| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina Romero-Ramos, Jose L Venero, Sonia Garcia-Rodriguez, Antonio Ayala, Alberto Machado, Josefina Can. Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system. Free radical research. vol 37. issue 9. 2004-05-20. PMID:14670008. |
we also studied the mrna levels for tyrosine hydroxylase (th) and the dopamine transporter (dat) by in situ hybridization. |
2004-05-20 |
2023-08-12 |
rat |
| Chin-Chang Huang, Tzu-Chen Yen, Tung-Sheng Shih, Ho-Yuan Chang, Nai-Shin Ch. Dopamine transporter binding study in differentiating carbon disulfide induced parkinsonism from idiopathic parkinsonism. Neurotoxicology. vol 25. issue 3. 2004-05-19. PMID:15019297. |
we performed clinical examinations, and laboratory studies including magnetic resonance imaging (mri) and dopamine transporter (dat) studies with (99m)tc-trodat-1 brain single photon emission computed tomography (spect) in three workers who had long-term exposure to cs(2). |
2004-05-19 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Melanie Banta, Anita Sidh. Comparative analyses of alpha-synuclein expression levels in rat brain tissues and transfected cells. Neuroscience letters. vol 358. issue 2. 2004-05-19. PMID:15026157. |
protein levels of alpha-synuclein, and its binding partner, the dopamine transporter (dat), were examined and semi-quantified in different rat brain regions and compared to the amounts of alpha-synuclein expressed in ltk(-) cells after transfection with known amounts of dna. |
2004-05-19 |
2023-08-12 |
rat |
| Alexander Storch, Yu-I Hwang, Debra A Gearhart, J Warren Beach, Edward J Neafsey, Michael A Collins, Johannes Schwar. Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086525. |
we addressed the importance of the dopamine transporter (dat) for selective dopaminergic toxicity by testing the differential cytotoxicity and cellular uptake of 12 betacs in human embryonic kidney hek-293 cells ectopically expressing the dat gene. |
2004-05-19 |
2023-08-12 |
human |
| Alexander Storch, Yu-I Hwang, Debra A Gearhart, J Warren Beach, Edward J Neafsey, Michael A Collins, Johannes Schwar. Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086525. |
consistently, only 2[n]-methylated betacs were transported into the cell through the dat with up to five times greater k(m) and 12-220 times smaller v(max) values compared with dopamine and mpp(+). |
2004-05-19 |
2023-08-12 |
human |
| Nianhang Chen, Maarten E A Reit. Interaction between dopamine and its transporter: role of intracellular sodium ions and membrane potential. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086531. |
the present study addresses the effect of intracellular na(+) and membrane potential on the binding of dopamine (da) to the dopamine transporter (dat). |
2004-05-19 |
2023-08-12 |
Not clear |
| Yi-Hsin Weng, Tzu-Chen Yen, Min-Chi Chen, Pan-Fu Kao, Kai-Yuan Tzen, Rou-Shayn Chen, Shiaw-Pyng Wey, Gann Ting, Chin-Song L. Sensitivity and specificity of 99mTc-TRODAT-1 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 45. issue 3. 2004-05-13. PMID:15001678. |
the imaging of dopamine transporter (dat) with (99m)tc-trodat-1 ([2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-n2,n2',s2,s2']oxo-[1r-(exo-exo)]-(99m)tc-technetium) and spect has been recently proposed to be a valuable and feasible means of assessment of the integrity of dopamine neurons. |
2004-05-13 |
2023-08-12 |
human |
| M F Salvatore, O Hudspeth, L E Arnold, P E Wilson, J A Stanford, C F MacTutus, R M Booze, G A Gerhard. Prenatal cocaine exposure alters potassium-evoked dopamine release dynamics in rat striatum. Neuroscience. vol 123. issue 2. 2004-05-12. PMID:14698755. |
we also measured total dopamine transporter (dat) and tyrosine hydroxylase protein levels in these offspring by blot immunolabeling and found a small, but significant, decrease in dat protein in striatum from offspring exposed at gd 8-21 and gd 15-21. |
2004-05-12 |
2023-08-12 |
rat |
| M F Salvatore, O Hudspeth, L E Arnold, P E Wilson, J A Stanford, C F MacTutus, R M Booze, G A Gerhard. Prenatal cocaine exposure alters potassium-evoked dopamine release dynamics in rat striatum. Neuroscience. vol 123. issue 2. 2004-05-12. PMID:14698755. |
collectively, these data demonstrate that prenatal cocaine exposure during dopamine neuron neurogenesis has long-lasting effects on da neuron function lasting into early adulthood which may be related in part to steady state dat protein levels. |
2004-05-12 |
2023-08-12 |
rat |
| C Roubert, C Spielewoy, P Soubrié, M Hamon, B Giros, C Betancu. Altered neurotensin mrna expression in mice lacking the dopamine transporter. Neuroscience. vol 123. issue 2. 2004-05-12. PMID:14698760. |
in the present study, we used mice lacking the dopamine transporter (dat) to investigate the consequences of a chronic hyperdopaminergic state on nt gene expression. |
2004-05-12 |
2023-08-12 |
mouse |
| Lifen Xu, Santosh S Kulkarni, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Stacey A Lomenzo, Amy Hauck Newman, Mark L Trudel. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. Journal of medicinal chemistry. vol 47. issue 7. 2004-05-10. PMID:15027858. |
3 beta-aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (dat), serotonin transporter (sert), norepinephrine transporter (net), and muscarinic (m(1)) receptors. |
2004-05-10 |
2023-08-12 |
Not clear |
| Jeffrey N Joyce, T C Der, Lynn Renish, Tracy Osredkar, Diane Hagner, Maria Reploge, Shinichi Sakakibara, Shuichi Ued. Loss of D3 receptors in the zitter mutant rat is not reversed by L-dopa treatment. Experimental neurology. vol 187. issue 1. 2004-05-10. PMID:15081599. |
in control sprague-dawley (sd) and zitter heterozygote (zi/-) rats that do not show a loss of d(3) receptors with vehicle treatment, l-dopa produced no change in d(3) receptor number or in da terminal density as measured by dopamine transporter (dat) binding and tyrosine hydroxylase immunoautoradiography (th-ir). |
2004-05-10 |
2023-08-12 |
rat |
| Keun-Ah Cheon, Young-Hoon Ryu, Kee Namkoong, Chan-Hyung Kim, Jae-Jin Kim, Jong Doo Le. Dopamine transporter density of the basal ganglia assessed with [123I]IPT SPECT in drug-naive children with Tourette's disorder. Psychiatry research. vol 130. issue 1. 2004-05-04. PMID:14972371. |
there is evidence that abnormalities in the dopaminergic system involving the dopamine transporter (dat) are involved in the pathophysiology of tourette's disorder (td) from previous studies using [(123)i]2beta-carbomethoxy-3-(4-iodophenyl)tropane ([(123)i]beta-cit) and single photon emission tomography (spect). |
2004-05-04 |
2023-08-12 |
Not clear |
| Rossella Ventura, Antonio Alcaro, Laura Mandolesi, Stefano Puglisi-Allegr. In vivo evidence that genetic background controls impulse-dependent dopamine release induced by amphetamine in the nucleus accumbens. Journal of neurochemistry. vol 89. issue 2. 2004-05-04. PMID:15056292. |
amphetamine is known to increase dopamine (da) release by acting directly on dopamine transporters (dat), primarily through a mechanism that is independent of impulse flow. |
2004-05-04 |
2023-08-12 |
mouse |
| Vicky Marshall, Donald Grosse. Role of dopamine transporter imaging in routine clinical practice. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 12. 2004-04-28. PMID:14673877. |
functional imaging of the dopamine transporter (dat) defines integrity of the dopaminergic system and has its main clinical application in patients with mild, incomplete, or uncertain parkinsonism. |
2004-04-28 |
2023-08-12 |
Not clear |
| Alasdair M Barr, Virginia Lehmann-Masten, Martin Paulus, Raul R Gainetdinov, Marc G Caron, Mark A Geye. The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14603268. |
mice that display elevated synaptic levels of dopamine due to a genetically engineered deletion of the dopamine transporter (dat) model behavioral deficits that simulate the above conditions. |
2004-04-27 |
2023-08-12 |
mouse |
| Z S Li, T D Pham, H Tamir, J J Chen, M D Gersho. Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 6. 2004-04-26. PMID:14960604. |
surgical ablation of sympathetic nerves by extrinsic denervation of loops of the bowel did not affect dat immunoreactivity but actually increased numbers of th-immunoreactive neurons, expression of mrna encoding th and dat, and enteric dopac (the specific dopamine metabolite). |
2004-04-26 |
2023-08-12 |
mouse |
| Hijiri Watanabe, Yasuko Muramatsu, Rumiko Kurosaki, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai, Tsutomu Arak. Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 2. 2004-04-19. PMID:15013024. |
in the present study, we further examined whether 7-nitroindazole can also protect against the alterations of th-, microtubule-associated protein 2a,b (map2)-, glial fibrillary acidic protein (gfap)-, parvalbumin (pv)-, dopamine transporter (dat)-, nnos- or endothelial nos (enos)-positive cells, in comparison with pargyline as a relatively selective inhibitor of the monoamine oxidase-b (mao-b). |
2004-04-19 |
2023-08-12 |
mouse |
| Andrea Varrone, Elena Salvatore, Giuseppe De Michele, Paolo Barone, Valeria Sansone, Maria Teresa Pellecchia, Imma Castaldo, Giovanni Coppola, Arturo Brunetti, Marco Salvatore, Sabina Pappatà, Alessandro Fill. Reduced striatal [123 I]FP-CIT binding in SCA2 patients without parkinsonism. Annals of neurology. vol 55. issue 3. 2004-04-12. PMID:14991822. |
in this study, dopamine transporter (dat) density with [123 i]fp-cit spect was studied in six sca2 patients with no parkinsonian signs, six parkinson's disease (pd) patients, and six controls. |
2004-04-12 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities. The pharmacogenomics journal. vol 3. issue 3. 2004-04-07. PMID:12815364. |
the human dopamine transporter (dat, slc6a3) is an important 15 exon gene for dopamine neurotransmission and dopamine recycling. |
2004-04-07 |
2023-08-12 |
human |