| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmet Yardım, Fatih Mehmet Kandemir, Selim Çomaklı, Selçuk Özdemir, Cuneyt Caglayan, Sefa Kucukler, Hamit Çeli. Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33201400. |
our results showed that cur significantly reduced mrna expression levels of nf-κb, tnf-α, il-6, inos and gfap whereas caused an increase in levels of nrf2, ho-1 and nqo1 in the spinal cord and sciatic nerve of ptx-induced rats. |
2021-08-09 |
2023-08-13 |
rat |
| Leila Noori, Somayeh Arabzadeh, Yousef Mohamadi, Sina Mojaverrostami, Tahmineh Mokhtari, Mohammad Akbari, Gholamreza Hassanzade. Intrathecal administration of the extracellular vesicles derived from human Wharton's jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes after spinal cord injury in rats. Neuroscience research. vol 170. 2021-08-04. PMID:32717259. |
our finding represented that intrathecally administrated of hwj-msc-evs significantly attenuated expression of the examined factors in both mrna (p < 0.05 and p ≤ 0.01) and protein levels (p < 0.05 and p ≤ 0.01), decreased gfap and increased nestin expression (p < 0.05), reduced cell death and revealed the higher number of typical neurons in ventral horn of spinal cord. |
2021-08-04 |
2023-08-13 |
human |
| Deeya Gaindh, Yun-Beom Choi, Michelle Marchese, Peter Dowling, Stuart Cook, Benjamin Blumberg, James H Park, Wei L. Prolonged Beneficial Effect of Brief Erythropoietin Peptide JM4 Therapy on Chronic Relapsing EAE. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 1. 2021-07-30. PMID:32959273. |
jm4 therapy concomitantly led to markedly decreased gfap bioluminescence in the brain and spinal cord in both acute and chronic relapsing eae mouse models. |
2021-07-30 |
2023-08-13 |
mouse |
| Emma J van Bodegraven, Jacqueline A Sluijs, A Katherine Tan, Pierre A J T Robe, Elly M Ho. New GFAP splice isoform (GFAPµ) differentially expressed in glioma translates into 21 kDa N-terminal GFAP protein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 3. 2021-07-26. PMID:33583081. |
21 kda gfap protein was detected in the if protein fraction isolated from human spinal cord as well. |
2021-07-26 |
2023-08-13 |
human |
| Cheng Huang, Yuanbing Liu, Jian Ding, Yongping Dai, Lixiang Le, Liangliang Wang, Erhu Ding, Jiandong Yan. Thermosensitive quaternized chitosan hydrogel scaffolds promote neural differentiation in bone marrow mesenchymal stem cells and functional recovery in a rat spinal cord injury model. Cell and tissue research. vol 385. issue 1. 2021-07-23. PMID:33760948. |
if staining and western blot were performed to detect the expression of neun, nf-200, gfap, cs56, and bax in the lesion sites of the injured spinal cord. |
2021-07-23 |
2023-08-13 |
rat |
| Martin Marsala, Kota Kamizato, Takahiro Tadokoro, Michael Navarro, Stefan Juhas, Jana Juhasova, Silvia Marsala, Hana Studenovska, Vladimir Proks, Tom Hazel, Karl Johe, Manabu Kakinohana, Shawn Driscoll, Thomas Glenn, Samuel Pfaff, Joseph Ciacc. Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats. Stem cells translational medicine. vol 9. issue 2. 2021-07-21. PMID:31800978. |
immunofluorescence staining and mrna sequencing analysis demonstrated a near-complete occupation of the spinal cord by injected cells, in which transplanted human nscs (hnscs) preferentially acquired glial phenotypes, expressing oligodendrocyte (olig2, apc) or astrocyte (gfap) markers. |
2021-07-21 |
2023-08-13 |
human |
| Erxian Zhao, Liying Bai, Shurong Li, Li Li, Zhongci Dou, Yunli Huang, Yan Li, Yunqi L. Dexmedetomidine Alleviates CCI-Induced Neuropathic Pain via Inhibiting HMGB1-Mediated Astrocyte Activation and the TLR4/NF-κB Signaling Pathway in Rats. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32607919. |
immunohistochemical and immunofluorescence analyses were used to detect the expression of high mobility group box-1 (hmgb1) protein and glial fibrillary acidic protein (gfap), and protein fluorescence intensity of gfap in spinal cord tissue, respectively. |
2021-07-09 |
2023-08-13 |
rat |
| Erxian Zhao, Liying Bai, Shurong Li, Li Li, Zhongci Dou, Yunli Huang, Yan Li, Yunqi L. Dexmedetomidine Alleviates CCI-Induced Neuropathic Pain via Inhibiting HMGB1-Mediated Astrocyte Activation and the TLR4/NF-κB Signaling Pathway in Rats. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32607919. |
the expression of hmgb1, gfap, tlr4, traf6, myd88, and p-p65 were greatly downregulated in the spinal cord tissues of the cci rats. |
2021-07-09 |
2023-08-13 |
rat |
| Min Xie, Menglin Cheng, Bojun Wang, Ming Jiao, Liangzhu Yu, Haili Zh. 2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33253369. |
in the spinal cord of rats with cfa-induced inflammatory pain, the expression of astrocyte-specific glial fibrillary acidic protein (gfap) and contents of proinflammatory cytokines il-1β and tnf-α were increased. |
2021-06-17 |
2023-08-13 |
rat |
| Alaa El-Din L Firgany, Nahla Reda Sarha. Quercetin mitigates monosodium glutamate-induced excitotoxicity of the spinal cord motoneurons in aged rats via p38 MAPK inhibition. Acta histochemica. vol 122. issue 5. 2021-06-07. PMID:32622428. |
cervical spinal cord specimens were obtained and prepared for routine histological study, immunohistochemical staining by caspase-3 and glial fibrillary acidic protein (gfap), assessment of oxidative stress, measurement of cytokines, assessment of caspase-3 activity and gfap levels as well as for western blotting of phosphorylated activating transcription factor 2 (atf2 |
2021-06-07 |
2023-08-13 |
rat |
| Stephanie Sánchez-Torres, Araceli Díaz-Ruíz, Camilo Ríos, María G Olayo, Guillermo J Cruz, Roberto Olayo, Juan Morales, Rodrigo Mondragón-Lozano, Omar Fabela-Sánchez, Carlos Orozco-Barrios, Angélica Coyoy-Salgado, Sandra Orozco-Suárez, Cristian González-Ruiz, Laura Álvarez-Mejía, Axayacatl Morales-Guadarrama, Vinnitsa Buzoianu-Anguiano, Pablo Damián-Matsumura, Hermelinda Salgado-Ceballo. Recovery of motor function after traumatic spinal cord injury by using plasma-synthesized polypyrrole/iodine application in combination with a mixed rehabilitation scheme. Journal of materials science. Materials in medicine. vol 31. issue 7. 2021-05-27. PMID:32607849. |
the implant of the biomaterial polypyrrole/iodine (ppy/i) synthesized by plasma (an unconventional synthesis method), in combination with a mixed rehabilitation scheme with swimming and enriched environment applied after a traumatic spinal cord injury, promotes expression of gap-43 and βiii-tubulin (molecules related to plasticity and nerve regeneration) and reduces the expression of gfap (molecule related to the formation of the glial scar). |
2021-05-27 |
2023-08-13 |
rat |
| Michael J Lacagnina, Jiahe Li, Sabina Lorca, Kenner C Rice, Kimberly Sullivan, James P O'Callaghan, Peter M Grac. A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33127584. |
such allodynia was associated with elevation of markers for activated microglia/macrophages (cd11b) and astrocytes/satellite glia (gfap) in the lumbar dorsal spinal cord and dorsal root ganglia (drg). |
2021-05-27 |
2023-08-13 |
rat |
| Nagla A El-Sherbeeny, Afaf T Ibrahiem, Howaida S Ali, Noha E Farag, Eman A Toraih, Sawsan A Zaiton. Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia. Archives of pharmacal research. vol 43. issue 7. 2021-05-17. PMID:32676893. |
spinal cord of carbamazepine-treated groups had enhanced expression of gap43 but lower content of cd11b and gfap. |
2021-05-17 |
2023-08-13 |
mouse |
| Sining Feng, Shuai Wang, Shi Sun, Hao Su, Lixin Zhan. Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649786. |
notably, combination therapy further alleviated sci‑induced spinal cord lesions and neuronal apoptosis, increased gap‑43, ngf and bdnf expression levels, downregulated gfap expression levels and inhibited activation of the raf/mek/erk signaling pathway in sci model rats compared with the corresponding monotherapy groups. |
2021-05-17 |
2023-08-13 |
rat |
| Jiaying Luo, Chong Xie, Wei Zhang, Yu Cai, Jie Ding, Yishu Wang, Yong Hao, Ying Zhang, Yangtai Gua. Experimental mouse model of NMOSD produced by facilitated brain delivery of NMO-IgG by microbubble-enhanced low-frequency ultrasound in experimental allergic encephalomyelitis mice. Multiple sclerosis and related disorders. vol 46. 2021-05-14. PMID:32919181. |
we found noticeable inflammation and demyelination concomitant with the loss of aquaporin-4 (aqp4) and glial fibrillary acidic protein (gfap) expression in the spinal cord, brain and optic nerve, as well as human igg and c9neo deposition. |
2021-05-14 |
2023-08-13 |
mouse |
| Yan Gao, Liying Bai, Wenjuan Zhou, Yin Yang, Jian Zhang, Liren Li, Mingjun Jiang, Yang Mi, Tong-Tong Li, Xuan Zhang, Wei Zhang, Ji-Tian X. PARP-1-regulated TNF-α expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32283287. |
in the spinal cord, parp-1 mainly colocalized with the neuronal marker neun and the astrocytic marker gfap specifically in the superficial lamina. |
2021-04-06 |
2023-08-13 |
rat |
| Xiaoling Hu, Yiming Liu, Junting Wu, Yu Liu, Wenjie Liu, Ji Chen, Fengrui Yan. Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32311494. |
immunofluorescence assay was employed to determine the levels of glial fibrillary acidic protein (gfap), ionized calcium binding adaptor molecule 1 (iba-1) and connexin 43 (cx43) in the spinal cord. |
2021-04-06 |
2023-08-13 |
rat |
| Divine C Nwafor, Sreeparna Chakraborty, Allison L Brichacek, Sujung Jun, Catheryne A Gambill, Wei Wang, Elizabeth B Engler-Chiurazzi, Duaa Dakhlallah, Anthony B Pinkerton, José Luis Millán, Stanley A Benkovic, Candice M Brow. Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis. Brain, behavior, and immunity. vol 84. 2021-03-12. PMID:31778743. |
however, the hot plate test uncovered a novel anti-nociceptive phenotype in our septic mice, and we speculate that this phenotype may be a consequence of sustained gfap astrogliosis and loss of tnap activity in the somatosensory cortex and spinal cord of septic mice. |
2021-03-12 |
2023-08-13 |
mouse |
| Haixia Huang, Ke Bai, Yueqiang Fu, Siwei Lu, Yunni Ran, Hongxing Dang, Jing L. Glial Fibrillary Acidic Protein Astrocytopathy in Pediatric Patients: A Retrospective Study. Frontiers in pediatrics. vol 8. 2021-02-12. PMID:33569363. |
our findings indicate that gfap astrocytopathy should be considered in children who are clinically diagnosed with meningoencephalitis, whether or not myelitis is present, and if the mri reveals enhancement of meninges or spinal cord, t2-hyperintense lesions, or a pattern of linear perivascular gadolinium enhancement. |
2021-02-12 |
2023-08-13 |
Not clear |
| Sebok K Halder, Richard Milne. The GFAP Monoclonal Antibody GA-5 Identifies Astrocyte Remodeling and Glio-Vascular Uncoupling During the Evolution of EAE. Cellular and molecular neurobiology. 2021-02-05. PMID:33544272. |
to examine how astrocyte activation is regulated at different phases of relapsing-remitting eae, we performed an immunofluorescent analysis of the spinal cord using the anti-glial fibrillary acidic protein (gfap) monoclonal antibody ga-5. |
2021-02-05 |
2023-08-13 |
Not clear |