| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LinLin Tian, Morvarid Karimi, Chris A Brown, Susan K Loftin, Joel S Perlmutte. In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment. Brain research. vol 1571. 2015-02-02. PMID:24845719. |
we then calculated the terminal arbor size and compared these measures with previously published data of quantified in vivo positron emission tomography (pet) measures of presynaptic dopaminergic neurons, autoradiographic measures of dat and vesicular monoamine transporter type 2 (vmat2), striatal dopamine, nigral cell counts, and parkinsonian motor ratings in the same animals. |
2015-02-02 |
2023-08-13 |
Not clear |
| Wen-Ting Hsieh, Been-Huang Chian. A well-refined in vitro model derived from human embryonic stem cell for screening phytochemicals with midbrain dopaminergic differentiation-boosting potential for improving Parkinson's disease. Journal of agricultural and food chemistry. vol 62. issue 27. 2015-02-02. PMID:24933592. |
the derived cells expressed many mda markers including tyrosine hydroxylase (th), β-iii tubulin, and dopamine transporter (dat). |
2015-02-02 |
2023-08-13 |
human |
| Amandine Valomon, Sebastian C Holst, Valérie Bachmann, Antoine U Viola, Christina Schmidt, Jurian Zürcher, Wolfgang Berger, Christian Cajochen, Hans-Peter Landol. Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. Chronobiology international. vol 31. issue 5. 2015-01-30. PMID:24625311. |
cerebral dopamine levels are regulated primarily by the dopamine transporter (dat) in the striatum and by catechol-o-methyl-transferase (comt) in the prefrontal cortex. |
2015-01-30 |
2023-08-12 |
Not clear |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. Environmental toxicology and pharmacology. vol 37. issue 3. 2015-01-29. PMID:24863964. |
the mrna and protein expression of orphan nuclear hormone (nurr1), tyrosine hydroxylase(th), vesicular monoaminetransporter 2 (vmat2), dopamine transporter (dat), monoamine (mao), and catechol-o-methyl transferase (comt) in the midbrain were examined by fluorescence pcr and western blot when the offspring reached six-month old or one year old .when measured 6 months post-treatment, the level of da and expression of nurr1, vmat2, dat and th were reduced in the striatum and substantia nigra, respectively. |
2015-01-29 |
2023-08-13 |
human |
| Walter Adriani, Francesca Zoratto, Giovanni Laviol. Brain processes in discounting: consequences of adolescent methylphenidate exposure. Current topics in behavioral neurosciences. vol 9. 2015-01-20. PMID:21956611. |
an "impulsive" behavioral profile appears to emerge more extremely in rats when forebrain dopamine (da) systems undergo remodeling, as in adolescence, or with experimental manipulation tapping onto the dopamine transporter (dat). |
2015-01-20 |
2023-08-12 |
human |
| Heli Chauhan, Bryan A Killinger, Cheryl V Miller, Anna Moszczynsk. Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum. International journal of molecular sciences. vol 15. issue 4. 2015-01-19. PMID:24717411. |
dopamine d2 receptor antagonists and dopamine transporter (dat) inhibitors protect against neurotoxicity of the drug by decreasing intracellular dopamine content and, consequently, dopamine autoxidation and production of reactive oxygen species. |
2015-01-19 |
2023-08-13 |
rat |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset. Neuropharmacology. vol 82. 2015-01-09. PMID:24447715. |
uwa-101, a dual, equipotent inhibitor of dopamine (dat) and serotonin (sert) transporters, has previously been shown to successfully extend duration of anti-parkinsonian benefit of l-dopa (on-time), without exacerbating dyskinesia, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned marmoset. |
2015-01-09 |
2023-08-12 |
marmoset |
| Susanne Nikolaus, Markus Beu, Angelica Maria De Souza Silva, Joseph P Huston, Hubertus Hautzel, Owen Y Chao, Christina Antke, Hans-Wilhelm Mülle. Relationship between L-DOPA-induced reduction in motor and exploratory activity and degree of DAT binding in the rat. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566000. |
the present study assessed the influence of l-dopa administration on neostriatal dopamine (da) transporter (dat) binding in relation to motor and exploratory behaviors in the rat. |
2015-01-08 |
2023-08-13 |
rat |
| Stephen H Braren, Damian Drapala, Ingrid K Tulloch, Peter A Serran. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566006. |
the hippocampus and dorsal striatum were assessed for expression of glutamate receptors subunits, glua2 and glun2b; dopamine markers, dopamine 1 receptor (d1), dopamine transporter (dat) and tyrosine hydroxylase (th); and memory markers, protein kinase m zeta (pkmζ) and protein kinase c zeta (pkcζ). |
2015-01-08 |
2023-08-13 |
mouse |
| Stephen H Braren, Damian Drapala, Ingrid K Tulloch, Peter A Serran. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566006. |
in the striatum, ma treatment increased cytosolic dat and th levels associated with dopamine hyperfunction. |
2015-01-08 |
2023-08-13 |
mouse |
| Barbara Cagniard, Tatyana D Sotnikova, Raul R Gainetdinov, Xiaoxi Zhuan. The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. Journal of neurogenetics. vol 28. issue 1-2. 2015-01-07. PMID:24673634. |
although both cocaine and amphetamine mainly target the dopamine transporter (dat) and cause psychomotor effects, they have very different mechanisms of actions. |
2015-01-07 |
2023-08-12 |
mouse |
| Barbara Cagniard, Tatyana D Sotnikova, Raul R Gainetdinov, Xiaoxi Zhuan. The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. Journal of neurogenetics. vol 28. issue 1-2. 2015-01-07. PMID:24673634. |
whereas amphetamine-induced increase in extracellular dopamine was drastically diminished in constitutive dat knockdown mice, cocaine-induced increase in extracellular dopamine had a faster onset in knockdown mice compared with wild-type controls. |
2015-01-07 |
2023-08-12 |
mouse |
| Danna Jennings, Andrew Siderowf, Matthew Stern, John Seibyl, Shirley Eberly, David Oakes, Kenneth Mare. Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology. vol 83. issue 19. 2014-12-30. PMID:25298306. |
the purpose of this study is to evaluate the relative risk of abnormal dopamine transporter (dat) imaging for subjects with and without hyposmia and the feasibility of acquiring a large, community-based, 2-tiered biomarker assessment strategy to detect prodromal parkinson disease (pd). |
2014-12-30 |
2023-08-13 |
human |
| Ajit S Shinto, Joppy Antony, Koramadai Kamaleshwaran, Krishnan Vijayan, Arul Selvan, Aruna Korde, Mythili Kameshwaran, Grace Samue. Correlative (99m)tc-labeled tropane derivative single photon emission computer tomography and clinical assessment in the staging of Parkinson disease. World journal of nuclear medicine. vol 13. issue 3. 2014-12-24. PMID:25538489. |
the imaging of dopamine transporter (dat) with (99m)tc-labeled tropane derivative (trodat-1) single photon emission computer tomography/computer tomography (spect/ct) has been proposed to be a valuable and feasible means of assessment of the integrity of dopamine neurons. |
2014-12-24 |
2023-08-13 |
human |
| Josiane W Bortolotto, Giana P Cognato, Raissa R Christoff, Laura N Roesler, Carlos E Leite, Luiza W Kist, Mauricio R Bogo, Monica R Vianna, Carla D Bona. Long-term exposure to paraquat alters behavioral parameters and dopamine levels in adult zebrafish (Danio rerio). Zebrafish. vol 11. issue 2. 2014-12-18. PMID:24568596. |
this study evaluated the effect of the systemic administration of pq on locomotion, learning and memory, social interaction, tyrosine hydroxylase (th) expression, dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels, and dopamine transporter (dat) gene expression in zebrafish. |
2014-12-18 |
2023-08-12 |
zebrafish |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
recent literature has shown that genetic and drug-induced elevations in dopamine transporter (dat) expression augment the neurochemical and behavioral potency of psychostimulant releasers. |
2014-12-18 |
2023-08-13 |
mouse |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
dat levels and dopamine uptake rates have been shown to follow a gradient in the striatum, with the highest levels in the dorsal regions and lowest levels in the nucleus accumbens shell; thus, we hypothesized that amphetamine potency would follow this gradient. |
2014-12-18 |
2023-08-13 |
mouse |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
using fast scan cyclic voltammetry in mouse brain slices, we examined dat inhibition and changes in exocytotic dopamine release by amphetamine across four striatal regions (dorsal and ventral caudate-putamen, nucleus accumbens core and shell). |
2014-12-18 |
2023-08-13 |
mouse |
| Cody A Siciliano, Erin S Calipari, Sara R Jone. Amphetamine potency varies with dopamine uptake rate across striatal subregions. Journal of neurochemistry. vol 131. issue 3. 2014-12-18. PMID:24988947. |
consistent with our hypothesis, amphetamine effects at the dat and on release decreased across regions from dorsal to ventral, and both measures of potency were highly correlated with dopamine uptake rates. |
2014-12-18 |
2023-08-13 |
mouse |
| D Leo, L Mus, S Espinoza, M C Hoener, T D Sotnikova, R R Gainetdino. Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Neuropharmacology. vol 81. 2014-12-15. PMID:24565640. |
in vivo evidence has indicated an inhibitory influence of taar1 on dopamine (da) neurotransmission, presumably via modulation of dopamine transporter (dat) or interaction with the d2 da receptor and/or activation of inwardly rectifying k(+) channels. |
2014-12-15 |
2023-08-12 |
mouse |