| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisanori Imai, Ravi S J Singh, Patrice E Fort, Thomas W Gardne. Neuroprotection for diabetic retinopathy. Developments in ophthalmology. vol 44. 2009-12-11. PMID:19494653. |
in this chapter, we summarize the evidence for the neurodegeneration in dr and review normal mechanisms for maintenance of postmitotic cells in the retina and alterations in normal maintenance pathways in dr with emphasis on 'neuroprotection'. |
2009-12-11 |
2023-08-12 |
Not clear |
| b' N Besz\\xc3\\xa9desov\\xc3\\xa1, E Budinsk\\xc3\\xa1, S Skorkovsk\\xc3\\xa. [Functional integrity of neural retina in 2. type diabetics]. Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti. vol 65. issue 4. 2009-10-02. PMID:19750829.' |
the purpose of this prospective longitudinal study was to investigate early defects in functional integrity of neural retina in 2. type diabetic patients without or with mild diabetic retinopathy (dr) since there is an evidence of early functional changes in neural retina before occurrence of clinical manifestation of dr. psychophysical test of contrast sensitivity (cs) was used for the detection of these changes. |
2009-10-02 |
2023-08-12 |
Not clear |
| b' N Besz\\xc3\\xa9desov\\xc3\\xa1, E Budinsk\\xc3\\xa1, S Skorkovsk\\xc3\\xa. [Functional integrity of neural retina in 2. type diabetics]. Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti. vol 65. issue 4. 2009-10-02. PMID:19750829.' |
in conclusion, it was not proved in this study that cs test is suitable for the screening for dr or early functional defects in neural retina before clinical manifestation of dr. |
2009-10-02 |
2023-08-12 |
Not clear |
| Raju V S Rajala, Ivana Ivanovic, Ashok Kumar Dill. Retinal insulin receptor signaling in hyperosmotic stress. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251051. |
in the diabetic eye, the increased accumulation of sorbitol in the retina has been implicated in the pathogenesis of diabetic retinopathy (dr). |
2009-06-23 |
2023-08-12 |
human |
| Raju V S Rajala, Ivana Ivanovic, Ashok Kumar Dill. Retinal insulin receptor signaling in hyperosmotic stress. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251051. |
neurodegeneration is an important component of dr as demonstrated by increased neural apoptosis in the retina during experimental and human diabetes. |
2009-06-23 |
2023-08-12 |
human |
| Jian-xing Ma, Sarah X Zhang, Joshua J Wan. Down-regulation of angiogenic inhibitors: a potential pathogenic mechanism for diabetic complications. Current diabetes reviews. vol 1. issue 2. 2009-02-13. PMID:18220594. |
diabetic macular edema (dme) resulting from increased vascular permeability in the retina and retinal neovascularization (nv) represent two major pathological changes in dr and are the primary causes of vision loss in diabetic patients. |
2009-02-13 |
2023-08-12 |
Not clear |
| Rajendra Acharya U, Chua Kuang Chua, E Y K Ng, Wenwei Yu, Caroline Che. Application of higher order spectra for the identification of diabetes retinopathy stages. Journal of medical systems. vol 32. issue 6. 2009-01-29. PMID:19058652. |
diabetic retinopathy (dr) is a condition where the retina is damaged due to fluid leaking from the blood vessels into the retina. |
2009-01-29 |
2023-08-12 |
human |
| Haitao Li, Janice W C Louey, Kwong Wai Choy, David T L Liu, Wai Man Chan, Yiu Man Chan, Nicholas S K Fung, Bao Jian Fan, Larry Baum, Juliana C N Chan, Dennis S C Lam, Chi Pui Pan. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Molecular vision. vol 14. 2008-11-14. PMID:18806884. |
we tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (dr). |
2008-11-14 |
2023-08-12 |
Not clear |
| Katrin Lorenz, Josef Troger, Reiner Fischer-Colbrie, Bernhard Kremser, Eduard Schmid, Martina Kralinger, Barbara Teuchner, Nikolaos Bechrakis, Gerhard Kieselbac. Substance P and secretoneurin in vitreous aspirates of patients with various vitreoretinal diseases. Peptides. vol 29. issue 9. 2008-10-27. PMID:18550223. |
sn was significantly decreased in patients with nonproliferative dr, active pdr and inactive pdr by more than 70% which seems to result from a reduced expression and/or secretion from the cilary epithelium and a reduced release from the retina both due to diabetes mellitus. |
2008-10-27 |
2023-08-12 |
Not clear |
| Jagadish Nayak, P Subbanna Bhat, Rajendra Acharya, C M Lim, Manjunath Kagath. Automated identification of diabetic retinopathy stages using digital fundus images. Journal of medical systems. vol 32. issue 2. 2008-07-30. PMID:18461814. |
diabetic retinopathy (dr) is caused by damage to the small blood vessels of the retina in the posterior part of the eye of the diabetic patient. |
2008-07-30 |
2023-08-12 |
human |
| G Bhanuprakash Reddy, A Satyanarayana, N Balakrishna, Radha Ayyagari, M Padma, K Viswanath, J Mark Petras. Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Molecular vision. vol 14. 2008-05-20. PMID:18385795. |
however, the relationship between hyperglycemia-induced activation of polyol pathway in retina and dr is still uncertain. |
2008-05-20 |
2023-08-12 |
human |
| Renata Frazão, Luciana Pinato, André V da Silva, Luiz R G Britto, José A Oliveira, Maria I Nogueir. Evidence of reciprocal connections between the dorsal raphe nucleus and the retina in the monkey Cebus apella. Neuroscience letters. vol 430. issue 2. 2008-04-18. PMID:18079059. |
our findings suggest that direct and reciprocal connections between the retina and dr may exist in cebus apella. |
2008-04-18 |
2023-08-12 |
monkey |
| Kamila C Silva, Camila C Pinto, Subrata K Biswas, Denise S Souza, José B Lopes de Faria, Jacqueline M Lopes de Fari. Prevention of hypertension abrogates early inflammatory events in the retina of diabetic hypertensive rats. Experimental eye research. vol 85. issue 1. 2007-09-17. PMID:17493613. |
as the inflammatory mechanisms play a pivotal role in the pathogenesis of dr, in the present study, we investigated the effects of diabetes, hypertension, and combination of diabetes and hypertension on early inflammatory phenomena in the retina, and the effects of blood pressure control on retinal inflammation. |
2007-09-17 |
2023-08-12 |
rat |
| M Rema, R Pradeep. Diabetic retinopathy: an Indian perspective. The Indian journal of medical research. vol 125. issue 3. 2007-09-17. PMID:17496357. |
diabetic retinopathy (dr) can be defined as damage to microvascular system in the retina due to prolonged hyperglycaemia. |
2007-09-17 |
2023-08-12 |
human |
| Tom A Gardiner, Desmond B Archer, Tim M Curtis, Alan W Stit. Arteriolar involvement in the microvascular lesions of diabetic retinopathy: implications for pathogenesis. Microcirculation (New York, N.Y. : 1994). vol 14. issue 1. 2007-04-18. PMID:17365659. |
nevertheless, it is useful to reevaluate the microvascular lesions that are manifest in the retina during diabetes in humans and long-term animal models, since in addition to providing useful clues to the pathogenic basis of dr as a disease entity, it is in the deterrence of such changes that the efficacy of any novel treatment regimes will be measured. |
2007-04-18 |
2023-08-12 |
human |
| I Matias, J W Wang, A Schiano Moriello, A Nieves, D F Woodward, V Di Marz. Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. Prostaglandins, leukotrienes, and essential fatty acids. vol 75. issue 6. 2007-02-13. PMID:17011761. |
in eyes with dr, significantly enhanced levels of aea were found in the retina ( approximately 1.8-fold), ciliary body ( approximately 1.5-fold) and, to a lesser extent, cornea ( approximately 1.3-fold). |
2007-02-13 |
2023-08-12 |
Not clear |
| Koichi Masuzawa, Subrina Jesmin, Seiji Maeda, Sohel Zaedi, Nobutake Shimojo, Takashi Miyauchi, Katsutoshi Got. Effect of endothelin dual receptor antagonist on VEGF levels in streptozotocin-induced diabetic rat retina. Experimental biology and medicine (Maywood, N.J.). vol 231. issue 6. 2006-07-05. PMID:16741055. |
diabetic retinopathy (dr), one of the most serious causes of blindness, is often associated with the upregulation of vascular endothelial growth factor (vegf) in retina. |
2006-07-05 |
2023-08-12 |
rat |
| Ana R Santiago, Tiago S Pereira, Manuel J Garrido, Armando J Cristóvão, Paulo F Santos, António F Ambrósi. High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas. Neurochemistry international. vol 48. issue 6-7. 2006-06-09. PMID:16513217. |
these results suggest that high glucose and diabetes increase the evoked release of d-aspartate in the retina, which may be correlated with the hypothesis of glutamate-induced retinal neurodegeneration in dr. |
2006-06-09 |
2023-08-12 |
rat |
| Mariano J Taverna, Jean-Louis Selam, Gérard Slam. Association between a protein polymorphism in the start codon of the vitamin D receptor gene and severe diabetic retinopathy in C-peptide-negative type 1 diabetes. The Journal of clinical endocrinology and metabolism. vol 90. issue 8. 2005-09-14. PMID:15899948. |
the plasma concentration of 1,25-dihydroxyvitamin d3 has been inversely correlated with the severity of diabetic retinopathy (dr), which raises the possibility that vd, through its antiinflammatory, antioxidant, antiproliferative, and antiangiogenic properties, may protect diabetic retina. |
2005-09-14 |
2023-08-12 |
Not clear |
| James A Kimble, Bari M Brandt, Gerald McGwi. Clinical examination accurately locates capillary nonperfusion in diabetic retinopathy. American journal of ophthalmology. vol 139. issue 3. 2005-04-04. PMID:15767077. |
to help the ophthalmologist who wishes to know the perfusion status of the retina outside the macula, we determined whether clinical examination can predict capillary nonperfusion in diabetic retinopathy (dr) as accurately as fluorescein angiography (fa). |
2005-04-04 |
2023-08-12 |
Not clear |