| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R De Paula, M S França, L K R Leão, A A Maciel, T A A Moura, S A S de Moraes, C P Bahia, R S Borges, E J O Batista, A C F Passos, K R H M Oliveira, A M Herculan. Total rupture of Achilles tendon induces inflammatory response and glial activation on the spinal cord of mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 56. 2023-10-21. PMID:37851789. |
this phenomenon was accompanied by overexpression of cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase-2 (nos-2) as well as hyperactivation of astrocytes and microglia in nociceptive areas of l5 spinal cord as evidenced by intense gfap and iba-1 immunostaining, respectively. |
2023-10-21 |
2023-11-08 |
mouse |
| Giulia Galimberti, Giada Amodeo, Giulia Magni, Benedetta Riboldi, Gianfranco Balboni, Valentina Onnis, Stefania Ceruti, Paola Sacerdote, Silvia Franch. Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model. Cells. vol 12. issue 18. 2023-09-28. PMID:37759478. |
these changes were in the presence of high gfap and cd11b mrna in the sciatic nerve and gfap in the spinal cord. |
2023-09-28 |
2023-10-07 |
mouse |
| Sheu-Ran Choi, Jaehak Lee, Ji-Young Moon, Seung Joon Baek, Jang-Hern Le. NAG-1/GDF-15 Transgenic Female Mouse Shows Delayed Peak Period of the Second Phase Nociception in Formalin-induced Inflammatory Pain. Experimental neurobiology. vol 32. issue 4. 2023-09-26. PMID:37749926. |
c-fos, glial fibrillary acidic protein (gfap), and ionized calcium binding adaptor molecule-1 (iba-1) immunoreactivity was examined in the spinal cord following observation of the formalin-induced nociceptive behaviors. |
2023-09-26 |
2023-10-07 |
mouse |
| Sheu-Ran Choi, Jaehak Lee, Ji-Young Moon, Seung Joon Baek, Jang-Hern Le. NAG-1/GDF-15 Transgenic Female Mouse Shows Delayed Peak Period of the Second Phase Nociception in Formalin-induced Inflammatory Pain. Experimental neurobiology. vol 32. issue 4. 2023-09-26. PMID:37749926. |
neither gfap nor iba-1 immunoreactivity was increased in the spinal cord of tg and wt female mice. |
2023-09-26 |
2023-10-07 |
mouse |
| C Cristiano, C Giorgio, P Cocchiaro, S Boccella, M C Cesta, V Castelli, F M Liguori, M R Cuozzo, L Brandolini, R Russo, M Allegrett. Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy. Cytokine. vol 171. 2023-09-18. PMID:37722320. |
c5ar1 activation by paclitaxel was found to be a key event in the induction of inflammatory factors in spinal cord, such as tnf-α, ionized calcium-binding adapter molecule 1 (iba-1), and glial fibrillary acidic protein (gfap). |
2023-09-18 |
2023-10-07 |
mouse |
| Qilong Deng, Lili Ma, Yu Yang, Ting Chen, Luding Zhan, Qiaoqiao He, Yingying Jiang, Lizhong M. Effect of Electroacupuncture Stimulation on Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Spinal Cord Injury. Molecular neurobiology. 2023-08-31. PMID:37650966. |
the spinal cord tissue of rats was subjected to immunohistochemical staining and real-time quantitative polymerase chain reaction (pcr) to detect the expressions of neurofilament nestin and glial fibrillary acidic protein (gfap). |
2023-08-31 |
2023-09-07 |
rat |
| Yizhong Peng, Xuanzuo Chen, Zilong Rao, Wei Wu, Huiyin Zuo, Kaibin Chen, Kanglu Li, Hui Lin, Sheng Liu, Yan Xiao, BaiChuan Wang, Daping Quan, Xiangcheng Qing, Ying Bai, Zengwu Sha. Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization. Acta biomaterialia. 2023-08-20. PMID:37598791. |
besides, ti-cnp-daf relieved mechanical hyperalgesia, reduced cgrp and substance p expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat disc herniation model. |
2023-08-20 |
2023-09-07 |
rat |
| Thomas Jacobus Geus, Glenn Franken, Bert Bert Jooste. Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. Molecular pain. 2023-07-25. PMID:37488684. |
the inflammatory balance and glial response were analyzed in the dorsal spinal cord based on rna expression of pro- and anti-inflammatory cytokines (tnf-α, il-1ß, il-4, il-10), a microglia marker (itgam), an astrocyte marker (gfap), a t-cell marker (cd3d), microglia proliferation markers (irf8, adgre1) and p2x4, p13-mapk, bdnf signaling markers (p2x4, mapk14, bdnf). |
2023-07-25 |
2023-08-14 |
Not clear |
| Carly Norris, Justin Weatherbee, Susan Murphy, Izabele Marquetti, Lana Maniakhina, Alan Boruch, Pamela VandeVor. A closed-body preclinical model to investigate blast-induced spinal cord injury. Frontiers in molecular neuroscience. vol 16. 2023-06-29. PMID:37383427. |
there were no significant changes in acute behavior; however, expression of β-app, iba1, and gfap significantly increased in the spinal cord following blast exposure ( |
2023-06-29 |
2023-08-14 |
Not clear |
| Nicolás Lobos, Sebastián Lux, Ramiro Javier Zepeda, Teresa Pelissier, José Luis Marcos, Gonzalo Bustos-Quevedo, Alejandro Hernández, Luis Constandi. Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37176065. |
the astrocytic and microglial responses in the spinal cord of paclitaxel-treated mice were also assessed by measuring gfap and cd11b proteins, respectively. |
2023-05-14 |
2023-08-14 |
mouse |
| Zepeng Wang, Yangyang Shen, Chenxu Huang, Yuwei Wang, Xinzhou Zhang, Feiyang Guo, Rongxin Weng, Xiaoli Ma, Haiji Su. Astrocytes in the spinal cord contributed to acute stress-induced gastric damage via the gap junction protein CX43. Brain research. 2023-05-08. PMID:37156321. |
the results showed that the expression of gfap, c-fos, cx43, and p-erk1/2 was significantly elevated in the spinal cord after rwis. |
2023-05-08 |
2023-08-14 |
rat |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
the effects of ast were examined on the motor function, spinal cord edema, integrity of blood-spinal cord barrier (bscb), and expression of high mobility group box 1 (hmgb1), toll-like receptor 4 (tlr4), nuclear factor-kappa b (nf-κb), glial fibrillary acidic protein (gfap), and aquaporin-4 (aqp4), and matrix metallopeptidase- 9 (mmp-9) post-sci. |
2023-05-05 |
2023-08-14 |
rat |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
we showed that ast potentially improved the recovery of motor function and inhibited the spinal cord edema via maintaining the integrity of bscb, reducing the expression of hmgb1, tlr4, and nf-κb, mmp-9 as well as downregulation of astrocyte activation (gfap) and aqp4 expression. |
2023-05-05 |
2023-08-14 |
rat |
| Ciara M Walsh, Jacek K Wychowaniec, Louise Costello, Dermot F Brougham, Dearbhaile Doole. An In Vitro and Ex Vivo Analysis of the Potential of GelMA Hydrogels as a Therapeutic Platform for Preclinical Spinal Cord Injury. Advanced healthcare materials. 2023-04-28. PMID:37114899. |
finally, it is shown for the first time that 3% gelma-a can support the ex vivo culture of primary murine organotypic spinal cord slices for 14 days with no direct effect on gfap |
2023-04-28 |
2023-08-14 |
Not clear |
| Sultan Khetani, Razieh Salahandish, Jason B Tabor, Matthew Chilvers, Sean Dukelow, Chester Ho, Christina Campbell, Arindom Sen, Chantel T Debert, Amir Sanati-Nezha. Nanoporous Carbon Immunosensor for Highly Accurate and Sensitive Clinical Detection of Glial Fibrillary Acidic Protein in Traumatic Brain Injury, Stroke, and Spinal Cord Injury. ACS biomaterials science & engineering. 2023-04-17. PMID:37067234. |
elevated glial fibrillary acidic protein (gfap) in the blood serum is one of the promising bodily fluid markers for the diagnosis of central nervous system (cns) injuries, including traumatic brain injury (tbi), stroke, and spinal cord injury (sci). |
2023-04-17 |
2023-08-14 |
Not clear |
| He-Yu Yang, Xu Sun, Shu-Qing Zhen, Liang-Zhu Yu, Jie-Qiong Ding, Ling Liu, Min Xie, Hai-Li Zh. GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation. PloS one. vol 18. issue 4. 2023-04-14. PMID:37058473. |
in spinal cord, neuroinflammation was triggered and presented as severe infiltration of inflammatory cells and up-regulated expressions of glial fibrillary acidic protein (gfap), nuclear factor-kappab (nf-κb), pyd domains-containing protein 3 (nlrp3), cysteinyl aspartate specific proteinase (caspase-1) and interleukin-1 beta (il-1β). |
2023-04-14 |
2023-08-14 |
mouse |
| Heyu Yang, Yujia Wang, Shuqing Zhen, Banghua Wang, Ming Jiao, Ling Liu, Dai Li, Haili Zhu, Min Xi. AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation. Acta biochimica et biophysica Sinica. 2023-03-27. PMID:36971458. |
activation of astrocytes marked by upregulated glial fibrillary acidic protein (gfap) and enhanced production of the proinflammatory cytokine interleukin-1β (il-1β) are accompanied by increased inflammatory infiltration in the spinal cord of cibp rats. |
2023-03-27 |
2023-08-14 |
rat |
| Pao-Hsien Chu, Shao-Chi Chen, Hsin-Yung Chen, Cheng-Bei Wu, Wei-Ting Huang, Hou-Yu Chian. Astrocyte-associated fibronectin promotes the proinflammatory phenotype of astrocytes through β1 integrin activation. Molecular and cellular neurosciences. 2023-03-22. PMID:36948232. |
in an in vivo experiment, intrathecal injection of pur4 considerably ameliorated fn deposition, gfap expression, and nf-κb activation in inflamed spinal cord, suggesting the therapeutic potential of pur4 for attenuating neuroinflammation and promoting neuronal function restoration. |
2023-03-22 |
2023-08-14 |
Not clear |
| Shuai Ouyang, Xianbin Wang, Yan Chen, Luoyi Deng, Xianglian Yang, Shouxing Hu, Shuang W. Swimming training combined with fecal microbial transplantation protects motor functions in rats with spinal cord injury by improving the intestinal system. Neuroscience letters. 2023-02-09. PMID:36758789. |
in addition, combined interventions significantly suppressed inflammatory factor levels (p<0.05) in the colon and spinal cords and significantly protected forefoot motor neurons (neun) in the spinal cord injury area, inhibiting astrocyte activation and reducing the expressions of the signature glial fibrillary acidic protein (gfap) and markers of microglia (iba-1) at the lesion site(p<0.05). |
2023-02-09 |
2023-08-14 |
rat |
| Giovanni Finesso, Elinor Willis, James Carmine Tarrant, Matthew Lanza, Justin Sprengers, Jillian Verrelle, Esha Banerjee, Els Hermans, Charles-Antoine Assenmacher, Enrico Radaell. Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG mice. Veterinary pathology. 2023-02-02. PMID:36727841. |
histopathology of brain and spinal cord and immunohistochemistry (ihc) for aif-1, gfap, cd34, and cd45 were performed. |
2023-02-02 |
2023-08-14 |
mouse |