| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masanari Itokawa, Zhicheng Lin, George R Uh. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480180. |
the dopamine transporter (dat) can mediate not only inward uptake of dopamine, but also its outward efflux by mechanisms that have been only partially elucidated. |
2003-06-16 |
2023-08-12 |
Not clear |
| Masanari Itokawa, Zhicheng Lin, George R Uh. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480180. |
alanine substitutions for six proline residues located in or near dat transmembrane domains increase apparent affinity and decrease v(max) values for dopamine efflux mediated by these mutant transporters. |
2003-06-16 |
2023-08-12 |
Not clear |
| Masanari Itokawa, Zhicheng Lin, George R Uh. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480180. |
mutant 12p572a displays increased dat efflux with reduced dependence on ion or dopamine concentrations. |
2003-06-16 |
2023-08-12 |
Not clear |
| Juei-Jueng Lin, Kuo-Chu Yueh, Dar-Cheng Chang, Chung-Yao Chang, Yung-Hsiang Yeh, Shinn-Zong Li. The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients. Journal of the neurological sciences. vol 209. issue 1-2. 2003-06-16. PMID:12686408. |
we investigated the role of variable number tandem repeat (vntr) polymorphism of the dopamine transporter gene (dat) in the pathogenesis of parkinson's disease (pd) in taiwanese. |
2003-06-16 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Anita Sidh. Attenuation of dopamine transporter activity by alpha-synuclein. Neuroscience letters. vol 340. issue 3. 2003-05-30. PMID:12672538. |
the alpha-synuclein-mediated decrease in dat activity occurred through diminished uptake velocity of dopamine, without changes in the affinity of hdat for dopamine. |
2003-05-30 |
2023-08-12 |
human |
| Christophe Wersinger, Anita Sidh. Attenuation of dopamine transporter activity by alpha-synuclein. Neuroscience letters. vol 340. issue 3. 2003-05-30. PMID:12672538. |
thus, under normal (non-toxic) expression conditions, alpha-synuclein negatively modulates dopamine uptake by dat. |
2003-05-30 |
2023-08-12 |
human |
| Vladimir I Chefer, Irina Zakharova, Toni S Shippenber. Enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684494. |
the kinetics of uptake, dopamine transporter (dat) expression, and [(3)h](-)-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate ([(3)h]win35428) binding were also examined. |
2003-05-30 |
2023-08-12 |
rat |
| F Scott Hall, I Sora, G R Uh. Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655306. |
sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (vmat2) and dopamine transporter (dat) knockout mice. |
2003-05-29 |
2023-08-12 |
mouse |
| F Scott Hall, I Sora, G R Uh. Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655306. |
humans display significant differences in expression of the vesicular and plasma membrane monoamine transporters important for monoaminergic functions, including the vesicular monoamine transporter (vmat2, slc18a2) and dopamine transporter (dat, slc6a3). |
2003-05-29 |
2023-08-12 |
mouse |
| b' M Salkovi\\xc4\\x87-Petrisi\\xc4\\x87, Z Lackovi\\xc4\\x8. Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 1. 2003-05-23. PMID:12541010.' |
by means of in situ hybridization, we have investigated the expression of dopamine, noradrenaline and serotonin transporter (dat, nat, 5-htt, respectively) mrnas, in the brain of alloxan- and streptozotcin-icv treated rats. |
2003-05-23 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, G Wang, Y Ding, S J Gatle. Mechanism of action of methylphenidate: insights from PET imaging studies. Journal of attention disorders. vol 6 Suppl 1. 2003-05-22. PMID:12685517. |
we have shown (a) that oral mph reaches peak concentration in the brain 60-90 minutes after its administration, (b) that therapeutic doses of mph block more than 50% of the dopamine transporters (dat), and (c) that of the two enantiomers that compose mph, it is d-threo-methylphenidate (d-mph) and not l-threo-methylphenidate (l-mph) that binds to the dat. |
2003-05-22 |
2023-08-12 |
human |
| Nicholas T Bello, Kristi L Sweigart, Joan M Lakoski, Ralph Norgren, Andras Hajna. Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter. American journal of physiology. Regulatory, integrative and comparative physiology. vol 284. issue 5. 2003-05-20. PMID:12521926. |
to further investigate the cellular mechanisms of these alterations, the present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (dat) protein density and mrna expression in restricted-fed and free-fed adult male rats. |
2003-05-20 |
2023-08-12 |
rat |
| Habibeh Khoshbouei, Hongwei Wang, James D Lechleiter, Jonathan A Javitch, Aurelio Gall. Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. The Journal of biological chemistry. vol 278. issue 14. 2003-05-19. PMID:12556446. |
amphetamine (amph) elicits its behavioral effects by acting on the dopamine (da) transporter (dat) to induce da overflow into the synaptic cleft. |
2003-05-19 |
2023-08-12 |
human |
| Xiaohong Wu, Howard H G. Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. Molecular pharmacology. vol 63. issue 3. 2003-05-12. PMID:12606774. |
dopamine transporter (dat) is a major target of cocaine, one of the most abused drugs. |
2003-05-12 |
2023-08-12 |
mouse |
| Sîan M J Hemmings, Craig J Kinnear, Dana J H Niehaus, Johanna C Moolman-Smook, Christine Lochner, James A Knowles, Valerie A Corfield, Dan J Stei. Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 13. issue 2. 2003-05-12. PMID:12650952. |
the distribution of selected polymorphic variants in the serotonin receptor type 2a and 1dbeta (5-ht(2a), 5-ht(1dbeta)), dopamine transporter (dat), dopamine receptor type 4 (drd4) and monoamine-oxidase a (mao-a) genes were analysed in 71 ocd cases and 129 control individuals in the genetically homogeneous afrikaner population, by means of case-control association studies. |
2003-05-12 |
2023-08-12 |
Not clear |
| Elisabeth Greiner, Thomas Prisinzano, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672246. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2003-05-08 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Pinglang Wang, Paul Blundell, Bertha K Madra. Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672255. |
methylphenidate (ritalin) binds stereoselectively and enantioselectively to the dopamine transporter (dat) and inhibits dopamine reuptake with in vitro and in vivo potency similar to that of cocaine. |
2003-05-08 |
2023-08-12 |
Not clear |
| Rebecca J Ralph-Williams, Martin P Paulus, Xiaoxi Zhuang, Rene Hen, Mark A Geye. Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biological psychiatry. vol 53. issue 4. 2003-05-07. PMID:12586455. |
dopamine transporter (dat) knockdown (kd) mice, with approximately 90% loss of expression of the dat, allow for the examination of the behavioral consequences of a chronically dysregulated dopamine system. |
2003-05-07 |
2023-08-12 |
mouse |
| Jitka Ourednik, Václav Ourednik, William P Lynch, Melitta Schachner, Evan Y Snyde. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nature biotechnology. vol 20. issue 11. 2003-05-01. PMID:12379867. |
functional assays paralleled the spatiotemporal recovery of tyrosine hydroxylase (th) and dopamine transporter (dat) activity, which, in turn, mirrored the spatiotemporal distribution of donor-derived cells. |
2003-05-01 |
2023-08-12 |
mouse |
| John Beard, Keith M Erikson, Byron C Jone. Neonatal iron deficiency results in irreversible changes in dopamine function in rats. The Journal of nutrition. vol 133. issue 4. 2003-04-30. PMID:12672939. |
we measured brain fe, dopamine transporters (dat) and dopamine receptor density in rats made iron deficient, or not, from postnatal day (pnd) 4 to pnd 14 or 21. |
2003-04-30 |
2023-08-12 |
human |