| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
in human embryonic kidney (hek)-293 cells expressing human dat (hek-hdat), pretreatment with dopamine (0.1-100 microm) followed by washout caused reductions in subsequent dopamine uptake (reflected in vmax) with effective dopamine concentrations in the 10 to 100 microm range and pretreatment times of 10 to 60 min. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
reductions assessed after 60-min pretreatment with 100 microm dopamine corresponded with decreases measured in surface dat by the noncleavable biotin method, which were caused, at least in part, by enhanced endocytosis as monitored with cleavable biotin. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
pretreatment of rat striatal synaptosomes with dopamine (10 and 100 microm) also caused reductions in dat uptake activity (vmax), and again the underlying mechanism seemed to be a diminished presence of dat at the surface of synaptosomes as measured by the noncleavable biotin method. |
2003-12-10 |
2023-08-12 |
human |
| Limen Chi, Maarten E A Reit. Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975490. |
the copresence of cocaine during pretreatment with dopamine prevented the down-regulation of surface dat. |
2003-12-10 |
2023-08-12 |
human |
| Christophe Wersinger, Delphine Prou, Philippe Vernier, Anita Sidh. Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 14. 2003-12-09. PMID:12958153. |
here, we suggest that modulation of the functional activity of the dopamine transporter (dat) by alpha-synuclein may be a key factor in the preferential degeneration of mesencephalic dopamine (da)-synthesizing neurons in pd. |
2003-12-09 |
2023-08-12 |
human |
| Sukumar Sakamuri, Istvan J Enyedy, Wahiduz A Zaman, Srihari R Tella, Alan P Kozikowski, Judith L Flippen-Anderson, Tivadar Farkas, Kenneth M Johnson, Shaomeng Wan. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 11. issue 6. 2003-11-24. PMID:12614900. |
there is considerable interest in developing dopamine transporter (dat) inhibitors as potential therapies for the treatment of cocaine abuse. |
2003-11-24 |
2023-08-12 |
mouse |
| Sukumar Sakamuri, Istvan J Enyedy, Wahiduz A Zaman, Srihari R Tella, Alan P Kozikowski, Judith L Flippen-Anderson, Tivadar Farkas, Kenneth M Johnson, Shaomeng Wan. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 11. issue 6. 2003-11-24. PMID:12614900. |
through 3-d-database pharmacophore searching, compound 12 was identified as a very weak dat inhibitor with k(i) values of 7.3 and 8.9 microm in [3h]mazindol binding and in inhibition of dopamine reuptake, respectively. |
2003-11-24 |
2023-08-12 |
mouse |
| John W Haycock, Laurence Becker, Lee Ang, Yoshiaki Furukawa, Oleh Hornykiewicz, Stephen J Kis. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535941. |
because age-related changes in brain dopaminergic innervation are assumed to influence human disorders involving dopamine (da), we measured the levels of several presynpatic daergic markers [da, homovanillic acid, tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), vesicular monoamine transporter 2 (vmat2), and dopamine transporter (dat)] in post-mortem human striatum (caudate and putamen) from 56 neurologically normal subjects aged 1 day to 103 years. |
2003-11-24 |
2023-08-12 |
human |
| Klaus-Henning Krause, Stefan H Dresel, Johanna Krause, Hank F Kung, Klaus Tatsch, Manfred Ackenhei. Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder. The international journal of neuropsychopharmacology. vol 5. issue 2. 2003-11-21. PMID:12135534. |
eleven adult patients with attention deficit hyperactivity disorder (adhd) without medication, consuming 7-40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (dat) measured by [99mtc]trodat-1 spect compared to 11 non-smoking drug-naive patients with adhd, matched for sex and age, despite higher adhd scores for the smokers. |
2003-11-21 |
2023-08-12 |
Not clear |
| Jeffrey S Gillette, Jeffrey R Bloomquis. Differential up-regulation of striatal dopamine transporter and alpha-synuclein by the pyrethroid insecticide permethrin. Toxicology and applied pharmacology. vol 192. issue 3. 2003-11-18. PMID:14575646. |
dopamine transporter (dat) protein as assayed by western blotting was increased to 115% in the 0.8 mg/kg group over that of control mice at t = 1 (p < 0.05). |
2003-11-18 |
2023-08-12 |
mouse |
| Jeffrey S Gillette, Jeffrey R Bloomquis. Differential up-regulation of striatal dopamine transporter and alpha-synuclein by the pyrethroid insecticide permethrin. Toxicology and applied pharmacology. vol 192. issue 3. 2003-11-18. PMID:14575646. |
at 200 mg/kg permethrin, dat protein was unchanged vs controls (t = 1), but had significantly increased by t = 14 and continued to increase at t = 28, suggesting that the reduced dopamine transport at this dose was due to nerve terminal stress and that recovery had occurred. |
2003-11-18 |
2023-08-12 |
mouse |
| Susana Peciña, Barbara Cagniard, Kent C Berridge, J Wayne Aldridge, Xiaoxi Zhuan. Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 28. 2003-11-17. PMID:14561867. |
a dopamine transporter (dat) knockdown mutation that preserves only 10% of normal dat, and therefore causes mutant mice to have 70% elevated levels of synaptic dopamine, was used to identify dopamine effects on food intake and reward. |
2003-11-17 |
2023-08-12 |
mouse |
| Chuen-Lin Huang, Nai-Kuei Huang, Song-Kun Shyue, Yijuang Cher. Hydrogen peroxide induces loss of dopamine transporter activity: a calcium-dependent oxidative mechanism. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911632. |
furthermore, an oxidizer (dithiodipyridine) also markedly suppressed the dopamine transporter (dat). |
2003-11-12 |
2023-08-12 |
Not clear |
| Virginia M V Fernandes, André R Massensini, Marco Antonio M Prado, Marco Aurélio Romano Silva, Tasso Moraes-Santos, Marcus Vinicius Gome. Effects of alpha-scorpion toxin, tityustoxin on the release of [3H] dopamine of rat brain prefrontal cortical slices. Neurochemistry international. vol 44. issue 2. 2003-11-12. PMID:12971911. |
in conclusion, part of the tstx-induced release [3h] dopamine may be due to an effect of the toxin on the reversal of the dopamine transporter (dat), but the majority of the toxin stimulated release of [3h] dopamine involves the mobilization of intracellular calcium stores. |
2003-11-12 |
2023-08-12 |
rat |
| David Lewis, Ying Zhang, Thomas Prisinzano, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter. Bioorganic & medicinal chemistry letters. vol 13. issue 7. 2003-11-03. PMID:12657288. |
a series of n-aromatic, n-heteroaromatic, and oxygenated n-phenylpropyl derivatives of 1-(2-benzhydryloxyethyl)-piperazine and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]piperazine, analogues of gbr 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (dat) and serotonin (sert) transporter binding properties. |
2003-11-03 |
2023-08-12 |
Not clear |
| V M Goettl, H Zhang, A C Burrows, T A Wemlinger, N H Neff, M Hadjiconstantino. GM1 enhances dopaminergic markers in the brain of aged rats. Experimental neurology. vol 183. issue 2. 2003-10-31. PMID:14552908. |
indeed, in the striatum of the aged rats there is a diminished capacity to transport dopamine (da), to bind the dopamine transporter (dat) marker mazindol, to bind the vesicular monoamine transporter 2 (vmat2) marker dihydrotetrabenazine, and to release da under basal conditions or after induction by k(+) or amphetamine. |
2003-10-31 |
2023-08-12 |
rat |
| Sun Yong Baek, Myong-Jong Lee, Hyun-Sil Jung, Hyun-Ju Kim, Choong-Ryeol Lee, Cheolin Yoo, Ji Ho Lee, Hun Lee, Chung Sik Yoon, Young Hoon Kim, Jungsun Park, Jae-Woo Kim, Beom S Jeon, Yangho Ki. Effect of manganese exposure on MPTP neurotoxicities. Neurotoxicology. vol 24. issue 4-5. 2003-10-27. PMID:12900079. |
densities of th- and dopamine transporter (dat)-ir axon terminals in the caudate-putamen (cpu) were also decreased in the mptp-treated groups. |
2003-10-27 |
2023-08-12 |
mouse |
| José A Morón, Irina Zakharova, Jasmine V Ferrer, Gerald A Merrill, Bruce Hope, Eileen M Lafer, Zhi Cheng Lin, Jia Bei Wang, Jonathan A Javitch, Aurelio Galli, Toni S Shippenber. Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 24. 2003-10-24. PMID:13679416. |
the dopamine transporter (dat) regulates the clearance of dopamine (da) released into the extracellular space and is an important site on which psychostimulants act to produce their effects. |
2003-10-24 |
2023-08-12 |
human |
| Aina Westrheim Ravna, Ingebrigt Sylte, Svein G Dah. Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12944499. |
cocaine also binds to the dopamine transporter (dat) and to the noradrenaline transporter (net) and inhibits presynaptic reuptake of dopamine and noradrenaline. |
2003-10-23 |
2023-08-12 |
Not clear |
| Joshua A Lile, Zhixia Wang, William L Woolverton, Jessica E France, Timothy C Gregg, Huw M L Davies, Michael A Nade. The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12954808. |
these drugs were chosen according to their selectivity for dopamine transporters (dat) and 5-hydroxytryptamine (serotonin) transporters (5-htt) as assessed in rodents and their duration of action. |
2003-10-23 |
2023-08-12 |
monkey |