| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiong Wang, Li Ma, En-Jing Zhang, Ji-Li Zou, Hao Guo, Si-Wei Peng, Jin-Hu W. Water Extract of Fructus Hordei Germinatus Shows Antihyperprolactinemia Activity via Dopamine D2 Receptor. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-09-25. PMID:25254056. |
and effect of wefhg on prl secretion, d2 receptors, and dopamine transporters (dat) was studied in mmq, gh3, and pc12 cells, respectively. |
2014-09-25 |
2023-08-13 |
rat |
| Andrii Domanskyi, Heike Alter, Miriam A Vogt, Peter Gass, Ilya A Vinniko. Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance. Frontiers in cellular neuroscience. vol 8. 2014-09-24. PMID:25249938. |
to directly assess their functions selectively in adult da neurons, we induced genetic deletions of foxa1/2 transcription factors in mice using a tamoxifen inducible tissue-specific creert2 recombinase expressed under control of the dopamine transporter (dat) promoter (datcreert2). |
2014-09-24 |
2023-08-13 |
mouse |
| Mark J Ferris, Rodrigo A España, Jason L Locke, Joanne K Konstantopoulos, Jamie H Rose, Rong Chen, Sara R Jone. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 26. 2014-09-23. PMID:24979798. |
using microdialysis and fast-scan cyclic voltammetry in rats, as well as wild-type and dopamine transporter (dat) knock-out mice, we demonstrate that dopamine uptake through the dat and the magnitude of subsecond dopamine release is inversely related to the magnitude of extracellular dopamine tone. |
2014-09-23 |
2023-08-13 |
mouse |
| Mark J Ferris, Rodrigo A España, Jason L Locke, Joanne K Konstantopoulos, Jamie H Rose, Rong Chen, Sara R Jone. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 26. 2014-09-23. PMID:24979798. |
using this approach, we have pinpointed the dat as a critical governor of diurnal variation in extracellular dopamine tone and, as a consequence, influencing the magnitude of electrically stimulated dopamine release. |
2014-09-23 |
2023-08-13 |
mouse |
| Jordy van Enkhuizen, Mark A Geyer, Adam L Halberstadt, Xiaoxi Zhuang, Jared W Youn. Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder. Journal of affective disorders. vol 155. 2014-09-17. PMID:24287168. |
a similar bpm profile is observed in mice that are hyperdopaminergic due to reduced dopamine transporter (dat) functioning. |
2014-09-17 |
2023-08-12 |
mouse |
| Kouta Kanno, Hiroki Kokubo, Aki Takahashi, Tsuyoshi Koide, Shoichi Ishiur. Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice. Journal of neuroscience research. vol 92. issue 3. 2014-09-10. PMID:24431082. |
we demonstrated previously that hesr1 and hesr2 modified expression of the dopamine transporter (dat) reporter gene. |
2014-09-10 |
2023-08-12 |
mouse |
| Kouta Kanno, Hiroki Kokubo, Aki Takahashi, Tsuyoshi Koide, Shoichi Ishiur. Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice. Journal of neuroscience research. vol 92. issue 3. 2014-09-10. PMID:24431082. |
furthermore, dat mrna was downregulated in hesr1 ko mice, whereas the dopamine d1 and d2 receptors were comparable. |
2014-09-10 |
2023-08-12 |
mouse |
| Mario Riverol, Cristina Ordóñez, María Collantes, Carla DiCaudo, Iván Peñuelas, Javier Arbizu, Irene Marcilla, María R Luqui. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076099. |
striatal dopamine transporter (dat) content, tyrosine hydroxylase (th) content and aromatic l-amino acid decarboxylase (aadc) content were assessed. |
2014-09-03 |
2023-08-12 |
monkey |
| Paul Cumming, Simone Maschauer, Patrick J Riss, Nuska Tschammer, Stefanie K Fehler, Markus R Heinrich, Torsten Kuwert, Olaf Prant. Radiosynthesis and validation of ¹⁸F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 7. 2014-09-02. PMID:24714035. |
to date there is no validated, (18)f-labeled dopamine transporter (dat) radiotracer with a rapid kinetic profile suitable for preclinical small-animal positron emission tomography (pet) studies in rodent models of human basal ganglia disease. |
2014-09-02 |
2023-08-13 |
human |
| Andres Urrutia, Noelia Granado, Maria Dolores Gutierrez-Lopez, Rosario Moratalla, Esther O'Shea, Maria Isabel Colad. The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum. The international journal of neuropsychopharmacology. vol 17. issue 2. 2014-08-26. PMID:24103647. |
this compound also failed to prevent the long-term loss of dopamine levels and dat observed 7 d following meth injection. |
2014-08-26 |
2023-08-12 |
mouse |
| Ying Wu, Xiaodong Na, Ying Zang, Yu Cui, Wenjun Xin, Ruiping Pang, Lijun Zhou, Xuhong Wei, Yongyong Li, Xianguo Li. Upregulation of tumor necrosis factor-alpha in nucleus accumbens attenuates morphine-induced rewarding in a neuropathic pain model. Biochemical and biophysical research communications. vol 449. issue 4. 2014-08-26. PMID:24845379. |
furthermore, sni reduced dopamine (da) level and upregulated dopamine transporter (dat) in the nacc, but did not affect total tyrosine hydroxylase (th) or phospho-th (p-th), a rate-limiting enzyme of catecholamine biosynthesis, in ventral tegmental area (vta). |
2014-08-26 |
2023-08-13 |
mouse |
| Natsuka Tashiro, Kaneyasu Nishimura, Kanako Daido, Tomoe Oka, Mio Todo, Asami Toshikawa, Jun Tsushima, Kazuyuki Takata, Eishi Ashihara, Kanji Yoshimoto, Kiyokazu Agata, Yoshihisa Kitamur. Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica. Biochemical and biophysical research communications. vol 449. issue 4. 2014-08-26. PMID:24858686. |
we identified a planarian dat gene, named it d. japonica dopamine transporter (djdat), and analyzed its expression and function. |
2014-08-26 |
2023-08-13 |
Not clear |
| Emis M Akbari, Soaleha Shams, Hiwote T Belay, Mo Kaiguo, Zak Razak, Clement F Kent, Tim Westwood, Marla B Sokolowski, Alison S Flemin. The effects of parity and maternal behavior on gene expression in the medial preoptic area and the medial amygdala in postpartum and virgin female rats: A microarray study. Behavioral neuroscience. vol 127. issue 6. 2014-08-22. PMID:24341715. |
within the mpoa there were significant main effects of pup exposure for the dopamine-related genes (drd4 and dopamine transporter, dat), the glucocorticoid-related gene (cypx1b1a), the opioid receptor μ-1 gene (oprm1) and the gamma-aminobutyric acid (gaba) receptor gene (gababrid). |
2014-08-22 |
2023-08-12 |
rat |
| Thomas Del'Guidice, Morgane Lemasson, Adeline Etiévant, Stella Manta, Luiz Alexandre V Magno, Guy Escoffier, François S Roman, Jean-Martin Beaulie. Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice. Psychopharmacology. vol 231. issue 1. 2014-08-18. PMID:23912772. |
psychostimulants such as amphetamine and methylphenidate, which target the dopamine transporter (dat), are the most frequently used drugs for the treatment of hyperactivity and cognitive deficits in humans with attention deficit hyperactivity disorder (adhd). |
2014-08-18 |
2023-08-12 |
mouse |
| Jianjun Sun, Evguenia Kouranova, Xiaoxia Cui, Robert H Mach, Jinbin X. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Neuroscience letters. vol 557 Pt B. 2014-08-18. PMID:24157858. |
here we characterized dj-1 and pink1 knockout rats both through expression profiling and using quantitative autoradiography to measure the densities of the dopamine d1, d2, d3 receptors, vesicular monoamine transporter type-2 (vmat2) and dopamine transporter (dat) in the striatum of transgenic rats and wild type controls. |
2014-08-18 |
2023-08-12 |
rat |
| Paolo Taurisano, Giuseppe Blasi, Raffaella Romano, Fabio Sambataro, Leonardo Fazio, Barbara Gelao, Gianluca Ursini, Luciana Lo Bianco, Annabella Di Giorgio, Francesca Ferrante, Apostolos Papazacharias, Annamaria Porcelli, Lorenzo Sinibaldi, Teresa Popolizio, Alessandro Bertolin. DAT by perceived MC interaction on human prefrontal activity and connectivity during emotion processing. Social cognitive and affective neuroscience. vol 8. issue 8. 2014-08-15. PMID:22842906. |
reuptake of dopamine from the synapse is performed by the dopamine transporter (dat), whose abundance is predicted by variation in its gene (dat 3'vntr; 10 > 9-repeat alleles). |
2014-08-15 |
2023-08-12 |
human |
| Sekar Sathiya, Vijayan Ranju, Periyathambi Kalaivani, Raju Jyothi Priya, Haridass Sumathy, Adoor Gopalan Sunil, Chidambaram Saravana Bab. Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice. Neuropharmacology. vol 73. 2014-08-13. PMID:23747572. |
in the present study, the effect of tel on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) induced motor dysfunctions and dopaminergic degeneration was ascertained through investigating the alterations in protein expression of dopamine transporter (dat), tyrosine hydroxylase (th) and syn in c57bl/6j mouse. |
2014-08-13 |
2023-08-12 |
mouse |
| Kirsty Danielson, Fraser Putt, Penelope Truman, Bronwyn M Kivel. The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain. Synapse (New York, N.Y.). vol 68. issue 2. 2014-08-11. PMID:23999947. |
this study has examined the acute and chronic effects of nicotine and a tobacco extract (tpm) on dopamine uptake by the dopamine and norepinephrine transporters (dat and net) ex vivo using rotating disk electrode voltammetry, and quantified dat and net protein and mrna expression in key brain regions. |
2014-08-11 |
2023-08-12 |
rat |
| Neivo Silva, Claudia M Szobot, Ming C Shih, Marcelo Q Hoexter, Carlos Eduardo Anselmi, Flavio Pechansky, Rodrigo A Bressan, Luis Augusto Rohd. Searching for a neurobiological basis for self-medication theory in ADHD comorbid with substance use disorders: an in vivo study of dopamine transporters using (99m)Tc-TRODAT-1 SPECT. Clinical nuclear medicine. vol 39. issue 2. 2014-08-06. PMID:23856832. |
although several studies have shown changes in striatal dopamine transporter (dat) density in these disorders, little is known about the neurobiological basis of the comorbidity. |
2014-08-06 |
2023-08-12 |
human |
| William C Motel, Jason R Healy, Eddy Viard, Buddy Pouw, Kelly Martin, Rae R Matsumoto, Andrew Coo. Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands. Bioorganic & medicinal chemistry letters. vol 23. issue 24. 2014-07-25. PMID:24211020. |
in the course of our studies to determine the optimal substituents in the σ2-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (dat), yielding a highly selective dat ligand. |
2014-07-25 |
2023-08-12 |
Not clear |