| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joshua A Lile, Drake Morgan, Anne M Birmingham, Zhixia Wang, William L Woolverton, Huw M L Davies, Michael A Nade. The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388646. |
the time of onset for dopamine transporter (dat) occupancy of the long-acting, high-affinity dat blocker 2beta-propanoyl-3beta-(4-tolyl)-tropane (ptt) was measured using an ex vivo binding assay in rodents and was determined to be significantly longer than for cocaine (30 min versus 2 min). |
2002-11-22 |
2023-08-12 |
monkey |
| Masataka Nishimura, Ryuji Kaji, Mitsuhiro Ohta, Ikuko Mizuta, Sadako Kun. Association between dopamine transporter gene polymorphism and susceptibility to Parkinson's disease in Japan. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 4. 2002-11-20. PMID:12210886. |
we studied a polymorphism in the dopamine transporter (dat) gene in 236 japanese patients with parkinson's disease (pd) and compared the results with 220 controls. |
2002-11-20 |
2023-08-12 |
Not clear |
| Joshua M Gulley, Suzanne Doolen, Nancy R Zahnise. Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423250. |
in heterologous expression systems, dopamine transporter (dat) cell-surface localization is reduced after relatively prolonged exposure to d-amphetamine (amph) or dopamine (da), suggesting a role for substrate-mediated regulation of transporter function. |
2002-11-20 |
2023-08-12 |
human |
| Aiveen Kirley, Ziarih Hawi, Grainne Daly, Mary McCarron, Celine Mullins, Niamh Millar, Irwin Waldman, Michael Fitzgerald, Michael Gil. Dopaminergic system genes in ADHD: toward a biological hypothesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 4. 2002-11-19. PMID:12377397. |
four dopamine related gene loci have been implicated, however: dat 1, drd 4, dbh, and drd 5. |
2002-11-19 |
2023-08-12 |
Not clear |
| Lars H Pinborg, Charlotte Videbaek, Claus Svarer, Stig Yndgaard, Olaf B Paulson, Gitte M Knudse. Quantification of [(123)I]PE2I binding to dopamine transporters with SPET. European journal of nuclear medicine and molecular imaging. vol 29. issue 5. 2002-11-13. PMID:11976800. |
the iodinated cocaine derivative [(123)i]pe2i is a new selective ligand for in vivo studies of the dopamine transporter (dat) with single-photon emission tomography (spet). |
2002-11-13 |
2023-08-12 |
human |
| Paul D Acton, Seok-Rye Choi, Karl Plössl, Hank F Kun. Quantification of dopamine transporters in the mouse brain using ultra-high resolution single-photon emission tomography. European journal of nuclear medicine and molecular imaging. vol 29. issue 5. 2002-11-13. PMID:11976810. |
in this study we aimed to demonstrate the feasibility of using ultra-high resolution spet in quantitative studies of dopamine transporters (dat) in the mouse brain. |
2002-11-13 |
2023-08-12 |
mouse |
| Andy N Mead, Beatriz A Rocha, David M Donovan, Jonathan L Kat. Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. The European journal of neuroscience. vol 16. issue 3. 2002-11-08. PMID:12193195. |
previously, it was reported that both norepinephrine transporter (net) and dopamine transporter (dat) knockout (ko) mice were sensitive to the reinforcing effects of cocaine. |
2002-11-08 |
2023-08-12 |
mouse |
| David J Vandenbergh, Christina J Bennett, Michael D Grant, Andrew A Strasser, Richard O'Connor, Rebecca L Stauffer, George P Vogler, Lynn T Kozlowsk. Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be different. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 4. issue 3. 2002-11-07. PMID:12215242. |
the dopamine transporter (dat) gene (slc6a3) encodes a protein that regulates synaptic levels of dopamine in the brain and is a candidate gene for addictive behaviors. |
2002-11-07 |
2023-08-12 |
human |
| Mayka Tomás-Camardiel, Antonio J Herrera, José L Venero, Mari Cruz Sánchez-Hidalgo, Josefina Cano, Alberto Machad. Differential regulation of glutamic acid decarboxylase mRNA and tyrosine hydroxylase mRNA expression in the aged manganese-treated rats. Brain research. Molecular brain research. vol 103. issue 1-2. 2002-11-06. PMID:12106697. |
we then studied the mrna levels for tyrosine hydroxylase (th) and the dopamine transporter (dat) by in situ hybridization. |
2002-11-06 |
2023-08-12 |
rat |
| K Lehmann, G Teuchert-Noodt, R R Dawir. Postnatal rearing conditions influence ontogeny of adult dopamine transporter (DAT) immunoreactivity of the striatum in gerbils. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 9. 2002-11-06. PMID:12203040. |
postnatal rearing conditions influence ontogeny of adult dopamine transporter (dat) immunoreactivity of the striatum in gerbils. |
2002-11-06 |
2023-08-12 |
Not clear |
| K Lehmann, G Teuchert-Noodt, R R Dawir. Postnatal rearing conditions influence ontogeny of adult dopamine transporter (DAT) immunoreactivity of the striatum in gerbils. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 9. 2002-11-06. PMID:12203040. |
at the age of postnatal day 90, dopamine fibers were stained immunocytochemically using an antibody against the dopamine transporter (dat). |
2002-11-06 |
2023-08-12 |
Not clear |
| Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kun. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). Journal of medicinal chemistry. vol 45. issue 21. 2002-11-05. PMID:12361398. |
in vitro binding assays using cell membrane homogenates of llc cells expressing sert, dopamine transporters (dat), or norepinephrine transporters (net) showed excellent binding affinity and selectivity for sert (k(i) = 0.05, 3020, and 650 nm for sert, dat, and net, respectively). |
2002-11-05 |
2023-08-12 |
rat |
| Maria Antonietta Casu, Dinuccio Dinucci, Giancarlo Colombo, Gian Luigi Gessa, Luca Pan. Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383975. |
to this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (dbh), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (dat), as markers for noradrenergic and dopaminergic fibers, respectively. |
2002-10-30 |
2023-08-12 |
rat |
| Saira K Shahani, Ratnakumari Lingamaneni, Hugh C Hemming. General anesthetic actions on norepinephrine, dopamine, and gamma-aminobutyric acid transporters in stably transfected cells. Anesthesia and analgesia. vol 95. issue 4. 2002-10-28. PMID:12351264. |
we analyzed the effects of representative volatile and iv general anesthetics on recombinant transporters for norepinephrine (human net), dopamine (rat dat), or gamma-aminobutyric acid (rat gat-1) stably expressed in a porcine kidney cell line (llc-pk(1)). |
2002-10-28 |
2023-08-12 |
human |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
the results of these studies have been consistent with the inhibition of dopamine uptake, at the dopamine transporter (dat), which results in a rapid and excessive accumulation of extracellular dopamine in the synapse as being the mechanism primarily responsible for the locomotor stimulant actions of cocaine. |
2002-10-24 |
2023-08-12 |
Not clear |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
many of these compounds bind potently and selectively to the dat, block dopamine reuptake, and are behaviorally cocaine-like in animal models of psychostimulant abuse. |
2002-10-24 |
2023-08-12 |
Not clear |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
structure-activity relationships between chemically diverse dopamine uptake inhibitors have suggested that different binding interactions, at the molecular level on the dat, as well as divergent actions at the other monoamine transporters may be related to the differing pharmacological actions of these compounds, in vivo. |
2002-10-24 |
2023-08-12 |
Not clear |
| A Ekue, J-F Boulanger, M Morissette, T Di Paol. Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice. Journal of neuroendocrinology. vol 14. issue 9. 2002-10-23. PMID:12213134. |
striatal specific binding to the dopamine transporter (dat) and to the vesicular monoamine transporter (vmat2) were measured using [125i] rti-121 and [3h] dihydrotetrabenazine autoradiography, respectively. |
2002-10-23 |
2023-08-12 |
mouse |
| A Ekue, J-F Boulanger, M Morissette, T Di Paol. Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice. Journal of neuroendocrinology. vol 14. issue 9. 2002-10-23. PMID:12213134. |
as with striatal dopamine concentrations, mptp treatment caused a decrease in dat and vmat2 specific binding. |
2002-10-23 |
2023-08-12 |
mouse |
| Susan L Ingram, Balakrishna M Prasad, Susan G Amar. Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nature neuroscience. vol 5. issue 10. 2002-10-22. PMID:12352983. |
here, whole-cell patch clamp and perforated-patch recordings show that substrates of the dopamine transporter (dat), such as dopamine (da) and amphetamine, increase the firing activity of rat da neurons in culture. |
2002-10-22 |
2023-08-12 |
rat |