| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
we propose that at least two discrete inhibitor-binding dat conformations or populations exist and that the dat conformation/population responsible for inhibitor high-affinity binding is less responsible for dopamine uptake. |
2003-08-15 |
2023-08-12 |
rat |
| C J Hong, C Y Cheng, L R R Shu, C Y Yang, S J Tsa. Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 4. 2003-08-08. PMID:12658362. |
the dopamine transporter (dat) and the serotonin transporter (5-htt) play important roles in methamphetamine (meth) dependence because they are the target of meth action. |
2003-08-08 |
2023-08-12 |
Not clear |
| Mu-Fa Zou, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. Journal of medicinal chemistry. vol 46. issue 14. 2003-08-07. PMID:12825932. |
extensive structure-activity relationships at the dopamine transporter (dat) have been developed around two classes of tropane-based ligands. |
2003-08-07 |
2023-08-12 |
rat |
| Mu-Fa Zou, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. Journal of medicinal chemistry. vol 46. issue 14. 2003-08-07. PMID:12825932. |
to further investigate this hypothesis, a series of (s)-2beta-carboalkoxy-3alpha-(bis[4-fluorophenyl]methoxy)tropanes (11a-f, 13-16) and their identically (r)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes (3, 5a-d) were prepared and evaluated for binding at the dat and for inhibition of [(3)h]dopamine uptake in rat brain. |
2003-08-07 |
2023-08-12 |
rat |
| Mohamed A Elwan, Takashi Ishii, Norio Sakuragaw. Characterization of the dopamine transporter gene expression and binding sites in cultured human amniotic epithelial cells. Neuroscience letters. vol 342. issue 1-2. 2003-07-31. PMID:12727318. |
in this study we sought to investigate whether the dopamine transporter, dat, and its binding sites are expressed in the human amniotic epithelial cells (haec) using reverse transcription-polymerase chain reaction (rt-pcr) and radioligand binding studies, respectively. |
2003-07-31 |
2023-08-12 |
human |
| Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, Jukka Hiltunen, Jari Tiihone. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse (New York, N.Y.). vol 48. issue 4. 2003-07-25. PMID:12687640. |
the aim of this study was to compare putative age-related alterations of dopamine transporters (dat) in dorsal and ventral striatum of healthy controls and alcoholics. |
2003-07-25 |
2023-08-12 |
human |
| Margaret R Davis, John R Votaw, J Douglas Bremner, Michael G Byas-Smith, Tracy L Faber, Ronald J Voll, John M Hoffman, Scott T Grafton, Clinton D Kilts, Mark M Goodma. Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 6. 2003-07-24. PMID:12791810. |
the aim of this study was to do an initial assessment of the usefulness of 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-(18)f-fluoroethyl)nortropane ((18)f-fecnt) pet scanning in determining in vivo brain dopamine transporter (dat) density in healthy humans and subjects with parkinson's disease (pd). |
2003-07-24 |
2023-08-12 |
human |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
we investigated the alterations of dopamine transporter (dat)-immunopositive cells against mptp neurotoxicity, in comparison with tyrosine hydroxylase (th)-immunopositive neurons and glial fibrillary acidic protein (gfap)-immunopositive cells. |
2003-07-24 |
2023-08-12 |
mouse |
| P Montagna, S Cevoli, N Marzocchi, G Pierangeli, L A Pini, P Cortelli, M Moch. The genetics of chronic headaches. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24 Suppl 2. 2003-07-23. PMID:12811592. |
in cdh, analgesic abuse was significantly associated with specific functional polymorphisms at the drd 4 and at the dopamine transporter (dat) genes, findings implicating dopamine-related genes in cdh with drug abuse. |
2003-07-23 |
2023-08-12 |
Not clear |
| Merewyn K Loder, Haley E Melikia. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12682063. |
the dopamine transporter (dat) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and methylphenidate (ritalin). |
2003-07-22 |
2023-08-12 |
rat |
| Merewyn K Loder, Haley E Melikia. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12682063. |
multiple lines of evidence demonstrate that protein kinase c (pkc) down-regulates dopamine transport, primarily by redistributing dat from the plasma membrane to endosomal compartments, although the mechanisms facilitating transporter sequestration are not defined. |
2003-07-22 |
2023-08-12 |
rat |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
exposure to meth (10 mg/kg 4x at two-hour intervals) produced deficits of dopamine transporters (dat) in mice striatum that are detectable three days after the treatment and are long lasting. |
2003-07-17 |
2023-08-12 |
mouse |
| Rudolph Spangler, Noel L Goddard, Nicole M Avena, Bartley G Hoebel, Sarah F Leibowit. Elevated D3 dopamine receptor mRNA in dopaminergic and dopaminoceptive regions of the rat brain in response to morphine. Brain research. Molecular brain research. vol 111. issue 1-2. 2003-07-16. PMID:12654507. |
tissues were assayed for d1, d2 and d3 dopamine receptor mrnas (d1r, d2r and d3r), as well as for mrnas for tyrosine hydroxylase (th) and the dopamine transporter (dat). |
2003-07-16 |
2023-08-12 |
rat |
| Brian Dean, Robyn Bradbury, David Leon Copolo. Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia. Biological psychiatry. vol 53. issue 7. 2003-07-11. PMID:12679236. |
this study investigated if changes in pre-synaptic markers on dopaminergic neurons (dopamine transporter [dat], tyrosine hydroxylase [th]) were present in the caudate from subjects with schizophrenia who had delta(9)(-)tetrahydrocannabinol (thc) in their blood at autopsy. |
2003-07-11 |
2023-08-12 |
human |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
phosphatidylinositol 3-kinase, protein kinase c, and mek1/2 kinase regulation of dopamine transporters (dat) require n-terminal dat phosphoacceptor sites. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
the dopamine transporter (dat) modulates dopamine neurotransmission and is a primary target for psychostimulant influences on locomotion and reward. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
selective dat expression by dopaminergic neurons has led to use of cocaine analog dat radioligands to assess rates of progression of dopamine neuronal degeneration in parkinson's disease. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
pi3k and mek1/2 modulators exert strong effects on dat expression patterns and dopamine uptake vmax. |
2003-07-10 |
2023-08-12 |
Not clear |
| Jos L Venero, Mati Revuelta, Leila Atiki, Marti Santiago, Mayka C Toms-Camardiel, Josefina Cano, Alberto Machad. Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy. Free radical biology & medicine. vol 34. issue 1. 2003-07-07. PMID:12498986. |
short-term adaptive axotomy-induced changes in substantia nigra included downregulation of nigral tyrosine hydroxylase (th) and dopamine transporter (dat) mrna expression and more intense th immunoreactivity. |
2003-07-07 |
2023-08-12 |
Not clear |
| Rohit B Kolhatkar, Sujit K Ghorai, Clifford George, Maarten E A Reith, Aloke K Dutt. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747792. |
all novel compounds were tested for their affinity at the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [3h]win 35 428, [3h]citalopram, and [3h]nisoxetine, respectively. |
2003-06-23 |
2023-08-12 |
Not clear |