| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
gh is believed to play a role in promoting insulin resistance in patients with diabetes and with gh excess. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
the means by which gh produces insulin resistance may be through direct suppression of glucose metabolism in target cells (insulin-independent) or by interfering with the ability of insulin to stimulate glucose metabolism (insulin-dependent). |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
in 3t3-f442a adipocytes, long term incubation (24-72 h) with gh directly inhibits glucose oxidation and lipid synthesis in the absence of insulin. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
cells were incubated for 48-72 h with gh and then treated with insulin. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
thus, gh directly suppresses basal lipid accumulation and lowers the response to insulin. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
when cells were exposed simultaneously to insulin and gh for 72 h, gh treatment inhibited the ability of insulin to stimulate lipid accumulation, and the degree of suppression by gh was related to the gh concentration present. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
these observations suggest that gh suppresses glucose metabolism not only in the absence but also in the presence of insulin. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
since short term (4-h) incubation with gh increases glucose metabolism transiently in gh-deficient preparations, we also examined the influence of short term incubation with gh on insulin responses. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
cells were incubated for 4 h with varying concentrations of insulin in the simultaneous presence or absence of gh. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
insulin stimulated the conversion of glucose to lipid when tested alone or in the presence of gh. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
the stimulation of lipid accumulation at insulin concentrations less than 5 ng/ml was greater with gh, but responses were comparable above 5 ng/ml insulin. |
1988-08-29 |
2023-08-11 |
human |
| C M Foster, P M Hale, H W Jing, J Schwart. Effects of human growth hormone on insulin-stimulated glucose metabolism in 3T3-F442A adipocytes. Endocrinology. vol 123. issue 2. 1988-08-29. PMID:3293980. |
the ability of insulin to bind to its receptor was not affected by prior treatment with gh for either short or prolonged time periods. |
1988-08-29 |
2023-08-11 |
human |
| R Sorv. Children with craniopharyngioma. Early growth failure and rapid postoperative weight gain. Acta paediatrica Scandinavica. vol 77. issue 4. 1988-08-25. PMID:3394513. |
serum insulin and insulin-like growth factor i (igf-i) were assessed in four children with growth hormone deficiency (ghd) who, after surgery for craniopharyngioma, were growing normally without gh substitution. |
1988-08-25 |
2023-08-11 |
Not clear |
| G S Meneilly, D Elahi, K L Minaker, J W Row. Somatostatin enhances insulin-mediated glucose disposal in elderly subjects. The Journal of clinical endocrinology and metabolism. vol 67. issue 2. 1988-08-24. PMID:2899090. |
basal plasma insulin, glucose, glucagon, gh, and glucose production and disappearance were similar on each occasion. |
1988-08-24 |
2023-08-11 |
human |
| T R Ziegler, L S Young, J M Manson, D W Wilmor. Metabolic effects of recombinant human growth hormone in patients receiving parenteral nutrition. Annals of surgery. vol 208. issue 1. 1988-08-11. PMID:3133995. |
with gh, serum blood urea nitrogen (bun) and potassium fell, whereas glucose and insulin tended to rise, and levels of insulin-like growth factor 1 increased three to fourfold. |
1988-08-11 |
2023-08-11 |
human |
| J A Ramsay, K Kovacs, S L Asa, M J Pike, M O Thorne. Reversible sellar enlargement due to growth hormone-releasing hormone production by pancreatic endocrine tumors in a acromegalic patient with multiple endocrine neoplasia type I syndrome. Cancer. vol 62. issue 2. 1988-08-10. PMID:2898285. |
preoperative plasma levels of insulin and growth hormone (gh) were markedly elevated and there was mild hyperprolactinemia. |
1988-08-10 |
2023-08-11 |
Not clear |
| J A Ramsay, K Kovacs, S L Asa, M J Pike, M O Thorne. Reversible sellar enlargement due to growth hormone-releasing hormone production by pancreatic endocrine tumors in a acromegalic patient with multiple endocrine neoplasia type I syndrome. Cancer. vol 62. issue 2. 1988-08-10. PMID:2898285. |
postoperatively, blood glucose, insulin, grh, and gh normalized and there was regression of acromegalic features with significant reduction in sellar size. |
1988-08-10 |
2023-08-11 |
Not clear |
| P Dessì-Fulgheri, A Pacifico, F Bandiera, S Rubattu, P Madeddu, N Glorioso, M Maioli, G Delitala, P Tomasi, A Rappell. Effect of nifedipine and verapamil on carbohydrate metabolism in hypertensive patients with impaired glucose tolerance. Journal of cardiovascular pharmacology. vol 10 Suppl 10. 1988-08-04. PMID:2455132. |
to evaluate the effects of chronic verapamil (v) and nifedipine (n) on carbohydrate metabolism, 12 hypertensive patients (who ii; aged 37-64 years) with igt underwent intravenous glucose tolerance tests (ivgtt) (0.33 g/kg body weight in 3 min), arginine (a) infusion (30 g/30 min), and hypoglycemic stress (regular insulin 0.15 u/kg body weight) during which blood levels of glucose (g), i, growth hormone (gh), glucagon (irg), and cortisol (c) were measured. |
1988-08-04 |
2023-08-11 |
Not clear |
| C Benelli, S Lopez, B Desbuquois, C Achagioti. Changes in low-Km cAMP phosphodiesterase activity in liver Golgi fractions from hyper- and hypoinsulinemic rats. Diabetes. vol 37. issue 6. 1988-08-04. PMID:2838352. |
after 7 wk, despite the further increase in insulinemia, the increase in golgi-associated camp pde became progressively less marked, and at 18 wk it was no longer detectable except in gh, suggesting the development of a hepatic insulin resistance. |
1988-08-04 |
2023-08-11 |
rat |
| C Benelli, S Lopez, B Desbuquois, C Achagioti. Changes in low-Km cAMP phosphodiesterase activity in liver Golgi fractions from hyper- and hypoinsulinemic rats. Diabetes. vol 37. issue 6. 1988-08-04. PMID:2838352. |
infusion of insulin through chronically implanted intracardiac catheters led to a 30-50% increase in golgi-associated camp pde, which occurred earlier in gi (3 h) than in gh (7 h) and persisted for greater than 96 h. injection of anti-insulin serum led to a 30-50% decrease in golgi-associated camp pde, which occurred sequentially in gl (5 min), gi (15 min), and gh (30 min) and affected predominantly gl and gh. |
1988-08-04 |
2023-08-11 |
rat |