| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenji Hashimot. Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30386243. |
in the learned helplessness paradigm, the protein levels of keap1 and nrf2 in the pfc and dg of hippocampus from rats with depression-like phenotype were also lower than control and resilient rats. |
2020-10-01 |
2023-08-13 |
mouse |
| Praveen K Pilly, Michael D Howard, Rajan Bhattacharyy. Modeling Contextual Modulation of Memory Associations in the Hippocampus. Frontiers in human neuroscience. vol 12. 2020-10-01. PMID:30473660. |
our adaptive contextual memory model comprises the lateral entorhinal cortex (lec), the dentate gyrus (dg) and areas ca3 and ca1 in the hippocampus, and assumes external inputs about context that originate in the prefrontal cortex (pfc). |
2020-10-01 |
2023-08-13 |
rat |
| Praveen K Pilly, Michael D Howard, Rajan Bhattacharyy. Modeling Contextual Modulation of Memory Associations in the Hippocampus. Frontiers in human neuroscience. vol 12. 2020-10-01. PMID:30473660. |
specifically, we propose that there is a top-down bias on the excitability of cells in the dg of the hippocampus that recruits a sub-population of cells to differentiate contexts, independent of experienced stimuli, expanding the "pattern separation" role typically attributed to the dg. |
2020-10-01 |
2023-08-13 |
rat |
| Edward H Beamer, Jeronimo Jurado-Arjona, Eva M Jimenez-Mateos, James Morgan, Cristina R Reschke, Aidan Kenny, Gioacchino de Leo, Luis A Olivos-Oré, Marina Arribas-Blázquez, Stephen F Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A Farrell, Donncha F O'Brien, Jesus Avila, Miguel Diaz-Hernandez, M Teresa Miras-Portugal, Antonio R Artalejo, Felix Hernandez, David C Henshall, Tobias Enge. MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:30618601. |
using this approach, we quantified differences in the rate of neurogenesis and migration, the structure of the apical dendritic tree and density and morphology of dendritic spines in newly-formed neurons.se resulted in an increased rate of hippocampal neurogenesis, including within the undamaged contralateral dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
mouse |
| Pascal Bielefeld, Marijn Schouten, Guido M Meijer, Marit J Breuk, Karlijne Geijtenbeek, Sedef Karayel, Alisa Tiaglik, Anna H Vuuregge, Ruth A L Willems, Diede Witkamp, Paul J Lucassen, Juan M Encinas, Carlos P Fitzsimon. Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30837840. |
convulsive seizures promote adult hippocampal neurogenesis (ahn) through a transient activation of neural stem/progenitor cells (nspcs) in the subgranular zone (sgz) of the dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
Not clear |
| Batoul Darwish, Farah Chamaa, Elie D Al-Chaer, Nayef E Saadé, Wassim Abou-Khei. Intranigral Injection of Endotoxin Suppresses Proliferation of Hippocampal Progenitor Cells. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31333405. |
in this study, we investigate the effect of mild inflammation, induced by unilateral injection of endotoxin (et) in the substantia nigra (sn)/ventral tegmental area, on the proliferation and survival of stem/progenitor cells in the dentate gyrus (dg) of the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Błażej Ruszczycki, Katarzyna Karolina Pels, Agnieszka Walczak, Katarzyna Zamłyńska, Michał Such, Andrzej Antoni Szczepankiewicz, Małgorzata Hanna Hall, Adriana Magalska, Marta Magnowska, Artur Wolny, Grzegorz Bokota, Subhadip Basu, Ayan Pal, Dariusz Plewczynski, Grzegorz Marek Wilczyńsk. Three-Dimensional Segmentation and Reconstruction of Neuronal Nuclei in Confocal Microscopic Images. Frontiers in neuroanatomy. vol 13. 2020-10-01. PMID:31481881. |
an essential prerequisite to any quantification is the segmentation of the nuclei which are typically tightly packed in the tissue, the extreme being the hippocampal dentate gyrus (dg), in which nuclei frequently appear to overlap due to limitations in microscope resolution. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiang Cheng, Haoming Li, Heyan Zhao, Wen Li, Jianbing Qin, Guohua Ji. Function and mechanism of long non-coding RNA Gm21284 in the development of hippocampal cholinergic neurons. Cell & bioscience. vol 9. 2020-10-01. PMID:31485323. |
our previous studies have demonstrated that enhanced cholinergic neurogenesis occurs in the subgranular zone (sgz) of the hippocampal dentate gyrus (dg) after cholinergic denervation, which is closely associated with the core transcription factor lhx8. |
2020-10-01 |
2023-08-13 |
Not clear |
| Akihiro Yamauchi, Takahiro Tone, Koji Sugimoto, Hong Seok Lim, Taiichi Kaku, Chihiro Tohda, Takayuki Shindo, Koji Tamada, Yoichi Mizukami, Eiichi Hiran. Porcine placental extract facilitates memory and learning in aged mice. Food science & nutrition. vol 7. issue 9. 2020-10-01. PMID:31572593. |
the numbers of nissl-positive cells in the hippocampal cornu ammonis 3 (ca3) and dentate gyrus (dg) regions were increased in sd-f-treated aged mice relative to controls. |
2020-10-01 |
2023-08-13 |
mouse |
| Omkar L Patkar, Arnauld Belmer, Kate Beecher, Angela Jacques, Selena E Bartlet. Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31849624. |
interestingly, studies have demonstrated that the development of alcohol-induced negative affective states is linked to disrupted neurogenesis in the dentate gyrus (dg) region of the hippocampus in alcohol-dependent animals. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu Rong Guo, Zi Wei Liu, Shuang Peng, Meng Yun Duan, Jing Wei Feng, Wei Feng Wang, Yan Hua Xu, Xi Tang, Xiang Zhi Zhang, Bo Xu Ren, Feng Ru Tan. The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis. Dose-response : a publication of International Hormesis Society. vol 17. issue 4. 2020-10-01. PMID:31903069. |
the radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (asmase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in balb/c mice by immunostaining of biomarkers for cell division (ki67), immature neurons (doublecortin or dcx), and interneurons (parvalbumin or pv) in the dentate gyrus (dg) of hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Tingting Zhang, Juan Hong, Tingting Di, Ling Che. MPTP Impairs Dopamine D1 Receptor-Mediated Survival of Newborn Neurons in Ventral Hippocampus to Cause Depressive-Like Behaviors in Adult Mice. Frontiers in molecular neuroscience. vol 9. 2020-10-01. PMID:27790091. |
five consecutive days of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) injection in mice (mptp-mice) reduced dopaminergic fibers in hippocampal dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
mouse |
| Noemí Pallas-Bazarra, Asta Kastanauskaite, Jesús Avila, Javier DeFelipe, María Llorens-Martí. GSK-3β Overexpression Alters the Dendritic Spines of Developmentally Generated Granule Neurons in the Mouse Hippocampal Dentate Gyrus. Frontiers in neuroanatomy. vol 11. 2020-10-01. PMID:28344548. |
moreover, a unique feature of the dg is the occurrence of adult hippocampal neurogenesis, a process that gives rise to newborn granule neurons throughout life. |
2020-10-01 |
2023-08-13 |
mouse |
| Luis E B Bettio, Joana Gil-Mohapel, Anna R Patten, Natasha F O'Rourke, Ronan P Hanley, Karthik Gopalakrishnan, Jeremy E Wulff, Brian R Christi. Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28656155. |
within this context, isoxazole 9 (isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (sgz) of the hippocampal dentate gyrus (dg), while also improving hippocampal function in healthy mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Daniele Lana, Filippo Ugolini, Daniele Nosi, Gary L Wenk, Maria G Giovannin. Alterations in the Interplay between Neurons, Astrocytes and Microglia in the Rat Dentate Gyrus in Experimental Models of Neurodegeneration. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28955220. |
the differential expression/activation of astroglia and the alteration of their intercommunication may be responsible for the different susceptibility of the dg in comparison to the ca1 and ca3 hippocampal areas to neurodegeneration during aging and inflammation. |
2020-09-30 |
2023-08-13 |
rat |
| Marita G Hansen, Litsa N Ledri, Deniz Kirik, Merab Kokaia, Marco Ledr. Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29375319. |
here, using selective optogenetic activation of pv cells in the hippocampus, we show that seizures, induced by rapid kindling (rk) stimulations, enhance gamma-aminobutyric acid (gaba) release from pv cells onto dentate gyrus (dg) granule cells (gc). |
2020-09-30 |
2023-08-13 |
mouse |
| Catherine-Alexandra Grégoire, Stephanie Tobin, Brianna L Goldenstein, Éric Samarut, Andréanne Leclerc, Anne Aumont, Pierre Drapeau, Stephanie Fulton, Karl J L Fernande. RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29706867. |
here, we show that running and running-independent ee differentially affect the hippocampal dentate gyrus (dg), a brain region critical for learning and memory. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cu. Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. Frontiers in neurology. vol 9. 2020-09-30. PMID:30083129. |
we utilized a controlled cortical impact to establish a mouse tbi model, and then stereotaxically administered 25 or 100 ng gdf-5 into the bilateral hippocampal dentate gyrus (dg) of each of the animals. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cu. Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. Frontiers in neurology. vol 9. 2020-09-30. PMID:30083129. |
as a result, we found that post-injury stereotaxical administration of gdf-5 can improve neural stem cell proliferation and differentiation in the dg of the hippocampus, evidenced by the increase in brdu, sox-2, and dcx-labeled cells, as well as the improvement in dendrite arborization and newborn neuron activation in response to gdf-5 treatment. |
2020-09-30 |
2023-08-13 |
mouse |
| Maryam Hatami, Sabine Conrad, Pooyan Naghsh, Gonzalo Alvarez-Bolado, Thomas Skutell. Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30483057. |
the dentate gyrus (dg) receives highly processed information from the associative cortices functionally integrated in the trisynaptic hippocampal circuit, which contributes to the formation of new episodic memories and the spontaneous exploration of novel environments. |
2020-09-30 |
2023-08-13 |
Not clear |