| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taleen Hanania, Joshua M Gulley, Danielle O Salaz, Gaynor A Larson, Nancy R Zahnise. Role of the dopamine transporter in the differential cocaine-induced locomotor activation of inbred long-sleep and short-sleep mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15199369. |
the locomotor-stimulant effects of cocaine, mediated through inhibition of the dopamine transporter (dat), can be influenced by environmental factors. |
2004-11-22 |
2023-08-12 |
mouse |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
cocaine conditioned place preference (cpp) is intact in dopamine transporter (dat) knockout (ko) mice and enhanced in serotonin transporter (sert) ko mice. |
2004-11-22 |
2023-08-12 |
mouse |
| Oliver Pogarell, Klaus Tatsch, Georg Juckel, Christine Hamann, Christoph Mulert, Gabriele Pöpperl, Malte Folkerts, Martina Choukèr, Michael Riedel, Michael Zaudig, Hans-Jürgen Möller, Ulrich Heger. Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15292904. |
the loudness dependence (ld) of the n1/p2 component of auditory evoked potentials has been proposed as a noninvasive indicator of central serotonergic function, whereas single photon emission computed tomography (spect) and [123i]beta-cit can be used to visualize both serotonin (sert) and dopamine transporters (dat). |
2004-11-22 |
2023-08-12 |
human |
| G Pöpperl, K Tatsch, E Ruzicka, A Storch, T Gasser, J Schwar. Comparison of alpha-dihydroergocryptine and levodopa monotherapy in Parkinson's disease: assessment of changes in DAT binding with [123I]IPT SPECT. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 8. 2004-11-19. PMID:15254792. |
aim of this pilot study was to compare the effects of monotherapy with the dopamine agonist alpha-dihydroergocryptine (dec) versus monotherapy with levodopa on nigrostriatal dopaminergic neurons as measured with dopamine transporter (dat) spect. |
2004-11-19 |
2023-08-12 |
Not clear |
| Ruth Reeves, Mona Thiruchelvam, Eric K Richfield, Deborah A Cory-Slecht. The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Toxicology and applied pharmacology. vol 200. issue 1. 2004-11-19. PMID:15451308. |
triadimefon (tdf) is a triazole fungicide that acts as an indirect dopamine (da) agonist by binding to the dopamine transporter (dat) and increasing levels of synaptic da. |
2004-11-19 |
2023-08-12 |
mouse |
| b' S\\xc3\\xa1rka Man\\xc3\\xa1kov\\xc3\\xa1, Katja A Puttonen, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. The roles of dopamine transporter and Bcl-2 protein in the protection of CV1-P cells from 6-OHDA-induced toxicity. Toxicology letters. vol 154. issue 1-2. 2004-11-16. PMID:15475185.' |
to test how 6-ohda penetrates into fibroblast cells and affects p53 levels, we investigated the presence of the dopamine transporter (dat) in cv1-p cells. |
2004-11-16 |
2023-08-12 |
monkey |
| Tatyana D Sotnikova, Evgeny A Budygin, Sara R Jones, Linda A Dykstra, Marc G Caron, Raul R Gainetdino. Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447669. |
it is believed that the locomotor-stimulating action of beta-pea, much like amphetamine, depends on its ability to increase extracellular dopamine (da) concentrations owing to reversal of the direction of dopamine transporter (dat)-mediated da transport. |
2004-11-15 |
2023-08-12 |
mouse |
| Rohit Kolhatkar, Charles D Cook, Sujit K Ghorai, Jeffrey Deschamps, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. Journal of medicinal chemistry. vol 47. issue 21. 2004-11-10. PMID:15456254. |
our structure-activity relationship (sar) study on piperidine analogues for monoamine transporters led to the development of a series of 3,6-disubstituted piperidine derivatives, structurally constrained versions of flexible piperidine analogues, with preferential affinity for the dopamine transporter (dat). |
2004-11-10 |
2023-08-12 |
mouse |
| Makoto Kimura, Tomoko Masuda, Koji Yamada, Masaki Mitani, Nobuo Kubota, Nobuyuki Kawakatsu, Kenichi Kishii, Masato Inazu, Yuji Kiuchi, Katsuji Oguchi, Takayuki Namik. Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter. Bioorganic & medicinal chemistry. vol 11. issue 18. 2004-11-09. PMID:12927856. |
the series was evaluated for dopamine transporter (dat) binding affinity with [3h]gbr12935 in rat striatal membranes. |
2004-11-09 |
2023-08-12 |
rat |
| Makoto Kimura, Tomoko Masuda, Koji Yamada, Masaki Mitani, Nobuo Kubota, Nobuyuki Kawakatsu, Kenichi Kishii, Masato Inazu, Yuji Kiuchi, Katsuji Oguchi, Takayuki Namik. Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter. Bioorganic & medicinal chemistry. vol 11. issue 18. 2004-11-09. PMID:12927856. |
most of the compounds showed moderate to high dat binding affinities and some were approximately equivalent in activity to compound 1 or gbr12909 as a dopamine uptake inhibitor, with ic(50) values of nanomolar range. |
2004-11-09 |
2023-08-12 |
rat |
| Hsing-Cheng Liu, Shih-Ku Lin, Shih-Kai Liu, Su-Lien Chen, Chaur-Jong Hu, Jan-Gowth Chang, Sy-Jye Le. DAT polymorphism and diverse clinical manifestations in methamphetamine abusers. Psychiatric genetics. vol 14. issue 1. 2004-11-09. PMID:15091313. |
the dopamine transporter (dat) is the main modulator of map/ap-induced dopamine release and dopamine neurotoxicity, and is also the major regulator of dopamine level in the brain. |
2004-11-09 |
2023-08-12 |
human |
| Ayon Nandi, Christina M Dersch, Manish Kulshrestha, Subramaniam Ananthan, Richard B Rothma. Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter. Synapse (New York, N.Y.). vol 53. issue 3. 2004-11-09. PMID:15236350. |
sori-6238 fully inhibited norepinephrine transporter (net) and dopamine transporter (dat) binding with ic(50) values of 12.1 microm and 5.8 microm, respectively. |
2004-11-09 |
2023-08-12 |
rat |
| Y Nakano, A C Hirko, A D Smith, M Oka, R Dawson, J Peris, N Terada, E M Meye. Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells. Neurochemistry international. vol 45. issue 7. 2004-11-09. PMID:15337306. |
these and other important dopaminergic genes found expressed in these cultures by rt-pcr included nurr1, vesicular monoamine transporter 2 (vmat2), th, dopamine transporter (dat), and glial cell line-derived neurotrophic factor (gdnf) receptors c-ret and gfralpha1. |
2004-11-09 |
2023-08-12 |
mouse |
| Norihiro Harada, Hiroyuki Ohba, Dai Fukumoto, Takeharu Kakiuchi, Hideo Tsukad. Potential of [(18)F]beta-CFT-FE (2beta-carbomethoxy-3beta-(4-fluorophenyl)-8-(2-[(18)F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain. Synapse (New York, N.Y.). vol 54. issue 1. 2004-10-28. PMID:15300883. |
a dopamine transporter (dat) ligand 2beta-carbomethoxy-3beta-(4-fluoro-phenyl)-8-(2-[(18)f]fluoroethyl)nortropane ([(18)f]beta-cft-fe) was synthesized and evaluated in comparison with [(11)c]beta-cft in monkey brain using animal positron emission tomography (pet). |
2004-10-28 |
2023-08-12 |
human |
| Josefina Quirante, Xavier Vila, Josep Bonjoch, Alan P Kozikowski, Kenneth M Johnso. 2,3-disubstituted 6-azabicyclo[3.2.1]octanes as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 12. issue 6. 2004-10-21. PMID:15018911. |
a series of cis and trans 3beta-aryl-2-carbomethoxy-6-azabicyclo[3.2.1]octanes, with different substitution at the para-position of the aryl group, were synthesized and examined for reuptake inhibition at the dopamine transporter (dat). |
2004-10-21 |
2023-08-12 |
Not clear |
| Joshua A Lile, Drake Morgan, Anne M Birmingham, Huw M L Davies, Michael A Nade. Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeys. Psychopharmacology. vol 174. issue 2. 2004-10-19. PMID:14735291. |
high-affinity, slow-onset, long-acting dopamine transporter (dat) inhibitors are being considered as potential agonist replacement therapies for cocaine addiction, and therefore the ability of these drugs to reinstate cocaine seeking and to selectively decrease cocaine-maintained responding should be assessed. |
2004-10-19 |
2023-08-12 |
monkey |
| Chan-Hyung Kim, Min-Seong Koo, Keun-Ah Cheon, Young-Hoon Ryu, Jong-Doo Lee, Hong-Shick Le. Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 12. 2004-10-05. PMID:14513291. |
in the present study, we investigated the dat density of the basal ganglia using iodine-123 labelled n-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ([123i]ipt) single-photon emission tomography (spet) and evaluated the activity of the presynaptic dopamine function in patients with ocd. |
2004-10-05 |
2023-08-12 |
Not clear |
| Chan-Hyung Kim, Min-Seong Koo, Keun-Ah Cheon, Young-Hoon Ryu, Jong-Doo Lee, Hong-Shick Le. Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 12. 2004-10-05. PMID:14513291. |
we performed brain spet 2 h after the intravenous administration of [123i]ipt and carried out both quantitative and qualitative analyses using the obtained spet data, which were reconstructed for the assessment of the specific/non-specific dopamine transporter (dat) binding ratio in the basal ganglia. |
2004-10-05 |
2023-08-12 |
Not clear |
| Manuela Contin, Paolo Martinelli, Mirella Mochi, Fiorenzo Albani, Roberto Riva, Cesa Scaglione, Maurizio Dondi, Stefano Fanti, Cinzia Pettinato, Agostino Baruzz. Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190232. |
to assess the potential association between dopamine transporter (dat) genotype, single photon emission ct (spect) measures using [123i]-n-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane ([123i]-fp-cit) of striatal dopaminergic function, and oral levodopa response pattern in a cohort of patients with parkinson disease. |
2004-09-27 |
2023-08-12 |
Not clear |
| Thomas Chaly, R M Baldwin, John L Neumeyer, Matthew J Hellman, Vijay Dhawan, Pradeep K Garg, Gilles Tamagnan, Julie K Staley, Mohammed S Al-Tikriti, Yankun Hou, Sami S Zoghbi, Xiao Hui Gu, R Zong, David Eidelber. Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-beta-Carbomethoxy-3-beta-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET. Nuclear medicine and biology. vol 31. issue 1. 2004-09-23. PMID:14741577. |
a synthetic procedure for the preparation of [18f]fpcbt, an imaging agent for the dopamine transporter (dat), has been developed. |
2004-09-23 |
2023-08-12 |
human |