| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M B Wigestrand, M Stenberg, S I Walaas, F Fonnum, P L Andersso. Non-dioxin-like PCBs inhibit [(3)H]WIN-35,428 binding to the dopamine transporter: a structure-activity relationship study. Neurotoxicology. vol 39. 2014-07-23. PMID:23933243. |
in a previous study we demonstrated that ndl-pcbs inhibit uptake of dopamine into rat brain synaptosomes, an effect most likely mediated by inhibition of the dopamine transporter (dat). |
2014-07-23 |
2023-08-12 |
rat |
| Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Hu, Wenge Cui, Yuh-Lin Yang, Ulhas Bhatt, Aruna Sambandam, Matthew Isherwood, Larry Yet, Michael T Herr, Sarah Ebeltoft, Carla Hassler, Linda Fleming, Anthony D Pechulis, Anne Payen-Fornicola, Nicholas Holman, Dennis Milanowski, Ian Cotterill, Vadim Mozhaev, Yuri Khmelnitsky, Peter R Guzzo, Bruce J Sargent, Bruce F Molino, Richard Olson, Dalton King, Snjezana Lelas, Yu-Wen Li, Kim Johnson, Thaddeus Molski, Anitra Orie, Alicia Ng, Roy Haskell, Wendy Clarke, Robert Bertekap, Jonathan O'Connell, Nicholas Lodge, Michael Sinz, Stephen Adams, Robert Zaczek, John E Maco. Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS medicinal chemistry letters. vol 5. issue 7. 2014-07-22. PMID:25050161. |
a series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) was discovered. |
2014-07-22 |
2023-08-13 |
mouse |
| Erin S Calipari, Mark J Ferris, Cody A Siciliano, Benjamin A Zimmer, Sara R Jone. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 349. issue 2. 2014-07-18. PMID:24566123. |
previous literature investigating neurobiological adaptations following cocaine self-administration has shown that high, continuous levels of cocaine intake (long access; lga) results in reduced potency of cocaine at the dopamine transporter (dat), whereas an intermittent pattern of cocaine administration (intermittent access; inta) results in sensitization of cocaine potency at the dat. |
2014-07-18 |
2023-08-12 |
Not clear |
| Erin S Calipari, Mark J Ferris, Ali Salahpour, Marc G Caron, Sara R Jone. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nature communications. vol 4. 2014-07-15. PMID:24193139. |
here we show that mph self-administration in rats increases dopamine transporter (dat) levels and enhances the potency of mph and amphetamine on dopamine responses and drug-seeking behaviours, without altering cocaine effects. |
2014-07-15 |
2023-08-12 |
mouse |
| Xin Li, Tao Feng, Qiao-hong Ouyang, Hong-xia Zhang, Fang L. [Comparative study on the diagnostic value of positron emission tomography and transcranial sonography in the diagnosis of Parkinson's disease]. Zhonghua yi xue za zhi. vol 93. issue 25. 2014-07-14. PMID:24169240. |
to evaluate the consistency of dopamine transporter (dat) positron emission tomography (pet) versus transcranial sonography (tcs) of parkinson's disease (pd) patients. |
2014-07-14 |
2023-08-12 |
Not clear |
| Ji Seon Kim, Jong Min Kim, Yu Kyeong Kim, Sang Eun Kim, Ji Young Yun, Beom S Jeo. Striatal dopaminergic functioning in patients with sporadic and hereditary spastic paraplegias with parkinsonism. Journal of Korean medical science. vol 28. issue 11. 2014-07-14. PMID:24265532. |
in the present study, the clinical features of patients with ssp/hsp were investigated, and nigrostriatal dopaminergic binding potential was assessed using dopamine transporter (dat) single-photon emission computer tomography (spect). |
2014-07-14 |
2023-08-12 |
human |
| Sven R Suwijn, Kora de Bruin, Rob M A de Bie, Jan Booi. The role of SPECT imaging of the dopaminergic system in translational research on Parkinson's disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262177. |
imaging of the dopaminergic system with single photon emission computed tomography (spect), and particularly of the dopamine transporter (dat) located in the striatum, is a well accepted tool in clinical practice to confirm or exclude loss of nigrostriatal dopamine (da) neurons in patients suspected to suffer from parkinson's disease (pd). |
2014-07-11 |
2023-08-12 |
human |
| Sven R Suwijn, Kora de Bruin, Rob M A de Bie, Jan Booi. The role of SPECT imaging of the dopaminergic system in translational research on Parkinson's disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262177. |
spect techniques were developed successfully to image neurotransmitter systems, including the presynaptic dat and postsynaptic dopamine d2/3 receptors, in rat and mouse models of pd. |
2014-07-11 |
2023-08-12 |
human |
| Sophie Sérrière, Clovis Tauber, Johnny Vercouillie, Denis Guilloteau, Jean-Bernard Deloye, Lucette Garreau, Laurent Galineau, Sylvie Chalo. In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999. Nuclear medicine and biology. vol 41. issue 1. 2014-07-10. PMID:24210285. |
we examined whether [(18)f]lbt-999 ((e)-n-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (pet) tracer for the quantification of the dopamine transporter (dat) in the healthy rat brain. |
2014-07-10 |
2023-08-12 |
rat |
| Kenneth Marek, John Seibyl, Shirley Eberly, David Oakes, Ira Shoulson, Anthony E Lang, Chris Hyson, Danna Jenning. Longitudinal follow-up of SWEDD subjects in the PRECEPT Study. Neurology. vol 82. issue 20. 2014-07-10. PMID:24759846. |
to compare the clinical and imaging characteristics of those precept (parkinson research examination of cep-1347 trial) subjects with a scan without evidence of dopaminergic deficit (swedd) to those with dopamine transporter (dat) deficit scans at study baseline and during a 22-month follow-up. |
2014-07-10 |
2023-08-13 |
human |
| Liang Liu, Guozhen Yuan, Zaohuo Cheng, Guofu Zhang, Xiaowei Liu, Huifang Zhan. Identification of the mRNA expression status of the dopamine D2 receptor and dopamine transporter in peripheral blood lymphocytes of schizophrenia patients. PloS one. vol 8. issue 9. 2014-07-07. PMID:24086483. |
the aim of this study was to detect the mrna expression levels of the dopamine d2 receptor (drd2) and dopamine transporter (dat) in peripheral blood leukocytes (pbls) of schizophrenia patients and to explore the relationship between the mrna expression levels and the clinical symptoms of schizophrenia. |
2014-07-07 |
2023-08-12 |
Not clear |
| Sucharita S Somkuwar, Chloe J Jordan, Kathleen M Kantak, Linda P Dwoski. Adolescent atomoxetine treatment in a rodent model of ADHD: effects on cocaine self-administration and dopamine transporters in frontostriatal regions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23822950. |
using the spontaneously hypertensive rat (shr) model of adhd, we reported that adolescent treatment with the stimulant methylphenidate, a dopamine (dat) and norepinephrine (net) transporter inhibitor, enhanced cocaine self-administration during adulthood, and was associated with increased dat function in mpfc. |
2014-07-01 |
2023-08-12 |
rat |
| Shigeyuki Yamamoto, Hiroyuki Ohba, Shingo Nishiyama, Norihiro Harada, Takeharu Kakiuchi, Hideo Tsukada, Edward F Domin. Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23880871. |
the effect of ketamine on the serotonin 1a receptor (5-ht1a-r) and dopamine transporter (dat) was also investigated in the same subjects studied with [(11)c]dasb. |
2014-07-01 |
2023-08-12 |
human |
| Rheaclare Fraser, Yongyue Chen, Bipasha Guptaroy, Kathryn D Luderman, Stephanie L Stokes, Asim Beg, Louis J DeFelice, Margaret E Gneg. An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter. Molecular pharmacology. vol 86. issue 1. 2014-06-30. PMID:24753048. |
the dopamine transporter (dat) reversibly transports dopamine (da) through a series of conformational transitions. |
2014-06-30 |
2023-08-13 |
human |
| Nicolas W Schuck, Peter A Frensch, Brit-Maren M Schjeide, Julia Schröder, Lars Bertram, Shu-Chen L. Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning. Neuropsychologia. vol 51. issue 13. 2014-06-25. PMID:24035787. |
of specific interest, polymorphisms of the dopamine- and camp-regulated neuronal phosphoprotein (darpp-32, rs907094) and dopamine transporter (dat, vntr) genes showed interactive effects on overall rts and verbal recall of the sequence in older but not in younger adults. |
2014-06-25 |
2023-08-12 |
human |
| Elizabeth D Cummins, Stephen B Griffin, Katherine C Burgess, Daniel J Peterson, Bryce D Watson, Matthew A Buendia, Gregg D Stanwood, Russell W Brow. Methylphenidate place conditioning in adolescent rats: an analysis of sex differences and the dopamine transporter. Behavioural brain research. vol 257. 2014-06-25. PMID:24084582. |
in two experiments, we analyzed the effects of methylphenidate (mph) on conditioned place preference (cpp) in adolescent male and female rats, and the effects of mph on the dopamine transporter (dat). |
2014-06-25 |
2023-08-12 |
rat |
| Elizabeth D Cummins, Stephen B Griffin, Katherine C Burgess, Daniel J Peterson, Bryce D Watson, Matthew A Buendia, Gregg D Stanwood, Russell W Brow. Methylphenidate place conditioning in adolescent rats: an analysis of sex differences and the dopamine transporter. Behavioural brain research. vol 257. 2014-06-25. PMID:24084582. |
analysis of the dat revealed that animals conditioned with the 5mg/kg dose of mph demonstrated a significant decrease of the dopamine transporter (dat) in the nucleus accumbens and striatum compared to controls. |
2014-06-25 |
2023-08-12 |
rat |
| Hee Kyung Park, Sun J Chun. New perspective on parkinsonism in frontotemporal lobar degeneration. Journal of movement disorders. vol 6. issue 1. 2014-06-24. PMID:24868417. |
dopamine transporter (dat) imaging revealed decreased uptake of dat, and imaging findings indicated atrophic changes of the basal ganglia. |
2014-06-24 |
2023-08-13 |
human |
| Ying Liu, Mei Han, Xingdang Liu, Yanping Deng, Yu Li, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Jinlong Ga. Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23715641. |
previous imaging studies have indicated that the levels of the dopamine transporter (dat) are reduced in the brains of heroin users. |
2014-06-23 |
2023-08-12 |
human |
| P J Hamilton, N G Campbell, S Sharma, K Erreger, F Herborg Hansen, C Saunders, A N Belovich, M A Sahai, E H Cook, U Gether, H S McHaourab, H J G Matthies, J S Sutcliffe, A Gall. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Molecular psychiatry. vol 18. issue 12. 2014-06-23. PMID:23979605. |
the dopamine transporter (dat) is a presynaptic membrane protein that regulates dopaminergic tone in the central nervous system by mediating the high-affinity reuptake of synaptically released da, making it a crucial regulator of da homeostasis. |
2014-06-23 |
2023-08-12 |
human |