| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R G Ahmed, M Abdel-Latif, F Ahme. Protective effects of GM-CSF in experimental neonatal hypothyroidism. International immunopharmacology. vol 29. issue 2. 2016-09-15. PMID:26453507. |
the hypothyroid conditions due to the administration of mmi produced inhibitory effects on neonatal serum thyroxine (t4), 3,5,3'-triiodothyronine (t3), neutrophil count in bone marrow and blood, cerebellar glutathione (gsh) and acetylcholinesterase (ache), although it induced stimulatory actions on serum thyrotropin (tsh), growth hormone (gh), insulin growth factor-ii (igf-ii), tumor necrosis factor alpha (tnf-α), and cerebellar malondialdehyde (mda) at pnd 19. |
2016-09-15 |
2023-08-13 |
rat |
| Artur Galimov, Angelika Hartung, Roman Trepp, Alexander Mader, Martin Flück, Axel Linke, Matthias Blüher, Emanuel Christ, Jan Krützfeld. Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance. Journal of molecular medicine (Berlin, Germany). vol 93. issue 12. 2016-09-09. PMID:26199111. |
however, gh replacement therapy (ghrt) is also associated with insulin resistance, but the mechanisms are incompletely understood. |
2016-09-09 |
2023-08-13 |
mouse |
| Heather Beckwith, Douglas Ye. Minireview: Were the IGF Signaling Inhibitors All Bad? Molecular endocrinology (Baltimore, Md.). vol 29. issue 11. 2016-08-29. PMID:26366975. |
the lack of use of biomarkers to define subsets of patients that may benefit from igf receptor blockade and compensatory signaling via other growth factor receptors such as the insulin, gh, and epidermal growth factor receptors may have played a role in the lack of efficacy of igf receptor inhibition in phase iii trials. |
2016-08-29 |
2023-08-13 |
Not clear |
| Hamdollah Karamifar, Mehran Karimi, Nargrs Sobhan. Insulin-like growth factor-1 levels in children with Beta-thalassemia minor. Turkish journal of haematology : official journal of Turkish Society of Haematology. vol 25. issue 3. 2016-08-29. PMID:27264705. |
some etiologies described for this condition are hemochromatosis, disturbed growth hormone (gh) / insulin growth factor-1 (igf-1) axis, undernutrition and hypermetabolism. |
2016-08-29 |
2023-08-13 |
human |
| Feida Li, Yong Li, Huan Liu, Xingju Zhang, Chuxin Liu, Kai Tian, Lars Bolund, Hongwei Dou, Wenxian Yang, Huanming Yang, Nicklas Heine Staunstrup, Yutao D. Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway. Transgenic research. vol 24. issue 6. 2016-08-23. PMID:26510874. |
gh binding to the growth hormone receptor (ghr) on hepatocytes prompts expression of insulin growth factor i (igf-1) involved in nutritionally induced compensatory hyperplasia of pancreatic β-cell islets and insulin release. |
2016-08-23 |
2023-08-13 |
human |
| Christopher J Romero, Andrew Wolfe, Yi Ying Law, ChenChen Z Costelloe, Ryan Miller, Fredric Wondisford, Sally Radovic. Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice. Metabolism: clinical and experimental. vol 65. issue 4. 2016-07-25. PMID:26975547. |
furthermore, both gh and insulin growth factor 1 (igf-1) may also play a direct or indirect role in adipose development. |
2016-07-25 |
2023-08-13 |
mouse |
| Manouk van der Steen, Annemieke J Lem, Daniëlle C M van der Kaay, Anita C S Hokken-Koeleg. Insulin Sensitivity and β-Cell Function in SGA Children Treated With GH and GnRHa: Results of a Long-Term Trial. The Journal of clinical endocrinology and metabolism. vol 101. issue 2. 2016-06-29. PMID:26653111. |
insulin sensitivity and β-cell function in sga children treated with gh and gnrha: results of a long-term trial. |
2016-06-29 |
2023-08-13 |
Not clear |
| Manouk van der Steen, Annemieke J Lem, Daniëlle C M van der Kaay, Anita C S Hokken-Koeleg. Insulin Sensitivity and β-Cell Function in SGA Children Treated With GH and GnRHa: Results of a Long-Term Trial. The Journal of clinical endocrinology and metabolism. vol 101. issue 2. 2016-06-29. PMID:26653111. |
because both gh and gnrha can negatively influence insulin sensitivity, combining these treatments has raised concerns. |
2016-06-29 |
2023-08-13 |
Not clear |
| Manouk van der Steen, Annemieke J Lem, Daniëlle C M van der Kaay, Anita C S Hokken-Koeleg. Insulin Sensitivity and β-Cell Function in SGA Children Treated With GH and GnRHa: Results of a Long-Term Trial. The Journal of clinical endocrinology and metabolism. vol 101. issue 2. 2016-06-29. PMID:26653111. |
the long-term gh dose effects on insulin sensitivity in children treated with combined gh/gnrha are unknown. |
2016-06-29 |
2023-08-13 |
Not clear |
| Sana Doubi, Zoubida Amrani, Hanan El Ouahabi, Saïd Boujraf, Farida Ajd. Exceptional Association Between Klinefelter Syndrome and Growth Hormone Deficiency. Genome integrity. vol 6. 2016-06-22. PMID:27330737. |
gh deficiency was isolated and confirmed by two dynamic tests (insulin - hypoglycemia tolerance test and clonidine) with normal hypothalamic magnetic resonance imaging (mri). |
2016-06-22 |
2023-08-13 |
Not clear |
| Erin R Hascup, Feiya Wang, John J Kopchick, Andrzej Bartk. Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 71. issue 3. 2016-06-14. PMID:25711529. |
whole body studies using long-lived growth hormone receptor gene disrupted or knock out (ghr-ko) mice report global gh resistance, increased insulin sensitivity, reduced insulin-like growth factor 1 (igf-1), and cognitive retention in old-age, however, little is known about the neurobiological status of these mice. |
2016-06-14 |
2023-08-13 |
mouse |
| P Harkitis, E P Daskalopoulos, F Malliou, M A Lang, M Marselos, A Fotopoulos, G Albucharali, M Konstand. Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver. PloS one. vol 10. issue 10. 2016-06-06. PMID:26466350. |
dopaminergic systems regulate the release of several hormones including growth hormone (gh), thyroid hormones, insulin, glucocorticoids and prolactin (prl) that play significant roles in the regulation of various cytochrome p450 (cyp) enzymes. |
2016-06-06 |
2023-08-13 |
rat |
| Carolina Di Somma, Alessandro Ciresi, Marco C Amato, Silvia Savastano, Maria Cristina Savanelli, Elisabetta Scarano, Annamaria Colao, Carla Giordan. Alteration of the growth hormone axis, visceral fat dysfunction, and early cardiometabolic risk in adults: the role of the visceral adiposity index. Endocrine. vol 49. issue 2. 2016-05-26. PMID:25381601. |
anthropometric measures, lipid profile, and glucose and insulin levels during oral glucose tolerance test, homa-ir and isi matsuda, igf-i and gh peak after ghrh plus arginine test were analyzed. |
2016-05-26 |
2023-08-13 |
human |
| Carolina Di Somma, Alessandro Ciresi, Marco C Amato, Silvia Savastano, Maria Cristina Savanelli, Elisabetta Scarano, Annamaria Colao, Carla Giordan. Alteration of the growth hormone axis, visceral fat dysfunction, and early cardiometabolic risk in adults: the role of the visceral adiposity index. Endocrine. vol 49. issue 2. 2016-05-26. PMID:25381601. |
the subjects with gh peak and igf-i unr under the cut-off showed significantly higher levels of vai, systolic and diastolic blood pressure, glucose and insulin levels, homa-ir, and lower isi matsuda, with a concomitant worse lipid profile (all p < 0.001). |
2016-05-26 |
2023-08-13 |
human |
| A Ciresi, M C Amato, C Giordan. Reduction in insulin sensitivity and inadequate β-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth hormone deficiency during 12 months of growth hormone treatment. Journal of endocrinological investigation. vol 38. issue 3. 2016-05-24. PMID:25273336. |
to evaluate the performance of various indexes of insulin sensitivity and secretion and to identify the most useful indicator of deterioration of glucose metabolism in a cohort of children with growth hormone (gh) deficiency (ghd) during gh treatment. |
2016-05-24 |
2023-08-13 |
Not clear |
| Ronaldo D Piovezan, Julio Abucham, Ronaldo Vagner Thomatieli Dos Santos, Marco Tulio Mello, Sergio Tufik, Dalva Poyare. The impact of sleep on age-related sarcopenia: Possible connections and clinical implications. Ageing research reviews. vol 23. issue Pt B. 2016-05-23. PMID:26216211. |
several protein synthesis and degradation pathways are mediated by growth hormone (gh), insulin-like growth factor-1 (igf-1), testosterone, cortisol and insulin, which act on the cellular and molecular levels to increase or reestablish muscle fiber, strength and function. |
2016-05-23 |
2023-08-13 |
Not clear |
| Lisa Arnetz, Mozhgan Dorkhan, Michael Alvarsson, Kerstin Brismar, Neda Rajamand Ekber. Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes. Acta diabetologica. vol 51. issue 2. 2016-05-19. PMID:23389468. |
excess cortisol and gh induce insulin resistance, a central feature of type 2 diabetes (t2d). |
2016-05-19 |
2023-08-12 |
Not clear |
| Danika Krupp, Thomas Remer, Katharina J Penczynski, Katja Bolzenius, Stefan A Wudy, Anette E Buyke. Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood. The British journal of nutrition. vol 115. issue 3. 2016-05-18. PMID:26628272. |
the growth hormone (gh) insulin-like growth factor (igf) axis has been linked to insulin metabolism and cancer risk. |
2016-05-18 |
2023-08-13 |
human |
| Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juu. Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment. The Journal of clinical endocrinology and metabolism. vol 101. issue 1. 2016-05-09. PMID:26588449. |
insulin resistance, and therefore adiposity, may alter sensitivity to gh. |
2016-05-09 |
2023-08-13 |
Not clear |
| Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juu. Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment. The Journal of clinical endocrinology and metabolism. vol 101. issue 1. 2016-05-09. PMID:26588449. |
we aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to gh treatment in short children born small for gestational age (sga). |
2016-05-09 |
2023-08-13 |
Not clear |