| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Paola Nieri, Rosamiria Greco, Barbara Adinolfi, Maria Cristina Breschi, Enrica Martinotti, Carla Nannetti, Adriano Podest\\xc3\\xa. CB1- and CB2-cannabinoid receptor-independent lipolysis induced by WIN 55,212-2 in male rat adipocytes. Naunyn-Schmiedeberg\'s archives of pharmacology. vol 368. issue 5. 2004-02-10. PMID:14566452.' |
the expression of genes encoding the cannabinoid cb(1) and cb(2) receptors and fatty acid amide hydrolase (faah) and the lipolytic activity of cannabinoid agonists were investigated in rat adipose tissue.rt-pcr studies indicated that the genes encoding cb(1) and cb(2) receptors and faah are not expressed in epididymal adipocytes. |
2004-02-10 |
2023-08-12 |
rat |
| María L López-Rodríguez, Alma Viso, Silvia Ortega-Gutiérrez, Christopher J Fowler, Gunnar Tiger, Eva de Lago, Javier Fernández-Ruiz, José A Ramo. Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. European journal of medicinal chemistry. vol 38. issue 4. 2004-02-06. PMID:12750028. |
the majority of compounds studied are highly potent (ic(50)=24-0.8 micro m) and selective endocannabinoid uptake inhibitors with very low affinities for either the enzyme fatty acid amide hydrolase (ic(50)=30-113 micro m) or for cannabinoid receptor subtype 1 (cb(1)), cannabinoid receptor subtype 2 (cb(2)) and vanilloid receptor subtype 1 (vr(1)) (k(i)=1000-10000 nm). |
2004-02-06 |
2023-08-12 |
Not clear |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
cannabinoid cb2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in alzheimer's disease brains. |
2003-12-23 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
we have studied the status of some of the components of the endocannabinoid system, fatty acid amide hydrolase and cannabinoid cb1 and cb2 receptors, in postmortem brains from patients with alzheimer's disease. |
2003-12-23 |
2023-08-12 |
human |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
our results show that both fatty acid amide hydrolase and cannabinoid cb2 receptors are abundantly and selectively expressed in neuritic plaque-associated astrocytes and microglia, respectively, whereas the expression of cb1 receptors remains unchanged. |
2003-12-23 |
2023-08-12 |
human |
| Tibor Harkany, Wolfgang Härtig, Paul Berghuis, Marton B Dobszay, Yuri Zilberter, Robert H Edwards, Ken Mackie, Patrik Ernfor. Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622230. |
presynaptic action of endocannabinoids is largely mediated by type 1 cannabinoid (cb1) receptors, while fatty-acid amide hydrolase (faah) is involved in inactivating some endocannabinoids postsynaptically. |
2003-12-19 |
2023-08-12 |
mouse |
| Michele K McKinney, Benjamin F Cravat. Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12734197. |
fatty acid amide hydrolase (faah) is a mammalian amidase signature enzyme that inactivates neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. |
2003-11-17 |
2023-08-12 |
Not clear |
| Alessia Ligresti, Tiziana Bisogno, Isabel Matias, Luciano De Petrocellis, Maria Grazia Cascio, Vittorio Cosenza, Giuseppe D'argenio, Giuseppe Scaglione, Maurizio Bifulco, Italo Sorrentini, Vincenzo Di Marz. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology. vol 125. issue 3. 2003-10-02. PMID:12949714. |
the levels of endocannabinoids, cannabinoid cb(1) and cb(2) receptors, and fatty acid amide hydrolase (faah, which catalyzes endocannabinoid hydrolysis) in colorectal carcinomas (crc), adenomatous polyps, and neighboring healthy mucosa; and (2). |
2003-10-02 |
2023-08-12 |
human |
| R K Razdan, A Mahadeva. Recent advances in the synthesis of endocannabinoid related ligands. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505687. |
the chemical strategies used for the synthesis of various ligands related to the endocannabinoid system namely anandamide (aea), 2-arachidonylglycerol (2-ara-gl), cb1/(vanilloid receptors) vr1, anandamide membrane transporter (amt) and fatty acid amide hydrolase (faah) are described in this review. |
2003-08-22 |
2023-08-12 |
Not clear |
| Benjamin F Cravatt, Aron H Lichtma. The enzymatic inactivation of the fatty acid amide class of signaling lipids. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505696. |
collectively, these studies promote faah as a central component of faa signaling pathways, especially those mediated by the endocannabinoid anandamide, and suggest that this enzyme may represent an attractive pharmaceutical target for the treatment of pain and related neurophysiological disorders. |
2003-08-22 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
fatty acid amide hydrolase (faah) catalyses hydrolysis of the endocannabinoid arachidonoylethanolamide ("anandamide") in vitro and regulates anandamide levels in the brain. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
to assess more widely the functions of faah in the brain and the potential impact of faah activity on the spatiotemporal dynamics of endocannabinoid signaling in different regions of the brain, here we have employed immunocytochemistry to compare the distribution of faah and cb(1) throughout the mouse brain, using faah(-/-) mice as negative controls to validate the specificity of faah-immunoreactivity observed in wild type animals. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
in these regions of the brain, faah may regulate postsynaptic formation of anandamide, thereby influencing the spatiotemporal dynamics of retrograde endocannabinoid signaling. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
however, in some regions of the brain such as the globus pallidus and substantia nigra pars reticulata, cb(1) receptors are abundant but with little or no associated faah expression and in these brain regions the spatial impact and/or duration of endocannabinoid signaling may be less restricted than in regions enriched with faah. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
here faah may nevertheless influence endocannabinoid signaling but more remotely. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
finally, there are regions of the brain where faah-immunoreactive neurons and/or oligodendrocytes occur in the absence of cb(1)-immunoreactive fibers and here faah may be involved in regulation of signaling mediated by other endocannabinoid receptors or by receptors for other fatty acid amide signaling molecules. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
in conclusion, by comparing the distribution of faah and cb(1) in the mouse brain, we have provided a neuroanatomical framework for comparative analysis of the role of faah in regulation of the spatiotemporal dynamics of retrograde endocannabinoid signaling in different regions of the brain. |
2003-07-30 |
2023-08-12 |
mouse |
| Giorgio Tarzia, Andrea Duranti, Andrea Tontini, Giovanni Piersanti, Marco Mor, Silvia Rivara, Pier Vincenzo Plazzi, Chris Park, Satish Kathuria, Daniele Piomell. Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 46. issue 12. 2003-07-11. PMID:12773040. |
fatty acid amide hydrolase (faah), an intracellular serine hydrolase enzyme, participates in the deactivation of fatty acid ethanolamides such as the endogenous cannabinoid anandamide, the intestinal satiety factor oleoylethanolamide, and the peripheral analgesic and anti-inflammatory factor palmitoylethanolamide. |
2003-07-11 |
2023-08-12 |
rat |
| Angela B Clement, E Gregory Hawkins, Aron H Lichtman, Benjamin F Cravat. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736361. |
mice lacking the enzyme fatty acid amide hydrolase [faah (-/-) mice] are severely impaired in their ability to degrade the endocannabinoid anandamide and therefore represent a unique animal model in which to examine the function of this signaling lipid in vivo. |
2003-06-19 |
2023-08-12 |
mouse |