| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tang-Kai Yin, Bi-Fang Lee, Yen Kuang Yang, Nan-Tsing Chi. Differences of various region-of-interest methods for measuring dopamine transporter availability using 99mTc-TRODAT-1 SPECT. TheScientificWorldJournal. vol 2014. 2015-03-30. PMID:25101323. |
this study was to investigate whether various region-of-interest (roi) methods for measuring dopamine transporter (dat) availabilities by single photon emission computed tomography (spect) are statistically different, whether results of medical research are thereby influenced, and causes of these differences. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lieuwe Appel, My Jonasson, Torsten Danfors, Dag Nyholm, Håkan Askmark, Mark Lubberink, Jens Sörense. Use of 11C-PE2I PET in differential diagnosis of parkinsonian disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 2. 2015-03-30. PMID:25593112. |
a dual examination using (123)i-fp-cit ((123)i-n-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane, or (123)i-ioflupane) spect and(18)f-fdg pet provides complementary information on dopamine transporter (dat) availability and overall brain functional activity, respectively. |
2015-03-30 |
2023-08-13 |
Not clear |
| Philippe Huot, Susan H Fox, Jonathan M Brotchi. Monoamine reuptake inhibitors in Parkinson's disease. Parkinson's disease. vol 2015. 2015-03-26. PMID:25810948. |
despite wide discrepancy in the methodology of the studies reviewed, the following conclusions can be drawn: (1) selective serotonin transporter (sert), selective noradrenaline transporter (net), and dual sert/net inhibitors are effective against pd depression; (2) selective dopamine transporter (dat) and dual dat/net inhibitors exert an anti-parkinsonian effect when administered as monotherapy but do not enhance the anti-parkinsonian actions of l-3,4-dihydroxyphenylalanine (l-dopa); (3) dual dat/sert inhibitors might enhance the anti-parkinsonian actions of l-dopa without worsening dyskinesia; (4) triple dat/net/sert inhibitors might exert an anti-parkinsonian action as monotherapy and might enhance the anti-parkinsonian effects of l-dopa, though at the expense of worsening dyskinesia. |
2015-03-26 |
2023-08-13 |
Not clear |
| Grazia Giana, Emilia Romano, Maria Cristina Porfirio, Roberto D'Ambrosio, Silvia Giovinazzo, Miriam Troianiello, Eleonora Barlocci, Domenica Travaglini, Oleg Granstrem, Esterina Pascale, Luigi Tarani, Paolo Curatolo, Giovanni Laviola, Walter Adrian. Detection of auto-antibodies to DAT in the serum: interactions with DAT genotype and psycho-stimulant therapy for ADHD. Journal of neuroimmunology. vol 278. 2015-03-23. PMID:25468771. |
we evaluated the auto-antibodies against dopamine transporter (dat aabs) in 61 children (46 adhd who met dsm-iv-tr criteria, 15 healthy controls). |
2015-03-23 |
2023-08-13 |
Not clear |
| Iroise Dumontheil, Sarah K G Jensen, Nicholas W Wood, Meghan L Meyer, Matthew D Lieberman, Sarah-Jayne Blakemor. Preliminary investigation of the influence of dopamine regulating genes on social working memory. Social neuroscience. vol 9. issue 5. 2015-03-09. PMID:24889756. |
here, we investigated in 131 healthy adults whether dopamine is similarly involved in social wm by testing whether social and nonsocial wm are influenced by genetic variants in three genes coding for molecules regulating the availability of dopamine in the brain: catechol-o-methyltransferase (comt), dopamine active transporter (dat), and monoamine-oxidase a (maoa). |
2015-03-09 |
2023-08-13 |
Not clear |
| Edson Bor-Seng-Shu, Andre C Felicio, Pedro Braga-Neto, Ilza Rosa Batista, Wellingson Silva Paiva, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Luis Augusto Franco de Andrade, Orlando Graziani Povoas Barsottini, Ming Chi Shih, Rodrigo A Bressan, Henrique Ballalai Ferra. Dopamine transporter imaging using 99mTc-TRODAT-1 SPECT in Parkinson's disease. Medical science monitor : international medical journal of experimental and clinical research. vol 20. 2015-03-09. PMID:25109468. |
although the decrease in striatal dopamine transporter (dat) density has been described in north american, european, and asian parkinson's disease (pd) patients, studies on this issue are required in the rest of the world. |
2015-03-09 |
2023-08-13 |
Not clear |
| Steven J O'dell, John F Marshal. Running wheel exercise before a binge regimen of methamphetamine does not protect against striatal dopaminergic damage. Synapse (New York, N.Y.). vol 68. issue 9. 2015-03-06. PMID:24899064. |
repeated administration of methamphetamine (mamph) to rodents in a single-day "binge" dosing regimen produces long-lasting damage to forebrain dopaminergic nerve terminals as measured by decreases in tissue dopamine (da) content and levels of the plasmalemmal da transporter (dat). |
2015-03-06 |
2023-08-13 |
rat |
| J R Gugusheff, Z Y Ong, B S Muhlhausle. Naloxone treatment alters gene expression in the mesolimbic reward system in 'junk food' exposed offspring in a sex-specific manner but does not affect food preferences in adulthood. Physiology & behavior. vol 133. 2015-02-19. PMID:24727340. |
we measured mrna expression of key components of the reward pathway (mu-opioid receptor, proenkephalin, tyrosine hydroxylase, d1 and d2 receptors and the dopamine active transporter (dat)) in the nucleus accumbens (nac) and ventral tegmental area (vta) of the offspring of control and cafeteria fed (jf) dams at weaning and after a 10-day naloxone treatment post-weaning and determined food preferences in adulthood in the remaining offspring. |
2015-02-19 |
2023-08-13 |
Not clear |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
the primary target of psychostimulants such as amphetamine and methamphetamine is the dopamine transporter (dat), the major regulator of extracellular dopamine levels in the brain. |
2015-02-19 |
2023-08-13 |
Not clear |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
we further examined the unique mechanisms by which amphetamine and methamphetamine regulate dat function and dopamine neurotransmission; in the present study we examined the impact of extracellular and intracellular amphetamine and methamphetamine on the spontaneous firing of cultured midbrain dopaminergic neurons and isolated dat-mediated current. |
2015-02-19 |
2023-08-13 |
Not clear |
| Lars Borre, Thorvald F Andreassen, Lei Shi, Harel Weinstein, Ulrik Gethe. The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of biological chemistry. vol 289. issue 37. 2015-02-19. PMID:25063810. |
the dopamine transporter (dat) belongs to the family of neurotransmitter:sodium symporters and controls dopamine (da) homeostasis by mediating na(+)- and cl(-)-dependent reuptake of da. |
2015-02-19 |
2023-08-13 |
xenopus_laevis |
| Yu-Wen Li, Shaun Langdon, Rick Pieschl, Todd Strong, Robert N Wright, Kenneth Rohrbach, Snjezana Lelas, Nicholas J Lodg. Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats. European journal of pharmacology. vol 737. 2015-02-13. PMID:24821570. |
at higher doses, sibutramine produces thermogenesis; dat inhibition and activation of dopamine d1 receptors are required for this effect. |
2015-02-13 |
2023-08-13 |
rat |
| John D Robinson, Christopher D Howard, Elissa D Pastuzyn, Diane L Byers, Kristen A Keefe, Paul A Garri. Methamphetamine-induced neurotoxicity disrupts pharmacologically evoked dopamine transients in the dorsomedial and dorsolateral striatum. Neurotoxicity research. vol 26. issue 2. 2015-02-12. PMID:24562969. |
here, we further investigated this disruption by assessing effects of meth pretreatment on da transients elicited by a drug cocktail of raclopride, a d2 da receptor antagonist, and nomifensine, an inhibitor of the dopamine transporter (dat). |
2015-02-12 |
2023-08-12 |
rat |
| Rejwi Acharya Dahal, Akula Bala Pramod, Babita Sharma, Danielle Krout, James D Foster, Joo Hwan Cha, Jianjing Cao, Amy Hauck Newman, John R Lever, Roxanne A Vaughan, L Keith Henr. Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. The Journal of biological chemistry. vol 289. issue 43. 2015-02-12. PMID:25179220. |
the dopamine transporter (dat) functions as a key regulator of dopaminergic neurotransmission via re-uptake of synaptic dopamine (da). |
2015-02-12 |
2023-08-13 |
rat |
| Anders V Pedersen, Thorvald F Andreassen, Claus J Lolan. A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter. The Journal of biological chemistry. vol 289. issue 50. 2015-02-12. PMID:25339174. |
in the human dopamine transporter (dat), the corresponding residues are arg-85 and asp-476. |
2015-02-12 |
2023-08-13 |
human |
| Tanuja Bordia, Matthew McGregor, Roger L Papke, Michael W Decker, J Michael McIntosh, Maryka Qui. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Experimental neurology. vol 263. 2015-02-09. PMID:25261754. |
the striatal dopamine transporter (dat), a marker of dopaminergic integrity, was reduced ~70% with lesioning. |
2015-02-09 |
2023-08-13 |
rat |
| Murad Hossain, Rochelle N Wickramasekara, Lucia Carvell. β-Phenylethylamine requires the dopamine transporter to increase extracellular dopamine in Caenorhabditis elegans dopaminergic neurons. Neurochemistry international. vol 73. 2015-02-02. PMID:24161617. |
a number of in vitro and behavioral studies suggest the dopamine transporter (dat) plays a role in the effects generated by βpea, however the mechanism through which βpea affects dat has not yet been elucidated. |
2015-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| Jon D Gaffaney, Madhur Shetty, Bruce Felts, Akula-Bala Pramod, James D Foster, L Keith Henry, Roxanne A Vaugha. Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. Neurochemistry international. vol 73. 2015-02-02. PMID:24269640. |
ligand-induced changes in the conformation of extracellular loop (el) 2 in the rat (r) dopamine transporter (dat) were examined using limited proteolysis with endoproteinase asp-n and detection of cleavage products by epitope-specific immunoblotting. |
2015-02-02 |
2023-08-12 |
human |
| Yvette Dehnes, Jufang Shan, Thijs Beuming, Lei Shi, Harel Weinstein, Jonathan A Javitc. Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry international. vol 73. 2015-02-02. PMID:24576496. |
the dopamine transporter (dat), a member of the neurotransmitter:sodium symporter family, mediates the reuptake of dopamine at the synaptic cleft. |
2015-02-02 |
2023-08-12 |
Not clear |
| LinLin Tian, Morvarid Karimi, Chris A Brown, Susan K Loftin, Joel S Perlmutte. In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment. Brain research. vol 1571. 2015-02-02. PMID:24845719. |
we determined axon integrity by measuring fiber length density with tyrosine hydroxylase (th) immunohistology and dopamine transporter (dat) density with dat immunohistology. |
2015-02-02 |
2023-08-13 |
Not clear |