| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guylène Page, Stéphanie Barc-Pain, Raymond Pontcharraud, Arnaud Cante, Alain Piriou, Laurence Barrie. The up-regulation of the striatal dopamine transporter's activity by cAMP is PKA-, CaMK II- and phosphatase-dependent. Neurochemistry international. vol 45. issue 5. 2004-09-16. PMID:15234104. |
the neuronal dopamine transporter (dat) is a presynaptic plasma membrane protein mediating the re-uptake of dopamine released from synaptic cleft into the nerve terminals. |
2004-09-16 |
2023-08-12 |
rat |
| Michael G Byas-Smith, Juan Li, Fania Szlam, Douglas C Eaton, John R Votaw, Donald D Denso. Isoflurane induces dopamine transporter trafficking into the cell cytoplasm. Synapse (New York, N.Y.). vol 53. issue 2. 2004-09-10. PMID:15170819. |
previous investigations have shown that the binding of a selective hydrophilic positron emission tomography radiotracer for the dopamine transporter (dat) (2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-18f-fluoroethyl)nortropane) decreased in monkey striatum during deep isoflurane anesthesia. |
2004-09-10 |
2023-08-12 |
human |
| Beth E Fisher, Giselle M Petzinger, Kerry Nixon, Elizabeth Hogg, Samuel Bremmer, Charles K Meshul, Michael W Jakowe. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. Journal of neuroscience research. vol 77. issue 3. 2004-09-09. PMID:15248294. |
the expression of proteins and genes involved in basal ganglia function including the dopamine transporter (dat), tyrosine hydroxylase (th), and the dopamine d1 and d2 receptors, as well as alterations on glutamate immunolabeling were determined. |
2004-09-09 |
2023-08-12 |
mouse |
| Chuantao Jiang, Xinhua Wan, Joseph Jankovic, Samuel T Christian, Zdenek B Pristupa, Hyman B Niznik, John S Sundsmo, Weidong L. Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Clinical neuropharmacology. vol 27. issue 2. 2004-09-09. PMID:15252266. |
one member of this new class, ipx-750, is a pro-drug dopamine-gluconamine designed to retain stereospecificity of binding at: glucose transporters (glut 1/glut 3 and intestinal na/glucose co-transporters sglt1), dopamine transporter (dat); and, dopaminergic receptors of the d1/d2 families. |
2004-09-09 |
2023-08-12 |
mouse |
| Mats B Lindström, Erik Ryding, Peter Bosson, Jan-Anders Ahnlide, Ingmar Rosén, Lil Träskman-Bend. Impulsivity related to brain serotonin transporter binding capacity in suicide attempters. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 4. 2004-09-07. PMID:15163439. |
in this study whole brain binding potential of the serotonin transporter (5htt) and dopamine transporter (dat) was measured by single photon emission computerised tomography (spect) in 12 patients after a serious suicide attempt and in 12 age, sex and season matched healthy controls. |
2004-09-07 |
2023-08-12 |
Not clear |
| Elise Morice, Cécile Denis, Bruno Giros, Marika Nosten-Bertran. Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background. The European journal of neuroscience. vol 20. issue 1. 2004-09-07. PMID:15245485. |
the dopamine transporter (dat) plays a critical role in calibrating the duration and intensity of dopamine (da) neurotransmission. |
2004-09-07 |
2023-08-12 |
mouse |
| Annalina Lapucci, Susanna Nencetti, Gian Carlo Demonti. Synthesis and affinity for serotonin and dopamine transporters of some benzophenone oxime ether derivatives. Farmaco (Societa chimica italiana : 1989). vol 58. issue 9. 2004-08-24. PMID:13679194. |
the present study describes the preparation of some new oxime derivatives and their capacity to inhibit serotonin (sert) and dopamine (dat) transporters expressed at the level of the rabbit cortex and the striatal membranes, respectively. |
2004-08-24 |
2023-08-12 |
rabbit |
| Manuel Miranda, Tatiana Sorkina, Tom N Grammatopoulos, W Michael Zawada, Alexander Sorki. Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. The Journal of biological chemistry. vol 279. issue 29. 2004-08-17. PMID:15128747. |
the plasma membrane dopamine transporter (dat) has an essential role in terminating dopaminergic neurotransmission by reuptake of dopamine into the presynaptic neurons. |
2004-08-17 |
2023-08-12 |
rat |
| Ki-Hwan Lee, Mi-Young Kim, Dong-Hwan Kim, Yong-Sung Le. Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter. Neurochemical research. vol 29. issue 7. 2004-08-10. PMID:15202772. |
the dopamine transporter (dat) regulates the extent and duration of dopamine receptor activation through sodium-dependant reuptake of dopamine into presynaptic neurons, resulting in termination of dopaminergic neurotransmission. |
2004-08-10 |
2023-08-12 |
human |
| Michael R Kilbourn, Elyse S Kemmerer, Timothy J Desmond, Philip S Sherman, Kirk A Fre. Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain. Experimental neurology. vol 188. issue 2. 2004-08-10. PMID:15246838. |
the in vivo equilibrium specific binding of d-threo-[3h]methylphenidate, a radioligand for the dopamine transporter (dat), and +-alpha-[3h]dihydrotetrabenazine, a radioligand for the vesicular monoamine transporter (vmat2), were examined in rat brain with and without prior administration of 5 mg/kg scopolamine. |
2004-08-10 |
2023-08-12 |
rat |
| Maren Carbon, Yilong Ma, Anna Barnes, Vijay Dhawan, Thomas Chaly, Maria Felice Ghilardi, David Eidelber. Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in Parkinsonism. NeuroImage. vol 21. issue 4. 2004-08-06. PMID:15050574. |
all subjects were scanned with [(18)f]fluoropropyl-betacit (fpcit) to measure striatal dopamine transporter (dat) binding and with [(15)o]water to assess activation during a sequence learning task where movements were made to a repeating sequence of eight targets. |
2004-08-06 |
2023-08-12 |
human |
| b' Marko Huotari, J Arturo Garc\\xc3\\xada-Horsman, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. D-amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice. Psychopharmacology. vol 172. issue 1. 2004-08-03. PMID:14574438.' |
further, when comt knockout mice were challenged with l-dopa or a dopamine transporter (dat) inhibitor, an accumulation of dopamine occurred and the neurochemical and locomotor effects of l-dopa and gbr 12909 were modified accordingly. |
2004-08-03 |
2023-08-12 |
mouse |
| Toshihiro Dohi, Shigeo Kitayama, Norimitsu Morioka, Kei Kumagai, Chieko Mitsuhata, Katsuya Morita, Katsuyuki Kozai, Zhicheng Lin, George R Uh. Regulation of dopamine and MPP+ transport by catecholamine transporters. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 2. 2004-07-30. PMID:15164608. |
following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (net) and dopamine transporter (dat) located on the plasma membrane. |
2004-07-30 |
2023-08-12 |
Not clear |
| György Szekeres, Szabolcs Kéri, Anna Juhász, Agnes Rimanóczy, István Szendi, Csongor Czimmer, Zoltán Jank. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 124B. issue 1. 2004-07-28. PMID:14681904. |
role of dopamine d3 receptor (drd3) and dopamine transporter (dat) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. |
2004-07-28 |
2023-08-12 |
Not clear |
| György Szekeres, Szabolcs Kéri, Anna Juhász, Agnes Rimanóczy, István Szendi, Csongor Czimmer, Zoltán Jank. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 124B. issue 1. 2004-07-28. PMID:14681904. |
in this study, we investigated the relationship of the ser9gly (s/g) polymorphism of the dopamine d3 receptor (drd3) and the variable number of tandem repeats (vntr) polymorphism of the dopamine transporter (dat) with therapeutic response to atypical antipsychotics (clozapine, olanzapine, quetiapine, risperidone) and cognitive functions. |
2004-07-28 |
2023-08-12 |
Not clear |
| Frédéric Limosin, Jean-Yves Loze, Claudette Boni, Louis-Philippe Fedeli, Michel Hamon, Frédéric Rouillon, Jean Adès, Philip Gorwoo. The A9 allele of the dopamine transporter gene increases the risk of visual hallucinations during alcohol withdrawal in alcohol-dependent women. Neuroscience letters. vol 362. issue 2. 2004-07-23. PMID:15193761. |
previous studies have found an association between the a9 allele (nine-copy repeat) of the dopamine transporter (dat) gene and two complications of alcohol withdrawal, namely delirium tremens (dt) and alcohol withdrawal seizures (aws). |
2004-07-23 |
2023-08-12 |
Not clear |
| Aina Westrheim Ravna, Ingebrigt Sylte, Svein G Dah. Molecular model of the neural dopamine transporter. Journal of computer-aided molecular design. vol 17. issue 5-6. 2004-07-21. PMID:14635728. |
the dopamine transporter (dat) regulates the action of dopamine by reuptake of the neurotransmitter into presynaptic neurons, and is the main molecular target of amphetamines and cocaine. |
2004-07-21 |
2023-08-12 |
Not clear |
| Li-Bin Li, Nianhang Chen, Sammanda Ramamoorthy, Limen Chi, Xiao-Nan Cui, Lijuan C Wang, Maarten E A Reit. The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. The Journal of biological chemistry. vol 279. issue 20. 2004-07-21. PMID:15024013. |
the present study addressed the role of n-linked glycosylation of the human dopamine transporter (dat) in its function with the help of mutants, in which canonical n-glycosylation sites have been removed (n181q, n181q,n188q, and n181q,n188q,n205q), expressed in human embryonic kidney-293 cells. |
2004-07-21 |
2023-08-12 |
human |
| Li-Bin Li, Nianhang Chen, Sammanda Ramamoorthy, Limen Chi, Xiao-Nan Cui, Lijuan C Wang, Maarten E A Reit. The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. The Journal of biological chemistry. vol 279. issue 20. 2004-07-21. PMID:15024013. |
non-glycosylated dat did not transport dopamine as efficiently as wild-type dat as judged from the sharp reduction in uptake v(max), and prevention of n-glycosylation enhanced the potency of cocaine-like drugs in inhibiting dopamine uptake into intact cells without changing their affinity for dat when measured in membrane preparations prepared from these cells. |
2004-07-21 |
2023-08-12 |
human |
| Richard B Rothman, Michael H Bauman. Monoamine transporters and psychostimulant drugs. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612135. |
we conclude that the brain contains high abundance nonclassical binding sites for cocaine-like drugs that have micromolar affinity for cocaine and that none of the clinically available amphetamine-type appetite suppressants are equipotent substrates for dopamine transporter (dat) and serotonin transporter (sert) proteins. |
2004-07-20 |
2023-08-12 |
Not clear |