced significant increase in gh at t2 (p < 0.05) and a significant decrease in insulin at t4 (p < 0.05) and a significant decrease in igfbp3 at t4 (p < 0.05) in trained group. |
2012-07-02 |
2023-08-12 |
human |
| Min Pi, L Darryl Quarle. Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks. Endocrinology. vol 153. issue 5. 2012-06-29. PMID:22374969. |
consistent with the existence of more complex endocrine networks, ablation of gprc6a in gprc6a(-/-) mice results in complex metabolic abnormalities, including obesity, glucose intolerance, hepatic steatosis, insulin resistance, hyperphosphatemia, osteopenia, plus several hormonal abnormalities, including decreased circulating testosterone, igf-i, and insulin and increased estradiol, lh, gh, and leptin. |
2012-06-29 |
2023-08-12 |
mouse |
| E B Foster, G Fisher, J L Sartin, T H Elsasser, G Wu, W Cowan, D D Pasco. Acute regulation of IGF-I by alterations in post-exercise macronutrients. Amino acids. vol 42. issue 4. 2012-06-25. PMID:21293890. |
samples were analyzed for growth hormone (gh), free igf-i, igfbp-1, igfbp-2, insulin, hematocrit, hemoglobin, serum leucine, matrix metalloproteinase-9 (mmp-9) proteolytic activity, and presence of igfbp-3 protease activity. |
2012-06-25 |
2023-08-12 |
Not clear |
| Michal M Masternak, Andrzej Bartke, Feiya Wang, Adam Spong, Adam Gesing, Yimin Fang, Adam B Salmon, Larry F Hughes, Teresa Liberati, Ravneet Boparai, John J Kopchick, Reyhan Westbroo. Metabolic effects of intra-abdominal fat in GHRKO mice. Aging cell. vol 11. issue 1. 2012-06-20. PMID:22040032. |
mice with targeted deletion of the growth hormone receptor (ghrko mice) are growth hormone (gh) resistant, small, obese, hypoinsulinemic, highly insulin sensitive and remarkably long-lived. |
2012-06-20 |
2023-08-12 |
mouse |