| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul W Czoty, Chinnasamy R Ramanathan, Nicole H Mutschler, Alexandros Makriyannis, Jack Bergma. Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15240827. |
injections of 0.3 mg/kg ma from saline, methamphetamine (0.01-0.3 mg/kg), and dopamine transporter (dat) inhibitors, including 1-[2-(bis(4-fluorophenyl)-methoxy)ethyl]-4-(3-phenylpropyl)piperazine (gbr 12909; 1.0-17.8 mg/kg) and its analogs am2502 (1.0-17.8 mg/kg), am2506 (1.0-30.0 mg/kg), am2515 (1.0-17.8 mg/kg), and am2517 (1.0-5.6 mg/kg), produced dose-related increases in responding on the ma-associated lever and, at the highest doses, full substitution. |
2005-01-25 |
2023-08-12 |
monkey |
| Matthew C Willett, Dean E Dluze. Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice. Brain research. vol 1029. issue 2. 2005-01-24. PMID:15542073. |
in experiment 3, we assessed whether these effects of tmx may be exerted upon the dopamine transporter (dat) by coinfusing da (1 microm) in the presence or absence of tmx (100 pg/ml). |
2005-01-24 |
2023-08-12 |
mouse |
| Gene-Jack Wang, Linda Chang, Nora D Volkow, Frank Telang, Jean Logan, Thomas Ernst, Joanna S Fowle. Decreased brain dopaminergic transporters in HIV-associated dementia patients. Brain : a journal of neurology. vol 127. issue Pt 11. 2005-01-18. PMID:15319273. |
therefore, we aimed to assess whether dopamine (da) d2 receptors and transporters (dat) are affected in the basal ganglia of subjects with hiv, and how these changes relate to dementia status. |
2005-01-18 |
2023-08-12 |
human |
| Nichole M Neugebauer, S Tiffany Cunningham, Jun Zhu, Rachel I Bryant, Lisa S Middleton, Linda P Dwoski. Effects of environmental enrichment on behavior and dopamine transporter function in medial prefrontal cortex in adult rats prenatally treated with cocaine. Brain research. Developmental brain research. vol 153. issue 2. 2005-01-13. PMID:15527889. |
the present study determined if environmental enrichment modifies the effects of prenatal cocaine on open field activity, social interaction and dopamine transporter (dat) function in the medial prefrontal cortex (mpfc) in rats. |
2005-01-13 |
2023-08-12 |
rat |
| Kenji Hashimoto, Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Takeharu Kakiuchi, Eiji Shimizu, Masaomi Iy. Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 11. 2005-01-11. PMID:15199373. |
we undertook the present study to determine whether intravenous administration of n-acetyl-l-cysteine (nac), a potent antioxidant drug, could attenuate the reduction of dopamine transporter (dat) in the striatum of monkey brain after administration of map. |
2005-01-11 |
2023-08-12 |
monkey |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |
| R Kurosaki, Y Muramatsu, Y Imai, H Kato, T Arak. Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice. Neurological research. vol 26. issue 6. 2005-01-07. PMID:15327754. |
in our immunohistochemical studies with antibodies against tyrosine hydroxylase (th), microtubule-associated protein 2a, b (map2), dopamine transporter (dat), parvalbumin (pv), glial fibrillary acidic protein (gfap) and cu/zn-superoxide dismutase (cu/zn-sod), the administration of perindopril significantly attenuated mptp-induced substantia nigra and striatal damage. |
2005-01-07 |
2023-08-12 |
mouse |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. Bioorganic & medicinal chemistry letters. vol 14. issue 12. 2005-01-06. PMID:15149693. |
a series of racemic 6-hydroxy and carboalkoxy substituted-4('),4"-difluorobenztropines was synthesized and evaluated for binding at the dopamine (dat), the serotonin (sert), the norepinephrine (net) transporters, and the muscarinic m1 receptor. |
2005-01-06 |
2023-08-12 |
Not clear |
| Jianjing Cao, John R Lever, Theresa Kopajtic, Jonathan L Katz, Anh T Pham, Muhsinah L Holmes, Joseph B Justice, Amy Hauck Newma. Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter. Journal of medicinal chemistry. vol 47. issue 25. 2005-01-06. PMID:15566284. |
potential irreversible ligands were prepared, based on a series of 3-(1-piperazinyl)propyl-n,n-bis(4-fluorophenyl)amines, as molecular probes for the dopamine transporter (dat). |
2005-01-06 |
2023-08-12 |
human |
| F Ivy Carroll, Scott P Runyon, Philip Abraham, Hernan Navarro, Michael J Kuhar, Gerald T Pollard, James L Howar. Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers. Journal of medicinal chemistry. vol 47. issue 25. 2005-01-06. PMID:15566309. |
the 2 beta,3beta-isomer showed the highest affinity for the dopamine transporter (dat), and the 2 beta,3 alpha-isomer showed the next highest affinity. |
2005-01-06 |
2023-08-12 |
mouse |
| Jeffrey C Bemis, Richard F Seega. PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicological sciences : an official journal of the Society of Toxicology. vol 80. issue 2. 2005-01-05. PMID:15115888. |
these reductions may involve inhibition of the dopamine transporter (dat) and the vesicular monoamine transporter (vmat) responsible, respectively, for the uptake of extracellular da and the packaging of nerve terminal cytosolic da into synaptic vesicles. |
2005-01-05 |
2023-08-12 |
rat |
| Tommi Tolmunen, Mikko Joensuu, Pirjo Irmeli Saarinen, Hanna Mussalo, Pasi Ahola, Ritva Vanninen, Jyrki Kuikka, Jari Tiihonen, Johannes Lehtone. Elevated midbrain serotonin transporter availability in mixed mania: a case report. BMC psychiatry. vol 4. 2004-12-30. PMID:15363105. |
results obtained from brain imaging studies indicate that serotonin transporter (sert) and dopamine transporter (dat) densities are altered in major depression. |
2004-12-30 |
2023-08-12 |
Not clear |
| Frederic Bois, Ronald M Baldwin, Nora S Kula, Ross J Baldessarini, Robert B Innis, Gilles Tamagna. Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). Bioorganic & medicinal chemistry letters. vol 14. issue 9. 2004-12-22. PMID:15080991. |
all 3'-substituted compounds displayed affinity for both serotonin (sert) and dopamine (dat), but much less for norepinephrine transporters (net), with selectivity for rat (r) or human (h) sert over net, but only 3'-iodo-substituted phenyltropanes showed selectivity for sert versus dat. |
2004-12-22 |
2023-08-12 |
human |
| Davor Stanic, Wanida Tripanichkul, John Drago, David I Finkelstein, Malcolm K Horn. Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra. Brain research. vol 1023. issue 1. 2004-12-21. PMID:15364022. |
following partial snpc lesions, density of dopamine transporter (dat) immunoreactive (-ir) terminals in the dorsal striatum returned to normal within 16 weeks of injury, suggesting that dopaminergic reinnervation of the striatum was complete. |
2004-12-21 |
2023-08-12 |
rat |
| Nancy R Zahniser, Alexander Sorki. Rapid regulation of the dopamine transporter: role in stimulant addiction? Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464127. |
dopamine (da) and the da transporter (dat) play important roles in psychomotor stimulant behavioral activation and reward. |
2004-12-20 |
2023-08-12 |
rat |
| Michael R Kilbour. Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain. Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219277. |
striatal binding of mph to the dopamine transporter (dat) showed a similar reproducibility over a five year period (dvr=2.17+/-0.39, n=52), again irrespective of radionuclide or sex. |
2004-12-14 |
2023-08-12 |
rat |
| Tomás González-Hernández, Pedro Barroso-Chinea, Ignacio De La Cruz Muros, María Del Mar Pérez-Delgado, Manuel Rodrígue. Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. The Journal of comparative neurology. vol 479. issue 2. 2004-12-13. PMID:15452855. |
numerous studies suggest that the dopamine transporter (dat), responsible for dopamine reuptake, may act as a vulnerability factor in the pathogenesis of parkinson's disease (pd) and the vesicular monoamine transporter (vmat2), responsible for its vesicular storage, as a neuroprotective factor. |
2004-12-13 |
2023-08-12 |
human |
| John R Votaw, Michael G Byas-Smith, Ronald Voll, Raghu Halkar, Mark M Goodma. Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans. Anesthesiology. vol 101. issue 5. 2004-12-06. PMID:15505448. |
isoflurane increases extracellular dopamine concentration and causes trafficking of the dopamine transporter (dat) in transfected cells. |
2004-12-06 |
2023-08-12 |
monkey |
| Victoria Armstrong, Carmela M Reichel, Jonathan F Doti, Cynthia A Crawford, Sanders A McDougal. Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen. European journal of pharmacology. vol 488. issue 1-3. 2004-11-29. PMID:15044042. |
the ability of repeated d-amphetamine (2 mg/kg) treatment to induce behavioral sensitization in rats and alter glial fibrillary acidic protein (gfap), dopamine transporter (dat) and glutamate transporter-1 (glt-1) immunoreactivities was assessed after a 10-day drug abstinence period. |
2004-11-29 |
2023-08-12 |
rat |
| Susan B Powell, Virginia D Lehmann-Masten, Martin P Paulus, Raul R Gainetdinov, Marc G Caron, Mark A Geye. MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. Psychopharmacology. vol 173. issue 3-4. 2004-11-22. PMID:14747902. |
mice lacking the gene for the dopamine transporter (dat) show a unique behavioral phenotype characterized by locomotor hyperactivity and repetitive circling in a novel environment. |
2004-11-22 |
2023-08-12 |
mouse |