| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie Yokoyama, Naoki Matsu. Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization. Frontiers in behavioral neuroscience. vol 10. 2020-09-30. PMID:27872586. |
in the hippocampal dentate gyrus (dg), exclusively separated ensemble reactivation was observed when mice were exposed to a novel context. |
2020-09-30 |
2023-08-13 |
mouse |
| Marie Yokoyama, Naoki Matsu. Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization. Frontiers in behavioral neuroscience. vol 10. 2020-09-30. PMID:27872586. |
our results suggest that the alternations in the ensemble representation within the dg, or in upstream structures that link the sensory cortex to the hippocampus, may underlie generalized contextual fear memory expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Tingting Zheng, Jiali Pu, Yanxing Chen, Yanfang Mao, Zhangyu Guo, Hongyu Pan, Ling Zhang, Heng Zhang, Binggui Sun, Baorong Zhan. Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28203202. |
we found that injected exosomes can spread from the dentate gyrus (dg) to other regions of hippocampus and to the cortex. |
2020-09-30 |
2023-08-13 |
mouse |
| Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattane. ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28232789. |
later, we observe a regional- and cellular-selective parvalbumin interneuron and perineuronal net (pnn) depletion in the dentate gyrus (dg), but not in other hippocampal regions of tgprongf#3 mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattane. ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28232789. |
these results demonstrate that, in the hippocampus, the dg is selectively vulnerable to altered prongf/ngf signaling. |
2020-09-30 |
2023-08-13 |
mouse |
| Yasuhisa Tamura, Yosky Kataok. PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28243610. |
neural stem cells are present in 2 neurogenic regions, the subventricular zone (svz) and the subgranular zone (sgz) of the hippocampal dentate gyrus (dg), and continue to generate new neurons throughout life. |
2020-09-30 |
2023-08-13 |
human |
| Vanessa M Machado, Ana Sofia Lourenço, Cláudia Florindo, Raquel Fernandes, Caetana M Carvalho, Inês M Araúj. Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28386216. |
selected cognitive tests were performed on the 3rd and 8th week after ka-induced lesion, and cell proliferation, migration and differentiation in the dentate gyrus (dg) of the hippocampus of adult mice were analyzed using specific markers. |
2020-09-30 |
2023-08-13 |
mouse |
| Gustavo R Morel, Micaela López León, Maia Uriarte, Paula C Reggiani, Rodolfo G Goy. Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28405590. |
in rats, learning and memory performance decline during normal aging, which is paralleled by a severe reduction of the levels of neurogenesis in the hippocampal dentate gyrus (dg). |
2020-09-30 |
2023-08-13 |
rat |
| Gustavo R Morel, Micaela López León, Maia Uriarte, Paula C Reggiani, Rodolfo G Goy. Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28405590. |
the dg is thought to be the main hippocampal structure involved in pattern separation memory and there is evidence that the level of neurogenesis in the dg is directly related to pattern separation performance in rodents. |
2020-09-30 |
2023-08-13 |
rat |
| Luis E B Bettio, Joana Gil-Mohapel, Anna R Patten, Natasha F O'Rourke, Ronan P Hanley, Karthik Gopalakrishnan, Jeremy E Wulff, Brian R Christi. Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28656155. |
within this context, isoxazole 9 (isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (sgz) of the hippocampal dentate gyrus (dg), while also improving hippocampal function in healthy mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Daniele Lana, Filippo Ugolini, Daniele Nosi, Gary L Wenk, Maria G Giovannin. Alterations in the Interplay between Neurons, Astrocytes and Microglia in the Rat Dentate Gyrus in Experimental Models of Neurodegeneration. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28955220. |
the differential expression/activation of astroglia and the alteration of their intercommunication may be responsible for the different susceptibility of the dg in comparison to the ca1 and ca3 hippocampal areas to neurodegeneration during aging and inflammation. |
2020-09-30 |
2023-08-13 |
rat |
| Marita G Hansen, Litsa N Ledri, Deniz Kirik, Merab Kokaia, Marco Ledr. Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29375319. |
here, using selective optogenetic activation of pv cells in the hippocampus, we show that seizures, induced by rapid kindling (rk) stimulations, enhance gamma-aminobutyric acid (gaba) release from pv cells onto dentate gyrus (dg) granule cells (gc). |
2020-09-30 |
2023-08-13 |
mouse |
| Catherine-Alexandra Grégoire, Stephanie Tobin, Brianna L Goldenstein, Éric Samarut, Andréanne Leclerc, Anne Aumont, Pierre Drapeau, Stephanie Fulton, Karl J L Fernande. RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29706867. |
here, we show that running and running-independent ee differentially affect the hippocampal dentate gyrus (dg), a brain region critical for learning and memory. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cu. Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. Frontiers in neurology. vol 9. 2020-09-30. PMID:30083129. |
we utilized a controlled cortical impact to establish a mouse tbi model, and then stereotaxically administered 25 or 100 ng gdf-5 into the bilateral hippocampal dentate gyrus (dg) of each of the animals. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cu. Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. Frontiers in neurology. vol 9. 2020-09-30. PMID:30083129. |
as a result, we found that post-injury stereotaxical administration of gdf-5 can improve neural stem cell proliferation and differentiation in the dg of the hippocampus, evidenced by the increase in brdu, sox-2, and dcx-labeled cells, as well as the improvement in dendrite arborization and newborn neuron activation in response to gdf-5 treatment. |
2020-09-30 |
2023-08-13 |
mouse |
| Maryam Hatami, Sabine Conrad, Pooyan Naghsh, Gonzalo Alvarez-Bolado, Thomas Skutell. Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30483057. |
the dentate gyrus (dg) receives highly processed information from the associative cortices functionally integrated in the trisynaptic hippocampal circuit, which contributes to the formation of new episodic memories and the spontaneous exploration of novel environments. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jose Eduardo Peixoto-Santos, Luciana Estefani Drumond de Carvalho, Ludmyla Kandratavicius, Paula Rejane Beserra Diniz, Renata Caldo Scandiuzzi, Roland Coras, Ingmar Blümcke, Joao Alberto Assirati, Carlos Gilberto Carlotti, Caio Cesar Marconato Simoes Matias, Carlos Ernesto Garrido Salmon, Antonio Carlos Dos Santos, Tonicarlo R Velasco, Marcio Flavio D Moraes, Joao Pereira Leit. Manual Hippocampal Subfield Segmentation Using High-Field MRI: Impact of Different Subfields in Hippocampal Volume Loss of Temporal Lobe Epilepsy Patients. Frontiers in neurology. vol 9. 2020-09-30. PMID:30524352. |
manual volumetry in controls revealed that the dentate gyrus (dg)+ca4 region, ca1, and subiculum accounted for almost 90% of the hippocampal volume. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiao-Ying Zhang, Wang Wei, You-Zhi Zhang, Qiang Fu, Wei-Dong Mi, Li-Ming Zhang, Yun-Feng L. The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30532709. |
this study is testing the hypothesis that the overexpression of tspo in hippocampus dentate gyrus (dg) could alleviate the anxiogenic-like response in the mice model of ptsd induced by foot-shock. |
2020-09-30 |
2023-08-13 |
mouse |
| Xiao-Ying Zhang, Wang Wei, You-Zhi Zhang, Qiang Fu, Wei-Dong Mi, Li-Ming Zhang, Yun-Feng L. The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30532709. |
in this study, hippocampal dg overexpression of tspo significantly reversed the increase of the contextual freezing response, the decrease of the percentage of both entries into and time spent in the open arms in elevated plus maze test and the decrease of the account of crossings from the dark to light compartments in light-dark transition test induced by electric foot-shocks procedure. |
2020-09-30 |
2023-08-13 |
mouse |
| Anthony J DeCostanzo, Chi Chung Alan Fung, Tomoki Fuka. Hippocampal Neurogenesis Reduces the Dimensionality of Sparsely Coded Representations to Enhance Memory Encoding. Frontiers in computational neuroscience. vol 12. 2020-09-30. PMID:30666194. |
adult neurogenesis in the hippocampal dentate gyrus (dg) of mammals is known to contribute to memory encoding in many tasks. |
2020-09-30 |
2023-08-13 |
Not clear |