| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Valea, M Carsote, C Ghervan, C Georgesc. Glycemic profile in patients with acromegaly treated with somatostatin analogue. Journal of medicine and life. vol 8 Spec Issue. 2016-05-02. PMID:26361517. |
the growth hormone (gh) excess displayed in acromegaly induces insulin resistance up to diabetes mellitus (dm). |
2016-05-02 |
2023-08-13 |
Not clear |
| Jaime Guevara-Aguirre, Arlan L Rosenbloo. Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency. Diabetologia. vol 58. issue 1. 2016-04-12. PMID:25316432. |
in ecuador there are ~100 living adults with lifelong igf-1 deficiency caused by a gh receptor (ghr) mutation who, despite a high percentage of body fat, have markedly increased insulin sensitivity compared with age- and bmi-matched control relatives, and no instances of diabetes, which is present in 6% of unaffected relatives. |
2016-04-12 |
2023-08-13 |
Not clear |
| Jose Cordoba-Chacon, Neena Majumdar, Naveen K Pokala, Manuel D Gahete, Rhonda D Kinema. Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 25. issue 4. 2016-04-07. PMID:25936582. |
islet insulin content and release are increased in male mice with elevated endogenous gh and igf-i, without evidence of systemic insulin resistance or alterations in β-cell mass. |
2016-04-07 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Neena Majumdar, Naveen K Pokala, Manuel D Gahete, Rhonda D Kinema. Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 25. issue 4. 2016-04-07. PMID:25936582. |
it is clear that elevations in circulating gh can lead to an increase in insulin levels. |
2016-04-07 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Neena Majumdar, Naveen K Pokala, Manuel D Gahete, Rhonda D Kinema. Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 25. issue 4. 2016-04-07. PMID:25936582. |
however, there is also in vitro and in vivo evidence that gh acts directly to increase β-cell proliferation and insulin production. |
2016-04-07 |
2023-08-13 |
mouse |
| Jose Cordoba-Chacon, Neena Majumdar, Naveen K Pokala, Manuel D Gahete, Rhonda D Kinema. Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 25. issue 4. 2016-04-07. PMID:25936582. |
this metabolic phenotype suggests that modest elevations in circulating gh and igf-i may enhance β-cell mass and/or function, in the absence of systemic insulin resistance, thus improving glucose homeostasis. |
2016-04-07 |
2023-08-13 |
mouse |
| N R Irani, K Venugopal, N Kontorinis, M Lee, R Sinniah, T R Bate. Glycogenic hepatopathy is an under-recognised cause of hepatomegaly and elevated liver transaminases in type 1 diabetes mellitus. Internal medicine journal. vol 45. issue 7. 2016-04-05. PMID:26134697. |
he was subsequently diagnosed with gh on liver biopsy, with the mainstay of treatment being reduction in caloric intake and insulin. |
2016-04-05 |
2023-08-13 |
Not clear |
| Klas Ekström, Mari-Anne Pulkkinen, Christine Carlsson-Skwirut, Anna-Lena Brorsson, Zhulin Ma, Jan Frystyk, Peter Ban. Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes. The Journal of clinical endocrinology and metabolism. vol 100. issue 11. 2016-02-17. PMID:26331550. |
type 1 diabetes is associated with portal insulin deficiency and disturbances in the gh-igf axis including low circulating igf-i and gh hypersecretion. |
2016-02-17 |
2023-08-13 |
Not clear |
| L Prokop, M Kaske, P Maccari, R Lucius, H-J Kunz, S Wiedeman. Intensive rearing of male calves during the first three weeks of life has long-term effects on number of islets of Langerhans and insulin stained area in the pancreas. Journal of animal science. vol 93. issue 3. 2016-02-12. PMID:26020877. |
plasma glucose, insulin, igf-1, and gh levels were assessed in wk 1, 2, 3, and 10 of life. |
2016-02-12 |
2023-08-13 |
Not clear |
| L Prokop, M Kaske, P Maccari, R Lucius, H-J Kunz, S Wiedeman. Intensive rearing of male calves during the first three weeks of life has long-term effects on number of islets of Langerhans and insulin stained area in the pancreas. Journal of animal science. vol 93. issue 3. 2016-02-12. PMID:26020877. |
intensive rearing led to increased plasma glucose, insulin, and igf-1 concentrations after 3 wk of life compared with rearing to the established standard protocol (all < 0.05), whereas gh was lower in int calves during the second week of life. |
2016-02-12 |
2023-08-13 |
Not clear |
| Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S Wiesenborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M Masterna. Thyroxine modifies the effects of growth hormone in Ames dwarf mice. Aging. vol 7. issue 4. 2016-02-02. PMID:25935838. |
treatment of juvenile df/df mice with gh alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. |
2016-02-02 |
2023-08-13 |
mouse |
| Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S Wiesenborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M Masterna. Thyroxine modifies the effects of growth hormone in Ames dwarf mice. Aging. vol 7. issue 4. 2016-02-02. PMID:25935838. |
expression of genes related to gh and insulin signaling in the skeletal muscle and white adipose tissue (wat) of female dwarfs was differentially affected by treatment with gh + t4 vs. gh alone. |
2016-02-02 |
2023-08-13 |
mouse |
| Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S Wiesenborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M Masterna. Thyroxine modifies the effects of growth hormone in Ames dwarf mice. Aging. vol 7. issue 4. 2016-02-02. PMID:25935838. |
differences in the effects of gh + t4 vs. gh alone on insulin target tissues may contribute to the differential effects of these treatments on longevity. |
2016-02-02 |
2023-08-13 |
mouse |
| Marion Piechotta, Lars Holzhausen, Marcelo Gil Araujo, Maike Heppelmann, Anja Sipka, Chistiane Pfarrer, Hans-Joachim Schuberth, Heinrich Bollwei. Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity of dairy cows. Journal of veterinary science. vol 15. issue 3. 2016-01-15. PMID:24962413. |
blood samples were drawn daily (day -17 until calving) and igf-i, gh, insulin, thyroid hormones, estradiol, and progesterone concentrations were measured. |
2016-01-15 |
2023-08-13 |
Not clear |
| F Y Obese, C MacCarthy, R Osei-Amponsah, R A Ayizanga, J K Dampte. Blood metabolite profiles in cycling and non-cycling Friesian-Sanga cross-bred cows grazing natural pasture during the post-partum period. Reproduction in domestic animals = Zuchthygiene. vol 50. issue 2. 2015-12-03. PMID:25683608. |
an experiment was conducted to investigate the effect of plasma concentrations of the metabolic hormones [growth hormone (gh), insulin and insulin-like growth factor -i (igf-i)] and nutritional metabolites (glucose, cholesterol, total protein, albumin, globulin, urea and creatinine) on the resumption of post-partum ovarian activity in sixteen friesian-sanga cows grazing extensively on native grassland. |
2015-12-03 |
2023-08-13 |
Not clear |
| F Y Obese, C MacCarthy, R Osei-Amponsah, R A Ayizanga, J K Dampte. Blood metabolite profiles in cycling and non-cycling Friesian-Sanga cross-bred cows grazing natural pasture during the post-partum period. Reproduction in domestic animals = Zuchthygiene. vol 50. issue 2. 2015-12-03. PMID:25683608. |
the concentrations of the metabolic hormones, gh and insulin were similar (p > 0.05) in the three ovarian activity groups, likewise the concentrations of the nutritional metabolites, glucose, total protein, globulin, urea and creatinine. |
2015-12-03 |
2023-08-13 |
Not clear |
| W Y So, Q Cheng, A Xu, K S L Lam, P S Leun. Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell death & disease. vol 6. 2015-11-30. PMID:25811804. |
furthermore, distorted islet morphology and impaired gsis were observed in ko mice, suggestive of islet dysfunction, whereas the enhanced insulin expression and impaired gsis in fgf21-ko mouse islets could be reversed by blockade of gh signaling. |
2015-11-30 |
2023-08-13 |
mouse |
| W Y So, Q Cheng, A Xu, K S L Lam, P S Leun. Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell death & disease. vol 6. 2015-11-30. PMID:25811804. |
our data indicate that fgf21 is important in the regulation of beta-cell proliferation and insulin synthesis, probably via modulation of gh signaling. |
2015-11-30 |
2023-08-13 |
mouse |
| L Cruz-Garcia, J Sánchez-Gurmaches, M Monroy, J Gutiérrez, I Navarr. Regulation of lipid metabolism and peroxisome proliferator-activated receptors in rainbow trout adipose tissue by lipolytic and antilipolytic endocrine factors. Domestic animal endocrinology. vol 51. 2015-11-24. PMID:25594950. |
cells were also incubated with gh, tumor necrosis factor α (tnfα), or insulin to analyze the gene expression of peroxisome proliferator-activated receptors (ppars) and lipid metabolism markers: hormone sensitive lipase, fatty acid synthase (fas), and lipoprotein lipase. |
2015-11-24 |
2023-08-13 |
Not clear |
| L Cruz-Garcia, J Sánchez-Gurmaches, M Monroy, J Gutiérrez, I Navarr. Regulation of lipid metabolism and peroxisome proliferator-activated receptors in rainbow trout adipose tissue by lipolytic and antilipolytic endocrine factors. Domestic animal endocrinology. vol 51. 2015-11-24. PMID:25594950. |
the anabolic action of insulin was demonstrated through its upregulation of lipogenic genes such as lipoprotein lipase, fas, and pparγ, whereas gh, by contrast, inhibited fas expression in adipose tissue. |
2015-11-24 |
2023-08-13 |
Not clear |