| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Puffenbarger, O Kapulina, J M Howell, D G Deutsc. Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698137. |
fatty acid amide hydrolase (faah) is critical for degradation of several important fatty acid amides including anandamide, an endocannabinoid, as well as oleamide, a sleep-inducing factor. |
2002-01-07 |
2023-08-12 |
mouse |
| b' M Maccarrone, L De Petrocellis, M Bari, F Fezza, S Salvati, V Di Marzo, A Finazzi-Agr\\xc3\\xb. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Archives of biochemistry and biophysics. vol 393. issue 2. 2001-10-18. PMID:11556820.' |
the effect of this endotoxin on faah was not mediated by aea-induced activation of cannabinoid receptors. |
2001-10-18 |
2023-08-12 |
human |
| B F Cravatt, K Demarest, M P Patricelli, M H Bracey, D K Giang, B R Martin, A H Lichtma. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 16. 2001-08-30. PMID:11470906. |
supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. |
2001-08-30 |
2023-08-12 |
mouse |
| B F Cravatt, K Demarest, M P Patricelli, M H Bracey, D K Giang, B R Martin, A H Lichtma. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 16. 2001-08-30. PMID:11470906. |
collectively, these results indicate that faah is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception. |
2001-08-30 |
2023-08-12 |
mouse |
| b' M Maccarrone, H Valensise, M Bari, N Lazzarin, C Romanini, A Finazzi-Agr\\xc3\\xb. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 12. 2001-08-23. PMID:11390466.' |
at variance with faah, the lymphocyte anandamide transporter and cannabinoid receptors were not affected by treatment with progesterone or cytokines. |
2001-08-23 |
2023-08-12 |
human |
| b' M Maccarrone, H Valensise, M Bari, N Lazzarin, C Romanini, A Finazzi-Agr\\xc3\\xb. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 12. 2001-08-23. PMID:11390466.' |
a clinical study performed on 100 healthy women showed that a low faah activity in lymphocytes correlates with spontaneous abortion, whereas anandamide transporter and cannabinoid receptors in these cells remain unchanged. |
2001-08-23 |
2023-08-12 |
human |
| M P Patricelli, B F Cravat. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. Biochemistry. vol 40. issue 20. 2001-08-16. PMID:11352748. |
fatty acid amide hydrolase (faah) is a mammalian integral membrane enzyme that catabolizes several neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide. |
2001-08-16 |
2023-08-12 |
Not clear |
| G B Quistad, S E Sparks, J E Casid. Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. Toxicology and applied pharmacology. vol 173. issue 1. 2001-06-14. PMID:11350214. |
thus, op pesticides and related inhibitors of faah potentiate the cannabinoid activity of anandamide in mice. |
2001-06-14 |
2023-08-12 |
mouse |
| T A Day, F Rakhshan, D G Deutsch, E L Barke. Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. Molecular pharmacology. vol 59. issue 6. 2001-06-07. PMID:11353795. |
role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. |
2001-06-07 |
2023-08-12 |
Not clear |
| P H Reggio, H Traor. Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106780. |
a membrane bound amidohydrolase (fatty acid amide hydrolase, faah), located intracellulary, hydrolyzes and inactivates anandamide and other endogenous cannabinoids such as 2-arachidonoylglycerol (2-ag). |
2001-01-11 |
2023-08-12 |
Not clear |
| P H Reggio, H Traor. Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106780. |
structure-activity relationships (sars) for endocannabinoid interaction with the cb receptors, the anandamide transporter and faah are currently emerging in the literature. |
2001-01-11 |
2023-08-12 |
Not clear |
| N Ueda, R A Puffenbarger, S Yamamoto, D G Deutsc. The fatty acid amide hydrolase (FAAH). Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106785. |
the distribution of faah in the major organs of the body is described as well as regional distribution in the brain and its correlation with cannabinoid receptors. |
2001-01-11 |
2023-08-12 |
mouse |
| N Ueda, R A Puffenbarger, S Yamamoto, D G Deutsc. The fatty acid amide hydrolase (FAAH). Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106785. |
since faah is recognized as a drug target, a large number of inhibitors have been synthesized and tested since 1994 and these are reviewed in terms of reversibility, potency, and specificity for faah and cannabinoid receptors. |
2001-01-11 |
2023-08-12 |
mouse |
| J L Wiley, M A Dewey, R G Jefferson, R L Winckler, D T Bridgen, K A Willoughby, B R Marti. Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects. Life sciences. vol 67. issue 13. 2000-09-22. PMID:10983852. |
the endogenous cannabinoid anandamide produces cannabimimetic effects similar to those produced by delta9-tetrahydrocannabinol (delta9-thc), but has a much shorter duration of action due to its rapid metabolism to arachidonic acid and polar metabolites via action of fatty acid amide hydrolase (faah). |
2000-09-22 |
2023-08-12 |
mouse |
| B R Martin, I Beletskaya, G Patrick, R Jefferson, R Winckler, D G Deutsch, V Di Marzo, O Dasse, A Mahadevan, R K Razda. Cannabinoid properties of methylfluorophosphonate analogs. The Journal of pharmacology and experimental therapeutics. vol 294. issue 3. 2000-09-12. PMID:10945879. |
methylarachidonylfluorophosphonate (mafp) and related analogs have been shown to inhibit fatty acid amidohydrolase activity (faah), the enzyme responsible for hydrolysis of the endogenous cannabinoid ligand anandamide. |
2000-09-12 |
2023-08-12 |
Not clear |
| M P Patricelli, B F Cravat. Clarifying the catalytic roles of conserved residues in the amidase signature family. The Journal of biological chemistry. vol 275. issue 25. 2000-08-16. PMID:10764768. |
fatty acid amide hydrolase (faah) is a mammalian integral membrane enzyme responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide. |
2000-08-16 |
2023-08-12 |
Not clear |
| D L Boger, H Sato, A E Lerner, M P Hedrick, R A Fecik, H Miyauchi, G D Wilkie, B J Austin, M P Patricelli, B F Cravat. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 10. 2000-06-13. PMID:10805767. |
the development of exceptionally potent inhibitors of fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. |
2000-06-13 |
2023-08-12 |
Not clear |
| S Yazulla, K M Studholme, H H McIntosh, D G Deutsc. Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina. The Journal of comparative neurology. vol 415. issue 1. 1999-12-02. PMID:10540359. |
immunocytochemical localization of cannabinoid cb1 receptor and fatty acid amide hydrolase in rat retina. |
1999-12-02 |
2023-08-12 |
rat |
| S Yazulla, K M Studholme, H H McIntosh, D G Deutsc. Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina. The Journal of comparative neurology. vol 415. issue 1. 1999-12-02. PMID:10540359. |
immunocytochemical methods were used to localize cannabinoid cb1 receptor immunoreactivity (cb1r-ir) and an endocannabinoid (anandamide and 2-arachidonylglycerol) degradative enzyme, fatty acid amide hydrolase (faah)-ir, in the rat retina. |
1999-12-02 |
2023-08-12 |
rat |
| K Tsou, M I Nogueron, S Muthian, M C Sañudo-Pena, C J Hillard, D G Deutsch, J M Walke. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neuroscience letters. vol 254. issue 3. 1999-06-22. PMID:10214976. |
the distribution in the rat brain of fatty acid amide hydrolase (faah) an enzyme that catalyzes the hydrolysis of the endogenous cannabinoid anandamide was studied by immunohistochemistry. |
1999-06-22 |
2023-08-12 |
rat |