| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mauro Maccarrone, Paolo Gubellini, Monica Bari, Barbara Picconi, Natalia Battista, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Paolo Calabres. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716433. |
here, we show that in a rat model of parkinson's disease induced by unilateral nigral lesion with 6-hydroxydopamine (6-ohda), the striatal levels of the endocannabinoid anandamide (aea) were increased, while the activity of its membrane transporter and hydrolase (fatty-acid amide hydrolase, faah) were decreased. |
2003-06-18 |
2023-08-12 |
rat |
| Mauro Maccarrone, Paolo Gubellini, Monica Bari, Barbara Picconi, Natalia Battista, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Paolo Calabres. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716433. |
remarkably, the anomalies in the endocannabinoid system, as well as those in glutamatergic activity, were completely reversed by chronic treatment of parkinsonian rats with levodopa, and the pharmacological inhibition of faah restored a normal glutamatergic activity in 6-ohda-lesioned animals. |
2003-06-18 |
2023-08-12 |
rat |
| Mauro Maccarrone, Paolo Gubellini, Monica Bari, Barbara Picconi, Natalia Battista, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Paolo Calabres. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716433. |
taken together, these data show that anomalies in the endocannabinoid system induced by experimental parkinsonism are restricted to the striatum and can be reversed by chronic levodopa treatment, and suggest that inhibition of faah might represent a possible target to decrease the abnormal cortical glutamatergic drive in parkinson's disease. |
2003-06-18 |
2023-08-12 |
rat |
| Giorgio Ortar, Alessia Ligresti, Luciano De Petrocellis, Enrico Morera, Vincenzo Di Marz. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochemical pharmacology. vol 65. issue 9. 2003-06-16. PMID:12732359. |
novel aromatic analogues of n-oleoylethanolamine and n-arachidonoylethanolamine (anandamide, aea) were synthesized and, based on the capability of similar compounds to interact with proteins of the endocannabinoid and endovanilloid signaling systems, were tested on: (i) cannabinoid cb(1) and cb(2) receptors; (ii) vanilloid vr1 receptors; (iii) anandamide cellular uptake (acu); and (iv) the fatty acid amide hydrolase (faah). |
2003-06-16 |
2023-08-12 |
human |
| I Matias, M Léonhardt, J Lesage, L De Petrocellis, J P Dupouy, D Vieau, V Di Marz. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cellular and molecular life sciences : CMLS. vol 60. issue 2. 2003-04-30. PMID:12678501. |
here we determined the effect of maternal under-nutrition during gestation, lactation, or both, on body weight, and on the levels of endocannabinoids and expression of cannabinoid cb1 receptors and fatty acid amide hydrolase in the hypothalamus of rat pups at weaning (21 days old) or adult rats (4 months old). |
2003-04-30 |
2023-08-12 |
mouse |
| I Matias, M Léonhardt, J Lesage, L De Petrocellis, J P Dupouy, D Vieau, V Di Marz. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cellular and molecular life sciences : CMLS. vol 60. issue 2. 2003-04-30. PMID:12678501. |
no significant change in the hypothalamic expression of either cannabinoid cb1 receptors or fatty acid amide hydrolase mrna was detected in any of the three groups of weaned pups. |
2003-04-30 |
2023-08-12 |
mouse |
| Luciano De Petrocellis, Tiziana Bisogno, Alessia Ligresti, Maurizio Bifulco, Dominique Melck, Vincenzo Di Marz. Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundamental & clinical pharmacology. vol 16. issue 4. 2003-04-10. PMID:12570018. |
indeed, long-term treatment of human breast cancer cells (hbccs) with pea downregulates the expression of the enzyme responsible for aea degradation, the fatty acid amide hydrolase, thereby leading to an enhancement of aea-induced, and cannabinoid cb1 receptor-mediated, cytostatic effect on hbccs. |
2003-04-10 |
2023-08-12 |
human |
| Satish Kathuria, Silvana Gaetani, Darren Fegley, Fernando Valiño, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Giovanna La Rana, Antonio Calignano, Arcangela Giustino, Maria Tattoli, Maura Palmery, Vincenzo Cuomo, Daniele Piomell. Modulation of anxiety through blockade of anandamide hydrolysis. Nature medicine. vol 9. issue 1. 2003-03-18. PMID:12461523. |
here we describe a class of potent, selective and systemically active inhibitors of fatty acid amide hydrolase, the enzyme responsible for the degradation of the endogenous cannabinoid anandamide. |
2003-03-18 |
2023-08-12 |
rat |
| b' Mauro Maccarrone, Sandra Cecconi, Gianna Rossi, Natalia Battista, Riccardo Pauselli, Alessandro Finazzi-Agr\\xc3\\xb. Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. Endocrinology. vol 144. issue 1. 2003-01-17. PMID:12488326.' |
these data demonstrate that sertoli cells partake in the peripheral endocannabinoid system, and that fsh reduces the apoptotic potential of aea by activating faah. |
2003-01-17 |
2023-08-12 |
mouse |
| Michael H Bracey, Michael A Hanson, Kim R Masuda, Raymond C Stevens, Benjamin F Cravat. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (New York, N.Y.). vol 298. issue 5599. 2002-12-24. PMID:12459591. |
here, we report the 2.8 angstrom crystal structure of the integral membrane protein fatty acid amide hydrolase (faah), an enzyme that degrades members of the endocannabinoid class of signaling lipids and terminates their activity. |
2002-12-24 |
2023-08-12 |
Not clear |
| Patricia H Reggi. Endocannabinoid structure-activity relationships for interaction at the cannabinoid receptors. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052032. |
a membrane bound amidohydrolase (fatty acid amide hydrolase, faah), located intracellularly, hydrolyzes and inactivates anandamide and other endogenous cannabinoids such as 2-ag. |
2002-12-06 |
2023-08-12 |
Not clear |
| D G Deutsch, N Ueda, S Yamamot. The fatty acid amide hydrolase (FAAH). Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052036. |
the fatty acid amide hydrolase (faah), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. |
2002-12-06 |
2023-08-12 |
mouse |
| D G Deutsch, N Ueda, S Yamamot. The fatty acid amide hydrolase (FAAH). Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052036. |
the distribution of faah in the major organs in the body is described as well as regional distribution in the brain and its correlation with cannabinoid receptors. |
2002-12-06 |
2023-08-12 |
mouse |
| E Frid. Endocannabinoids in the central nervous system--an overview. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052038. |
for therapeutic purposes, inhibitors of faah may provide more specific cannabinoid activities than direct agonists, and several such molecules have already been developed. |
2002-12-06 |
2023-08-12 |
Not clear |
| b' M Maccarrone, K Falciglia, M Di Rienzo, A Finazzi-Agr\\xc3\\xb. Endocannabinoids, hormone-cytokine networks and human fertility. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052045.' |
here, we review the roles of aea, of the aea-binding cannabinoid (cb) receptors, of the selective aea membrane transporter (amt), and of the aea-hydrolyzing enzyme fatty acid amide hydrolase (faah), in human gestation. |
2002-12-06 |
2023-08-12 |
mouse |
| Isabel Matias, Pierre Pochard, Pierangelo Orlando, Michel Salzet, Joel Pestel, Vincenzo Di Marz. Presence and regulation of the endocannabinoid system in human dendritic cells. European journal of biochemistry. vol 269. issue 15. 2002-09-09. PMID:12153574. |
here we have analyzed human dendritic cells for the presence of the endocannabinoids, anandamide and 2-arachidonoylglycerol (2-ag), the cannabinoid cb1 and cb2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (faah). |
2002-09-09 |
2023-08-12 |
human |
| Mario van der Stelt, J Albert van Kuik, Monica Bari, Guus van Zadelhoff, Bas R Leeflang, Gerrit A Veldink, Alessandro Finazzi-Agrò, Johannes F G Vliegenthart, Mauro Maccarron. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. Journal of medicinal chemistry. vol 45. issue 17. 2002-09-04. PMID:12166944. |
oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. |
2002-09-04 |
2023-08-12 |
Not clear |
| Mario van der Stelt, J Albert van Kuik, Monica Bari, Guus van Zadelhoff, Bas R Leeflang, Gerrit A Veldink, Alessandro Finazzi-Agrò, Johannes F G Vliegenthart, Mauro Maccarron. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. Journal of medicinal chemistry. vol 45. issue 17. 2002-09-04. PMID:12166944. |
this study was aimed at finding structural requirements for the interaction of the acyl chain of endocannabinoids with cannabinoid receptors, membrane transporter protein, and fatty acid amide hydrolase (faah). |
2002-09-04 |
2023-08-12 |
Not clear |
| Paolo Gubellini, Barbara Picconi, Monica Bari, Natalia Battista, Paolo Calabresi, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Mauro Maccarron. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 16. 2002-09-04. PMID:12177188. |
moreover, we observed a decreased activity of the anandamide membrane transporter (amt) and of the anandamide hydrolase [fatty acid amide hydrolase (faah)], whereas the binding of anandamide to cannabinoid receptors was unaffected. |
2002-09-04 |
2023-08-12 |
rat |
| b' Mauro Maccarrone, Tiziana Bisogno, Herbert Valensise, Natalia Lazzarin, Filomena Fezza, Claudio Manna, Vincenzo Di Marzo, Alessandro Finazzi-Agr\\xc3\\xb. Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer. Molecular human reproduction. vol 8. issue 2. 2002-07-24. PMID:11818522.' |
the blood levels of the other endocannabinoid, 2-arachidonoylglycerol, or of the aea congener, n-palmitoylethanolamine, which are metabolized by enzymes different from faah, was not different between the pregnant and nonpregnant women, nor was there any difference in the activity of the aea membrane transporter or the amounts of cannabinoid receptors in lymphocytes. |
2002-07-24 |
2023-08-12 |
human |