| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lyles R Clark, Sanghee Yun, Nana K Acquah, Priya L Kumar, Hannah E Metheny, Rikley C C Paixao, Akivas S Cohen, Amelia J Eisc. Mild Traumatic Brain Injury Induces Transient, Sequential Increases in Proliferation, Neuroblasts/Immature Neurons, and Cell Survival: A Time Course Study in the Male Mouse Dentate Gyrus. Frontiers in neuroscience. vol 14. 2021-01-26. PMID:33488351. |
mtbis can impair hippocampal-based functions such as memory and cause network hyperexcitability of the dentate gyrus (dg), a key entry point to hippocampal circuitry. |
2021-01-26 |
2023-08-13 |
mouse |
| Lyles R Clark, Sanghee Yun, Nana K Acquah, Priya L Kumar, Hannah E Metheny, Rikley C C Paixao, Akivas S Cohen, Amelia J Eisc. Mild Traumatic Brain Injury Induces Transient, Sequential Increases in Proliferation, Neuroblasts/Immature Neurons, and Cell Survival: A Time Course Study in the Male Mouse Dentate Gyrus. Frontiers in neuroscience. vol 14. 2021-01-26. PMID:33488351. |
one candidate for mediating mtbi-induced hippocampal cognitive and physiological dysfunction is injury-induced changes in the process of dg neurogenesis. |
2021-01-26 |
2023-08-13 |
mouse |
| Lyles R Clark, Sanghee Yun, Nana K Acquah, Priya L Kumar, Hannah E Metheny, Rikley C C Paixao, Akivas S Cohen, Amelia J Eisc. Mild Traumatic Brain Injury Induces Transient, Sequential Increases in Proliferation, Neuroblasts/Immature Neurons, and Cell Survival: A Time Course Study in the Male Mouse Dentate Gyrus. Frontiers in neuroscience. vol 14. 2021-01-26. PMID:33488351. |
here we utilized a clinically relevant rodent model of mtbi (lateral fluid percussion injury, lfpi), gold-standard markers and quantification of the neurogenesis process, and three time points post-injury to generate a comprehensive picture of how mtbi affects adult hippocampal dg neurogenesis. |
2021-01-26 |
2023-08-13 |
mouse |
| Julieta Correa, Santiago Ronchetti, Florencia Labombarda, Alejandro F De Nicola, Luciana Pietraner. Activation of the G Protein-Coupled Estrogen Receptor (GPER) Increases Neurogenesis and Ameliorates Neuroinflammation in the Hippocampus of Male Spontaneously Hypertensive Rats. Cellular and molecular neurobiology. vol 40. issue 5. 2021-01-25. PMID:31784921. |
abnormalities of the hippocampus of shr include decreased neurogenesis in the dentate gyrus (dg), partial loss of neurons in the hilus of the dg, micro and astrogliosis and inflammation. |
2021-01-25 |
2023-08-13 |
rat |
| Julieta Correa, Santiago Ronchetti, Florencia Labombarda, Alejandro F De Nicola, Luciana Pietraner. Activation of the G Protein-Coupled Estrogen Receptor (GPER) Increases Neurogenesis and Ameliorates Neuroinflammation in the Hippocampus of Male Spontaneously Hypertensive Rats. Cellular and molecular neurobiology. vol 40. issue 5. 2021-01-25. PMID:31784921. |
we found that g1 activation of gper increased dcx+ cells in the dg and reduced gfap+ astrogliosis and iba1+ microgliosis in the ca1 region of hippocampus. |
2021-01-25 |
2023-08-13 |
rat |
| Amanda M Canto, Alexandre H B Matos, Alexandre B Godoi, André S Vieira, Beatriz B Aoyama, Cristiane S Rocha, Barbara Henning, Benilton S Carvalho, Vinicius D B Pascoal, Diogo F T Veiga, Rovilson Gilioli, Fernando Cendes, Iscia Lopes-Cende. Multi-omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy. Hippocampus. vol 31. issue 2. 2021-01-25. PMID:33037862. |
we used a multi-omics approach to determine the profile of transcript and protein expression in the dorsal and ventral hippocampal dentate gyrus (dg) and cornu ammonis 3 (ca3) in an animal model of mtle induced by pilocarpine. |
2021-01-25 |
2023-08-13 |
rat |
| Amanda M Canto, Alexandre H B Matos, Alexandre B Godoi, André S Vieira, Beatriz B Aoyama, Cristiane S Rocha, Barbara Henning, Benilton S Carvalho, Vinicius D B Pascoal, Diogo F T Veiga, Rovilson Gilioli, Fernando Cendes, Iscia Lopes-Cende. Multi-omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy. Hippocampus. vol 31. issue 2. 2021-01-25. PMID:33037862. |
our results indicate differences in the transcriptomic and proteomic profiles among the dg and the ca3 subfields of the hippocampus. |
2021-01-25 |
2023-08-13 |
rat |
| Magdalena Miranda, Juan Facundo Morici, Francisco Gallo, Dinka Piromalli Girado, Noelia V Weisstaub, Pedro Bekinschtei. Molecular mechanisms within the dentate gyrus and the perirhinal cortex interact during discrimination of similar nonspatial memories. Hippocampus. vol 31. issue 2. 2021-01-25. PMID:33064924. |
although pattern separation has been localized to the dentate gyrus (dg) of the hippocampus and shown to occur in a spatial domain, this cognitive function takes place also during processing of other types of information. |
2021-01-25 |
2023-08-13 |
Not clear |
| Lou-Yan Ma, Song-Fang Liu, Jun-Hui Du, Yu Niu, Peng-Fei Hou, Qing Shu, Ran-Ran Ma, Song-Di Wu, Qiu-Min Qu, Ya-Li L. Chronic ghrelin administration suppresses IKK/NF-κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ-diabetic rats. Neurobiology of learning and memory. vol 169. 2021-01-19. PMID:31904547. |
then, primary rat hippocampal neurons were isolated and treated with high glucose, followed by ghrelin and dg, pp1 or ikk. |
2021-01-19 |
2023-08-13 |
rat |
| Kolja Meier, Andrea Merseburg, Dirk Isbrandt, Stephan Lawrence Marguet, Fabio Morellin. Dentate Gyrus Sharp Waves, a Local Field Potential Correlate of Learning in the Dentate Gyrus of Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 37. 2021-01-19. PMID:32817247. |
each of the three major hippocampal subfields, dentate gyrus (dg), ca3, and ca1, has a unique function in memory formation and consolidation, and also exhibit distinct local field potential (lfp) signatures during memory consolidation processes in non-rapid eye movement (nrem) sleep. |
2021-01-19 |
2023-08-13 |
mouse |
| Soheil Ghassemi, Tara Asgari, Hadi Mirzapour-Delavar, Shayan Aliakbari, Hamid Gholami Pourbadie, Christophe Prehaud, Monique Lafon, Alireza Gholami, Kayhan Azadmanesh, Nima Naderi, Mohammad Sayya. Lentiviral Expression of Rabies Virus Glycoprotein in the Rat Hippocampus Strengthens Synaptic Plasticity. Cellular and molecular neurobiology. 2021-01-19. PMID:33462779. |
this study was conducted to investigate the effect of rvg on synaptic function in the hippocampal dentate gyrus (dg) of rat. |
2021-01-19 |
2023-08-13 |
rat |
| Masoomeh Nazifi, Shahrbanoo Oryan, Delaram Eslimi Esfahani, Manoochehr Ashrafpoo. The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease. Life sciences. vol 265. 2021-01-13. PMID:33242524. |
the present study investigated the effect of piperine and piperine-donepezil co-administration on cognitive functions and synaptic plasticity at hippocampal perforant pathway (pp) to dentate gyrus (dg) synapses in an experimental model of alzheimer's disease (ad). |
2021-01-13 |
2023-08-13 |
rat |
| Suwarna Chakraborty, Sunil Jamuna Tripathi, B N Srikumar, T R Raju, B S Shankaranarayana Ra. N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes. Neurochemistry international. vol 132. 2021-01-07. PMID:31751620. |
the antidepressive-like and procognitive effects of nac was associated with normalization of volume loss in ca1, dentate gyrus (dg) and hilar subfields of the hippocampus. |
2021-01-07 |
2023-08-13 |
rat |
| Wanting Li, Yan Yu, Dongze Li, Na Xu, Jidong Fang, Yeying Sun, Maolei Xu, Xi Wang, Xin Han, Xiuli Zhang, Changjun Lv, Fang Ha. TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits. International immunopharmacology. vol 81. 2021-01-06. PMID:32058931. |
additionally, seriously damaged neurons and abnormally activated glia were observed in the ca1 and dentate gyrus (dg) areas of the hippocampus. |
2021-01-06 |
2023-08-13 |
mouse |
| Daiane B Fraga, Ana Paula Costa, Gislaine Olescowicz, Anderson Camargo, Francis L Pazini, Andiara E Freitas, Morgana Moretti, Patricia S Brocardo, Ana Lúcia S Rodrigue. Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31476335. |
), ketamine (1 mg/kg, i.p., a fast-acting antidepressant) and fluoxetine (10 mg/kg, p.o., conventional antidepressant) were investigated on: a) behavioral performance in the novelty suppressed feeding (nsf) test; b) hippocampal synaptic protein immunocontent; c) dendritic spine density and morphology in the dorsal and ventral dentate gyrus (dg) of the hippocampus and d) hippocampal dendritic arborization. |
2021-01-04 |
2023-08-13 |
mouse |
| Caitlin Pook, Jamie M Ahrens, Margaret Clagett-Dam. Expression pattern of Nav2 in the murine CNS with development. Gene expression patterns : GEP. vol 35. 2021-01-04. PMID:32081718. |
it is expressed in the cornu ammonis (ca) and dentate gyrus (dg) throughout hippocampal development. |
2021-01-04 |
2023-08-13 |
mouse |
| Ke Zhao, Peng Ren, Ming-Yue Li, Qing-Hua Jin, Bin Xia. [Chronic stress increases dopamine levels in hippocampal dentate gyrus and impairs spatial learning and memory in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 6. 2020-12-23. PMID:33349836. |
the objective of this study was to elucidate the effect of chronic stress (cs) on dopamine (da) level and synaptic efficiency in the hippocampal dentate gyrus (dg) during spatial learning and memory. |
2020-12-23 |
2023-08-13 |
rat |
| Ke Zhao, Peng Ren, Ming-Yue Li, Qing-Hua Jin, Bin Xia. [Chronic stress increases dopamine levels in hippocampal dentate gyrus and impairs spatial learning and memory in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 6. 2020-12-23. PMID:33349836. |
these results suggest that cs may impair spatial learning and memory abilities in rats through the enhancement of the da levels in the hippocampal dg. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the model of perimenopausal depression was established by ovx and cus; the level of anxiety and depression was evaluated by open field test; the levels of interleukin-1β(il-1β) and interleukin-6(il-6) mrna in rat hippocampus were detected by real-time qpcr; double staining immunofluorescence was used to detect the expression of ionized calcium binding adaptor molecule-1(iba-1) and inducible nitric oxide synthase(inos) in microglia of rat dentate gyrus(dg); western blot was used to detect the protein expression of iba-1 and inos of microglia in dg region of rat hippocampus. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the results showed that in the model group, the number of horizontal movement, the number of vertical movement and central residence time were significantly reduced, and the grooming time was significantly prolonged(p<0.05 or p<0.01); the levels of il-1β and il-6 in hippocampus increased significantly(p<0.05); the number of positive cells with co-expression of iba-1/inos of microglia cells in dg region of hippocampus increased; the expression levels of iba-1 and inos protein in hippocampus were significantly increased(p<0.01), suggesting that microglia in dg region of hippocampus was activated and polarized toward m1 type in rats with stress. |
2020-12-23 |
2023-08-13 |
rat |