| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pitna Kim, Chang Soon Choi, Jin Hee Park, So Hyun Joo, Soo Young Kim, Hyun Myung Ko, Ki Chan Kim, Se Jin Jeon, Seung Hwa Park, Seol-Heui Han, Jong Hoon Ryu, Jae Hoon Cheong, Jung Yeol Han, Ki Narm Ko, Chan Young Shi. Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring. Journal of neuroscience research. vol 92. issue 5. 2014-11-04. PMID:24510599. |
as a mechanistic link, both protein and mrna expression of dopamine transporter (dat), a key determinant of adhd-like phenotypes in experimental animals and humans, were significantly decreased by paternal etoh exposure in cerebral cortex and striatum of offspring mice along with increased methylation of a cpg region of the dat gene promoter. |
2014-11-04 |
2023-08-12 |
mouse |
| Jing Bai, Kevin Blot, Eleni Tzavara, Marika Nosten-Bertrand, Bruno Giros, Satoru Otan. Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23236206. |
combined with the well-documented involvement of dopamine transporters (dats) in the regulation of pfc-dependent cognitive processes, it is important to test whether this form of plasticity can be modulated by dat activity in the pfc. |
2014-10-29 |
2023-08-12 |
rat |
| Jing Bai, Kevin Blot, Eleni Tzavara, Marika Nosten-Bertrand, Bruno Giros, Satoru Otan. Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23236206. |
the excess amount of extracellular dopamine caused by dat inhibition acted critically on d1-like receptors to impair depression. |
2014-10-29 |
2023-08-12 |
rat |
| Jing Bai, Kevin Blot, Eleni Tzavara, Marika Nosten-Bertrand, Bruno Giros, Satoru Otan. Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 4. 2014-10-29. PMID:23236206. |
we suggest that abnormal increases of the extracellular dopamine level by dat inhibition impair synaptic depression in the pfc through over-stimulation of d1-like receptors. |
2014-10-29 |
2023-08-12 |
rat |
| Yunsung Nam, Eun-Joo Shin, Seung Woo Shin, Yong Kwang Lim, Jong Ho Jung, Jeong Hyun Lee, Jong Ryul Ha, Jong Seok Chae, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang, Hyoung-Chun Ki. YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24394491. |
furthermore, yy162 attenuated reductions in p-trkb, bdnf, dopamine transporter (dat) and norepinephrine transporter (net) expression. |
2014-10-28 |
2023-08-12 |
mouse |
| Floor van Heesch, Jolanda Prins, Jan Pieter Konsman, Gerdien A H Korte-Bouws, Koen G C Westphal, Joanna Rybka, Berend Olivier, Aletta D Kraneveld, S Mechiel Kort. Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice. European journal of pharmacology. vol 725. 2014-10-28. PMID:24444442. |
less is known about the effect of lps on the biological activity of dopamine transporters (dat) and norepinephrine transporters (net). |
2014-10-28 |
2023-08-12 |
mouse |
| Raja Settivari, Natalia VanDuyn, Jennifer LeVora, Richard Nas. The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. Neurotoxicology. vol 38. 2014-10-24. PMID:23721876. |
finally, we show that the mn-induced da neuron degeneration is independent of the dopamine transporter dat, but is largely dependent on the caspases ced-3 and the novel caspase csp-1. |
2014-10-24 |
2023-08-12 |
caenorhabditis_elegans |
| Lieuwe Appel, Mats Bergström, Jørgen Buus Lassen, Bengt Långströ. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 2. 2014-10-21. PMID:24239329. |
this positron emission tomography (pet) study, using [¹¹c]βcit-fe, aimed to assess the degree of the dopamine transporter (dat) occupancy, at constant te plasma levels, following different oral, multiple doses of te during totally 8-12 days. |
2014-10-21 |
2023-08-12 |
human |
| Lieuwe Appel, Mats Bergström, Jørgen Buus Lassen, Bengt Långströ. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 2. 2014-10-21. PMID:24239329. |
further, these results suggest that the previously reported dose-dependent weight loss, in te treated subjects, was in part mediated by an up-regulation of dopaminergic pathways due to enhanced amounts of synaptic dopamine after blockade of dat. |
2014-10-21 |
2023-08-12 |
human |
| Gilberto Gerra, Lorenzo Somaini, Claudio Leonardi, Elena Cortese, Icro Maremmani, Matteo Manfredini, Claudia Donnin. Association between gene variants and response to buprenorphine maintenance treatment. Psychiatry research. vol 215. issue 1. 2014-10-17. PMID:24274990. |
the frequency of dopamine transporter (dat) gene polymorphism (slc6a3/dat1), allele 10, was evidently much higher in "non-responder" than in "responder" individuals (64.9% vs. 55.93%) whereas the frequency of the category of other alleles (6, 7 and 11) was higher in responder than in non-responder individuals (11.02% vs. 2.13% respectively). |
2014-10-17 |
2023-08-12 |
Not clear |
| Jonathon A Nye, John R Votaw, J Douglas Bremner, Margaret R Davis, Ronald J Voll, Vernon M Camp, Mark M Goodma. Quantification of dopamine transporter density with [18F]FECNT PET in healthy humans. Nuclear medicine and biology. vol 41. issue 3. 2014-10-15. PMID:24533985. |
fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane ([(18)f]fecnt) binds reversibly to the dopamine transporter (dat) with high selectivity. |
2014-10-15 |
2023-08-12 |
human |
| Walter Sandtner, Diethart Schmid, Klaus Schicker, Klaus Gerstbrein, Xaver Koenig, Felix P Mayer, Stefan Boehm, Michael Freissmuth, Harald H Sitt. A quantitative model of amphetamine action on the 5-HT transporter. British journal of pharmacology. vol 171. issue 4. 2014-10-14. PMID:24251585. |
amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (dat), noradrenaline (net) and 5-ht (sert); influx of amphetamine leads to efflux of substrates. |
2014-10-14 |
2023-08-12 |
Not clear |
| Olli Kärkkäinen, Jukka Kupila, Merja Häkkinen, Virpi Laukkanen, Erkki Tupala, Hannu Kautiainen, Jari Tiihonen, Markus Storvi. AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: a whole-hemisphere autoradiography study. Psychiatry research. vol 214. issue 3. 2014-10-10. PMID:24119876. |
there was also a significant negative correlation between [(3)h] ampa binding and previously published results of dopamine transporter (dat) density in the acc in these same brain samples (r=-0.95, p=0.001). |
2014-10-10 |
2023-08-12 |
human |
| Haya Kisos, Tziona Ben-Gedalya, Ronit Sharo. The clathrin-dependent localization of dopamine transporter to surface membranes is affected by α-synuclein. Journal of molecular neuroscience : MN. vol 52. issue 2. 2014-10-06. PMID:24048740. |
abnormalities in α-synuclein (α-syn) and dopamine transporter (dat) are implicated in the pathogenesis of pd. |
2014-10-06 |
2023-08-12 |
mouse |
| John S Markowitz, Hao-Jie Zhu, Kennerly S Patric. Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability. Journal of child and adolescent psychopharmacology. vol 23. issue 10. 2014-10-06. PMID:24261661. |
a wide range of mph analogues (dl-α-[2-piperidyl]-phenylacetic acid esters) have been synthesized with the dopamine transporter (dat) and norepinephrine transporter (net) as principle neuropharmacological targets. |
2014-10-06 |
2023-08-12 |
Not clear |
| Freja H Hansen, Tina Skjørringe, Saiqa Yasmeen, Natascha V Arends, Michelle A Sahai, Kevin Erreger, Thorvald F Andreassen, Marion Holy, Peter J Hamilton, Viruna Neergheen, Merete Karlsborg, Amy H Newman, Simon Pope, Simon J R Heales, Lars Friberg, Ian Law, Lars H Pinborg, Harald H Sitte, Claus Loland, Lei Shi, Harel Weinstein, Aurelio Galli, Lena E Hjermind, Lisbeth B Møller, Ulrik Gethe. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of clinical investigation. vol 124. issue 7. 2014-10-06. PMID:24911152. |
the sodium-coupled dopamine transporter (dat) controls dopamine homeostasis, but its contribution to disease remains poorly understood. |
2014-10-06 |
2023-08-13 |
Not clear |
| Freja H Hansen, Tina Skjørringe, Saiqa Yasmeen, Natascha V Arends, Michelle A Sahai, Kevin Erreger, Thorvald F Andreassen, Marion Holy, Peter J Hamilton, Viruna Neergheen, Merete Karlsborg, Amy H Newman, Simon Pope, Simon J R Heales, Lars Friberg, Ian Law, Lars H Pinborg, Harald H Sitte, Claus Loland, Lei Shi, Harel Weinstein, Aurelio Galli, Lena E Hjermind, Lisbeth B Møller, Ulrik Gethe. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of clinical investigation. vol 124. issue 7. 2014-10-06. PMID:24911152. |
in heterologous cells, both dat variants exhibited markedly reduced dopamine uptake capacity but preserved membrane targeting, consistent with impaired catalytic activity. |
2014-10-06 |
2023-08-13 |
Not clear |
| Ryo Shimada, Keiichi Abe, Rui Furutani, Kazuhiko Kibayash. Changes in dopamine transporter expression in the midbrain following traumatic brain injury: an immunohistochemical and in situ hybridization study in a mouse model. Neurological research. vol 36. issue 3. 2014-09-25. PMID:24512017. |
dopamine transporter (dat) is mainly expressed in the sn, ventral tegmental area (vta), and retrorubral field (rrf) of the ventral midbrain. |
2014-09-25 |
2023-08-12 |
mouse |
| Yoshiyuki Kasahara, Yumiko Kubo, Ichiro Sor. [Analysis of dopamine transporter knockout mice as an animal model of AD/HD]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 5-6. 2014-09-25. PMID:25069256. |
dopamine transporter (dat) knockout (ko) mice have been suggested to constitute an animal model of ad/hd. |
2014-09-25 |
2023-08-13 |
mouse |
| Yoshiyuki Kasahara, Yumiko Kubo, Ichiro Sor. [Analysis of dopamine transporter knockout mice as an animal model of AD/HD]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 5-6. 2014-09-25. PMID:25069256. |
dat ko mice exhibit persistently and profoundly elevated extracellular dopamine levels in the striatum and nucleus accumbens. |
2014-09-25 |
2023-08-13 |
mouse |