| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Marianna Dankov\\xc3\\xa1, Iveta Domor\\xc3\\xa1kov\\xc3\\xa1, Zuzana Fagov\\xc3\\xa1, Milan Stebnick\\xc3\\xbd, Alexandra Kunov\\xc3\\xa1, Eva Mech\\xc3\\xadrov\\xc3\\xa. Bradykinin and noradrenaline preconditioning influences level of antioxidant enzymes SOD, CuZn-SOD, Mn-SOD and catalase in the white matter of spinal cord in rabbits after ischemia/reperfusion. European journal of histochemistry : EJH. vol 63. issue 4. 2019-12-24. PMID:31631645.' |
the aim of present work is to assess the effects of bradykinin (br) or noradrenaline (nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (sod), copper, zinc superoxide dismutase (cuzn-sod), manganese superoxide dismutase (mn-sod) and catalase in ischemia/reperfusion (i/r) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (gfap) and ubiquitin immunoreaction in glial cells. |
2019-12-24 |
2023-08-13 |
rabbit |
| Jarred M Griffin, Barbara Fackelmeier, Dahna M Fong, Alexander Mouravlev, Deborah Young, Simon J O'Carrol. Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury. Gene therapy. vol 26. issue 5. 2019-12-18. PMID:30962538. |
astrocyte-selective aav gene therapy through the endogenous gfap promoter results in robust transduction in the rat spinal cord following injury. |
2019-12-18 |
2023-08-13 |
rat |
| Hari Prasad Joshi, Sung Bum Kim, Seungki Kim, Hemant Kumar, Min-Jae Jo, Hyemin Choi, Juri Kim, Jae Won Kyung, Seil Sohn, Kyoung-Tae Kim, Jin-Ki Kim, In-Bo Ha. Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2. Molecular neurobiology. vol 56. issue 8. 2019-12-12. PMID:30637664. |
rt-pcr and western blot analyses on days 7 and 14, revealed that treatment with corm-2-slns resulted in greater reductions in the cci-elevated levels of heme-oxygenase-2 (ho-2); inducible nitric oxide synthase (inos); neuronal nos (nnos); and inflammatory mediators (tnf-α, iba-1, and gfap) in the spinal cord and dorsal root ganglions compared with treatment with corm-2. |
2019-12-12 |
2023-08-13 |
rat |
| Nehal M Elsherbiny, Eman Ahmed, Ghada Abdel Kader, Yousra Abdel-Mottaleb, Mohamed H ElSayed, Amal M Youssef, Sawsan A Zaiton. Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators. International immunopharmacology. vol 70. 2019-08-27. PMID:30785087. |
spinal cord of diabetic mice showed greater histopathologic score, increased cd11b and glia fibrillary acidic protein (gfap) immunostaining than vehicle treated mice. |
2019-08-27 |
2023-08-13 |
mouse |
| Chao-Lin Lee, Kai-Chen Wang, Shyi-Jou Chen, Chieh-Min Chen, Ching-Piao Tsai, Shao-Yuan Che. Repetitive intrathecal injection of human NMO-IgG with complement exacerbates disease severity with NMO pathology in experimental allergic encephalomyelitis mice. Multiple sclerosis and related disorders. vol 30. 2019-08-09. PMID:30825702. |
compared to mice given normal human igg, eae mice injected with nmo-igg had markedly decreased aqp4 and glial fibrillary acidic protein (gfap) expression and fluorescent intensity in the brain and spinal cord but more scattered deposition of complement (c9neo). |
2019-08-09 |
2023-08-13 |
mouse |
| Roberto Demontis, Ernesto d'Aloja, Cristina Manieli, Antonio Carai, Marianna Boi, Maria Pina Serra, Marina Quart. Case report of sudden death after a gunshot wound to the C2 vertebral bone without direct spinal cord injury: Histopathological analysis of spinal-medullary junction. Forensic science international. vol 301. 2019-07-16. PMID:31230858. |
histopathological analysis of spinal cord and medulla oblongata was performed by means of conventional stainings, and glial fibrillary acidic protein (gfap) and neurofilaments 200kd (nf) immunohistochemistry. |
2019-07-16 |
2023-08-13 |
Not clear |
| Christopher D Johnson, Anthony R D'Amato, Devan L Puhl, Douglas M Wich, Amanda Vesperman, Ryan J Gilber. Electrospun fiber surface nanotopography influences astrocyte-mediated neurite outgrowth. Biomedical materials (Bristol, England). vol 13. issue 5. 2019-07-15. PMID:29762127. |
western blot results show that the differences in morphology were not associated with significant changes in glial fibrillary acidicprotein (gfap) or vinculin in either astrocyte population, suggesting that surface pits and divots do not induce a reactive phenotype in either cortical or spinal cord astrocytes. |
2019-07-15 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Zhigang Cheng, Yunjiao Wang, Nianyue Bai, Zhenghua H. [mTOR signaling pathway of spinal cord is involved in peripheral nerve injury-induced hyperalgesia in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 4. 2019-05-30. PMID:31113912. |
the gfap immunohistochemistry positive area and absorbance value in the dorsal horn of the lumbar spinal cord in the cci rats were decreased in the cci+early rapa group compared with the cci+early dmso group (p<0.05 or p<0.01), and which were also decreased in the cci+later rapa group compared with the cci+later dmso group (p<0.05 or p<0.01).
conclusion: mtor signaling pathway may be involved in hyperalgesia induced by peripheral nerve injury via spinal astrocyte activation in the dorsal horn of the spinal cord. |
2019-05-30 |
2023-08-13 |
rat |
| Natasha J Olby, Ji-Hey Lim, Nikki Wagner, Natalia Zidan, Peter J Early, Christopher L Mariani, Karen R Muñana, Eric Labe. Time course and prognostic value of serum GFAP, pNFH, and S100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion. Journal of veterinary internal medicine. vol 33. issue 2. 2019-05-10. PMID:30758078. |
time course and prognostic value of serum gfap, pnfh, and s100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion. |
2019-05-10 |
2023-08-13 |
Not clear |
| Suzanne Doolen, Tommaso Iannitti, Renee R Donahue, Benjamin C Shaw, Carolyn M Grachen, Bradley K Taylo. Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. Pain. vol 159. issue 2. 2019-03-21. PMID:29140922. |
fingolimod also reduced cellular markers of central sensitization of neurons in the dorsal horn of the spinal cord: glutamate-evoked ca signaling and stimulus-evoked phospho-extracellular signal-related kinase erk (perk) expression, as well as upregulation of astrocytes (gfap) and macrophage/microglia (iba1) immunoreactivity. |
2019-03-21 |
2023-08-13 |
mouse |
| Noriko Muto, Yoshikazu Matsuoka, Kyosuke Arakawa, Masako Kurita, Hiroki Omiya, Arata Taniguchi, Ryuji Kaku, Hiroshi Morimats. Quercetin Attenuates Neuropathic Pain in Rats with Spared Nerve Injury. Acta medica Okayama. vol 72. issue 5. 2019-02-19. PMID:30369602. |
we measured pain behaviors on the hind paw and glial fibrillary acidic protein (gfap) in the dorsal root ganglion (drg) and spinal cord. |
2019-02-19 |
2023-08-13 |
rat |
| Jiannan Zhang, Bingxu Ren, Kun Ni, Yue Liu, Zhengliang M. [Intrathecal injection of AG-490 reduces bone-cancer-induced spinal cord astrocyte reaction and thermal hyperalgesia in a mouse model]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 11. 2019-02-13. PMID:30643061. |
the lumbar enlargement of spinal cord (l3-l5) was isolated, and real-time rt-pcr and western blot were used to detect the expression of spinal glial fibrillary acidic protein (gfap) and jak2 mrna and protein, respectively. |
2019-02-13 |
2023-08-13 |
mouse |
| Jiannan Zhang, Bingxu Ren, Kun Ni, Yue Liu, Zhengliang M. [Intrathecal injection of AG-490 reduces bone-cancer-induced spinal cord astrocyte reaction and thermal hyperalgesia in a mouse model]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 11. 2019-02-13. PMID:30643061. |
pain behaviors and spinal cord gfap mrna and protein expression were observed at the given time points after intrathecal administration of jak2 antagonist ag-490.
results: the pwl at 10, 14, 21 d after operation in bcp model group were significantly shorter than that in the sham group (p<0.05); the spinal gfap and jak2 mrna and protein levels were higher in the bcp model group in comparison to mice in the sham group (p<0.05); intrathecal injection of jak2 agonist ag-490 (30 or 90 nmol) significantly alleviated pwl, and downregulated the expression of spinal gfap mrna and protein (p<0.05).
conclusion: the il-6-jak2 signaling pathway plays an important role in maintaining the bcp by regulating the expression of gfap in the spinal cord. |
2019-02-13 |
2023-08-13 |
mouse |
| Flávia Possatti, Thalita Evani Silva de Oliveira, Raquel Arruda Leme, Everson Zotti, Alais Maria Dall Agnol, Alice Fernandes Alfieri, Selwyn Arlington Headley, Amauri Alcindo Alfier. Pathologic and molecular findings associated with atypical porcine pestivirus infection in newborn piglets. Veterinary microbiology. vol 227. 2019-01-31. PMID:30473350. |
an ihc assay designed to detect the proliferation of glial fibrillary acidic protein (gfap) in affected areas of the brain and spinal cord revealed that the proliferation of gfap + cells and fibers was predominant in appv-infected piglets relative to asymptomatic piglets of the same age group. |
2019-01-31 |
2023-08-13 |
Not clear |
| Zhen-Song Jiang, Jian-Ru Zhan. LncRNA SNHG5 enhances astrocytes and microglia viability via upregulating KLF4 in spinal cord injury. International journal of biological macromolecules. vol 120. issue Pt A. 2019-01-02. PMID:30076931. |
results showed that gfap and iba-1 (specific proteins for astrocytes and microglia respectively) were upregulated in spinal cord of sci rats. |
2019-01-02 |
2023-08-13 |
rat |
| Pilar Larrodé, Ana Cristina Calvo, Laura Moreno-Martínez, Miriam de la Torre, Leticia Moreno-García, Nora Molina, Tomás Castiella, Cristina Iñiguez, Luis Fernando Pascual, Francisco Javier Miana Mena, Pilar Zaragoza, Santiago Ramón Y Cajal, Rosario Ost. DREAM-Dependent Activation of Astrocytes in Amyotrophic Lateral Sclerosis. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28840473. |
the main aim of this study was focused on the characterization of dream and glial fibrillary acid protein (gfap) in the brain and spinal cord tissues from transgenic sod1 |
2018-12-11 |
2023-08-13 |
Not clear |
| Xiaoqing Chen, Cheng Chen, Jie Hao, Rongqing Qin, Baiyu Qian, Kai Yang, Jiyun Zhang, Feng Zhan. AKR1B1 Upregulation Contributes to Neuroinflammation and Astrocytes Proliferation by Regulating the Energy Metabolism in Rat Spinal Cord Injury. Neurochemical research. vol 43. issue 8. 2018-10-26. PMID:29948725. |
further experiments showed akr1b1 was co-located with akt protein in gfap positive cells and immunoprecipitated with akt in injured spinal cord as well. |
2018-10-26 |
2023-08-13 |
rat |
| Xiaolian Nong, Yuyan La. Picroside II Attenuates CCI-Induced Neuropathic Pain in Rats by Inhibiting Spinal Reactive Astrocyte-Mediated Neuroinflammation Through the NF-κB Pathway. Neurochemical research. vol 43. issue 5. 2018-09-27. PMID:29671236. |
here, we explored the analgesic effects of pii on a model of cci-induced np and investigated the levels of the gfap protein and the mrna and protein levels of pro-inflammatory cytokines in the spinal cord, including interleukin-1β (il-1β), interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α). |
2018-09-27 |
2023-08-13 |
rat |
| Jiping Nie, Jian Chen, Jianguo Yang, Qinqin Pei, Jing Li, Jia Liu, Lixin Xu, Nan Li, Youhao Chen, Xiaohua Chen, Hao Luo, Tiansheng Su. Inhibition of mammalian target of rapamycin complex 1 signaling by n-3 polyunsaturated fatty acids promotes locomotor recovery after spinal cord injury. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436695. |
additionally, rats in the high‑n‑3 pufa group showed improved motor function recovery, spinal cord repair‑related protein expression level (mbp, galc and gfap). |
2018-08-30 |
2023-08-13 |
rat |
| Okan Ozkunt, Kerim Sariyilmaz, Halil Can Gemalmaz, Seren Gülsen Gürgen, Ulaş Yener, Fatih Dikic. Investigation of efficacy of treatment in spinal cord injury: Erythropoietin versus methylprednisolone. Journal of orthopaedic surgery (Hong Kong). vol 25. issue 3. 2018-05-23. PMID:29121822. |
investigation of the expression of platelet-derived growth factor (pdgf)-β and glial fibrillary acidic protein (gfap) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (epo) and methylprednisolone (mp). |
2018-05-23 |
2023-08-13 |
rat |