| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wiebke Bensmann, Nicolas Zink, Larissa Arning, Christian Beste, Ann-Kathrin Stoc. The Presynaptic Regulation of Dopamine and Norepinephrine Synthesis Has Dissociable Effects on Different Kinds of Cognitive Conflicts. Molecular neurobiology. vol 56. issue 12. 2020-04-06. PMID:31183808. |
only norepinephrine seemed to also modulate subliminal conflict processing, as evidenced by better performance of the dbh rs1611122 cc genotype in case of high subliminal conflict load. |
2020-04-06 |
2023-08-13 |
human |
| Wen-Jie Du, Rong-Wei Zhang, Jia Li, Bai-Bing Zhang, Xiao-Lan Peng, Song Cao, Jie Yuan, Cheng-Dong Yuan, Tian Yu, Jiu-Lin D. The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism. Cell reports. vol 24. issue 12. 2019-12-09. PMID:30231998. |
local lesion of lc neurons via two-photon laser-based ablation or genetic depletion of norepinephrine (ne; a neuromodulator released by lc neurons) via crispr/cas9-based mutation of dopamine-β-hydroxylase (dbh) accelerates induction into and retards emergence from general anesthesia. |
2019-12-09 |
2023-08-13 |
zebrafish |
| Bojana Stefanovic, Natasa Spasojevic, Predrag Jovanovic, Sladjana Dronja. Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression. Canadian journal of physiology and pharmacology. vol 97. issue 7. 2019-12-02. PMID:30773040. |
this entailed quantifying the norepinephrine, epinephrine, mrna, and protein levels of tyrosine hydroxylase (th), dopamine-β-hydroxylase (dbh), phenylethanolamine |
2019-12-02 |
2023-08-13 |
rat |
| Lu Liu, Jia Cheng, Yi Su, Ning Ji, Qian Gao, Haimei Li, Li Yang, Li Sun, Qiujin Qian, Yufeng Wan. Deficiency of Sustained Attention in ADHD and Its Potential Genetic Contributor MAOA. Journal of attention disorders. vol 22. issue 9. 2019-09-18. PMID:25784069. |
to investigate the genetic contributors to adhd sustained attention deficit among noradrenergic genes responsible for the synthesis (dopamine-β-hydroxylase gene, dbh), transport (norepinephrine transporter gene, net1), reception (alpha-2a adrenergic receptor gene, adra2a), and metabolism (monoamine oxidase a gene, maoa) of noradrenalin (ne). |
2019-09-18 |
2023-08-13 |
Not clear |
| Katharina Schmidt, Martina Ralle, Thomas Schaffer, Samuel Jayakanthan, Bilal Bari, Abigael Muchenditsi, Svetlana Lutsenk. ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase. The Journal of biological chemistry. vol 293. issue 52. 2019-04-08. PMID:30341172. |
dopamine is converted to norepinephrine by dopamine-β-hydroxylase (dbh), which acquires its essential cu cofactor from atp7a. |
2019-04-08 |
2023-08-13 |
mouse |
| Siqi Tang, Bin Yao, Na Li, Shuhuang Lin, Zunnan Huan. Association of Dopamine Beta-Hydroxylase Polymorphisms with Alzheimer's Disease, Parkinson's Disease and Schizophrenia: Evidence Based on Currently Available Loci. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 1. 2018-12-11. PMID:30453293. |
dopamine beta-hydroxylase (dbh), a gene located in the chromosomal region 9q34, plays a crucial role in the process of converting dopamine into norepinephrine (ne). |
2018-12-11 |
2023-08-13 |
Not clear |
| Esther L Sabban, Lidia I Serova, Elizabeth Newman, Nurit Aisenberg, Irit Akira. Changes in Gene Expression in the Locus Coeruleus-Amygdala Circuitry in Inhibitory Avoidance PTSD Model. Cellular and molecular neurobiology. vol 38. issue 1. 2018-08-13. PMID:28889197. |
in the lc, mrna levels of norepinephrine (ne) biosynthetic enzymes (th, dbh), ne transporter (net), npy receptors (y1r, y2r), and cb1 receptor of endocannabinoid system were elevated. |
2018-08-13 |
2023-08-13 |
rat |
| Toyanji Joseph Punchaichira, Sanjay Kumar Dey, Anirban Mukhopadhyay, Suman Kundu, B K Thelm. Characterization of SNPs in the dopamine-β-hydroxylase gene providing new insights into its structure-function relationship. Neurogenetics. vol 18. issue 3. 2018-04-24. PMID:28707163. |
dopamine-β-hydroxylase (dbh, ec 1.14.17.1), an oxido-reductase that catalyses the conversion of dopamine to norepinephrine, is largely expressed in sympathetic neurons and adrenal medulla. |
2018-04-24 |
2023-08-13 |
Not clear |
| Jessica N Peoples, David G Taylor, Alexander N Katchman, Steven N Eber. Intact calcium signaling in adrenergic-deficient embryonic mouse hearts. Biochemical and biophysical research communications. vol 495. issue 4. 2018-02-22. PMID:29288665. |
mouse embryos that lack the ability to produce the adrenergic hormones, norepinephrine (ne) and epinephrine (epi), due to disruption of the dopamine beta-hydroxylase (dbh |
2018-02-22 |
2023-08-13 |
mouse |
| Li Hui, Mei Han, Guang Zhong Yin, Yingyang Zhang, Xu Feng Huang, Zheng Kang Qian, Wei Guo Gu, Xiao Chu Gu, Xiao Min Zhu, Jair C Soares, Yuping Ning, Yingjun Zheng, Xiang Dong Du, Xiang Yang Zhan. Association between DBH 19bp insertion/deletion polymorphism and cognition in schizophrenia with and without tardive dyskinesia. Schizophrenia research. vol 182. 2018-01-02. PMID:27776953. |
dopamine beta-hydroxylase (dbh) gene associated with dopamine and norepinephrine systems influences cognition. |
2018-01-02 |
2023-08-13 |
Not clear |
| Karl T Schmidt, Jason P Schroeder, Stephanie L Foster, Katherine Squires, Brilee M Smith, Elizabeth G Pitts, Michael P Epstein, David Weinshenke. Norepinephrine regulates cocaine-primed reinstatement via α1-adrenergic receptors in the medial prefrontal cortex. Neuropharmacology. vol 119. 2017-08-31. PMID:28392265. |
cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine β-hydroxylase (dbh) inhibitors, which prevent norepinephrine (ne) synthesis, or by α1-adrenergic receptor (α1ar) antagonists, indicating functional modulation by the noradrenergic system. |
2017-08-31 |
2023-08-13 |
rat |
| Joseph F Cubells, Jason P Schroeder, Elizabeth S Barrie, Daniel F Manvich, Wolfgang Sadee, Tiina Berg, Kristina Mercer, Taylor A Stowe, L Cameron Liles, Katherine E Squires, Andrew Mezher, Patrick Curtin, Dannie L Perdomo, Patricia Szot, David Weinshenke. Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. PloS one. vol 11. issue 5. 2017-07-17. PMID:27148966. |
dopamine β-hydroxylase (dbh) converts dopamine (da) to norepinephrine (ne) in noradrenergic/adrenergic cells. |
2017-07-17 |
2023-08-13 |
mouse |
| Amy C Arnold, Emily M Garland, Jorge E Celedonio, Satish R Raj, Naji N Abumrad, Italo Biaggioni, David Robertson, James M Luther, Cyndya A Shiba. Hyperinsulinemia and Insulin Resistance in Dopamine β-Hydroxylase Deficiency. The Journal of clinical endocrinology and metabolism. vol 102. issue 1. 2017-06-20. PMID:27778639. |
dopamine β-hydroxylase (dbh) deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine. |
2017-06-20 |
2023-08-13 |
mouse |
| Cristiano G Moreira, Regan Russell, Animesh Anand Mishra, Sanjeev Narayanan, Jennifer M Ritchie, Matthew K Waldor, Meredith M Curtis, Sebastian E Winter, David Weinshenker, Vanessa Sperandi. Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut. mBio. vol 7. issue 3. 2017-06-01. PMID:27273829. |
c. rodentium has a decreased ability to colonize dopamine β-hydroxylase knockout (dbh(-/-)) mice, which do not produce epinephrine and norepinephrine. |
2017-06-01 |
2023-08-13 |
mouse |
| Sarah E Bradshaw, Kara L Agster, Barry D Waterhouse, Jill A McGaugh. Age-related changes in prefrontal norepinephrine transporter density: The basis for improved cognitive flexibility after low doses of atomoxetine in adolescent rats. Brain research. vol 1641. issue Pt B. 2017-05-02. PMID:26774596. |
a second study in adolescent rats investigated changes in norepinephrine transporter (net) and dopamine beta hydroxylase (dbh) density in five functionally distinct sub-regions of the prefrontal cortex: infralimbic, prelimbic, anterior cingulate, medial and lateral orbitofrontal cortices. |
2017-05-02 |
2023-08-13 |
human |
| M Pravenec, V Landa, V Zídek, P Mlejnek, J Šilhavý, S A Mir, S M Vaingankar, J Wang, T W Kurt. Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats. Physiological research. vol 65. issue 6. 2017-03-29. PMID:27959576. |
we found modestly increased adrenal expression of dbh in transgenic rats versus shr non-transgenic controls that was associated with reduced adrenal levels of dopamine and increased plasma levels of norepinephrine and epinephrine. |
2017-03-29 |
2023-08-13 |
rat |
| Winton Cheng, Ya-Wen Ka, Chin-Chyuan Chan. Dopamine beta-hydroxylase participate in the immunoendocrine responses of hypothermal stressed white shrimp, Litopenaeus vannamei. Fish & shellfish immunology. vol 59. 2017-03-21. PMID:27793743. |
the effects of hypothermal stress showed that lvdbh expression in thoracic ganglia, haemocytes and hepatopancreas as well as the dbh contents in haemocytes and dopamine (da) and norepinephrine (ne) levels in haemolymph are obviously up-regulated. |
2017-03-21 |
2023-08-13 |
Not clear |
| Toyanji J Punchaichira, Suman Prasad, Smita N Deshpande, B K Thelm. Deep sequencing identifies novel regulatory variants in the distal promoter region of the dopamine-β-hydroxylase gene. Pharmacogenetics and genomics. vol 26. issue 7. 2017-03-16. PMID:26959714. |
dopamine-β-hydroxylase (dbh), an enzyme that converts dopamine into norepinephrine, is a drug target in cardiovascular and neuropsychiatric disorders. |
2017-03-16 |
2023-08-13 |
Not clear |
| Bao-Zhu Yang, Iris M Balodis, Cheryl M Lacadie, Jiansong Xu, Marc N Potenz. A Preliminary Study of DBH (Encoding Dopamine Beta-Hydroxylase) Genetic Variation and Neural Correlates of Emotional and Motivational Processing in Individuals With and Without Pathological Gambling. Journal of behavioral addictions. vol 5. issue 2. 2017-01-30. PMID:27194378. |
dopamine beta-hydroxylase (dbh) converts dopamine to norepinephrine; the t allele of a functional single-nucleotide polymorphism rs1611115 (c-1021t) in the dbh gene is associated with less dbh activity and has been linked to emotional processes and addiction. |
2017-01-30 |
2023-08-13 |
human |
| Shilei Chen, Changhong Du, Mingqiang Shen, Gaomei Zhao, Yang Xu, Ke Yang, Xinmiao Wang, Fengju Li, Dongfeng Zeng, Fang Chen, Song Wang, Mo Chen, Cheng Wang, Ting He, Fengchao Wang, Aiping Wang, Tianmin Cheng, Yongping Su, Jinghong Zhao, Junping Wan. Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation. Blood. vol 127. issue 8. 2016-08-08. PMID:26644453. |
here, we demonstrate that both continual noise and exhaustive exercise elevate peripheral platelet levels in normal and splenectomized mice, but not in dopamine β-hydroxylase-deficient (dbh(-/-)) mice that lack norepinephrine (ne) and epinephrine (epi). |
2016-08-08 |
2023-08-13 |
mouse |