| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongqing Zhao, Yang Liu, Na Cai, Xiaolin Liao, Lin Tang, Yuhong Wan. Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs. Drug design, development and therapy. vol 18. 2024-06-17. PMID:38882045. |
more recent efforts have emphasized that inhibition of two major endogenous cannabinoid hydrolases, monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), indirectly activates cannabinoid receptors by increasing endogenous cannabinoid levels in the synaptic gap, circumventing receptor desensitization resulting from direct enhancement of endogenous cannabinoid signaling. |
2024-06-17 |
2024-06-19 |
Not clear |
| Xin Gu, Xuewei Wang, Wenyan Cai, Yujie Han, Qi-Wei Zhan. Monofluorophore-based Two-Photon Ratiometric Fluorescent Probe for the Quantitative Imaging of Fatty Acid Amide Hydrolase in Live Neurons and Mouse Brain Tissues. ACS sensors. 2024-06-08. PMID:38850514. |
fatty acid amide hydrolase (faah) plays a crucial role in the metabolism of the endocannabinoid system by hydrolyzing a series of bioactive amides, whose abnormal levels are associated with neuronal disorders including alzheimer's disease (ad). |
2024-06-08 |
2024-06-11 |
mouse |
| Elif Hilal Vural, Gokce Sevim Ozturk Fincan, Yagmur Okcay, Celil Ilker Askin, Merve Gudul Bacanli, Ismail Mert Vura. Interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue. Naunyn-Schmiedeberg's archives of pharmacology. vol 397. issue 6. 2024-05-22. PMID:38032490. |
interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue. |
2024-05-22 |
2024-05-27 |
rat |
| Hernan A Bazan, Surjyadipta Bhattacharjee, Madigan M Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey A St Pierre, Neehar Desai, Patrick W Daly, Jessica A Cucinello-Ragland, Scott Edwards, Javier Recio, Julio Alvarez-Builla, James J Cai, Nicolas G Baza. Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region. Scientific reports. vol 14. issue 1. 2024-05-15. PMID:38750093. |
single-cell transcriptomics of pag uncovered that srp-001 and apap also share modulation of pain-related gene expression and cell signaling pathways/networks, including endocannabinoid signaling, genes pertaining to mechanical nociception, and fatty acid amide hydrolase (faah). |
2024-05-15 |
2024-05-27 |
mouse |
| Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Leste. Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors. Behavioral neuroscience. vol 138. issue 2. 2024-04-25. PMID:38661670. |
the indirect cannabinoid agonist n-arachidonoyl serotonin (aa-5-ht) indirectly agonizes the cannabinoid system by preventing the metabolism of endocannabinoids through fatty acid amide hydrolase inhibition while also inhibiting transient receptor potential vanilloid type 1 channels. |
2024-04-25 |
2024-04-28 |
mouse |
| Sebastiaan Dalle, Charlotte Hiroux, Katrien Kopp. Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation. Biochimica et biophysica acta. Molecular basis of disease. 2024-04-23. PMID:38653357. |
cachexic mice exhibited a lower muscle cb1 expression (-43 %; p < 0.001) and abundance of the endocannabinoid anandamide (aea; -22 %; p = 0.044), as well as a lower expression of the aea-synthesizing enzyme nape-pld (-37 %; p < 0.001), whereas the expression of the aea degrading enzyme faah was higher (+160 %; p < 0.001). |
2024-04-23 |
2024-04-26 |
mouse |
| Shreya Desai, Clara G Zundel, Julia M Evanski, Leah C Gowatch, Amanpreet Bhogal, Samantha Ely, Carmen Carpenter, MacKenna Shampine, Emilie O'Mara, Christine A Rabinak, Hilary A Marusa. Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence. Behavioural brain research. 2024-02-29. PMID:38423255. |
in adults, neuroimaging studies link a common genetic variant in fatty acid amide hydrolase (faah c385a)-an enzyme that regulates endocannabinoid signaling-to reduced risk of anxiety and depression, and altered threat- and reward-related neural activity. |
2024-02-29 |
2024-03-03 |
Not clear |
| C Medina-Saldivar, G V E Pardo, L F Pacheco-Otalor. Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-02-21. PMID:38381881. |
mch1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (faah), an enzyme responsible for endocannabinoid metabolism. |
2024-02-21 |
2024-02-24 |
mouse |
| C Medina-Saldivar, G V E Pardo, L F Pacheco-Otalor. Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-02-21. PMID:38381881. |
the present study aimed to evaluate the effect of the in vivo administration of mch1 (3, 10, and 30 mg/kg, ip) in 2-month-old balb/c male mice (n=97) on forced swimming test (fst), light-dark box (ldb), and open field test (oft) and on early gene expression changes 2 h after drug injection related to the endocannabinoid system (cnr1 and faah) and dopaminergic signaling (drd1 and drd2) in the nac core. |
2024-02-21 |
2024-02-24 |
mouse |
| Daniela Kovacs, Enrica Flori, Emanuela Bastonini, Sarah Mosca, Emilia Migliano, Carlo Cota, Marco Zaccarini, Stefania Briganti, Giorgia Cardinal. Targeting Fatty Acid Amide Hydrolase Counteracts the Epithelial-to-Mesenchymal Transition in Keratinocyte-Derived Tumors. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139209. |
inhibiting faah (fatty acid amide hydrolase), the degradation enzyme of the endocannabinoid anandamide (aea) leads to the increase in aea levels, thus enhancing its biological effects. |
2023-12-23 |
2023-12-25 |
human |
| b' A Pa\\xc5\\x99\\xc3\\xadzek, J Suchop\\xc3\\xa1r, Z La\\xc5\\xa1t\\xc5\\xafvka, M Alblov\\xc3\\xa1, M Hill, M Du\\xc5\\xa1kov\\xc3\\xa. The Endocannabinoid System and Its Relationship to Human Reproduction. Physiological research. vol 72. issue S4. 2023-12-20. PMID:38116770.' |
only an exceptional interplay of enzymes such as nape-pdl or faah, endogenous cannabinoids and cannabinoid receptors cb1 and cb2 can ensure the proper functioning of the reproductive organs and thus lead to delivery on time. |
2023-12-20 |
2023-12-23 |
human |
| Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Miriam Francavilla, Sara Facchetti, Cristina Tassorell. URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia. Pharmaceuticals (Basel, Switzerland). vol 16. issue 11. 2023-11-25. PMID:38004491. |
the inhibition of the fatty acid amide hydrolase (faah), the degrading enzyme of the endocannabinoid anandamide, has received attention as an alternative to cannabinoids in the treatment of neuropathic pain. |
2023-11-25 |
2023-11-28 |
rat |
| Mallika Tripathy, Amy Bui, Jared Henderson, Jeffrey Sun, Christian Rutan Woods, Soumya Somani, Thao Doan, Anto Sam Crosslee Louis Sam Titus, Chandra Moha. FAAH inhibition ameliorates breast cancer in a murine model. Oncotarget. vol 14. 2023-11-03. PMID:37921652. |
faah inhibition was more effective than exogenous endocannabinoid treatment, and the combination of faah inhibitors and endocannabinoids was the most effective in inducing apoptosis of breast cancer cells |
2023-11-03 |
2023-11-08 |
Not clear |
| K Taboada-Rosell, F A Castro-García, C Medina-Saldívar, S R Cruz-Visalaya, L F Pacheco-Otalor. The novel FAAH inhibitor, MCH1, reduces the infarction area in the motor cortex-related region but does not affect the sensorimotor function or memory and spatial learning in rats exposed to transient middle cerebral artery occlusion. Brain research. 2023-10-21. PMID:37865139. |
this deduction comes from its ability to inhibit the fatty acid amide hydrolase activity, an enzyme related to the endocannabinoid anandamide hydrolysis. |
2023-10-21 |
2023-11-08 |
rat |
| Lisa Bornscheuer, Andreas Lundin, Yvonne Forsell, Catharina Lavebratt, Philippe A Mela. Functional Variation in the Genes. vol 14. issue 9. 2023-09-28. PMID:37761966. |
functional variation in the fatty acid amide hydrolase (faah) is an enzyme that degrades anandamide, an endocannabinoid that modulates mesolimbic dopamine release and, consequently, influences states of well-being. |
2023-09-28 |
2023-10-07 |
Not clear |
| Alessandro Papa, Ilaria Cursaro, Luca Pozzetti, Chiara Contri, Martina Cappello, Silvia Pasquini, Gabriele Carullo, Anna Ramunno, Sandra Gemma, Katia Varani, Stefania Butini, Giuseppe Campiani, Fabrizio Vincenz. Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents. Archiv der Pharmazie. 2023-09-26. PMID:37750286. |
aiming to simultaneously modulate the endocannabinoid system (ecs) functions and the epigenetic machinery, we selected the fatty acid amide hydrolase (faah) and histone deacetylase (hdac) enzymes as desired targets to develop potential neuroprotective multitarget-directed ligands (mtdls), expecting to achieve an additive or synergistic therapeutic effect in oxidative stress-related conditions. |
2023-09-26 |
2023-10-07 |
human |
| Anthony H Taylor, Panos Bachkangi, Justin C Konj. Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta. Histochemistry and cell biology. 2023-09-26. PMID:37750996. |
here we examined the expression of the n-acylethanolamine-modulating enzymes fatty acid amide hydrolase (faah) and n-acyl-phosphatidylethanolamine-specific phospholipase-d (nape-pld) and of the cannabinoid receptors (cb1 and cb2) in the placenta and their activation in an in vitro model of the third-trimester placenta to determine if those expressions change with labour and have functional significance. |
2023-09-26 |
2023-10-07 |
human |
| Danielle M Gerhard, Nathaniel Tse, Francis S Lee, Heidi C Meye. Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice. Developmental psychobiology. vol 65. issue 6. 2023-08-22. PMID:37607892. |
for this, we used knock-in mice containing a common human mutation in the gene for fatty acid amide hydrolase (faah), the primary catabolic enzyme for the endocannabinoid anandamide (faah-in). |
2023-08-22 |
2023-09-07 |
mouse |
| Joao P De Aquin. Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility. Biological psychiatry. vol 94. issue 5. 2023-08-09. PMID:37558315. |
fatty acid amide hydrolase, neurodevelopment, and alcohol: illuminating the intricacies of the endocannabinoid system in addiction susceptibility. |
2023-08-09 |
2023-08-16 |
Not clear |
| Gina Granja-Galeano, Ana Paula Dominguez Rubio, C Daniel Zappia, Manuel Wolfson, Sara Sanz Blasco, Julieta Aisemberg, Maria Zorrilla Zubilete, Natalia Fernandez, Ana Franchi, Carlos P Fitzsimons, Federico Monczo. CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation. Neuropharmacology. 2023-08-04. PMID:37541383. |
furthermore, we provide primary evidence for the mechanism responsible for this crosstalk between cannabinoid and glucocorticoid-mediated signaling pathways, showing that dexamethasone regulates endocannabinoid metabolism by inhibiting the activity of the fatty acid amide hydrolase (faah), an integral membrane enzyme that hydrolyzes endocannabinoids and related amidated signaling lipids. |
2023-08-04 |
2023-08-14 |
Not clear |