| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M K Hahn, R D Blakel. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. The pharmacogenomics journal. vol 2. issue 4. 2003-02-10. PMID:12196911. |
the norepinephrine, dopamine and serotonin transporters (net, dat and sert, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. |
2003-02-10 |
2023-08-12 |
human |
| Bruce R Stevens, Daniel H Feldman, Zhilin Liu, William R Harve. Conserved tyrosine-147 plays a critical role in the ligand-gated current of the epithelial cation/amino acid transporter/channel CAATCH1. The Journal of experimental biology. vol 205. issue Pt 16. 2003-02-07. PMID:12124378. |
this tyrosine residue is conserved within the third transmembrane domain in members of the na(+):neurotransmitter transporter family (snf), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (sert), dopamine (dat) and norepinephrine (net) transporters. |
2003-02-07 |
2023-08-12 |
xenopus_laevis |
| Masami Nakai, Atsushi Mori, Akihito Watanabe, Yasuhide Mitsumot. 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Experimental neurology. vol 179. issue 1. 2003-01-30. PMID:12504872. |
at this time point, tyrosine hydroxylase (th) and dopamine transporter (dat) protein levels were not altered, but both decreased at 7 days after mpp+ (40 nmol) infusion. |
2003-01-30 |
2023-08-12 |
rat |
| Masami Nakai, Atsushi Mori, Akihito Watanabe, Yasuhide Mitsumot. 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Experimental neurology. vol 179. issue 1. 2003-01-30. PMID:12504872. |
in addition, gbr-12909 partially attenuated mpp+ (40 nmol)-caused a loss of striatal nerve terminal as indicated by decreases in th and dat immunoreactivities as well as dopamine and its metabolites levels. |
2003-01-30 |
2023-08-12 |
rat |
| Sang-Hun Lee, Mi-Yoon Chang, Dae-Joon Jeon, Dong-Yul Oh, Hyeon Son, Chang-Ho Lee, Young-Seek Lee, Yong-Sung Le. The functional domains of dopamine transporter for cocaine analog, CFT binding. Experimental & molecular medicine. vol 34. issue 1. 2003-01-29. PMID:11989984. |
cocaine analogue, cft (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) binding to dopamine transporter (dat) in different species is quite heterogeneous. |
2003-01-29 |
2023-08-12 |
human |
| Chien-Nan Lin, Hsiu-Chih Liu, Shih-Jen Tsai, Tsung-Yun Liu, Chen-Jee Hon. Association study for Parkinson's disease and a dopamine transporter gene polymorphism (1215A/G). European neurology. vol 48. issue 4. 2003-01-28. PMID:12422069. |
the dopamine transporter (dat) may play a role in the pathogenesis of parkinson's disease (pd) because dopamine-specific neurotoxins are taken into dopaminergic nerve terminals via the dat. |
2003-01-28 |
2023-08-12 |
Not clear |
| Miho Inoue-Murayama, Satomi Adachi, Noriko Mishima, Hiroaki Mitani, Osamu Takenaka, Keiji Terao, Ikuo Hayasaka, Shin'ichi Ito, Yuichi Murayam. Variation of variable number of tandem repeat sequences in the 3'-untranslated region of primate dopamine transporter genes that affects reporter gene expression. Neuroscience letters. vol 334. issue 3. 2003-01-28. PMID:12453630. |
genetic polymorphism has been reported in the 3'-untranslated region (3'-utr) of the human dopamine transporter (dat) gene and the variable number of tandem repeat (vntr) polymorphism has been proposed to be associated with normal personal traits or psychoneurological disorders. |
2003-01-28 |
2023-08-12 |
human |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
several studies have shown that repeated cocaine administration, followed by withdrawal, alters dopamine transporter (dat) levels in the rat. |
2003-01-23 |
2023-08-12 |
rat |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
previously, our laboratory developed an approach to measure the synthesis rate, degradation rate constant, and half-life of dat in the rat striatum and nucleus accumbens after administration of the irreversible dopamine transporter ligand, rti-76 [3beta-(3-p-chlorophenyl)tropan-2beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride]. |
2003-01-23 |
2023-08-12 |
rat |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
these initial studies showed that: 1) the half-life of the transporter was between 2 and 3 days in these two brain regions; 2) pretreatment with dopamine d1 and d2 receptor agonists and antagonists over several days differentially altered dat half-lives in the striatum and nucleus accumbens; and 3) pretreatment with cocaine for several days increased the half-life of dat by decreasing the degradation rate constant in both brain regions. |
2003-01-23 |
2023-08-12 |
rat |
| Christoph Scherfler, Eveline Donnemiller, Michael Schocke, Katja Dierkes, Clemens Decristoforo, Michael Oberladstätter, Christian Kolbitsch, Fritz Zschiegner, Georg Riccabona, Werner Poewe, Gregor Wennin. Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT. NeuroImage. vol 17. issue 1. 2003-01-14. PMID:12482072. |
striatal dopamine transporter (dat) function was evaluated in rats by in vivo spect-mri coregistration using the radioligand 2-beta-carbomethoxy-3-beta-(4-[123i]iodophenyl)tropane (beta-[123i]cit). |
2003-01-14 |
2023-08-12 |
rat |
| Simona Scheggi, Benedetta Leggio, Flavio Masi, Silvia Grappi, Carla Gambarana, Giulio Nanni, Riccardo Rauggi, Maria Graziella De Monti. Selective modifications in the nucleus accumbens of dopamine synaptic transmission in rats exposed to chronic stress. Journal of neurochemistry. vol 83. issue 4. 2002-12-24. PMID:12421362. |
as the activity of the neuronal dopamine (da) transporter (dat) is considered to be a critical mechanism for determining the extent of da receptor activation, we investigated whether a 3-week exposure to unavoidable stress, which produces a reduction in da output in the nucleus accumbens shell (nacs) and medial prefrontal cortex (mpfc), would affect dat density and da d1 receptor complex activity in the nacs, mpfc and caudate-putamen (cpu). |
2002-12-24 |
2023-08-12 |
rat |
| b' Marko Huotari, Miklos Santha, Louis R Lucas, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438556.' |
for dopaminergic neurons, uptake by the high-affinity dopamine transporter (dat) is the most effective mechanism, and the contribution of glial comt remains secondary under normal conditions. |
2002-12-24 |
2023-08-12 |
mouse |
| b' Marko Huotari, Miklos Santha, Louis R Lucas, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438556.' |
despite the possible interaction between dat and extraneuronal uptake (and subsequently comt), the role of comt in dopamine elimination is still minimal in conditions when dat is inhibited. |
2002-12-24 |
2023-08-12 |
mouse |
| Chin-Chang Huang, Tzu-Chen Yen, Yi-Hsin Weng, Chin-Song L. Normal dopamine transporter binding in dopa responsive dystonia. Journal of neurology. vol 249. issue 8. 2002-12-23. PMID:12195447. |
the dopamine transporter (dat) imaging with (99m)tc-trodat-1 was performed in the 2 probands, 8 patients with young onset parkinson disease (yopd) and 16 normal controls. |
2002-12-23 |
2023-08-12 |
Not clear |
| J W Grimm, Y Shaham, B T Hop. Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats. Behavioural pharmacology. vol 13. issue 5-6. 2002-12-23. PMID:12394414. |
we also examined whether the time-dependent changes in cocaine seeking correlate with the levels of the dopamine transporter (dat) and tyrosine hydroxylase (th) proteins in the amygdala, nucleus accumbens, prefrontal cortex and orbitofrontal cortex. |
2002-12-23 |
2023-08-12 |
rat |
| Jeffrey R Bloomquist, Rebecca L Barlow, Jeffrey S Gillette, Wen Li, Michael L Kirb. Selective effects of insecticides on nigrostriatal dopaminergic nerve pathways. Neurotoxicology. vol 23. issue 4-5. 2002-12-16. PMID:12428726. |
western blot analysis confirmed increased levels of dopamine transporter (dat) protein in the striatum of mice treated with heptachlor and permethrin. |
2002-12-16 |
2023-08-12 |
mouse |
| Stacy E Stephans, Gary W Miller, Allan I Levey, J Timothy Greenamyr. Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells. Neurotoxicology. vol 23. issue 4-5. 2002-12-16. PMID:12428729. |
a human neuroblastoma cell line expressing the dopamine transporter (dat) was utilized to examine the effects of mpp+ on acute physiologic responses and subsequent cell death. |
2002-12-16 |
2023-08-12 |
human |
| C A Nurse, I M Fearo. Carotid body chemoreceptors in dissociated cell culture. Microscopy research and technique. vol 59. issue 3. 2002-12-10. PMID:12384969. |
in the rat, type 1 cells are immunopositive for several monoaminergic markers, including tyrosine hydroxylase (th), dopamine transporter (dat), and 5-ht. |
2002-12-10 |
2023-08-12 |
rat |
| Kentaro Wakayama, Sumio Ohtsuki, Hitomi Takanaga, Ken-ichi Hosoya, Tetsuya Terasak. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neuroscience research. vol 44. issue 2. 2002-12-04. PMID:12354632. |
mrna expression of norepinephrine transporter (net) and serotonin transporter (sert) has been detected in a conditionally immortalized mouse brain capillary endothelial cell line (tm-bbb4) used as an in vitro model of the bbb, whereas no dopamine transporter (dat) was detected. |
2002-12-04 |
2023-08-12 |
mouse |