| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter C Meltzer, Mark McPhee, Bertha K Madra. Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. Bioorganic & medicinal chemistry letters. vol 13. issue 22. 2004-07-06. PMID:14592523. |
it is therefore likely that the binding site for these compounds on the dat is not the same as that for dopamine. |
2004-07-06 |
2023-08-12 |
rat |
| Kristopher M Kahlig, Jonathan A Javitch, Aurelio Gall. Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier. The Journal of biological chemistry. vol 279. issue 10. 2004-07-06. PMID:14699142. |
dopaminergic neurotransmission is fine-tuned by the rate of removal of dopamine (da) from the extracellular space via the na(+)/cl(-)-dependent da transporter (dat). |
2004-07-06 |
2023-08-12 |
human |
| Evgeny A Budygin, Mark S Brodie, Tatyana D Sotnikova, Yolanda Mateo, Carrie E John, Michel Cyr, Raul R Gainetdinov, Sara R Jone. Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 20. 2004-07-06. PMID:15136721. |
the interaction of amphetamine (amph) with the dopamine (da) transporter (dat) is thought to be critically important for the da-elevating actions of this drug. |
2004-07-06 |
2023-08-12 |
mouse |
| Shupeng Li, Kun Yang Kim, Jong Hun Kim, Jin Hoi Kim, Moon Seok Park, Jong Yoon Bahk, Myeong Ok Ki. Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Neuroscience letters. vol 363. issue 1. 2004-07-06. PMID:15157990. |
previous pharmacokinetics and electrophysiological results indicated an important role of nicotine in the modulation of dopamine transporter (dat). |
2004-07-06 |
2023-08-12 |
rat |
| Deborah Pareto, Albert Cot, Javier Pavía, Carles Falcón, Ignacio Juvells, Francisco Lomeña, Domènec Ro. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging. European journal of nuclear medicine and molecular imaging. vol 30. issue 10. 2004-07-02. PMID:12845485. |
the dopamine transporter (dat) has been shown to be a sensitive indicator of nigrostriatal dopamine function. |
2004-07-02 |
2023-08-12 |
Not clear |
| Kimberly P Lindsey, Kristin M Wilcox, John R Votaw, Mark M Goodman, Christophe Plisson, F Ivy Carroll, Kenner C Rice, Leonard L Howel. Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14982963. |
the dopamine transporter (dat) is a critical recognition site for cocaine and contributes to its significant abuse liability. |
2004-07-01 |
2023-08-12 |
human |
| Kimberly P Lindsey, Kristin M Wilcox, John R Votaw, Mark M Goodman, Christophe Plisson, F Ivy Carroll, Kenner C Rice, Leonard L Howel. Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14982963. |
the drugs studied included a selective dat inhibitor, [1-(2[bis(4-fluorophenyl-) methoxy]ethyl)-4-(3-phenylpropyl)piperazine] bimesylate hydrate (gbr 12909); an inhibitor with equal potency at dopamine and norepinephrine transporters, [3beta-(4-chlorophenyl)tropane-2beta-(3-phenylisoxazol-5-yl)] hcl (rti-177); and a nonselective inhibitor of dopamine, norepinephrinem and serotonin transporters, [(-)-3beta-(3'-methyl-4-chlorophenyl)tropane-2beta-carboxylic acid methyl ester] tartrate (rti-112). |
2004-07-01 |
2023-08-12 |
human |
| R H Segman, T Goltser, U Heresco-Levy, B Finkel, R Shalem, M Schlafman, A Yakir, D Greenberg, R Strous, A Lerner, A Shelevoy, B Lere. Association of dopaminergic and serotonergic genes with tardive dyskinesia in patients with chronic schizophrenia. The pharmacogenomics journal. vol 3. issue 5. 2004-06-29. PMID:14583797. |
we examined three polymorphisms in the dopamine d2 receptor gene (drd2), two sites in the 3' region of the dopamine transporter (dat) gene, two sites in the promoter and coding region of the dopamine d4 (drd4) receptor gene, as well as polymorphic sites in the serotonin 6 receptor gene, the serotonin transporter gene and the tryptophan hydroxylase gene, for association with td susceptibility. |
2004-06-29 |
2023-08-12 |
Not clear |
| Trent J Volz, M Kim, James O Schen. Covalent and noncovalent chemical modifications of arginine residues decrease dopamine transporter activity. Synapse (New York, N.Y.). vol 52. issue 4. 2004-06-24. PMID:15103693. |
rotating disk electrode voltammetry was used to measure dopamine (da) transport in rat striatum and in human embryonic kidney cells expressing the rat dopamine transporter (dat). |
2004-06-24 |
2023-08-12 |
human |
| Anita Sidhu, Christophe Wersinger, Philippe Vernie. alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS letters. vol 565. issue 1-3. 2004-06-23. PMID:15135042. |
here, we review a vital role of alpha-synuclein in the modulation of dopamine transporter (dat) function, and describe how disruption of this modulatory process permits increased re-uptake of high levels of intracellular dopamine by dat, causing profound neurotoxicity. |
2004-06-23 |
2023-08-12 |
Not clear |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
the purpose of this study was to analyze proteins and mrna transcripts of genes involved in dopamine biosynthesis (tyrosine hydroxylase; th) and uptake (dopamine transporter; dat) with regard to time course (7-90 days) after mptp lesioning. |
2004-06-21 |
2023-08-12 |
mouse |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
these results suggest that th and dat may differ in their time course of expression in surviving dopaminergic neurons and may play a role in mediating the return of striatal dopamine. |
2004-06-21 |
2023-08-12 |
mouse |
| Ruth Reeves, Mona Thiruchelvam, Eric K Richfield, Deborah A Cory-Slecht. Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon. Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592684. |
tdf induction/expression of behavioral sensitization was associated with long-term, perhaps permanent modulation of dopaminergic function that included increases in striatal dihydroxyphenylacetic acid (dopac) and da turnover, increases in medial prefrontal cortex (mpfc) dopamine transporter (dat) binding, as well as decreases in da d1 and increases in da d2 and dat receptor binding that appeared to target the nucleus accumbens shell (nas) subregion. |
2004-06-18 |
2023-08-12 |
mouse |
| Anthony J Baucum, Kristi S Rau, Evan L Riddle, Glen R Hanson, Annette E Fleckenstei. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056723. |
multiple high-dose administrations of methamphetamine (meth) both rapidly (within hours) decrease plasmalemmal dopamine (da) uptake and cause long-term deficits in da transporter (dat) levels and other dopaminergic parameters persisting weeks to months in rat striatum. |
2004-06-18 |
2023-08-12 |
rat |
| Michael Byas-Smith, John Votaw, Jian Hua, Ronald Voll, Laurent Martarello, Allan I Levey, Mark Goodma. Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum. Molecular imaging and biology. vol 5. issue 4. 2004-06-15. PMID:14499136. |
8-(2-[18f]fluoroethyl)-2 beta-carbomethoxy-3beta-(4-chlorophenyl)nortropane ([18f]fecnt) is a radiotracer for positron emission tomography (pet) used to trace the location and binding potential (bp) of the dopamine transporter (dat). |
2004-06-15 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Philippe Vernier, Anita Sidh. Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant. Biochemistry. vol 43. issue 5. 2004-06-08. PMID:14756560. |
trypsin increased dopamine uptake in rat primary mesencephalic neurons, suggesting that dat activity is also subjected to modulation by alpha-synuclein in these neurons that endogenously coexpress both proteins. |
2004-06-08 |
2023-08-12 |
human |
| Karen Minzer, Olivia Lee, John J Hong, Harvey S Singe. Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum. Journal of the neurological sciences. vol 219. issue 1-2. 2004-06-04. PMID:15050438. |
samples from caudate, putamen, ventral striatum, and prefrontal cortex (brodmann's area 9, ba9) were analyzed by semiquantitative immunoblotting for relative densities of dopamine receptors (d1, d2), transporter (dat), monoamine terminals (vesicular monoamine transporter type 2), vesicular docking and release proteins (vamp-2, synaptotagmin, snap-25, syntaxin, synaptophysin), and receptors inhibiting dopamine release (alpha 2-adrenergic receptors, alpha-2a). |
2004-06-04 |
2023-08-12 |
human |
| Nianhang Chen, Juan Zhen, Maarten E A Reit. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140185. |
the different psychomotor-stimulant effects of cocaine, gbr12909, and benztropine may partially stem from their different molecular actions on the dopamine transporter (dat). |
2004-06-04 |
2023-08-12 |
Not clear |
| Christer Halldin, Nina Erixon-Lindroth, Stefan Pauli, Yuan-Hwa Chou, Yoshiro Okubo, Per Karlsson, Camilla Lundkvist, Hans Olsson, Denis Guilloteau, Patrick Emond, Lars Fard. [(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain. European journal of nuclear medicine and molecular imaging. vol 30. issue 9. 2004-06-01. PMID:12811422. |
the aim of this study was to explore the potential of a new selective dopamine transporter (dat) compound as a radioligand for positron emission tomography (pet) examination of dat in the human brain. |
2004-06-01 |
2023-08-12 |
human |
| Steven P Presgraves, Tariq Ahmed, Sabine Borwege, Jeffrey N Joyc. Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists. Neurotoxicity research. vol 5. issue 8. 2004-05-25. PMID:15111235. |
we characterized undifferentiated (un) and three differentiation conditions of the sh-sy5y neuroblastoma cell line for phenotypic markers of dopaminergic cells, sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (mpp+), the requirement to utilize the dopamine (da) transporter (dat) for mpp+ toxicity, and the neuroprotective effects of pramipexole. |
2004-05-25 |
2023-08-12 |
mouse |